Tomihara Kei 冨原圭

… Alternative Names

TOMIHARA Kei 冨原圭

冨原圭トミハラケイ

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Researcher Number	70404738
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学系, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 新潟大学, 医歯学系, 教授 2019 – 2021: 富山大学, 学術研究部医学系, 准教授 2017 – 2018: 富山大学, 大学院医学薬学研究部(医学), 准教授 2016: 富山大学, 附属病院, 講師 2014 – 2015: 富山大学, 大学病院, 講師 … More 2014: 富山大学, 大学院医学薬学研究部, 助教 2013: 富山大学, 大学病院, 助教 2013: 富山大学, 大学院医学薬学研究部, 講師 2011 – 2012: 富山大学, 大学病院, 医員 2008: 札幌医大, 医学部, 研究員 2007: Sapporo Medical University, 医科部, 研究員 2006: 札幌医科大学, 医学部, 研究員 Less
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 口腔癌 / 免疫抑制 / マウスモデル / 免疫抑制性細胞 / 免疫療法 / MDSC / 免疫老化 / 好中球 / 免疫チェックポイント / 口腔がん … More / 腫瘍関連好中球 / 好中球・リンパ球数比 / 腫瘍関連免疫抑制性細胞 / 免疫チェックポイント阻害剤 / 加齢変化 / 免疫チェックポイント分子 / 破骨細胞分化 / 癌関連線維芽細胞 / 局所浸潤 / 骨髄由来免疫抑制性細胞 / PD-L1 / 免疫抑制細胞 / 免疫 / 抗腫瘍免疫 / ミエロイド系抑制性細胞 / 歯学 / 免疫学 / 癌 / 免疫遺伝子治療 / 樹状細胞 … More Except Principal Investigator 口腔癌 / 口腔がん / 免疫抑制性細胞 / 免疫 / 貪食 / 死細胞 / 免疫療法 / 免疫抑制 / 骨髄由来免疫抑制性細胞 / 破骨細胞分化 / 顎骨浸潤 / 異所性核酸 / 骨再生 / 顎骨壊死モデル / BRONJ / 浸潤 / 骨髄由来抑制性細胞 / 口腔扁平上皮癌 / 腫瘍免疫 / 細胞死 / コレステロール / 脂質クオリティ / 死細胞貪食 / 脂質 / 免疫チェックポイント / 免疫抑制細胞 / 化学療法 / 免疫逃避 / 好中球 / 免疫チェックポイント阻害 / 治療標的化 / 免疫チェックポイント阻害薬 / マウスモデル / 破骨細胞 / 局所浸潤 / 癌関連線維芽細胞 / 局所浸潤過程 / 上皮細胞 / 相乗作用 / 細胞毒性 / カルシウム / ビスフォスフォネート / 免疫学 Less

歯周炎併発BRONJモデルの作成とその治療法展開
- Principal Investigator
  
  石田陽子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Niigata University
Immune escape mechanisms induced by dead cell-derived ectopic nucleic acids in oral cancer
- Principal Investigator
  
  山崎学
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Niigata University
腫瘍関連免疫抑制性細胞を標的とした口腔癌に対する新たな免疫療法の開発研究Principal Investigator
- Principal Investigator
  
  冨原圭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Niigata University
Dead cell-mediated activation mechanisms in oral cancer: Exploring the changes in lipid quality by dead cell phagocytosis
- Principal Investigator
  
  Yamazaki Manabu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Niigata University
Basic study on the control of diffusely invasive oral squamous cell carcinoma by immunological approach
- Principal Investigator
  
  NOGUCHI Makoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of Toyama
Development of novel therapy by targeting Immune escape mechanisms in oral cancer
- Principal Investigator
  
  Imaue Shuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of Toyama
Novel strategy for oral cancer targeting myeloid-derived suppressor cellsPrincipal Investigator
- Principal Investigator
  
  Tomihara Kei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Niigata University
  University of Toyama
Novel strategy targeting myeloid cells-mediated invasion of oral cancer
- Principal Investigator
  
  Noguchi Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of Toyama
Targeting strategy against myeloid suppressor cells in mouse model of aged oral cancerPrincipal Investigator
- Principal Investigator
  
  Tomihara Kei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Toyama
Anti-tumor effect of myeloid derived suppressor cell(MDSC) in a mouse model of oral cancerPrincipal Investigator
- Principal Investigator
  
  TOMIHARA KEI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Toyama
An in vitro study on the role of calcium in bisphosphonate-related osteonecrosis of jaw.
- Principal Investigator
  
  ARAI Naoya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
  University of Toyama
A novel strategy against bone invasion of oral cancer
- Principal Investigator
  
  NOGUCHI Makoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Toyama
Myeloid derived suppressor cell(MDSC)-targeted immunotherapy for oral cancerPrincipal Investigator
- Principal Investigator
  
  TOMIHARA Kei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  University of Toyama
口腔癌に対するCD154遺伝子治療に関する研究Principal Investigator
- Principal Investigator
  
  冨原圭
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
CD40リガンド遺伝子導入樹状細胞による口腔癌に対する抗腫瘍効果の解析Principal Investigator
- Principal Investigator
  
  冨原圭
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University

All 2023 2022 2021 2019 2018 2016 2014 2013 2012 2011 2008 2007 Other

All Journal Article Presentation

[Journal Article] Neutrophil-to-lymphocyte ratio as an early marker of outcomes in patients with recurrent oral squamous cell carcinoma treated with nivolumab2023
- Author(s)
  Tachinami H, Tomihara K,Yamada S, Ikeda A, Imaue S, Hirai H, Nakai H, Sonoda T, Kurohara K, Yoshioka Y, Hasegawa T, Naruse T, Niiyama T, Shimane T, Ueda M, Yanamoto S, Akashi M, Umeda M, Kurita H, Miyazaki A, Arai N, Hayashi R, Noguchi M
- Journal Title
  
  British Journal of Oral and Maxillofacial Surgery
  
  Volume: 61 Issue: 4 Pages: 320-326
- DOI
  10.1016/j.bjoms.2023.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10214, KAKENHI-PROJECT-21K17111, KAKENHI-PROJECT-20K10157, KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-23K27794
[Journal Article] Complete Response to Cetuximab Plus Paclitaxel Therapy in Nivolumab-Refractory Patients in Distant Metastasis of Squamous Cell Carcinoma of the Tongue: A Report of Two Cases2023
- Author(s)
  Tachinami Hidetake、Tomihara Kei、Takatsuka Danki、Ikeda Atsushi、Yamada Shin-ichi、Noguchi Makoto
- Journal Title
  
  Cureus
  
  Volume: 15
- DOI
  10.7759/cureus.49198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-21K17111
[Journal Article] Successful treatment with nivolumab in a patient with unresectable oral squamous cell carcinoma following ineffective chemoradiotherapy2023
- Author(s)
  Sekido Katsuhisa、Imaue Shuichi、Tachinami Hidetake、Tomihara Kei、Naruto Norihito、Yamagishi Kentaro、Ikeda Atsushi、Fujiwara Kumiko、Noguchi Makoto
- Journal Title
  
  Clinical Case Reports
  
  Volume: 11 Issue: 12
- DOI
  10.1002/ccr3.8219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-21K17111
[Journal Article] Presurgical imaging of the subscapular artery with three‐dimensional‐computed tomography angiography: Application to harvesting subscapular system free‐flaps2023
- Author(s)
  Imaue Shuichi、Osada Ryusuke、Heshiki Wataru、Sekido Katsuhisa、Zukawa Mineyuki、Fujiwara Kumiko、Tomihara Kei、Noguchi Makoto
- Journal Title
  
  Clinical Anatomy
  
  Volume: 37 Issue: 2 Pages: 161-168
- DOI
  10.1002/ca.24053
- Data Source
  KAKENHI-PROJECT-21K10065
[Journal Article] Complete response to cetuximab plus paclitaxel therapy in nivolumab-refractory patients in distant metastasis of squamous cell carcinoma of the tongue: a report of two cases2022
- Author(s)
  Tachinami Hidetake、Tomihara Kei、Takatsuka Danki、Ikeda Atsushi、Yamada Shinichi、Noguchi Makoto
- Journal Title
  
  Clinical Case Reports
  
  Volume: in press
- DOI
  10.22541/au.165881754.43971495/v1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-21K17111
[Journal Article] Durable complete response to immunotherapy with anti-PD-1 antibody nivolumab in a patient with oral squamous cell carcinoma presenting with lung metastasis: A case report.2021
- Author(s)
  Sekido K, Imaue, Tomihara K, Tachinami H, Yamagishi K, Okazawa S, Ikeda A, Fujiwara K, Noguchi M.
- Journal Title
  
  Clin Case Rep.
  
  Volume: 9 Issue: 9
- DOI
  10.1002/ccr3.4545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10262, KAKENHI-PROJECT-19K19049, KAKENHI-PROJECT-19K24088, KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-21K17111
[Journal Article] Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma2021
- Author(s)
  Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Nguyen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M, Sasahara M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 118 Issue: 19
- DOI
  10.1073/pnas.2019580118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08265, KAKENHI-PROJECT-19H04446, KAKENHI-PROJECT-21H02713, KAKENHI-PROJECT-21K08296, KAKENHI-PROJECT-21K08342, KAKENHI-PROJECT-21K10065
[Journal Article] Central mucoepidermoid carcinoma of the maxilla developing from a calcifying odontogenic cyst: A rare case report.2021
- Author(s)
  Isshiki-Murakami M, Tachinami H, Tomihara K, Noguchi A, Sekido K, Imaue S, Fujiwara K, Imura J, Noguchi M.
- Journal Title
  
  Clin Case Rep.
  
  Volume: 9 Issue: 10
- DOI
  10.1002/ccr3.4928
- Data Source
  KAKENHI-PROJECT-21K10065
[Journal Article] Neutrophil-to-Lymphocyte Ratio (NLR)as a Predictive Indicator of the Response to Nivolumab in Patients with Oral Squamous Cell Carcinoma.2021
- Author(s)
  Tachinami H, Tomihara K, Ikeda A, Sekido K, Sakurai K, Imaue S, Fujiwara K, Hayashi R, Noguchi M
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 48 Pages: 1485-1490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10157
[Journal Article] Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells2021
- Author(s)
  Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M.
- Journal Title
  
  Oral Surg Oral Med Oral Pathol Oral Radiol.
  
  Volume: 132 Issue: 5 Pages: 549-565
- DOI
  10.1016/j.oooo.2021.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K24088, KAKENHI-PROJECT-21K09856, KAKENHI-PROJECT-21K10065, KAKENHI-PROJECT-21K17111
[Journal Article] Neutrophil-to-Lymphocyte Ratio (NLR)as a Predictive Indicator of the Response to Nivolumab in Patients with Oral Squamous Cell Carcinoma.2021
- Author(s)
  Tachinami H, Tomihara K, Ikeda A, Sekido K, Sakurai K, Imaue S, Fujiwara K, Hayashi R, Noguchi M.
- Journal Title
  
  Gan To Kagaku Ryoho.
  
  Volume: 48 Pages: 1485-1490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10262
[Journal Article] Neutrophil-to-Lymphocyte Ratio(NLR)as a Predictive Indicator of the Response to Nivolumab in Patients with Oral Squamous Cell Carcinoma2021
- Author(s)
  Tachinami H, Tomihara K, Ikeda A, Sekido K, Sakurai K, Imaue S, Fujiwara K, Hayashi R, Noguchi M.
- Journal Title
  
  gan to kagaku Ryoho
  
  Volume: 48 Pages: 1485-1490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10065
[Journal Article] Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.2014
- Author(s)
  Tomihara Kei
- Journal Title
  
  Oral Oncology
  
  Volume: 50 Issue: 5 Pages: 457-467
- DOI
  10.1016/j.oraloncology.2014.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861922, KAKENHI-PROJECT-26462998
[Journal Article] Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer2014
- Author(s)
  Tomihara K, Fuse H, Heshiki W, Takei R, Zhang B, Arai N, Nakamori K, Noguchi M
- Journal Title
  
  Oral Oncol
  
  Volume: 50 Pages: 457-467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592957
[Journal Article] Optimization of immunotherapy in elderly cancer patients2013
- Author(s)
  Tomihara K, Curiel TJ, Zhang B
- Journal Title
  
  Crit Rev Oncog
  
  Volume: 18(6) Pages: 573-583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592957
[Journal Article] In vitro synergistic effects of zoledronic acid and calcium on viability of human epithelial cells2013
- Author(s)
  Arai N, Inoue S, Tomihara K, Tsuno H, Noguchi M
- Journal Title
  
  Oral Dis
  
  Volume: 19 Pages: 200-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592957
[Journal Article] CD44 and SSEA-4 positive cells in an oral cancer cell line HSC-4 possess cancer stem-like cell characteristics2013
- Author(s)
  Noto Z, Yoshida T, Okabe M, Koike C, Fathy M, Tsuno H, Tomihara K, Arai N, Noguchi M, Nikaido T
- Journal Title
  
  Oral Oncol
  
  Volume: 49 Pages: 787-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592957
[Journal Article] Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction2012
- Author(s)
  Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
- Journal Title
  
  Aging Cell
  
  Volume: 11 Pages: 128-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592957
[Journal Article] Aging-associated B7-DC(+) B cells enhance anti-tumor immunity via Th1 and Th17 induction2012
- Author(s)
  Tomihara K, Shin T, Hurez VJ, Yagita H, Pardoll DM, Zhang B, Curiel TJ, Shin T
- Journal Title
  
  Aging Cell
  
  Volume: 11 Issue: 1 Pages: 128-138
- DOI
  10.1111/j.1474-9726.2011.00764.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23890069
[Journal Article] Gene transfer of CD40-Ligand to Dendritic cells stimulates interferon-γ production to induce growth arrest and aiptosis of tumor cells2008
- Author(s)
  Tomihara Kei
- Journal Title
  
  Gene Therapy 15
  
  Pages: 203-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791511
[Journal Article] IFN-γ induces NK-mediated anti-tumor effects against oral aquamous cell carcimoma cells2007
- Author(s)
  Tomihara Kei
- Journal Title
  
  Int J Oral Maxillofac Surg 36
  
  Pages: 1086-1086
- Data Source
  KAKENHI-PROJECT-18791511
[Journal Article] Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against carcinoma cells2007
- Author(s)
  Kei Tomihara
- Journal Title
  
  International journal of cancer Vol120, No 7
  
  Pages: 1491-1498
- Data Source
  KAKENHI-PROJECT-18791511
[Presentation] Vascularized scapula bone graft using angular branch in maxillofacial reconstruction2023
- Author(s)
  Imaue S, Tomihara K, Yamada S, Ikeda A, Tachinami H, Sakurai K, Takaichi M, Ishizaka R, Fujiwara K, Noguchi M
- Organizer
  13th Joint Scientific Meeting of NAOMS and JSOMS
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Applications of the hyperdried human amniotic membrane in oral surgery2023
- Author(s)
  Tachinami H, Arai N, Tsuno H, Fujiwara K, Imaue S, Kurohara K, Yamada S, Tomihara K, Noguchi M
- Organizer
  2nd Japanese-German CMF Symposium
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Immunotherapy in oral cancer: Current state of future perspective of immune checkpoint inhibitors2023
- Author(s)
  Tomihara Kei
- Organizer
  The 12th International Scientific Meeting in Dentistry (TIIKG) in conjunction with the 8th International Conference on Biophysical Technology in Dentistry (ICoBTD)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10214
[Presentation] Salvage therapy for immunotherapy-rafractory oral cancer with combination chemotherapy2023
- Author(s)
  Tomihara Kei
- Organizer
  13th Joint Scientific Meeting of Nepal Association of Oral and Maxillofacial Surgeons (NAOMS) and Japanese Society of Oral and Maxillofacial Surgeons (JSOMS) and PG Convention
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10214
[Presentation] 癌化学療法の口腔粘膜炎治療の基礎的研究2023
- Author(s)
  山口百々穂, 立浪秀剛, 高塚団貴, 高市真由, 冨原圭, 山田慎一, 野口誠
- Organizer
  第68回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Rapamycin induces phenotypic alterations of oral cancer cells that facilitate antitumor T cell response2023
- Author(s)
  Yonesi Amrimoezz, 冨原圭, 高塚団貴, 立浪秀剛, 山崎学, 高市真由, Younesi Amirreza, 山田慎一, 田沼順一, 野口誠
- Organizer
  第77回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 口腔癌におけるPAK4阻害による免疫学的修飾作用2023
- Author(s)
  高塚団貴, 立浪秀剛, 櫻井航太郎, 高市真由, 冨原圭, 山田慎一, 野口誠
- Organizer
  第68回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 肩甲骨皮弁採取における肩甲下動脈を標的とした術前3D CT angiographyの有用性2023
- Author(s)
  今上修一, 石戸克尚, 高市真由, 藤原久美子, 冨原圭, 立浪秀剛, 櫻井航太郎, 池田篤司, 山田慎一, 野口誠
- Organizer
  第66回NPO法人日本口腔科学会中部地方会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] ニボルマブ投与後に救済化学療法が奏功した舌癌の2例2022
- Author(s)
  28) 高塚団貴，立浪秀剛，冨原　圭，池田篤司，今上修一，藤原久美子，山田慎一，野口　誠
- Organizer
  第67回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-20K10157
[Presentation] 口腔がんにおける脂質代謝を介した免疫抑制機能の解析2022
- Author(s)
  高市真由, 櫻井航太朗, 立浪秀剛, 高塚団貴, 冨原　圭, 山田慎一, 野口　誠
- Organizer
  第67回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Treatment Outcome of Patients with StageIVB Oral Squamous cell carcinoma(OSCC).2022
- Author(s)
  1) Imaue S, Ikeda A, Tachinami H, Sakurai K, Takaichi M, Ishizaka R, Fujiwara K, Tomihara K, Noguchi M.
- Organizer
  12th Annual Conference of Nepalese Association of Oral and Maxillofacial Surgeons and Joint Meeting with Japanese Society of Oral and Maxillofacial Surgeons
- Data Source
  KAKENHI-PROJECT-20K10157
[Presentation] Rapamycin induces phenotypic alterations of oral cancer cells that facilitate antitumor T cell response2022
- Author(s)
  Yonesi Amirmoezz，冨原　圭，高塚団貴，立浪秀剛，櫻井航太朗, 野口　誠
- Organizer
  第76回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] ニボルマブ投与後に救済化学療法が奏功した舌癌の2例2022
- Author(s)
  高塚団貴，立浪秀剛，冨原　圭，池田篤司，今上修一，藤原久美子，山田慎一，野口　誠
- Organizer
  第67回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Neutrophil-to-lymphocyte ratio as an early marker of outcomes in patients with recurrent oral squamous cell carcinoma treated with nivolumab: a pilot study.2022
- Author(s)
  Tachinami H, Tomihara K, Yamada S, Miyazaki A, Arai N, Hayashi R, Noguchi M
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Treatment Outcome of Patients with StageIVB Oral Squamous cell carcinoma(OSCC).2022
- Author(s)
  Imaue S, Ikeda A, Tachinami H, Sakurai K, Takaichi M, Ishizaka R, Fujiwara K, Tomihara K, Noguchi M
- Organizer
  12th Annual Conference of Nepalese Association of Oral and Maxillofacial Surgeons and Joint Meeting with Japanese Society of Oral and Maxillofacial Surgeons
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 口腔扁平上皮癌・手術不能局所進展例の治療戦略2022
- Author(s)
  今上修一, 池田篤司, 石戸克尚, 立浪秀剛, 桜井航太郎, 冨原　圭, 野口　誠
- Organizer
  第40回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 口腔癌に対するPAK4阻害による免疫学的修飾作用の解析2021
- Author(s)
  高塚団貴, 冨原　圭, 立浪秀剛, 櫻井航太朗, 高市真由, Yonesi Amirmoezz, 野口　誠
- Organizer
  第75回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] Rapamycin induces phenotypic alterations of oral cancer cells that facilitate antitumor T cell response.2021
- Author(s)
  Yonesi Amirmoezz, 冨原　圭, 高塚団貴, 立浪秀剛, 櫻井航太朗, 野口　誠
- Organizer
  第75回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] 口腔癌に対するPAK4阻害による免疫学的修飾作用の解析．2021
- Author(s)
  高塚団貴，冨原　圭，立浪秀剛，櫻井航太朗，高市真由，Yonesi Amirmoezz，野口　誠.
- Organizer
  66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] メトトレキサート服用患者の上顎歯肉に認めた骨壊死を伴うEBウイルス陽性粘膜皮膚潰瘍の1例.2021
- Author(s)
  前田　智，櫻井航太郎，冨原　圭，今上修一，藤原久美子，野口　映，野口　誠．
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 非外科療法を適用した口腔扁平上皮癌の治療成績.2021
- Author(s)
  櫻井航太郎，今上修一，池田篤司，冨原　圭，野口　誠.
- Organizer
  第39回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 口腔扁平上皮癌に対するニボルマブの効果と好中球/リンパ球比に関する研究．2021
- Author(s)
  立浪　秀剛，冨原　圭，池田篤司，今上修一，岡本準也，中井裕美，黒原一人，宮﨑晃亘，新井直也，野口　誠．
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Prediction of inferior alveolar nerve injury during third molar extraction based on assessment of computed tomography images of multiple anatomical features.2021
- Author(s)
  Tachinami H, Takatsuka D, Younesi A, Tomihara K, Noguchi M.
- Organizer
  11th Annual Conference of Nepalese Association of Oral and Maxillofacial Surgeons and Joint Meeting with Japanese Society of Oral and Maxillofacial Surgeons
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] Rapamycin induces phenotypic alterations of oral cancer cells that facilitate antitumor T cell response．2021
- Author(s)
  Yonesi Amirmoezz，冨原　圭，高塚団貴，立浪秀剛，櫻井航太朗, 野口　誠.
- Organizer
  第75回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] 口腔癌に対するPAK4阻害による免疫学的修飾作用の解析．2021
- Author(s)
  高塚団貴，冨原　圭，立浪秀剛，櫻井航太朗，高市真由，Yonesi Amirmoezz，野口　誠.
- Organizer
  第75回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K10065
[Presentation] Neutrophil-to-lymphocyte ratio as a predictable biomarker for response to nivolumab in oral squamous cell carcinoma2019
- Author(s)
  Tachinami H, Tomihara K, Noguchi M
- Organizer
  The 78th J Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-18K09741
[Presentation] 腫瘍に集積するミエロイド系細胞の違いはPD-L1阻害剤との併用免疫療法効果に影響を与える2019
- Author(s)
  立浪秀剛，西井　直人，加島　義久，冨原　圭，野口　誠，東　みゆき
- Organizer
  第73回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09741
[Presentation] 老齢口腔癌マウスを用いた免疫細胞および抗腫瘍免疫応答に関する研究2019
- Author(s)
  石戸克尚，立浪秀剛，櫻井航太郎，平識　亘，冨原　圭，野口　誠
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K09741
[Presentation] 老齢口腔癌マウスを用いた免疫細胞および抗腫瘍免疫応答に関する研究2019
- Author(s)
  石戸克尚，立浪秀剛，櫻井航太郎，平識　亘，冨原　圭，野口　誠
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] 口腔癌におけるnivolumab投与による好中球数/リンパ球数比の変化2019
- Author(s)
  立浪秀剛，冨原　圭，石戸克尚，池田篤司，藤原久美子，野口　誠
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K09741
[Presentation] Clinical efficacy and safety of immunotherapy using checkpoint inhibitor in advanced oral cancer.2019
- Author(s)
  Tomihara K
- Organizer
  9th Nepal-Japan Joint Scientific Meeting of Oral and Maxillofacial Surgeons
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] 口腔扁平上皮癌における骨髄由来免疫抑制細胞（MDSC）の破骨細胞分化との関連2019
- Author(s)
  石戸克尚、冨原　圭、平識　亘、櫻井航太郎、野口　誠
- Organizer
  第73回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] 口腔扁平上皮癌における骨髄由来免疫抑制細胞（MDSC）の破骨細胞分化との関連2019
- Author(s)
  石戸克尚，冨原　圭，平識　亘，櫻井航太郎，野口　誠
- Organizer
  第73回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09741
[Presentation] 腫瘍に集積するミエロイド系細胞の違いはPD-L1阻害剤との併用免疫療法効果に影響を与える2019
- Author(s)
  立浪秀剛，西井　直人，加島　義久，冨原　圭，野口　誠，東　みゆき
- Organizer
  第73回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] Neutrophil-to-lymphocyte ratio as a predictable biomarker for response to nivolumab in oral squamous cell carcinoma2019
- Author(s)
  Tachinami H, Tomihara K, Noguchi M
- Organizer
  The 78th J Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K10262
[Presentation] ミエロイド系抑制細胞を標的とした口腔癌に対する新たな治療戦略の開発2018
- Author(s)
  冨原　圭
- Organizer
  第72回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-16K11720
[Presentation] Chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer2016
- Author(s)
  冨原　圭
- Organizer
  International conference on oral, mouth and throat cancer
- Place of Presentation
  Portland, USA
- Year and Date
  2016-08-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11720
[Presentation] CTLA4-mediated inhibition of osteoclast differentiation by regulatory T cells (Tregs) in oral cancer2013
- Author(s)
  Noguchi M, Tomihara K
- Organizer
  21th International conference on oral and maxillofacial surgery (ICOMS)
- Place of Presentation
  Balcelona
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] CTLA4-mediated inhibition of osteoclast differentiation by regulatory T cells (Tregs) in oral cancer.2013
- Author(s)
  Noguchi M, Tomihara K
- Organizer
  21th International conference on oral and maxillofacial surgery (ICOMS)
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] CTLA4-mediated inhibitory effect on osteoclastgenesis by Tregs in oral cancer2013
- Author(s)
  Tomihara K, Noguchi M
- Organizer
  The American Association of Immunologists AAI Annual Meeting
- Place of Presentation
  Honolulu
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] CTLA4-mediated inhibitory effect on osteoclastogenesis by Tregs in oral cancer.2013
- Author(s)
  冨原　圭
- Organizer
  The American Association of Immunologists AAI Annual Meeting
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] Gemcitabine induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.2013
- Author(s)
  冨原　圭
- Organizer
  21th International conference on oral and maxillofacial surgery (ICOMS)
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] アルカリ環境におけるリン酸カルシウム塩の形成とzoredronateの上皮細胞毒性の増強2013
- Author(s)
  新井直也、井上さやか、冨原　圭、平識　亘、古川健一朗、野口　誠
- Organizer
  第58回日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24592983
[Presentation] マウスモデルを用いた口腔癌における制御性T細胞の解析2012
- Author(s)
  冨原圭、井上さやか、能登善弘、津野宏彰、立浪秀剛、新井直也、野口誠
- Organizer
  第66回日本口腔科学会学術集会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] マウス口腔癌モデルを用いた制御性T細胞の解析2012
- Author(s)
  冨原圭、井上さやか、武井理恵、今上修一、新井直也、野口誠
- Organizer
  第30回日本口腔腫瘍学会総会・学術大会
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] Characterization of regulatory T cells (Tregs) in oral cancer2012
- Author(s)
  Tomihara K, Inoue S, Takei R, Imaue S, Arai N, Noguchi M
- Organizer
  10^<th>Asian congress on oral and maxillofacialsurgery
- Place of Presentation
  Bali Indonesia
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] Characterization of regulatory T cells (Tregs) in oral cancer2012
- Author(s)
  Tomihara K, Inoue S, Takei R, Imaue S, Arai N, Noguchi M
- Organizer
  10^<th> Asian Congress on Oral and Maxillofacial Surgery
- Place of Presentation
  Bali
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] 口腔癌における制御性T細胞の解析2012
- Author(s)
  冨原圭、井上さやか、新井直也、野口誠
- Organizer
  第57回日本口腔外科学会総会・学術大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] Regulatory T cells in oral cancer2012
- Author(s)
  Tomihara K, Inoue S, Arai N, Noguchi M.
- Organizer
  71^<th>Annual Meeting of the Japanese Cancer Association,第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] Characterization of regulatory T cells(Tregs) in oral cancer.2012
- Author(s)
  冨原　圭、井上さやか、武井理恵、今上修一、新井直也、野口　誠
- Organizer
  10th Asian Congress on Oral and Maxillofacial Surgery
- Place of Presentation
  Bali, Indonesia
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] Analysis of the characterization of regulatory T cells in a mouse model for oral cancer2011
- Author(s)
  Tomihara K., Inoue S., Arai N., Noguchi M.
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] Effect of clinically-relevant concentrations of zoledronate acid on cultured humanoral cancer cells2011
- Author(s)
  Inoue S., Arai N., Tomihara K., Noguchi M.
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23592957
[Presentation] Analysis of the characterization of regulatory T cells in a mouse model for oral cancer2011
- Author(s)
  Tomihara Kei, et al.
- Organizer
  70^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-23890069
[Presentation] IFN-γ induces NK-mediated anti-tumor effects against oral aquamous cell carcinoma cells2007
- Author(s)
  Tomihara Kei
- Organizer
  18th International Conference on Oral and Maxillo facial Surgery
- Place of Presentation
  インド・バンがロール
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-18791511
[Presentation] Chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer
- Author(s)
  Kei Tomihara, Naoya Arai, Makoto Noguchi
- Organizer
  11th Asian congress on oral and maxillofacial surgery
- Place of Presentation
  西安、中国
- Year and Date
  2014-08-22 – 2014-08-25
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer
- Author(s)
  Kei Tomihara
- Organizer
  4th International conference on translational medicine
- Place of Presentation
  Navada, USA
- Year and Date
  2014-11-03 – 2014-11-05
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] Sarcomatoid salivary duct carcinoma of the palate
- Author(s)
  Kei Tomihara, Makoto Noguchi
- Organizer
  3rd International conference and exhibition on pathology
- Place of Presentation
  Texas, USA
- Year and Date
  2014-04-14 – 2014-04-15
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] 口腔癌におけるmyeloid derived suppressor cell(MDSC)の機能解析
- Author(s)
  冨原　圭、平識　亘、野口　誠
- Organizer
  第68回　日本口腔科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-05-07 – 2014-05-09
- Data Source
  KAKENHI-PROJECT-25861922
[Presentation] ビスフォスフォネートの上皮細胞毒性とカルシウムの相乗作用
- Author(s)
  新井直也、井上さやか、冨原圭、津野宏彰、野口誠
- Organizer
  日本口腔外科学会（総会）
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24592983
[Presentation] Synergistic effects of bisphosphonate and calcium on viability of epithelial cells; An in vitro study
- Author(s)
  Arai N, Inoue S, Tomihara K, Tsuno H, Noguchi M
- Organizer
  アジア口腔顎顔面外科学会
- Place of Presentation
  インドネシア　バリ
- Data Source
  KAKENHI-PROJECT-24592983

1. NOGUCHI Makoto (50208328)

# of Collaborated Projects: 7 results

# of Collaborated Products: 52 results
2. Yamazaki Manabu (10547516)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
3. ARAI Naoya (80323723)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. 藤原久美子 (60404737)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. 阿部達也 (70634856)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 丸山智 (30397161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 田沼順一 (20305139)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Imaue Shuichi (80456392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 笹原正清 (20154015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 泉健次 (80242436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 立浪秀剛 (30850268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 石田陽子 (10377187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 前川知樹 (50625168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 牧野輝彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 清水忠道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 八木田秀雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomihara Kei 冨原 圭

TOMIHARA Kei 冨原 圭

冨原 圭 トミハラ ケイ

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腫瘍関連免疫抑制性細胞を標的とした口腔癌に対する新たな免疫療法の開発研究Principal Investigator

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Novel strategy for oral cancer targeting myeloid-derived suppressor cellsPrincipal Investigator

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Targeting strategy against myeloid suppressor cells in mouse model of aged oral cancerPrincipal Investigator

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Anti-tumor effect of myeloid derived suppressor cell(MDSC) in a mouse model of oral cancerPrincipal Investigator

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Myeloid derived suppressor cell(MDSC)-targeted immunotherapy for oral cancerPrincipal Investigator

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口腔癌に対するCD154遺伝子治療に関する研究Principal Investigator

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Tomihara Kei 冨原圭

TOMIHARA Kei 冨原圭

冨原圭トミハラケイ