HAGIWARA Akari 萩原明

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Hagiwara Akari 萩原明

萩原明ハギワラアカリ

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Researcher Number	70402849
Other IDs
Affiliation (Current)	2025: 東京理科大学, 創域理工学部生命生物科学科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京理科大学, 創域理工学部生命生物科学科, 准教授 2021 – 2022: 東京理科大学, 理工学部応用生物科学科, 准教授 2020: 山梨大学, 大学院総合研究部, 准教授 2014 – 2016: 山梨大学, 総合研究部, 講師 2013: 山梨大学, 医学工学総合研究部, 助教 2006: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 61060:Kansei informatics-related / Basic Section 56060:Ophthalmology-related / Basic / Social brain science / Neurophysiology / General neuroscience Except Principal Investigator Basic Section 46010:Neuroscience-general-related / Cell biology
Keywords	Principal Investigator CAST / Cre-loxPシステム / アクティブゾーン / 視細胞動態 / CAST/ELKS欠損 / 網膜変性 / AAV / 視覚機能 / ELKS / 網膜 … More / 異所性局在 / 水平細胞 / 視細胞 / プレシナプス / リボンシナプス / 網膜変性疾患 / ホルモン調節 / 神経回路網 / ネグレクト / ストレス / オキシトシン / 放出制御 / 神経伝達物質 / 養育行動 / シナプス微細構造 / 脳領域特異的ELKS欠損マウス / アクティブゾーン構成蛋白質 / Cre-loxP / 条件付き遺伝子欠損 / 脳機能 / 神経回路 / シナプス … More Except Principal Investigator ELKS / CAST / アクティブゾーン / プロテオミクス / 近位依存性ビオチン標識 / 液―液相分離 / シナプス / Bassoon / 近位依存性ビオチン標識法 / 液-液相分離 / ビオチンリガーゼ / knockout mouse / live imaging / reconstirution / cytoskeleton / nervous system / brain / tissue / cell / protein / biomolecule / 生化学 / 電子顕微鏡 / マススペクトロメトリー / 光退色後蛍光回復法 / ノックアウトマウス / ライブイメージング / 再構成系 / 脳・神経 / 細胞・組織 / 蛋白質 / 生体分子 / GTP / 光退色後蛍光回復 / 拡散障壁 / 膜骨格 / 細胞骨格 Less

cFos依存的な神経活動標識法を応用した痛みと感性の神経動態の解明Principal Investigator
- Principal Investigator
  
  萩原明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 61060:Kansei informatics-related
- Research Institution
  Tokyo University of Science
アクティブゾーン分子複合体の動態制御機構と多様性の理解
- Principal Investigator
  
  大塚稔久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Analysis of the retina degeneration mechanism in the absence of synaptic protein CAST/ELKSPrincipal Investigator
- Principal Investigator
  
  Hagiwara Akari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tokyo University of Science
  University of Yamanashi
Molecular and structural basis and modification mechanisms of the active zones regulating synaptic transmission efficiency
- Principal Investigator
  
  Ohtsuka Toshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Absence of release machinery protein impaired maternal behaviorPrincipal Investigator
- Principal Investigator
  
  HAGIWARA Akari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic / Social brain science
- Research Institution
  University of Yamanashi
Molecular basis analysis for the regulation of presynaptic terminal and neural networkPrincipal Investigator
- Principal Investigator
  
  HAGIWARA Akari
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  University of Yamanashi
Analysis of the mechanism of septin polymerization and depolymerization
- Principal Investigator
  
  KINOSHITA Makoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2016 2007 Other

All Journal Article Presentation

[Journal Article] Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad2023
- Author(s)
  Hagiwara Akari、Mizutani Ayako、Kawamura Saki、Abe Manabu、Hida Yamato、Sakimura Kenji、Ohtsuka Toshihisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 8 Pages: 7251-7251
- DOI
  10.3390/ijms24087251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09769, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-23K23980
[Journal Article] 心・意識を科学する～神経科学2021
- Author(s)
  萩原　明
- Journal Title
  
  理大・科学フォーラム
  
  Volume: 426 Pages: 24-29
- NAID
  40022766007
- Data Source
  KAKENHI-PROJECT-20K09769
[Journal Article] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021
- Author(s)
  Hamada Shun、Nagase Masashi、Yoshizawa Tomohiko、Hagiwara Akari、Isomura Yoshikazu、Watabe Ayako M.、Ohtsuka Toshihisa
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-021-01977-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09769, KAKENHI-PROJECT-20K15936, KAKENHI-PUBLICLY-19H04758, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-19K16299, KAKENHI-PUBLICLY-20H05053, KAKENHI-PROJECT-19H03342, KAKENHI-PROJECT-19H04062, KAKENHI-PROJECT-20H03855, KAKENHI-PROJECT-21K18564, KAKENHI-PROJECT-16H06276
[Journal Article] CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.2020
- Author(s)
  Hagiwara, A., Hamada, S., Hida, Y., Ohtsuka, T.*
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 13-13
- DOI
  10.1186/s13041-020-0557-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams2020
- Author(s)
  Hagiwara, A., Sugiyama, N., Ohtsuka, T.*
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5238-5238
- DOI
  10.1038/s41598-020-62072-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H03324
[Journal Article] Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of ・-synuclein2007
- Author(s)
  Ihara M, Yamasaki N, Hagiwara A, Tomimoto H, Kitano A, Tanigaki A
- Journal Title
  
  Neuron 53(3)
  
  Pages: 519-533
- Data Source
  KAKENHI-PROJECT-18370077
[Journal Article] Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of a-synuclein neurotoxicity2007
- Author(s)
  Ihara, M., Yamasaki, N., Hagiwara, A., Tomimoto, H., Kitano, A., Tanigaki, A., Hikawa, E., Noda, M., Takanashi, M., Mori, H., Hattori, N., Miyakawa,T., Kinoshita, M
- Journal Title
  
  Neuron 53
  
  Pages: 519-533
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370077
[Presentation] Depletion of LKB1 at cerebellar synapses causes progressive locomotion dysfunction linked to the reduced neuromuscular transmission.2023
- Author(s)
  Sota Sawada, Ryo Kozawa, Masataka Yamamoto, Yuhei Mizunoe, Ryo Goitsuka, Toshihisa Ohtsuka, Hiroshi Takemura, and Akari Hagiwara.
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] 水平細胞及び視細胞シナプス形成における水平細胞LKB1の作用機序の解析2022
- Author(s)
  川村早紀、萩原明
- Organizer
  パラレル脳センシング技術研究部門第2回　公開シンポジウム
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] シナプス足場タンパク質CAST欠損マウスの網膜形態解析2022
- Author(s)
  水谷紋子、萩原明
- Organizer
  パラレル脳センシング技術研究部門第2回　公開シンポジウム
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] Depletion of LKB1 in the cerebellar granule cells induces locomotor dysfunction in aged mice.2022
- Author(s)
  Mayu Kitamura, Akari Hagiwara, Shun Hamada, and Toshihisa Ohtsuka
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] 網膜・視細胞シナプスの形成における水平細胞LKB1の作用機序の解析2022
- Author(s)
  川村早紀、飛田耶馬人、大塚稔久、萩原明
- Organizer
  日本顕微鏡学会
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] Morphological examination of the role of LKB1 in retinal horizontal cell remodeling using the AAV-based labeling system2022
- Author(s)
  Saki Kawamura, Toshihisa Ohtsuka, Yamato Hida, Akari Hagiwara
- Organizer
  第４５回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23980
[Presentation] Morphological examination of the role of LKB1 in retinal horizontal cell remodeling using the AAV-based labeling system2022
- Author(s)
  Saki Kawamura, Yamato Hida, Toshihisa Ohtsuka, and Akari Hagiwara
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] AAV標識システムを用いた LKB1の網膜水平細胞リモデリングに関する形態学的検討2022
- Author(s)
  川村早紀、大塚稔久、飛田耶馬人、萩原明
- Organizer
  Neuro2022（第45回日本神経科学大会)
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] Retinal morphology analysis of mice deficient in synaptic scaffolding protein CAST2022
- Author(s)
  水谷紋子、飛田耶馬人、大塚稔久、萩原明
- Organizer
  日本顕微鏡学会
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] Liver Kinase B1を欠損させた網膜水平細胞の形態解析2021
- Author(s)
  川村早紀、萩原明
- Organizer
  東京理科大・パラレル脳センシング・公開シンポジウム
- Data Source
  KAKENHI-PROJECT-20K09769
[Presentation] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021
- Author(s)
  Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu　Isomura, Ayako M. Watabe, and Toshihisa Ohtsuka
- Organizer
  第44回日本神経科学大会（CJK第１回国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03324
[Presentation] 養育行動に関連する神経伝達・作用機序の探索2016
- Author(s)
  Akari Hagiwara, Naoko Sugiyama, Toshihisa Ohtsuka
- Organizer
  日本神経科学学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K12774
[Presentation] 養育行動に関連する神経伝達・作用機序の探索2016
- Author(s)
  Akari Hagiwara, Naoko Sugiyama, and Toshihisa Ohtsuka
- Organizer
  日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K12774
[Presentation] 網膜における異所性シナプスの形成に対するアクティブゾーン構成タンパク質CAST/ELKSの作用機序
- Author(s)
  Akari Hagiwara, Manabu Abe, Wataru Kakegawa, Yamato Hida, Takahisa Furukawa, Michisuke Yuzaki, Kenji Sakimura, and Toshihisa Ohtsuka
- Organizer
  第120回日本解剖学会総会・全国学術集会
- Place of Presentation
  神戸国際会議場　(兵庫県神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25830008
[Presentation] アクティブゾーン構成タンパク質CASTおよびELKSの網膜におけるシナプス構造とその機能に対する作用
- Author(s)
  Akari Hagiwara, Manabu Abe, Yamato Hida, Naoko Sugiyama, Kei Moriya, Takahisa Furukawa, Kenji Sakimura, and Toshihisa Ohtsuka
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜　(神奈川県横浜市）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25830008

1. Ohtsuka Toshihisa (40401806)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. KINOSHITA Makoto (30273460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HAGIWARA Akari 萩原 明

Hagiwara Akari 萩原 明

萩原 明 ハギワラ アカリ

Research Projects

Research Products

Co-Researchers

cFos依存的な神経活動標識法を応用した痛みと感性の神経動態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アクティブゾーン分子複合体の動態制御機構と多様性の理解

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the retina degeneration mechanism in the absence of synaptic protein CAST/ELKSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular and structural basis and modification mechanisms of the active zones regulating synaptic transmission efficiency

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Absence of release machinery protein impaired maternal behaviorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis analysis for the regulation of presynaptic terminal and neural networkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism of septin polymerization and depolymerization

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 心・意識を科学する～神経科学2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of ・-synuclein2007

Author(s)

Journal Title

Data Source

[Journal Article] Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of a-synuclein neurotoxicity2007

Author(s)

Journal Title

HAGIWARA Akari 萩原明

Hagiwara Akari 萩原明

萩原明ハギワラアカリ