MIZUGUCHI Yoshiaki 水口義昭

Researcher Number	70409217
Affiliation (based on the past Project Information) *help	2018: 日本医科大学, 医学部, 助教 2017: 日本医科大学, 医学部, 助手 2012 – 2016: 日本医科大学, 医学部, 助教 2007: 日本医大, 医学部, 助手 2007: 日本医科大学, 医学部, 特別研究生 2006: 日本医科大学, 医学部, 助手 2005: Nippon Medical School, Graduate School of Medicine, Post doctor, 大学院・医学研究科, ポストドクター
Review Section/Research Field	Principal Investigator Digestive surgery / Virology Except Principal Investigator Digestive surgery / Urology
Keywords	Principal Investigator microRNA-200 / TGF-bta1 / EMT / microRNA 200 family / TGF-beta1 / HBV / microRNA / バイオテクノロジー / 遺伝子 Except Principal Investigator RNAi … More / TEX101 / 新規バイオマーカー / 次世代シーケンサー / 化学療法効果予測因子 / 化学療法の効果予測 / 術前化学療法 / long noncoding RNA / 膵癌 / reproductive biology / GPI / mouse testis / 精子 / 精巣 / 生殖医学 / GPI蛋白質 / マウス精巣 / Sequencing / Bioinformatics / Hepatitis B virus / MicroRNA / Hepatocellular carcinoma / マイクロRNA / バイオテクノロジー / 遺伝子 / TGF beta receptor II / TGF beta / gene therapy / liver injury / RNA interference / TGF-β recepter II / TGF-β receptor II / TGF-β1 / 遺伝子治療 / 肝障害 / RNA干渉 / ノンコーディングRNA / 胆嚢癌 / 胆管癌 / 胆道外科学 / 癌 Less

Search for biomarkers and identification of miRNAs for pancreatic cancer treatment prognoses
- Principal Investigator
  
  Nakamura Yoshiharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School
胆管癌上皮間葉移行におけるTGF-β/miR-200ファミリーの直接交絡Principal Investigator
- Principal Investigator
  
  水口義昭
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School
Identification of biliary duct cancer-associated long non-coding RNAs and their diagnostic and therapeutic application
- Principal Investigator
  
  TAKIZAWA Toshihiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School
Clarification of the mechanistic analysis of the samll RNA derived from HBV geneome and its asociation for hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Yoshiaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nippon Medical School
RNA干渉法での癌関連遺伝子群ダブルノックダウンによる胆道癌遺伝子治療Principal Investigator
- Principal Investigator
  
  水口義昭
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School
Sequencing based quantitative and qualitative analyses of the microRNA transcriptome in hepatitis B related hepatocellular carcinoma.
- Principal Investigator
  
  TAJIRI Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School
RNAi-knockdown analysis of a germ-cell-specific antigen, TEX101, in mouse testis
- Principal Investigator
  
  ISHIKAWA Tomoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Nippon Medical School
Gene therapy of chronic liver injury with RNAi vector targeting TGF-beta receptor
- Principal Investigator
  
  TAJIRI Takashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nippon Medical School

All 2015 2014 2013 2012 2011 2008 2007 2005 2004

All Journal Article Book Patent

[Book] Bioinfromatics2012
- Author(s)
  Yoshiaki Mizuguchi, Takuya Mishima, Eiji Uchida, Toshihiro Takizawa
- Total Pages
  11
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-24590559
[Journal Article] Dysregulated microRNAs in progression of hepatocellular carcinoma: A systematic review.2015
- Author(s)
  Mizuguchi Y, Takizawa T, Yoshida H, Uchida E.
- Journal Title
  
  Hepatol Res.
  
  Volume: NA Issue: 5 Pages: 391-406
- DOI
  10.1111/hepr.12606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
[Journal Article] Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication.2015
- Author(s)
  Mizuguchi Y, Takizawa T, Uchida E.
- Journal Title
  
  World J Hepatol.
  
  Volume: 7(4) Issue: 4 Pages: 696-702
- DOI
  10.4254/wjh.v7.i4.696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
[Journal Article] Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia.2015
- Author(s)
  Mizuguchi Y, Specht S, Isse K, Sasatomi E, Lunz JG 3rd, Takizawa T, Demetris AJ.
- Journal Title
  
  J Hepatol.
  
  Volume: 63(2) Issue: 2 Pages: 399-407
- DOI
  10.1016/j.jhep.2015.02.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
[Journal Article] Small proline rich protein 2a in benign and malignant liver disease2014
- Author(s)
  Yoshiaki mizuguchi
- Journal Title
  
  Hepatology
  
  Volume: 53 Issue: 3 Pages: 1130-53
- DOI
  10.1002/hep.26889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590559
[Journal Article] Mir-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line.2013
- Author(s)
  Iwaki J, Kikuchi K, Mizuguchi Y, Kawahigashi Y, Yoshida H, Uchida E, Takizawa T.
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 7 Pages: e69496-e69496
- DOI
  10.1371/journal.pone.0069496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591908, KAKENHI-PROJECT-24590559
[Journal Article] SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity2012
- Author(s)
  Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ.
- Journal Title
  
  BMC Mol Biol
  
  Volume: 13:20 Issue: 1
- DOI
  10.1186/1471-2199-13-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590559
[Journal Article] Gene Suppression of Mouse Testis In Vivo Using Small Interfering RNA Derived from Plasmid Vectors2012
- Author(s)
  Takizawa Ta, Ishikawa T, Kosuge T, Mizuguchi Y, Sato Y, Koji T, Araki Y, Takizawa To.
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 45 Issue: 1 Pages: 77-81
- DOI
  10.1267/ahc.11024
- NAID
  130001854310
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592115, KAKENHI-PROJECT-24570237, KAKENHI-PROJECT-24590559
[Journal Article] Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics2012
- Author(s)
  Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ.
- Journal Title
  
  Plos one
  
  Volume: 7 Issue: 2 Pages: e32449-e32449
- DOI
  10.1371/journal.pone.0032449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590559
[Journal Article] SnoN/SKIL modulates proliferationthrough control of hsa-miR-720 transcription in esophageal cancer cells.2011
- Author(s)
  Eriko Shinozuka, Masao Miyashita, Yoshiaki Mizuguchi, Ichiro Akagi, Kunio Kikuchi, Hiroshi Makino, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Eiji Uchida, Toshihiro Takizawa.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 430(1) Issue: 1 Pages: 101-106
- DOI
  10.1016/j.bbrc.2012.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791553, KAKENHI-PROJECT-24590559
[Journal Article] MicroRNA cloning analysis reveals sex differences in microRNA expression profiles between adult mouse testis and ovary2008
- Author(s)
  Takuya Mishima, Takami Takizawa, Shan-shun Luo, Osamu Ishibashi, Yutaka Kawahigashi, Yoshiyuki Mizuguchi, Tomoko Ishikawa, Miki Mori, Tomohiro Kanda, Tadashi Goto, Takizawa Takizawa
- Journal Title
  
  Reproduction 136(6)
  
  Pages: 811-822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591786
[Journal Article] Therapeutic use of short hairpin RNA in acute liver failure.2007
- Author(s)
  Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Takizawa T, Tajiri T.
- Journal Title
  
  Nippon Med Sch. 74(1).
  
  Pages: 74-6
- NAID
  130004146890
- Data Source
  KAKENHI-PROJECT-18390372
[Journal Article] Therapeutic use of short hairpin RNA in acute liver failure2007
- Author(s)
  Yoshiaki Mizuguchi
- Journal Title
  
  J Nippon Med Sch 74・1
  
  Pages: 74-76
- NAID
  130004146890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591786
[Journal Article] Therapeutic use of short hairpin RNA in acute liver failure.2007
- Author(s)
  Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Takizawa T, Tajiri T
- Journal Title
  
  Nippon Med Sch. 74(1)
  
  Pages: 74-76
- NAID
  130004146890
- Data Source
  KAKENHI-PROJECT-18790980
[Journal Article] Short hairpin RNA modulates transforming growth factor beta signaling in life-threatening liverfailure in mice.2005
- Author(s)
  Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Kanda T, Yoshida H, Takizawa T, Tajiri T.
- Journal Title
  
  Gastroenterology 129
  
  Pages: 1654-1662
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591364
[Patent] Sequences of RNA functioning as RNA interference targeting human and mouse transforming growth factor betal receptor 22004
- Inventor(s)
  水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
- Industrial Property Rights Holder
  水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
- Filing Date
  2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591364
[Patent] Sequences of RNA functioning as RNA interference targeting human and mouse transforming growth factor beta1 receptor 22004
- Inventor(s)
  水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
- Industrial Property Rights Holder
  水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
- Filing Date
  2004
- Data Source
  KAKENHI-PROJECT-16591364

1. TAKIZAWA Toshihiro (90271220)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. YOSHIDA Hiroshi (60246999)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. TAJIRI Takashi (20163462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. ARIMA Yasuo (30168025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. YOKOMURO Shigeki (30267223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. TANIAI Nobuhiko (20287725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AKIMARU Koho (40142541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIKAWA Tomoko (70212850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Nakamura Yoshiharu (90318519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 内藤善哉 (20237184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 内田英二 (70176684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 松下晃 (70449263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. DEMETRIS Anthony J

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. KIKUCHI Kunio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUGUCHI Yoshiaki 水口 義昭

Research Projects

Research Products

Co-Researchers

Search for biomarkers and identification of miRNAs for pancreatic cancer treatment prognoses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胆管癌上皮間葉移行におけるTGF-β/miR-200ファミリーの直接交絡Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of biliary duct cancer-associated long non-coding RNAs and their diagnostic and therapeutic application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the mechanistic analysis of the samll RNA derived from HBV geneome and its asociation for hepatocarcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNA干渉法での癌関連遺伝子群ダブルノックダウンによる胆道癌遺伝子治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sequencing based quantitative and qualitative analyses of the microRNA transcriptome in hepatitis B related hepatocellular carcinoma.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAi-knockdown analysis of a germ-cell-specific antigen, TEX101, in mouse testis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy of chronic liver injury with RNAi vector targeting TGF-beta receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Bioinfromatics2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Dysregulated microRNAs in progression of hepatocellular carcinoma: A systematic review.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small proline rich protein 2a in benign and malignant liver disease2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mir-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line.2013

Author(s)

Journal Title

MIZUGUCHI Yoshiaki 水口義昭