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MIZUGUCHI Yoshiaki  水口 義昭

ORCIDConnect your ORCID iD *help
Researcher Number 70409217
Affiliation (based on the past Project Information) *help 2018: 日本医科大学, 医学部, 助教
2017: 日本医科大学, 医学部, 助手
2012 – 2016: 日本医科大学, 医学部, 助教
2007: 日本医大, 医学部, 助手
2007: 日本医科大学, 医学部, 特別研究生
2006: 日本医科大学, 医学部, 助手
2005: Nippon Medical School, Graduate School of Medicine, Post doctor, 大学院・医学研究科, ポストドクター
Review Section/Research Field
Principal Investigator
Digestive surgery / Virology
Except Principal Investigator
Digestive surgery / Urology
Keywords
Principal Investigator
microRNA-200 / TGF-bta1 / EMT / microRNA 200 family / TGF-beta1 / HBV / microRNA / バイオテクノロジー / 遺伝子
Except Principal Investigator
RNAi … More / TEX101 / 新規バイオマーカー / 次世代シーケンサー / 化学療法効果予測因子 / 化学療法の効果予測 / 術前化学療法 / long noncoding RNA / 膵癌 / reproductive biology / GPI / mouse testis / 精子 / 精巣 / 生殖医学 / GPI蛋白質 / マウス精巣 / Sequencing / Bioinformatics / Hepatitis B virus / MicroRNA / Hepatocellular carcinoma / マイクロRNA / バイオテクノロジー / 遺伝子 / TGF beta receptor II / TGF beta / gene therapy / liver injury / RNA interference / TGF-β recepter II / TGF-β receptor II / TGF-β1 / 遺伝子治療 / 肝障害 / RNA干渉 / ノンコーディングRNA / 胆嚢癌 / 胆管癌 / 胆道外科学 / 癌 Less
  • Research Projects

    (8 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (14 People)
  •  Search for biomarkers and identification of miRNAs for pancreatic cancer treatment prognoses

    • Principal Investigator
      Nakamura Yoshiharu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School
  •  胆管癌上皮間葉移行におけるTGF-β/miR-200ファミリーの直接交絡Principal Investigator

    • Principal Investigator
      水口 義昭
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School
  •  Identification of biliary duct cancer-associated long non-coding RNAs and their diagnostic and therapeutic application

    • Principal Investigator
      TAKIZAWA Toshihiro
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School
  •  Clarification of the mechanistic analysis of the samll RNA derived from HBV geneome and its asociation for hepatocarcinogenesisPrincipal Investigator

    • Principal Investigator
      MIZUGUCHI Yoshiaki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Nippon Medical School
  •  RNA干渉法での癌関連遺伝子群ダブルノックダウンによる胆道癌遺伝子治療Principal Investigator

    • Principal Investigator
      水口 義昭
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School
  •  Sequencing based quantitative and qualitative analyses of the microRNA transcriptome in hepatitis B related hepatocellular carcinoma.

    • Principal Investigator
      TAJIRI Takashi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School
  •  RNAi-knockdown analysis of a germ-cell-specific antigen, TEX101, in mouse testis

    • Principal Investigator
      ISHIKAWA Tomoko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Nippon Medical School
  •  Gene therapy of chronic liver injury with RNAi vector targeting TGF-beta receptor

    • Principal Investigator
      TAJIRI Takashi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nippon Medical School

All 2015 2014 2013 2012 2011 2008 2007 2005 2004

All Journal Article Book Patent

  • [Book] Bioinfromatics2012

    • Author(s)
      Yoshiaki Mizuguchi, Takuya Mishima, Eiji Uchida, Toshihiro Takizawa
    • Total Pages
      11
    • Publisher
      Intech
    • Data Source
      KAKENHI-PROJECT-24590559
  • [Journal Article] Dysregulated microRNAs in progression of hepatocellular carcinoma: A systematic review.2015

    • Author(s)
      Mizuguchi Y, Takizawa T, Yoshida H, Uchida E.
    • Journal Title

      Hepatol Res.

      Volume: NA Issue: 5 Pages: 391-406

    • DOI

      10.1111/hepr.12606

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
  • [Journal Article] Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication.2015

    • Author(s)
      Mizuguchi Y, Takizawa T, Uchida E.
    • Journal Title

      World J Hepatol.

      Volume: 7(4) Issue: 4 Pages: 696-702

    • DOI

      10.4254/wjh.v7.i4.696

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
  • [Journal Article] Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia.2015

    • Author(s)
      Mizuguchi Y, Specht S, Isse K, Sasatomi E, Lunz JG 3rd, Takizawa T, Demetris AJ.
    • Journal Title

      J Hepatol.

      Volume: 63(2) Issue: 2 Pages: 399-407

    • DOI

      10.1016/j.jhep.2015.02.047

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10199, KAKENHI-PROJECT-26670610
  • [Journal Article] Small proline rich protein 2a in benign and malignant liver disease2014

    • Author(s)
      Yoshiaki mizuguchi
    • Journal Title

      Hepatology

      Volume: 53 Issue: 3 Pages: 1130-53

    • DOI

      10.1002/hep.26889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590559
  • [Journal Article] Mir-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line.2013

    • Author(s)
      Iwaki J, Kikuchi K, Mizuguchi Y, Kawahigashi Y, Yoshida H, Uchida E, Takizawa T.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 7 Pages: e69496-e69496

    • DOI

      10.1371/journal.pone.0069496

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591908, KAKENHI-PROJECT-24590559
  • [Journal Article] SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity2012

    • Author(s)
      Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ.
    • Journal Title

      BMC Mol Biol

      Volume: 13:20 Issue: 1

    • DOI

      10.1186/1471-2199-13-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590559
  • [Journal Article] Gene Suppression of Mouse Testis In Vivo Using Small Interfering RNA Derived from Plasmid Vectors2012

    • Author(s)
      Takizawa Ta, Ishikawa T, Kosuge T, Mizuguchi Y, Sato Y, Koji T, Araki Y, Takizawa To.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 45 Issue: 1 Pages: 77-81

    • DOI

      10.1267/ahc.11024

    • NAID

      130001854310

    • ISSN
      0044-5991, 1347-5800
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592115, KAKENHI-PROJECT-24570237, KAKENHI-PROJECT-24590559
  • [Journal Article] Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics2012

    • Author(s)
      Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ.
    • Journal Title

      Plos one

      Volume: 7 Issue: 2 Pages: e32449-e32449

    • DOI

      10.1371/journal.pone.0032449

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590559
  • [Journal Article] SnoN/SKIL modulates proliferationthrough control of hsa-miR-720 transcription in esophageal cancer cells.2011

    • Author(s)
      Eriko Shinozuka, Masao Miyashita, Yoshiaki Mizuguchi, Ichiro Akagi, Kunio Kikuchi, Hiroshi Makino, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Eiji Uchida, Toshihiro Takizawa.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430(1) Issue: 1 Pages: 101-106

    • DOI

      10.1016/j.bbrc.2012.11.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791553, KAKENHI-PROJECT-24590559
  • [Journal Article] MicroRNA cloning analysis reveals sex differences in microRNA expression profiles between adult mouse testis and ovary2008

    • Author(s)
      Takuya Mishima, Takami Takizawa, Shan-shun Luo, Osamu Ishibashi, Yutaka Kawahigashi, Yoshiyuki Mizuguchi, Tomoko Ishikawa, Miki Mori, Tomohiro Kanda, Tadashi Goto, Takizawa Takizawa
    • Journal Title

      Reproduction 136(6)

      Pages: 811-822

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591786
  • [Journal Article] Therapeutic use of short hairpin RNA in acute liver failure.2007

    • Author(s)
      Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Takizawa T, Tajiri T.
    • Journal Title

      Nippon Med Sch. 74(1).

      Pages: 74-6

    • NAID

      130004146890

    • Data Source
      KAKENHI-PROJECT-18390372
  • [Journal Article] Therapeutic use of short hairpin RNA in acute liver failure2007

    • Author(s)
      Yoshiaki Mizuguchi
    • Journal Title

      J Nippon Med Sch 74・1

      Pages: 74-76

    • NAID

      130004146890

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591786
  • [Journal Article] Therapeutic use of short hairpin RNA in acute liver failure.2007

    • Author(s)
      Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Takizawa T, Tajiri T
    • Journal Title

      Nippon Med Sch. 74(1)

      Pages: 74-76

    • NAID

      130004146890

    • Data Source
      KAKENHI-PROJECT-18790980
  • [Journal Article] Short hairpin RNA modulates transforming growth factor beta signaling in life-threatening liverfailure in mice.2005

    • Author(s)
      Mizuguchi Y, Yokomuro S, Mishima T, Arima Y, Shimizu T, Kawahigashi Y, Kanda T, Yoshida H, Takizawa T, Tajiri T.
    • Journal Title

      Gastroenterology 129

      Pages: 1654-1662

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591364
  • [Patent] Sequences of RNA functioning as RNA interference targeting human and mouse transforming growth factor betal receptor 22004

    • Inventor(s)
      水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
    • Industrial Property Rights Holder
      水口義昭, 三嶋拓也, 瀧澤敏広, 田尻孝, 横室茂樹
    • Filing Date
      2004
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591364
  • [Patent] Sequences of RNA functioning as RNA interference targeting human and mouse transforming growth factor beta1 receptor 22004

    • Inventor(s)
      水口 義昭, 三嶋 拓也, 瀧澤 敏広, 田尻 孝, 横室 茂樹
    • Industrial Property Rights Holder
      水口 義昭, 三嶋 拓也, 瀧澤 敏広, 田尻 孝, 横室 茂樹
    • Filing Date
      2004
    • Data Source
      KAKENHI-PROJECT-16591364
  • 1.  TAKIZAWA Toshihiro (90271220)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  YOSHIDA Hiroshi (60246999)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  TAJIRI Takashi (20163462)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  ARIMA Yasuo (30168025)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  YOKOMURO Shigeki (30267223)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  TANIAI Nobuhiko (20287725)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  AKIMARU Koho (40142541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ISHIKAWA Tomoko (70212850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  Nakamura Yoshiharu (90318519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  内藤 善哉 (20237184)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  内田 英二 (70176684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  松下 晃 (70449263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  DEMETRIS Anthony J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  KIKUCHI Kunio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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