HIROHARA Shiho 廣原志保

Researcher Number	70413804
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2020: 宇部工業高等専門学校, 物質工学科, 教授 2015: 宇部工業高等専門学校, その他部局等, 准教授 2012 – 2015: 宇部工業高等専門学校, 物質工学科, 准教授 2009 – 2011: 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Bio-related chemistry / Chemistry related to living body Except Principal Investigator Polymer chemistry / Radiation science / Biomedical engineering/Biological material science
Keywords	Principal Investigator ポルフィリン誘導体 / PET / ポルフィリン / セラノスティクス / BNCT / セラノスティクスがん医療 / がん治療効果 / がん集積性 / 水溶性 / 色素内包高分子ミセル … More / 高分子ポリマー / 機能性色素 / がんセラノスティクス / がん治療 / がん診断 / 色素 / 高分子ミセル / 糖鎖 / PDT / Theragnosis / がん診断(PET) / がん治療(PDT) / 腫瘍集積時間促進置換基 / 腫瘍集積性置換基 / 光細胞毒性試験 / がん診断（PDD） / がん治療（PDT） / Theranostics / メルカプトエタノール鎖 / グルコース鎖 / がん治療法(PDT) / がん診断法(PET) / ポルフィリン亜鉛錯体 / 薬剤取り込み / 子宮頚部ガン由来細胞株(HeLa) / 薬剤取り込み量 / 活性酸素除去剤 / trans-2置換グルコース連結ポルフィリン / ラット正常胃粘膜細胞株 / ラット胃癌用細胞株 / α-トコフェロール / 糖連結ポルフィリン金属錯体 / Ｘ線増感剤 / X線 / 放射線治療 / 細胞毒性 / 細胞取り込み / ガン細胞 / グルコース連結ポルフィリン金属錯体 / X線増感剤 … More Except Principal Investigator 精密重合 / カルボラン / ホウ素中性子捕捉療法 / 高分子ミセル / グルコース誘導体 / 糖代謝イメージング / 2-Iodo glucose / 新規SPECT製剤 / 放射性ヨウ素 / Iodo deoxy glucose / 放射性医薬品 / 放射性薬剤 / 糖代謝診断薬 / FDG / 糖代謝診断 / SPECT / イメージング / 核医学 / 核薬学 / ドラッグデリバリーシステム / 糖質高分子 / リビングラジカル重合 / 星型高分子 / 金属含有高分子 / がん治療 / 高分子薬剤 / スターポリマー / X線増感 / ナノメディスン / ナノバイオロジー Less

Development of PET-BNCT dual-functional porphyrin for theranostics drugsPrincipal Investigator
- Principal Investigator
  
  Shiho Hirohara
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Ube National College of Technology
Development of Boron Carrier for BNCT by Precision Polymerization Technique
- Principal Investigator
  
  OBATA Makoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Polymer chemistry
- Research Institution
  University of Yamanashi
Developmet and basic evaluation of sugar metabolism measuremet tracer for SPECT imaging
- Principal Investigator
  
  Kanai Yasukazu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Osaka University of Pharmaceutical Sciences
  Osaka University
Development of water-soluble Zinc porphyrin aimed at TheranosticsPrincipal Investigator
- Principal Investigator
  
  HIROHARA SHIHO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Ube National College of Technology
Precision Synthesis of Block Glycopolymers for DDS Carrier targeting Macrophages
- Principal Investigator
  
  OBATA Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Polymer chemistry
- Research Institution
  University of Yamanashi
Development of glycoconjugated porphyrin metal complexes for X-ray dynamic therapyPrincipal Investigator
- Principal Investigator
  
  HIROHARA Shiho
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Ube National College of Technology
  Nara Institute of Science and Technology
Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals
- Principal Investigator
  
  ANDO Tsuyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Nara Institute of Science and Technology

All 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] Spectroscopic Tools for the Diagnosis and Treatment of Cancer2017
- Author(s)
  N.Miyoshi, K.Hirakawa, H. Horiuchi, S.Okazaki, S-I. Ogura, M.Obata, S.Hirohara
- Total Pages
  164
- Publisher
  三恵社
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] Development of Porphyrin Derivatives for Theranostics2021
- Author(s)
  S. Hirohara
- Journal Title
  
  Nippon Laser Igakkaishi
  
  Volume: 41 Issue: 4 Pages: 394-401
- DOI
  10.2530/jslsm.jslsm-41_0022
- NAID
  130007968905
- ISSN
  0288-6200, 1881-1639
- Year and Date
  2021-01-15
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05327
[Journal Article] Effect of the hydrophobic segment of an amphiphilic block copolymer on micelle formation, zinc phthalocyanine loading, and photodynamic activity2021
- Author(s)
  M. Obata, S. Masuda, M. Takahashi, K. Yazaki, S. Hirohara
- Journal Title
  
  European Polymer Journal
  
  Volume: 147(15) Pages: 110325-110335
- DOI
  10.1016/j.eurpolymj.2021.110325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05327
[Journal Article] Synthesis, Photophysical Properties, and Photodynamic Activity of Positional Isomers of TFPP-Glucose Conjugates2018
- Author(s)
  Arif Fadlan, Hiroki Tanimoto, Tatsuya Ito, Yusuke Aritomi, Maho Ueno, Masaya Tokuda, *Shiho Hirohara, Makoto Obata, Tsumoru Morimoto, Kiyomi Kakiuchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 8 Pages: 1848-1858
- DOI
  10.1016/j.bmc.2018.02.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K17856, KAKENHI-PROJECT-17K05877
[Journal Article] Evaluation of the performance of glycosylated porphyrin platinum complex as an X-ray sensitizer2018
- Author(s)
  Tomomi Kubo, Ayano Hashimoto, Kohei Sharyo, Makoto Obata, Masato Tamura, Hirofumi Matsui, Shiho Hirohara
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: 7(2) Pages: 13-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05327
[Journal Article] Click Synthesis of Tetraphenylporphyrin Derivatives bearing 2-Deoxy-2-iodo-D-glucose as an FDG Analogue for Photodynamic Therapy2018
- Author(s)
  Shiho Hirohara, Keigo Uda, Tomomi Kubo, Masao Tanihara, Hirofumi Matsui, Makoto Obata, Kiyomi Kakiuchi
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: 7(2) Pages: 25-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05327
[Journal Article] RAFT synthesis of polystyrene-block-poly(polyethylene glycol monomethyl ether acrylate) for zinc phthalocyanine-loaded polymeric micelles as photodynamic therapy photosensitizers2017
- Author(s)
  Obata Makoto、Tanaka Shuto、Mizukoshi Hiroshi、Ishihara Eika、Takahashi Masaki、Hirohara Shiho
- Journal Title
  
  Journal of Polymer Science Part A: Polymer Chemistry
  
  Volume: 56 Issue: 5 Pages: 560-570
- DOI
  10.1002/pola.28929
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05877, KAKENHI-PROJECT-17K14482
[Journal Article] Synthesis of Amphiphilic Block Copolymer consisting of Glycopolymer and Poly(L-lactide) and Preparation of Sugar-coated Polymer Aggregates2016
- Author(s)
  M. Obata, R. Otobuchi, T. Kuroyanagi, M. Takahashi, S. Hirohara
- Journal Title
  
  J. Polym. Sci. Part A: Polym. Chem.
  
  Volume: 55 Issue: 3 Pages: 395-403
- DOI
  10.1002/pola.28401
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] Syntheses, photophysical properties, and photocytotoxicities of tetrakis(fluorophenyl)porphyrin derivatives bearing 2-hydroxyethylthio groups2016
- Author(s)
  M. Obata, S. Hirohara
- Journal Title
  
  J. Photochem. Photobiol. B: Biol.
  
  Volume: 162 Pages: 324-331
- DOI
  10.1016/j.jphotobiol.2016.07.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] Effect of polymer matrix on the performance of pressure-sensitive paint comprising 5,10,15,20-tetrakis (pentafluorophenyl)porphinato platinum(II) and poly(1,1,1,3,3,3-hexafluoroisopropyl-co- tert-butyl methacrylates)2015
- Author(s)
  M. Obata, R. Asato, S. Hirohara, K. Mitsuo
- Journal Title
  
  J. Appl. Polym. Sci.
  
  Volume: ｘｘｘ Issue: 16
- DOI
  10.1002/app.43316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26410189, KAKENHI-PROJECT-25410126
[Journal Article] Encapsulation of rat bone marrow stromal cells using a poly-ion complex gel of chitosan and succinylated poly(Pro–Hyp–Gly)2015
- Author(s)
  Yuni Kusumastuti, Yoshiaki Shibasaki, Shiho Hirohara, Mime Kobayashi, Kayo Terada,Tsuyoshi Ando, Masao Tanihara
- Journal Title
  
  J Tissue Eng Regen Med
  
  Volume: xxx Issue: 3 Pages: 869-876
- DOI
  10.1002/term.1987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] 光化学ガン医療のための糖連結ポルフィリンの開発2015
- Author(s)
  廣原志保
- Journal Title
  
  The 37th Anual Meeting of The Japanese Society for Photomedicine and Photobiology
  
  Volume: 37th Pages: 44-44
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] RAFT Synthesis of Statistical and Block Copolymers of 2-(α-D-Mannopyranosyloxy)ethyl Methacrylate with 2-(N,N-Dimethylamino)ethyl Methacrylate and Application for Nonviral Gene Delivery2015
- Author(s)
  Makoto Obata, Tomoya Kobori, Shiho Hirohara, Masao Tanihara
- Journal Title
  
  Polymer Chemistry
  
  Volume: 6 Issue: 10 Pages: 1793-1804
- DOI
  10.1039/c4py01652a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25410126, KAKENHI-PROJECT-26410189
[Journal Article] Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy2015
- Author(s)
  S. Hirohara, C. Oka, M. Totani, M. Obata, J. Yuasa, H. Ito, M. Tamura, H. Matsui, K. Kakiuchi, T. Kawai, M. Kawaichi, M. Tanihara
- Journal Title
  
  J. Med. Chem.
  
  Volume: 58 Issue: 21 Pages: 8658-8670
- DOI
  10.1021/acs.jmedchem.5b01262
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410189, KAKENHI-PROJECT-14J07186, KAKENHI-PROJECT-25410126
[Journal Article] Synthesis and PDT Effect of Polysaccharide-conjugated Porphyrins2014
- Author(s)
  Shiho Hirohara, Kohei Sharyo, Makoto Obata, Hayato Akahoshi, Masahiro Shiraishi, Kyosuke Fujitsu, Naoto Akiyama, Kenji Sugimoto, Kenji, Yoichi Nakano, Masato Tamura, Hirofumi Matsui and Masao Tanihara
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: 3(1) Pages: 11-21
- NAID
  40020244921
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] Selective accumulation of [62Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells2014
- Author(s)
  M. Tamura, H. Matsui, S. Hirohara, K. Kakiuchi, M. Tanihara, N. Takahashi, K. Nakai, Y. Kanai, H. Watabe, J. Hatazawa
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 8 Pages: 2563-2570
- DOI
  10.1016/j.bmc.2014.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192, KAKENHI-PUBLICLY-24106503, KAKENHI-PROJECT-24229008
[Journal Article] Synthesis of Fluoroporphyrin comprising Glucose and Ethylene Glycol and Evaluation of Its Photodynamic Effect2014
- Author(s)
  Shiho Hirohara, Masahiro Shiraishi, Naoto Akiyama, Makoto Obata, Masato Tamura, Hiromu Ito, Hirofumi Matui, Kiyomi Kakiuchi
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: 3(2) Pages: 61-69
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410189
[Journal Article] Rapid synthesis of ^<62>Zn-labeled S-glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging2014
- Author(s)
  M. Tamura, H. Matsui, S. Hirohara, K. Kakiuchi, M. Tanihara, N. Takahashi, K. Nakai, Y. Kanai, H. Watabe, J. Hatazawa
- Journal Title
  
  Chem. Lett.
  
  Volume: (in press) Issue: 6 Pages: 778-780
- DOI
  10.1246/cl.140056
- NAID
  130004868163
- Year and Date
  2014-02-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Rapid synthesis of 62Zn-labeled S-glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging2014
- Author(s)
  M. Tamura, H. Matsui, S. Hirohara, K. Kakiuchi, M. Tanihara, N. Takahashi, K. Nakai, Y. Kanai, H. Watabe, J. Hatazawa
- Journal Title
  
  Chem. Lett.
  
  Volume: XXX
- NAID
  130004868163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Synthesis and photoproperties of Eu(III)-bearing star polymers as luminescent materials2013
- Author(s)
  A. Kusumaatmaja, T. Ando, K. Terada, S. Hirohara, T. Nakashima, T. Kawai, T. Terashima, M. Tanihara
- Journal Title
  
  J. Polym. Sci. Part A : Polym. Chem.
  
  Volume: Vol.51 Issue: 12 Pages: 2527-2535
- DOI
  10.1002/pola.26652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192, KAKENHI-PROJECT-24750104
[Journal Article] Radical Polymerization of Trifluoromethyl- substituted Methyl Methacrylates and Their Application for Use in Pressure-Sensitive Paint2013
- Author(s)
  M.Obata, R.Asato, K. Mitsuo, S. Hirohara
- Journal Title
  
  J. Polym. Sci. Part A: Polym. Chem.
  
  Volume: 52 Issue: 7 Pages: 963-972
- DOI
  10.1002/pola.27076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192, KAKENHI-PROJECT-25410126
[Journal Article] Synthesis of Hydroxyethyloxy- conjugated Porphyrin Derivatives and Evaluation of Their Photodynamic Effect2013
- Author(s)
  K. Fujitake, T. Tomiyama, S. Fujiyama, M. Obata, M. Tamura, H. Matsui, S. Hirohara
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: 2 (1) Pages: 47-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Synthesis of Hydroxyethyloxy-conjugated Porphyrin Derivatives and Evaluation of Their Photodynamic Effect2013
- Author(s)
  K. Fujitake, T. Tomiyama, S. Fujiyama, M. Obata, M. Tamura, H. Matsui, S. Hirohara
- Journal Title
  
  ALA-Porphyrin Science
  
  Volume: Vol.2(1) Pages: 47-56
- URL
  http://porphyrin-ala.com/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Trans-Bisglyco- conjugation is an Efficient and Robust Architecture for PDT Photosensitizers based on 5,10,15,20-Tetrakis(pentafluorophenyl)porphyrin Derivatives2013
- Author(s)
  S. Hirohara, K. Sharyo, Y. Kawasaki, M. Totani, A. Tomotsuka, R. Funasako, N. Yasui, Y. Hasegawa, J. Yuasa, T. Nakashima, T. Kawai, C. Oka, M. Kawaichi, M. Obata, M. Tanihara
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 86 Issue: 11 Pages: 1295-1308
- DOI
  10.1246/bcsj.20130131
- NAID
  130004153161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192, KAKENHI-PROJECT-25410126
[Journal Article] Porphyrin Derivatives act as Vinylene Monomers in TEMPO-mediated Radical Copolymerization with Styrene2012
- Author(s)
  M. Obata, E. Ohtake, S. Hirohara, M. Tanihara, S. Yano
- Journal Title
  
  J. Polym. Sci. Part A : Polym. Chem.
  
  Volume: Vol.50 Issue: 17 Pages: 3592-3597
- DOI
  10.1002/pola.26147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Sugar and Heavy Atom Effects of Glycoconjugated Chlorin Palladium Complex on Photocytotoxicity2012
- Author(s)
  S. Hirohara, Y. Kawasaki, R. Funasako, N. Yasui, M. Totani, H. Alitomo, J. Yuasa, T. Kawai, C. Oka, M. Kawaichi, M. Obata, M. Tanihara
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: Vol.23 Issue: 9 Pages: 1881-1890
- DOI
  10.1021/bc300223j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Synthesis of poly[2-(a-D-mannopyranosyloxy)ethyl-co-2-dimethylaminoethylmethacrylates] and its lectin-binding and DNA-condensing properties2012
- Author(s)
  M. Obata, T. Kobari, S. Hirohara, M. Tanihara
- Journal Title
  
  J. Polym. Sci. Part A: Polym. Chem.,
  
  Volume: 53 Issue: 21 Pages: 4672-4677
- DOI
  10.1016/j.polymer.2012.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Journal Article] Synthesis, Characterization and Cellular Internalization of Poly(2-hydroxyethyl methacrylate) bearingα-D-Mannopyranose2011
- Author(s)
  M. Obata, M. Shimizu, T. Ohta, A. Matsushige, K. Iwai, S. Hirohara, M. Tanihara
- Journal Title
  
  Polym. Chem.
  
  Volume: Vol.2 Issue: 3 Pages: 651-658
- DOI
  10.1039/c0py00326c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750192
[Patent] 両親媒性ブロック共重合体2020
- Inventor(s)
  廣原志保、小幡誠
- Industrial Property Rights Holder
  廣原志保、小幡誠
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-151697
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05327
[Patent] 悪性腫瘍のPET診断用トレーサー2014
- Inventor(s)
  松井裕史,田村磨聖,廣原志保,谷原正夫,垣内喜代三
- Industrial Property Rights Holder
  国立大学法人筑波大学,国立大学法人奈良先端科学技術大学院大学,国立高等専門学校機構
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-03
- Overseas
- Data Source
  KAKENHI-PROJECT-23750192
[Patent] 悪性腫瘍のPET診断用トレーサー2014
- Inventor(s)
  松井裕史、田村磨聖、廣原志保、谷原正夫、垣内喜代三
- Industrial Property Rights Holder
  松井裕史、田村磨聖、廣原志保、谷原正夫、垣内喜代三
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-03
- Overseas
- Data Source
  KAKENHI-PROJECT-23750192
[Patent] 悪性腫瘍のPET診断用トレーサー2013
- Inventor(s)
  松井裕史,田村磨聖,廣原志保,谷原正夫,垣内喜代三
- Industrial Property Rights Holder
  国立大学法人筑波大学,国立大学法人奈良先端科学技術大学院大学,国立高等専門学校機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-159132
- Filing Date
  2013-07-31
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ポルフィリンを用いたセラノスティクス薬剤の創成2017
- Author(s)
  廣原志保
- Organizer
  フォトダイナミックセラノスティクス研究会
- Place of Presentation
  静岡大学浜松キャンパス
- Year and Date
  2017-01-21
- Invited
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 高専教員として私が工夫していること～教育と研究を両立させる方法～2017
- Author(s)
  廣原志保
- Organizer
  第17回日本化学会男女共同参画シンポジウム
- Place of Presentation
  慶應義塾大学　日吉キャンパス
- Year and Date
  2017-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] ２つの置換基を持つクロリンの物性評価2016
- Author(s)
  廣原志保、小幡誠、松井裕史、垣内喜代三
- Organizer
  第６回ポルフィリンALA学会
- Place of Presentation
  東京大学・医科学研究所
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] Mn ポルフィリンの合成と物性評価2016
- Author(s)
  松村神奈、小幡誠、松井裕史、廣原志保
- Organizer
  第６回ポルフィリンALA学会
- Place of Presentation
  東京大学・医科学研究所
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 2つの置換基を有するフッ素クロリンの光細胞毒性2016
- Author(s)
  廣原志保、小幡誠、松井裕史、垣内喜代三
- Organizer
  第２６回日本光線力学学会学術講演会（シンポジウム：フォトダイナミックセラノスティクスのためのポルフィリン薬剤の創成）
- Place of Presentation
  はまぎんホールヴィアマーレ（横浜）
- Year and Date
  2016-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 抗酸化剤としてのポルフィリン金属錯体の合成と評価2016
- Author(s)
  松村神奈、小幡誠、伊藤紘、松井裕史、廣原志保
- Organizer
  第31回日本酸化ストレス学会関東部会
- Place of Presentation
  芝浦工業大学　豊洲キャンパス
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] メルカプトエタノール連結クロリンの合成とPDT評価2016
- Author(s)
  井町美晴、松村神奈、廣原志保、小幡誠、松井裕史
- Organizer
  第31回日本酸化ストレス学会関東部会
- Place of Presentation
  芝浦工業大学　豊洲キャンパス
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] Znポルフィリン誘導体の合成と物性評価2016
- Author(s)
  松丸直睦、須子望加、廣原志保、伊藤紘、松井裕史
- Organizer
  第31回日本酸化ストレス学会関東部会
- Place of Presentation
  芝浦工業大学　豊洲キャンパス
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 光増感剤のための高分子キャリアの精密合成2016
- Author(s)
  小幡誠、筒井雄也、廣原志保
- Organizer
  第２６回日本光線力学学会学術講演会（シンポジウム：フォトダイナミックセラノスティクスのためのポルフィリン薬剤の創成）
- Place of Presentation
  はまぎんホールヴィアマーレ（横浜）
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] PDT effect of TFPP derivatives having two different functional groups2015
- Author(s)
  S. Hirohara, Y. Kubota, N. Akiyama, M. Obata, H. Matsui, K. Kakiuchi
- Organizer
  The 3rd International ALA and Porphyrin Symposium (IAPS3)
- Place of Presentation
  Hawai
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 光化学ガン医療のための糖連結ポルフィリンの開発2015
- Author(s)
  廣原志保
- Organizer
  第37回日本光医学・光生物学会
- Place of Presentation
  宮崎
- Year and Date
  2015-07-18
- Invited
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] Synthesis and characterization of water-soluble polymers bearing porphyrin moiety at the initiating end for photodynamic therapy2015
- Author(s)
  M. Obata, Y. Tsutsui, S. Hirohara
- Organizer
  Pacifichem 2015
- Place of Presentation
  Bench to Bedside: Chemistry of Health Care, Hawai
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] Synthesis and characterization of water-soluble polymers bearing porphyrin moiety at the initiating end for photodynamic therapy2015
- Author(s)
  Makoto Obata, Yuya Tsutsui, Shiho Hirohara
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Honolulu, Hawai, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25410126
[Presentation] 二つの水溶性置換基を有するポルフィリン誘導体の合成とin vitro評価2015
- Author(s)
  廣原志保, 小幡誠, 松井裕史, 垣内喜代三
- Organizer
  第25回日本光線力学学会
- Place of Presentation
  東京
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] RAFT重合によるカチオン性糖質高分子の合成と核酸キャリアへの応用2015
- Author(s)
  小幡誠、小堀智也、廣原志保、谷原正夫
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25410126
[Presentation] Synthesis and photocytotoxicity of fluorophyenylporphyrin derivatives having two different functional groups2015
- Author(s)
  S. Hirohara, Y. Kubota, N. Akiyama, M. Obata, H. Matsui, K. Kakiuchi
- Organizer
  Pacifichem 2015
- Place of Presentation
  Bench to Bedside: Chemistry of Health Care, Hawai
- Year and Date
  2015-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] ２種類の置換基を導入したクロリンパラジウム錯体の開発2014
- Author(s)
  赤星迅人、伊藤由美子、藤竹香澄、小幡誠、松井裕史、田村磨聖、廣原志保
- Organizer
  日本化学会　第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 2種類の置換基を導入したクロリンパラジウム錯体の開発2014
- Author(s)
  赤星迅人,藤竹香澄,小幡誠,松井裕史,田村磨聖,廣原志保
- Organizer
  第93回日本化学会春季年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ＳＯＤ製剤のための糖連結ポルフィリンマンガン錯体の合成と物性評価2014
- Author(s)
  藤津恭介、赤星迅人、白石昌大、藤竹香澄、小幡誠、松井裕史、田村磨聖、伊藤紘、廣原志保
- Organizer
  日本化学会　第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ２つの置換基を有するフッ素クロリンの合成と物性評価2014
- Author(s)
  秋山直澄, 窪田雄介, 廣原志保, 小幡誠, 松井裕史, 谷本裕樹, 垣内喜代三
- Organizer
  第29 回日本酸化ストレス学会関東支部会
- Place of Presentation
  東京
- Year and Date
  2014-12-20
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] ポルフィリン金属錯体のX線感受性試験2014
- Author(s)
  廣原志保, 田村磨聖, 松井裕史, 小幡誠
- Organizer
  第4回ポルフィリンALA学会
- Place of Presentation
  神戸
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 異なる置換基を有するポルフィリンの合成と光細胞毒性2014
- Author(s)
  白石昌大、富山泰至、藤竹香澄、藤山真治、小幡誠、松井裕史、廣原志保
- Organizer
  日本化学会　第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ポルフィリン金属錯体のX線感受性試験2014
- Author(s)
  廣原志保、田村磨聖、松井裕史、小幡誠
- Organizer
  第4回ポルフィリンALA学会
- Place of Presentation
  ニチイ学会神戸ポートアイランドセンター
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 異なる置換基を有するポルフィリンの合成と光細胞毒性2014
- Author(s)
  白石昌大,藤竹香澄,富山泰至,藤山真治,小幡誠,松井裕史,田村磨聖,廣原志保
- Organizer
  第93回日本化学会春季年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結クロリンのPDT評価2014
- Author(s)
  廣原志保, 谷原正夫, 岡千緒, 川市正史, 垣内喜代三, 小幡誠, 松井裕史
- Organizer
  第29 回日本酸化ストレス学会関東支部会
- Place of Presentation
  東京
- Year and Date
  2014-12-20
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] SOD製剤のための糖連結ポルフィリンマンガン錯体の合成と物性評価2014
- Author(s)
  藤津恭介,赤星迅人,白石昌大,藤竹香澄,小幡誠,松井裕史,田村磨聖,伊藤紘,廣原志保
- Organizer
  第93回日本化学会春季年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 亜鉛ポルフィリンの合成と細胞評価2013
- Author(s)
  藤山真治,富山泰至,藤竹香澄,田村磨聖,松井裕史,廣原志保
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  茨城
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] エチレングリコール連結ポルフィリン用いたPET診断薬の合成法の開発2013
- Author(s)
  佐伯茉耶、藤山真治、廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 水溶性を変化させたPEG連結ポルフィリンの合成と光細胞毒性2013
- Author(s)
  藤山真治,藤竹香澄,田村磨聖,松井裕史,廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 様々な癌細胞株を用いた糖連結ポルフィリンのPDT試験2013
- Author(s)
  藤竹香澄,田村磨聖,松井裕史,廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 水溶性置換基を有するフッ素ポルフィリンの合成とin vitro評価2013
- Author(s)
  富山泰至, 藤竹香澄, 廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 水溶性を変化させたPEG連結ポルフィリンの合成と光細胞毒性2013
- Author(s)
  藤山真治、藤竹香澄、田村磨聖、松井裕史、廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 水溶性置換基を有するフッ素ポルフィリンの合成とin vitro評価2013
- Author(s)
  富山泰至,藤竹香澄,廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結Mnポルフィリンの合成と機能評価2013
- Author(s)
  藤竹香澄、井上葵、伊藤由美子、佐伯茉耶、田村磨聖、松井裕史、小幡誠、廣原志保
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  東京工業大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 様々な癌細胞株を用いた糖連結ポルフィリンのPDT試験2013
- Author(s)
  藤竹香澄、田村磨聖、松井裕史、廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結Mnポルフィリンの合成と機能評価2013
- Author(s)
  藤竹香澄,井上葵,伊藤由美子,佐伯茉耶,田村磨聖,松井裕史,小幡誠,廣原志保
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  茨城
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] エチレングリコール連結ポルフィリン用いたPET診断薬の合成法の開発2013
- Author(s)
  佐伯茉耶,藤山真治,廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 亜鉛ポルフィリンの合成と細胞評価2013
- Author(s)
  藤山真治、富山泰至、藤竹香澄、田村磨聖、松井裕史、廣原志保
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  東京工業大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] エチレングリコール連結ポルフィリンの合成と光細胞毒性2013
- Author(s)
  富山泰至、西谷雄矢、藤山真治、藤竹香澄、船迫亮太、廣原志保、田村磨聖、松井裕史、小幡誠、谷原正夫
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  東京工業大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ポルフィリン金属錯体のX線感受性試験2013
- Author(s)
  廣原志保,田村磨聖,松井裕史,小幡誠
- Organizer
  第4回ポルフィリンALA学会
- Place of Presentation
  神戸
- Year and Date
  2013-04-26
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 2置換クロリンの合成とPDT評価2013
- Author(s)
  伊藤由美子,藤竹香澄,廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] エチレングリコール連結ポルフィリンの合成と光細胞毒性2013
- Author(s)
  富山泰至,西谷雄矢,藤山真治,藤竹香澄,船迫亮太,廣原志保,田村磨聖,松井裕史,小幡誠,谷原正夫
- Organizer
  第3回ポルフィリンALA学会
- Place of Presentation
  茨城
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 2置換クロリンの合成とPDT評価2013
- Author(s)
  伊藤由美子、藤竹香澄、廣原志保
- Organizer
  2013年日本化学会中国四国支部大会
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結Mnポルフィリンの合成と機能評価2013
- Author(s)
  藤竹　香澄、井上　葵、伊藤　由美子、佐伯　茉耶、田村　磨聖、松井　裕史、小幡　誠、廣原　志保
- Organizer
  ポルフィリンALA学会
- Place of Presentation
  神奈川県
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結マンガンポルフィリンの合成と光細胞毒性評価2012
- Author(s)
  井上葵,廣原志保,田村磨聖,松井裕史
- Organizer
  第27回中国四国地区高分子若手研究会
- Place of Presentation
  山口
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] グルコース連結マンガンポルフィリンの合成と光細胞毒性評価2012
- Author(s)
  井上葵, 廣原志保, 田村磨聖, 松井裕史
- Organizer
  第27回中国四国地区高分子若手研究会
- Place of Presentation
  山口県
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 位置選択的糖修飾により発現するポルフィリンの特異な体内動態と高効率光線力学効果2012
- Author(s)
  廣原志保, 戸谷匡康, 湯浅順平, 中島琢也, 河合壯, 岡千緒, 川市正史, 小幡誠, 谷原正夫
- Organizer
  光化学討論会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] Eu-bearing Star Polymers : Syntheses by Living Radical Polymerization and Their Photoproperties2012
- Author(s)
  Ahmad Kusumaatmaja, Kayo Terada, Shiho Hirohara, Tsuyoshi Ando, Masao Tanihara
- Organizer
  第61回高分子学会年次大会
- Place of Presentation
  横浜
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-21300164
[Presentation] PET診断のためのIDG連結ポルフィリン誘導体の合成2012
- Author(s)
  廣原志保,宇田圭吾,谷原正夫,小幡誠,高橋成人,篠原厚,金井泰和,畑澤順,垣内喜代三
- Organizer
  第15回ヨウ素学会シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2012-09-11
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] エチレングリコール連結フッ素ポルフィリンの合成と光細胞毒性評価2012
- Author(s)
  西谷雄矢,船迫亮太,田村磨聖,廣原志保,小幡誠,松井裕史,谷原正夫
- Organizer
  第27回中国四国地区高分子若手研究会
- Place of Presentation
  山口
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 位置選択的糖修飾により発現するポルフィリンの特異な体内動態と高効率光線力学効果2012
- Author(s)
  廣原志保,戸谷匡康,湯浅順平,中島琢也,河合壯,岡千緒,川市正史,小幡誠,谷原正夫
- Organizer
  2012年光化学討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 位置選択的グルコース修飾により発現するポルフィリンの特異な体内動態と高効率光線力学効果2012
- Author(s)
  廣原志保,戸谷匡康,湯浅順平,河合壯,岡千緒,川市正史,小幡誠,谷原正夫
- Organizer
  第92回日本化学会春季年会
- Place of Presentation
  神奈川県
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 光線力学療法のための新規物質の開発2012
- Author(s)
  廣原志保,田村磨聖,高橋成人,中井浩二,金井泰和,渡部浩司,谷原正夫,垣内喜代三,松井裕史,篠原厚,畑澤順
- Organizer
  第22回日本光線力学学会
- Place of Presentation
  茨城
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 糖連結フッ素ポルフィリン類の光細胞毒性に対する構造活性相関2011
- Author(s)
  廣原志保,戸谷匡康,湯浅順平,河合壯,岡千緒,川市正史,小幡誠,谷原正夫
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  茨城県
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] 核に多数のルテニウムを有する星型ポリマーの合成とX線増感作用の評価2011
- Author(s)
  増岡志寿香、安藤剛、寺田佳世、廣原志保、谷原正夫
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-21300164
[Presentation] メルカプトエタノールを連結したフッ素ポルフィリンの合成と光細胞毒性
- Author(s)
  小幡誠, 廣原志保
- Organizer
  第24回日本光線力学学会
- Place of Presentation
  静岡
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] 位置選択的グルコース修飾により発現するポルフィリンの特異な体内動態と高効率光線力学効果
- Author(s)
  廣原志保・戸谷匡康・湯浅順平・河合壯・岡千緒・川市正史・小幡誠・谷原正夫
- Organizer
  第92回日本化学会　春季年会
- Place of Presentation
  神奈川県 (横浜市）
- Data Source
  KAKENHI-PROJECT-23750192
[Presentation] ２つの水溶性置換基を有するポルフィリン誘導体の開発
- Author(s)
  窪田雄介, 秋山直澄, 藤津恭介, 白石昌大, 赤星迅人, 小幡誠, 松井裕史, 廣原志保
- Organizer
  2014年日本化学会中国四国支部大会
- Place of Presentation
  山口
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] メルカプトエタノールとグルコースを有するクロリンの合成と細胞評価
- Author(s)
  秋山直澄, 窪田雄介, 藤津恭介, 白石昌大, 赤星迅人, 小幡誠, 松井裕史, 廣原志保
- Organizer
  2014年日本化学会中国四国支部大会
- Place of Presentation
  山口
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26410189
[Presentation] グルコース鎖とエチレングリコール鎖を用いたポルフィリンの合成と細胞評価
- Author(s)
  廣原志保, 白石昌大, 小幡誠, 松井裕史
- Organizer
  第24回日本光線力学学会
- Place of Presentation
  静岡
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-26410189

1. OBATA Makoto (70343267)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
2. ANDO Tsuyoshi (60324654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. TANIHARA Masao (50294286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Kanai Yasukazu (60397643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 垣内喜代三 (60152592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小倉俊一郎 (90343160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Naka Sadahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Sakai Toshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Tamura Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 谷本裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROHARA Shiho 廣原 志保

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Development of PET-BNCT dual-functional porphyrin for theranostics drugsPrincipal Investigator

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Development of Boron Carrier for BNCT by Precision Polymerization Technique

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Developmet and basic evaluation of sugar metabolism measuremet tracer for SPECT imaging

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Development of water-soluble Zinc porphyrin aimed at TheranosticsPrincipal Investigator

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Precision Synthesis of Block Glycopolymers for DDS Carrier targeting Macrophages

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Development of glycoconjugated porphyrin metal complexes for X-ray dynamic therapyPrincipal Investigator

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Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals

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[Book] Spectroscopic Tools for the Diagnosis and Treatment of Cancer2017

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[Journal Article] Development of Porphyrin Derivatives for Theranostics2021

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[Journal Article] Effect of the hydrophobic segment of an amphiphilic block copolymer on micelle formation, zinc phthalocyanine loading, and photodynamic activity2021

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[Journal Article] Synthesis, Photophysical Properties, and Photodynamic Activity of Positional Isomers of TFPP-Glucose Conjugates2018

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[Journal Article] Evaluation of the performance of glycosylated porphyrin platinum complex as an X-ray sensitizer2018

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[Journal Article] Click Synthesis of Tetraphenylporphyrin Derivatives bearing 2-Deoxy-2-iodo-D-glucose as an FDG Analogue for Photodynamic Therapy2018

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[Journal Article] RAFT synthesis of polystyrene-block-poly(polyethylene glycol monomethyl ether acrylate) for zinc phthalocyanine-loaded polymeric micelles as photodynamic therapy photosensitizers2017

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HIROHARA Shiho 廣原志保