MAENO Koichiro 前野耕一郎

Researcher Number	70403269
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2018: 神戸大学, 医学研究科, 医学研究員 2016: 神戸大学, 医学研究科, 助教 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 助教 2014: 神戸大学, 医学研究科, 助教 2010 – 2012: 神戸大学, 医学研究科, 助教 … More 2011: 神戸大学, 大学院・医学研究科, 助教 2008 – 2009: 神戸大学, 医学部附属病院, 助教 2008: Kobe University, 医学部・附属病院, 助教 2007: Kobe University, 医学部・附属病院, 医員 2006 – 2007: 神戸大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Medical systems / Orthopaedic surgery / Medical systems
Keywords	Principal Investigator Fas / 椎間板 / FasL / 椎間板変性 / 炎症性サイトカイン / アポトーシス / シグナル伝達 / Rictor / mTORC1阻害薬 / セネッセンス … More / オートファジー / siRNA / Raptor / mTOR / reverse signaling / 共培養 / 脊索由来細胞 / 創外固定型モデル / 抗炎症作用 / 硬膜外脂肪組織 / 変性 / 硬膜外脂肪 / adiponectin / マクロファージ / ADAM10 / Fas ligand / 脊椎脊髄病学 / 過剰発現 / RNA干渉 / ヒト椎間板不死化細胞株 / 再生医学 / 遺伝子 / VEGFR / VEGF / 血管新生 / MRI / MMP-3 / イリザロフ型創外固定器 / 椎間板変性モデル … More Except Principal Investigator 椎間板変性 / 椎間板 / 腰痛 / 棘突起間スペーサー / 腰部脊柱管狭窄症 / 低侵襲治療システム / 変性 / 低侵襲治療 / 椎間板ヘルニア / RNA干渉 / 遺伝子治療 / Raptor / mTOR経路 / 免疫特権 / オートファジー / 低侵襲脊椎手術 / 低侵襲手術システム / 固定術 / 脊椎疾患 / 動物モデル / 腰部脊柱管狭窄 / 椎間板組織 / integrinα５β１ / メカノレセプター / 抗老化 / なし / マクロファージ / 神経障害性疼痛 / 侵害受容性疼痛 / 高齢者医療 / 低侵襲手術 / 頸椎症性脊髄症 / Fas ligand / 退行性脊椎疾患 / 臨床 / 老化 / in vivo研究 / 硬膜外圧測定 / 大型動物(ブタ)モデル / 最小侵襲手術 / 経皮的手術 / Fas-L / 遺伝予治療 / Fas-Ligand / 蛋白分解酵素 / 再生医療 / 超音波 Less

The approach of molecular treatments for the intervertebral disc degeneration.Principal Investigator
- Principal Investigator
  
  Maeno Koichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system
- Principal Investigator
  
  Nishida Kotaro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
The pathomechanism of nociceptive pain and neuropathic pain in herniated disc disease
- Principal Investigator
  
  TAKADA Toru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
The clarify of the pain generating mechanism derived from the intervertebral disc degeneration.Principal Investigator
- Principal Investigator
  
  MAENO Koichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
application of mechanoreceptors for the care of intervertebral disc degeneration
- Principal Investigator
  
  DOITA Minoru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
The clarify of the signal transduction which induces the apoptosis of nucleus proposes cellsPrincipal Investigator
- Principal Investigator
  
  MAENO Koichiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
Patho-mechanism ofdegenerated disc disorders of lumbar spine and development of the minimally invasive treatment system
- Principal Investigator
  
  NISHIDA Kotaro
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
頚椎症性脊髄症に対する低侵襲手術システムの開発
- Principal Investigator
  
  西田康太郎
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
The analysis of intervertebral disc degeneration mechanismPrincipal Investigator
- Principal Investigator
  
  MAENO Koichiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
Development of minimally invasive system for surgical treatment of lumbar spinal-canal stenosis
- Principal Investigator
  
  NISHIDA Kotaro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
Development of minimally invasive system for treatment of low back pain using therapeutic gene
- Principal Investigator
  
  DOITA Minoru (MINORU Minoru)
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
椎間板変性メカニズムの解析Principal Investigator
- Principal Investigator
  
  前野耕一郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Gene Therapy Applications. Kang C (Ed) Captor 8: Potential gene therapy for intervertebral disc degeneration
- Author(s)
  Nishida K, Maeno K, Kakutani K, Yurube T, Kurosaka M
- Publisher
  Intech, Croatia
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Miyazaki S, Kuroda R, Nishida K.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: 25 Issue: 12 Pages: 2134-2146
- DOI
  10.1016/j.joca.2017.08.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03033, KAKENHI-PROJECT-15K10406, KAKENHI-PROJECT-16K20051
[Journal Article] A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.2014
- Author(s)
  Hirata H, Yurube T, Kakutani K, Maeno K, Takada T, Yamamoto J, Kurakawa T, Akisue T, Kuroda R, Kurosaka M, Nishida K.
- Journal Title
  
  J Orthop Res
  
  Volume: 32 Issue: 3 Pages: 455-63
- DOI
  10.1002/jor.22533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592195, KAKENHI-PROJECT-24592196
[Journal Article] Functional Impact of Integrin alpha5beta1 on the Homeostasis of Intervertebral Discs: A Study of Mechanotransduction Pathways Using a Novel Dynamic Loading Organ Culture System2014
- Author(s)
  Kurakawa, T.Kakutani, K.Morita, Y.　Kato, Y.Yurube, T.Ｈirata, H.　Miyazaki, S.　Terashima, Y.Maeno, K　Takada, T.　Doita, M.　Kurosaka, M.　Inoue, N.　Masuda, K.　Nishida, K.　　.
- Journal Title
  
  Spine J
  
  Volume: 15 Issue: 3 Pages: 417-26
- DOI
  10.1016/j.spinee.2014.12.143
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592197
[Journal Article] Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells2013
- Author(s)
  Yamamoto J
- Journal Title
  
  J Orthop Res
  
  Volume: 31(4) Issue: 4 Pages: 608-15
- DOI
  10.1002/jor.22274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189, KAKENHI-PROJECT-24592196
[Journal Article] Intervertebral disc and macrophage interaction induce mechanical hyperalgesia and cytokine production in a herniated disc model.2012
- Author(s)
  Takada T, Nishida K, Maeno K, Kakutani K, Yurube T, Doita M, Kurosaka M
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64(8) Pages: 2601-2610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] Development of percutaneously insertable/removable interspinous process spacer for treatment of posture-dependent lumbar spinal-canal stenosis: preclinical feasibility study using porcine model2012
- Author(s)
  Nishida K, Doita M, Kakutani K, Maeno K, Yurube T, Kurosaka M
- Journal Title
  
  Eur Spine J
  
  Volume: 21(6) Pages: 1178-1185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloprote inases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.2012
- Author(s)
  Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] Modified house-keeping gene expression in a rat tail compression loading-induced disc degeneration model.2011
- Author(s)
  Yurube T, Takada T, Hirata H, Kakutani K, Maeno K, Zhang Z, Yamamoto J, Doita M, Kurosaka M, Nishida K
- Journal Title
  
  J Orthop Res
  
  Volume: 29(8) Pages: 1284-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model.2010
- Author(s)
  Yurube T, Nishida K,Suzuki T, Kaneyama S, Zhang Z, Kakutani K, MaenoK, Takada T, Fujii M, Kurosaka M, Doita M
- Journal Title
  
  J Orthop Res
  
  Volume: 28(8) Pages: 1026-1032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300189
[Journal Article] A prospective clinical evaluation of the posterior lumbar surgery in our hospital using JOA Back Pain Evaluation Questionnaire(JOABPEQ)2009
- Author(s)
  Maeno K, et al
- Journal Title
  
  J Jpn Society Spine Surg Related Research 20
  
  Pages: 713-717
- NAID
  10027504962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] Prolonged down regulation of specific gene expression in nucleus pulposus cells mediated by RNA interference in vitro2009
- Author(s)
  Kakutani K, Nishida K, Uno K, Takada T, Shimomura T, Maeno K, Kurosaka M, Doita M.
- Journal Title
  
  J Orthop Res 24
  
  Pages: 1271-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] Gene therapy approach for disc degeneration and associated spinal disorders2009
- Author(s)
  Nishida K, Suzuki T, Kakutani K, YurubeT, Maeno K, Kurosaka M, Doita M.
- Journal Title
  
  Eur Spine J 17
  
  Pages: 459-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] Sustained long term RNA interference in nucleus pulposus cells in vivo mediated by unmodified small interfering RNA2009
- Author(s)
  Suzuki T, Nishida K, Kakutani K, Maeno K, Yurube T, Takada T, Kurosaka M, Doita M.
- Journal Title
  
  Eur Spine J 18
  
  Pages: 263-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration2009
- Author(s)
  Kaneyama S, Nishida K, Takada T, Suzuki T, Shimomura T, Maeno K, Kurosaka M, Doita M.
- Journal Title
  
  J Orthop Science 13
  
  Pages: 130-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] 腰椎変性疾患に対する分子生物学的狭窄症治療の応用の可能性2008
- Author(s)
  西田康太郎, 土井田稔, 下村隆敏, 前野耕一郎, 他2名
- Journal Title
  
  脊椎脊髄ジャーナル 21巻4号
  
  Pages: 309-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300169
[Journal Article] 椎間板の免疫特権と腰痛との関係2008
- Author(s)
  西田康太郎、前野耕一郎、土井田稔, 他3名
- Journal Title
  
  日本腰痛学会雑誌 14(1)
  
  Pages: 50-57
- Data Source
  KAKENHI-PROJECT-18300169
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス・セネッセンスを誘導するが、細胞外基質代謝への影響は少ない2018
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K.
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] 椎間板髄核におけるオートファジーの重要性とその脊索表現型保持への関与の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田徹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its possible contribution to the maintenance of notochordal cell homeostasis2017
- Author(s)
  Takashi Yurube, Hiroaki Hirata, Masaaki Ito, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Shingo Miyazaki, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる。2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] 脊椎椎間板変性へのオートファジーの関与とその脊索由来細胞における恒常性維持機構の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田　徹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる。2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor in human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Ito M, Takeoka Y, Terashima Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORC1阻害薬テムシロリムスはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第36回運動器移植再生医学研究会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence, resulting in reduced cellularity, in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田　徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017
- Author(s)
  Masaaki Ito, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] ヒト椎間板髄核臍傍におけるmTOR阻害薬の細胞死、細胞老化、細胞外基質分解抑止効果の比較。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Selective mTORC1 inhibition through RNA interference for RAPTOR is protective against human intervertebral disc cellular apoptosis, senescence, and extracellular matrix degradation with Akt and autophagy induction.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor for protecting human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Takeoka Y, Ito M, Kakutani K, Maeno K, Takada T, Terashima Y, Kuroda R, Nishida K.
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor in human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Ito M, Takeoka Y, Terashima Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  8th Annual Meeting of Cervical Spine Research Society -Asia Pacific Section-
- Place of Presentation
  Kobe (JAPAN)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  8th Annual Meeting of Cervical Spine Research Society -Asia Pacific Section-
- Place of Presentation
  Kobe (JAPAN)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORC1阻害薬テムシロリスムはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction.2016
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kakiuchi Y, Kurosaka M, Nishida K.
- Organizer
  43th Annual Meeting of the International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore (SINGAPORE)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction.2016
- Author(s)
  Ito M, Yurube T, Maeno K, et.al.,
- Organizer
  The 43rd annual meeting of International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し，ヒト椎間板細胞における細胞死，細胞老化と細胞外基質分解を抑制する：　椎間板遺伝子治療の可能性2016
- Author(s)
  伊藤雅明, 由留部崇, 角谷賢一朗, 前野耕一郎, 高田徹, 寺嶋良樹, 垣内裕司, 武岡由樹, 黒田良祐, 西田康太郎
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県博多市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はAktの活性化およびオートファジーを誘導し、ヒト椎間板における細胞死、老化と細胞外基質分解を抑制する。2016
- Author(s)
  伊藤雅明, 由留部崇, 角谷　賢一朗, 前野耕一郎, 高田徹, 宮崎　真吾, 寺嶋良樹, 垣内裕司, 黒坂昌弘, 西田康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Intervertebral disc nucleus pulposus has intensive involvement of autophagy compared to other musculoskeletal tissues and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T., Hirata H., Ito M., Kakiuchi Y., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  to M., Yurube T., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kakiuchi Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する：オートファジー制御による椎間板変性予防の可能性2016
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] mTORシグナル経路への選択的な干渉はAktの活性化およびオートファジーを誘導し、ヒト椎間板における細胞死・老化と細胞外基質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、前野耕一郎ほか
- Organizer
  第45回日本脊椎脊髄病学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、老化と細胞外気質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、垣内裕司、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目指した棘突起間スペーサーの開発2016
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部　崇、高田　徹、伊藤雅明、寺嶋良樹、垣内裕司、武岡由樹
- Organizer
  第２４回　日本腰痛学会
- Place of Presentation
  山梨
- Year and Date
  2016-09-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 神戸大式棘突起間スペーサーの開発2015
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部崇
- Organizer
  第１４回　関西MISt 研究会
- Place of Presentation
  大阪
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] The Functional Integrin α5β1 Mechanotransduction in Rat Intervertebral Discs under Dynamic Loading.2014
- Author(s)
  Kurakawa T, Kakutani K, Morita Y, Yurube T, Takada T, Maeno K, Doita M, Kurosaka M, Masuda K, Inoue N, Nishida K
- Organizer
  The 60th Annual meeting of the Orthopaedic Research Society (ORS)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] The role of α5β1 integrin in the mechanically initiated intervertebral disc degeneration.2013
- Author(s)
  Kurakawa T. Kakutani K., Morita Y., Takada T. Maeno K. Yurube T. Zhang Z. Yamamoto J., Hirata H., Doita M., Kurosaka M., Nishida K.
- Organizer
  米国整形外科学会
- Place of Presentation
  米国
- Data Source
  KAKENHI-PROJECT-24592197
[Presentation] M1 MACROPHAGE EXISTS IN THE NON-HERNIATED DEGENERATIVE DISC.2013
- Author(s)
  T. Takada, K. Maeno, K. Kakutani, T. Yurube, J. Yamamoto, H. Hirata, T. Kurakawa, S. Miyazaki, M. Kurosaka, K. Nishida
- Organizer
  2013 The International Society for Study of the Lumbar Spine
- Place of Presentation
  Scottsdale　USA
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] Fas Ligand on Human Nucleus Pulposus Cells Plays an Important Role in the Production of Pro-inflammatory Cytokines.2013
- Author(s)
  Yamamoto J, Maeno K, Takada T, Kakutani K, Yurube T, Zhang Z, Hirata H, Kurakawa T, Miyazaki S, Sakai D, Mochida J, Doita M, Kurosaka M, Nishida K.
- Organizer
  The 59th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] 非ヘルニア変性椎間板には古典的活性化(M1)マクロファージが存在する2013
- Author(s)
  高田徹、前野耕一郎、角谷賢一朗、張　鍾穎、由留部　崇、山本潤哉、平田裕亮、蔵川拓外、宮崎真吾、土井田　稔、黒坂　昌弘、西田　康太郎
- Organizer
  第42回脊椎脊髄病学会
- Place of Presentation
  沖縄　コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] Loss of notochordal cells triggers extracellular matrix degradation.2013
- Author(s)
  Hirata H, Yurube T, Kakutani K, Maeno K, Takada T, Yamamoto J, Kurakawa T, Miyazaki S, Kurosaka M, Nishida K
- Organizer
  The 41th Annual meetnig of the International society for the Study of the Lumbar Spine (ISSLS)
- Place of Presentation
  Scottsdale, USA
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] Fas-Ligand plays an Important Role in the Production of Pro-inflammatory Cytokines in the Human Nucleus Pulposus Cells2012
- Author(s)
  山本潤哉、前野耕一郎
- Organizer
  第58回米国整形外科研究会議(ORS)
- Place of Presentation
  USA, San Francisco
- Data Source
  KAKENHI-PROJECT-22791380
[Presentation] Fas-Ligand plays an important role in the production of pro-inflammatory cytokines in human nucleus pulposus cells2012
- Author(s)
  山本潤哉、前野耕一郎
- Organizer
  第58回米国整形外科研究会議(ORS)
- Place of Presentation
  USA, San Francisco
- Data Source
  KAKENHI-PROJECT-22791380
[Presentation] 椎間板ヘルニアにおける炎症性反応には髄核細胞に発現するFas ligandが関与する.-椎間板ヘルニアの疼痛発生機序解明に向けて-2012
- Author(s)
  山本潤哉、前野耕一郎
- Organizer
  第41回日本脊椎脊髄病学会学術集会
- Place of Presentation
  久留米
- Data Source
  KAKENHI-PROJECT-22791380
[Presentation] 共培養モデルを用いた椎間板ヘルニアにおける疼痛発生機序の検討2012
- Author(s)
  山本潤哉、前野耕一郎、高田徹、角谷賢一朗、由留部崇、張鍾穎、平田裕亮、蔵川拓外、酒井大輔、持田譲治、土井田稔、黒坂昌弘、西田康太郎
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] Biologic Responses of Rat Intervertebral Discs to mechanical load using dynamic organ culture system2012
- Author(s)
  Kurakawa T. Kakutani K., Morita Y., Takada T. Maeno K. Yurube T. Zhang Z. Yamamoto J., Hirata H., Doita M., Kurosaka M., Nishida K.
- Organizer
  国際腰椎学会
- Place of Presentation
  オランダ
- Data Source
  KAKENHI-PROJECT-24592197
[Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目的とした腰椎棘突起間スペーサーの開発 -ヒト屍体と大型動物を用いた前臨床研究-2011
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部崇、張鐘穎、山本潤哉、平田裕亮、黒坂昌弘
- Organizer
  第40回日本脊椎脊髄病学会(震災のため Web 開催)
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] ヒト椎間板髄核細胞においてFas ligandは炎症性サイトカイン産生に関与する2011
- Author(s)
  山本潤哉、前野耕一郎
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-22791380
[Presentation] 頚髄症に対する単純MRI, Kinematic MRI, Myelographyを用いた狭窄高位の評価Myelographyは必要か?2011
- Author(s)
  前野耕一郎, 他
- Organizer
  日本脊椎脊髄病学会
- Place of Presentation
  (震災のためWeb開催)
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21650128
[Presentation] Fas-Ligand plays an important role in the production of pro-inflammatory cytokines in human nucleus pulposus cells2011
- Author(s)
  山本潤哉、前野耕一郎
- Organizer
  第38回国際腰痛研究学会議(ISSLS)
- Place of Presentation
  Sweden, Gothenburg
- Data Source
  KAKENHI-PROJECT-22791380
[Presentation] Actin-beta should not be used as an endogenous control in real-time RT-PCR for intervertebral disc research under mechanical loading stress condition2010
- Author(s)
  Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
- Organizer
  37th International Society for the Study of the Lumbar Spine (ISSLS)
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] Activated apoptotic mitochondrial pathway in a rat tail compression loading-induced disc degeneration model2010
- Author(s)
  Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
- Organizer
  37th ISSLS
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] Imbalanced catabolic relative to anabolic gene alterations in a rat tail compression loading-induced disc degeneration model.2010
- Author(s)
  Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
- Organizer
  37th ISSLS
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] Development of a novel percutaneously insertable/removable interspinous process spacer for treatment of LSS patients: feasibility study using porcine model.2010
- Author(s)
  Nishida K, Doita M, Maeno K, Kakutani K, Yurube T, Zhang Z, Yamamoto J, Iguchi T, Kurosaka M
- Organizer
  37th ISSLS
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] Activated mitochondrial pathway of apoptosis in a rat tail compression loading-induced disc degeneration model2010
- Author(s)
  Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
- Organizer
  56th ORS
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] Imbalanced catabolic and anabolic gene alterations in a rat tail compression loading-induced disc degeneration model2010
- Author(s)
  Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
- Organizer
  56th Orthopaedic Research Society(ORS)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21300189
[Presentation] 基質代謝関連遺伝子の発現変動からみた椎間板静的圧迫モデルを用いた長期の検討-2009
- Author(s)
  由留部崇、西田康太郎、前野耕一郎、土井田稔, 他6名
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18300169
[Presentation] in vivo椎間板へのrna干渉を用いた内因性期間の発現抑制の試み2009
- Author(s)
  鈴木哲平、西田康太郎、前野耕一郎、土井田稔, 他2名
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18300169
[Presentation] 持続的な圧負荷は椎間板髄核における異的に増大させる-ラット尾椎椎間板変性モデルを用いた椎間板変性機序の解明-2009
- Author(s)
  由留部崇、西田康太郎、前野耕一郎、土井田稔, 他5名
- Organizer
  第38回日本脊椎脊髄病学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18300169
[Presentation] 椎間板細胞に対するadiponectinの抗炎症効果
- Author(s)
  寺嶋良樹、前野耕一郎
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] 椎間板動的圧迫負荷による脊索由来髄核細胞の変化
- Author(s)
  蔵川　拓外*、角谷　賢一朗*、森田　有亮、加藤　優喜、寺嶋　良樹*、宮崎　真吾*、平田　裕亮*、由留部　崇*、髙田　徹*、前野　耕一郎*、土井田　稔、舛田　浩一、井上　望、黒坂　昌弘*、西田　康太郎*
- Organizer
  第43回日本脊椎脊髄病学会
- Place of Presentation
  神戸
- Year and Date
  2014-04-17 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-24592197
[Presentation] The expression of Adiponectin Receptor 1 and 2 of rat intervertebral disc cells.
- Author(s)
  Yoshiki Terashima, Koichiro Maeno
- Organizer
  61st Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-24592196
[Presentation] M1 MACROPHAGE EXISTS IN THE DEGENERATIVE DISC
- Author(s)
  T. Takada, K. Maeno, K. Kakutani, T. Yurube, H. Hirata, T. Kurakawa, S. Miyazaki, Y. Terashima, M Doita, M. Kurosaka, K. Nishida
- Organizer
  International Society for the study of Lumbar Spine
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-06-03 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24592195
[Presentation] 動的圧迫負荷による脊索由来椎間板髄核細胞の変化
- Author(s)
  蔵川　拓外*、角谷　賢一朗*、森田　有亮、加藤　優喜、寺嶋　良樹*、宮崎　真吾*、平田　裕亮*、由留部　崇*、前野　耕一郎*、髙田　徹*、舛田　浩一、井上　望、黒坂　昌弘*、西田　康太郎*
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592197
[Presentation] Integrin alpha5/beta1 mechanotransduction is involved with notochordal-cell disappearance in early intervertebral disc degeneration.
- Author(s)
  "Takuto Kurakawa*, Kenichiro Kakutani*, Yusuke Morita, Yuki　Kato, Yoshiki Terashima*, Shingo Miyazaki*, Hiroaki Hirata*, Takashi Yurube*, Toru Takada*, Koichiro Maeno*, Masahiro Kurosaka*, Koichi Masuda, Nozomu Inoue, Kotaro Nishida*
- Organizer
  41st Annual Meeting of the International Society for the Study of the Lumber Spine
- Place of Presentation
  韓国（ソウル）
- Year and Date
  2014-06-03 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24592197
[Presentation] 脊椎変性疾患の変性椎間板にはM1マクロファージが存在する
- Author(s)
  高田　徹、前野　耕一郎、角谷　賢一朗、由留部　崇、平田　裕亮、蔵川　拓外、宮崎　真吾　寺嶋　良樹
- Organizer
  第４３回脊椎脊髄病学会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-04-17 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-24592195

1. NISHIDA Kotaro (00379372)

# of Collaborated Projects: 10 results

# of Collaborated Products: 65 results
2. KAKUTANI Kenichiro (10533739)

# of Collaborated Projects: 8 results

# of Collaborated Products: 57 results
3. DOITA Minoru (60237170)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
4. TAKADA Toru (00598526)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 下村隆敏 (50403267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 由留部崇 (10514648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
7. YAMAMOTO Junya

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. TERASHIMA Yoshiki

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
9. HIRATA Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KURAKAWA Takuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. Miyazaki Shingo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. Ito Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
13. Takeoka Yoshiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
14. Kakiuti Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

MAENO Koichiro 前野 耕一郎

Research Projects

Research Products

Co-Researchers

The approach of molecular treatments for the intervertebral disc degeneration.Principal Investigator

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Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system

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The pathomechanism of nociceptive pain and neuropathic pain in herniated disc disease

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The clarify of the pain generating mechanism derived from the intervertebral disc degeneration.Principal Investigator

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application of mechanoreceptors for the care of intervertebral disc degeneration

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The clarify of the signal transduction which induces the apoptosis of nucleus proposes cellsPrincipal Investigator

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Patho-mechanism ofdegenerated disc disorders of lumbar spine and development of the minimally invasive treatment system

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頚椎症性脊髄症に対する低侵襲手術システムの開発

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The analysis of intervertebral disc degeneration mechanismPrincipal Investigator

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Development of minimally invasive system for surgical treatment of lumbar spinal-canal stenosis

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Development of minimally invasive system for treatment of low back pain using therapeutic gene

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椎間板変性メカニズムの解析Principal Investigator

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[Book] Gene Therapy Applications. Kang C (Ed) Captor 8: Potential gene therapy for intervertebral disc degeneration

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MAENO Koichiro 前野耕一郎