Itoh Mai 伊藤真以

… Alternative Names

ITOH Mai 伊藤真以

大澤真以オオサワマイ

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Researcher Number	70415545
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help	2012 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2010 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 2006: 東京都医学研究機構, 研究員
Review Section/Research Field	Principal Investigator Laboratory medicine / Pediatrics
Keywords	Principal Investigator 低酸素培養 / 低酸素 / 白血病 / 骨髄ニッチ / 白血病幹細胞 / 急性白血病 / 自己複製能 / 薬剤感受性試験 / 白血病細胞 / 骨髄環境 / 臨床血液学

Research Projects
(3 results)
Research Products
(42 results)

Molecular target treatment based on the pathological analysis of leukemia stem cells under mimicking bone marrow microenviroment in hypoxiaPrincipal Investigator
- Principal Investigator
  
  ITOH Mai
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Medical and Dental University
New drug sensitivity test for leukemia mimicking bone marrow microenvironment in hypoxiaPrincipal Investigator
- Principal Investigator
  
  ITOH Mai
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Medical and Dental University
糖鎖機能を利用した組換えリソソーム酵素の開発および治療法の確立Principal Investigator
- Principal Investigator
  
  大澤真以
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Establishment of a quenching probe method for detection of NPM1 mutations in acute myeloid leukemia cells.2016
- Author(s)
  Kawaguchi-Ihara N, Itoh M, Murohashi I, Tohda S
- Journal Title
  
  Oncology Letters
  
  Volume: 11 Issue: 4 Pages: 2429-2432
- DOI
  10.3892/ol.2016.4225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860404
[Journal Article] Effect of EPH-Ephrin signaling on the growth of human leukemia cells.2014
- Author(s)
  Takahashi Y, Itoh M, Nara N, Tohda S.
- Journal Title
  
  Anticancer Research
  
  Volume: 34 Pages: 2913-2918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860404
[Journal Article] Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells2013
- Author(s)
  Ono A, Oike R, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S
- Journal Title
  
  Anticancer Res
  
  Volume: 33 Pages: 809-13
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23482748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells.2013
- Author(s)
  Okuhashi Y, Itoh M, Nara N, Tohda S
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 4293-4298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860404
[Journal Article] Comparative Effects of PP242 and Rapamycin on mTOR Signalling and NOTCH Signalling in Leukemia Cells.2013
- Author(s)
  Ono A, Oike R, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S.
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 809-813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Effects of the HIF1 inhibitor, echinomycin, on growth and NOTCH signalling in leukaemia cells.2013
- Author(s)
  Yonekura S, Itoh M, Okuhashi Y, Takahashi Y, Ono A, Nara N, Tohda S
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 3099-3103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860404
[Journal Article] Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells.2012
- Author(s)
  Kanamori E, Itoh M, Tojo N, Koyama T, Nara N, Tohda S.
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 4 Pages: 397-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells2012
- Author(s)
  Kanamori E, Itoh M, Tojo N, Koyama T, Nara N, Tohda S
- Journal Title
  
  Exp Ther Med
  
  Volume: 4 Issue: 3 Pages: 397-400
- DOI
  10.3892/etm.2012.633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523, KAKENHI-PROJECT-23590662
[Journal Article] Advantages of the quenching probe method over otherPCR-based methods for detection of theJAK2 V617F mutation2012
- Author(s)
  Ono A, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S
- Journal Title
  
  Oncology Lett
  
  Volume: 4 Issue: 2 Pages: 205-8
- DOI
  10.3892/ol.2012.741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523, KAKENHI-PROJECT-23590662
[Journal Article] Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells.2012
- Author(s)
  Takahashi Y, Ishigaki T, Okuhashi Y, Ono A, Itoh M, Nara N, Tohda S.
- Journal Title
  
  Anticancer Research
  
  Volume: 32 Pages: 2813-2818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Effects of BMP4 on the growth and clonogenicity of human leukemia and lymphoma cells2012
- Author(s)
  Takahashi Y, Ishigaki T, Okuhashi Y, Ono A, Itoh M, Nara N, Tohda S
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 2813-7
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22753742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Advantage of quenching probe method over other PCR-based methods for detection of JAK2 V617F mutation2012
- Author(s)
  Ono A, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S
- Journal Title
  
  Oncology Letters
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Effects of combination of Notch inhibitor plus Hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells2011
- Author(s)
  Okuhashi Y, Itoh M, Nara N, Tohda S
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 893-6
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21498710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] Promotion of the self-renewal capacity of human leukemia cells by sonic hedgehog protein2011
- Author(s)
  Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Murohashi I, Nara N, Tohda S
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 781-4
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21498696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] γ-Secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines2010
- Author(s)
  Okuhashi Y, Itoh M, Arai A, Nara N, Tohda S
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 4071-4
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21036721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Journal Article] γ-Secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines
- Author(s)
  Okuhashi Y, Itoh M, Arai A, Nara N, Tohda S
- Journal Title
  
  Anticancer Research
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] Highly sensitive detection of MYD88 mutation by combination of allele-specific PCR and quenching probe method2016
- Author(s)
  Shohei Nogami, Mai Itoh, Shuji Tohda
- Organizer
  The 14th Asian Society for Clinical Pathology and Laboratory Medicine Congress
- Place of Presentation
  台北（台湾）
- Year and Date
  2016-03-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] リンパ腫・白血病細胞株の増殖に対するMYD88阻害薬とBTK阻害薬の作用2015
- Author(s)
  白鳥恵理香、野上祥平、王詩淳、大高美香、伊藤真以、東田修二
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] 白血病・リンパ腫細胞に対するBMI1阻害剤の細胞分子生物学的作用2015
- Author(s)
  大高美香、白鳥恵理香、王詩淳、野上祥平、伊藤真以、東田修二
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Notchシグナル阻害剤に耐性を示す白血病細胞の分子病態2015
- Author(s)
  奥橋佑基、伊藤真以、細萱茂実、東田修二
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] リンパ系腫瘍におけるMYD88遺伝子変異の新規検査法の開発2015
- Author(s)
  野上祥平、井原寛子、王詩淳、白鳥恵理香、大高美香、伊藤真以、東田修二
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] 白血病細胞における糖転移酵素の発現とNotchシグナル活性化との関連2015
- Author(s)
  王詩淳、野上祥平、白鳥恵理香、大高美香、伊藤真以、東田修二
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] BCR-ABL融合遺伝子の定量RT-PCR法と定性RT-Nested PCR法での検出感度の比較2014
- Author(s)
  白鳥恵理香、大高美香、高橋祐介、伊藤真以、東田修二
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-11-24
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Quenching probe法を用いたNPM1遺伝子変異の検出2014
- Author(s)
  井原寛子、伊藤真以、室橋郁生、東田修二
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-11-24
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] 白血病細胞の増殖に対するBmi1阻害剤の作用2014
- Author(s)
  大高美香、高橋祐介、白鳥恵理香、伊藤真以、東田修二
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-11-24
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Wntシグナル、Hedgehogシグナル関連遺伝子のノックダウンが及ぼす白血病への効果2014
- Author(s)
  奥橋佑基、高橋祐介、伊藤真以、東田修二
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-11-24
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Effects of GLI1 and CTNNB1 knockdown on Notch signaling and proliferation of AML and T-ALL cell lines2014
- Author(s)
  Okuhashi Y, Takahashi Y, Ohtaka M, Shiratori E, O S, Itoh M, Tohda S
- Organizer
  American Society of Hematology,The 56th Annual Meeting and Exposition
- Place of Presentation
  サンフランシスコ、アメリカ
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Effects of hypoxia on HIF, Notch, Akt, and NF-κB signaling in leukemia cell lines2013
- Author(s)
  Itoh M, Takahashi Y, Okuhashi Y, Tohda S
- Organizer
  The 55th American Society of Hematology
- Place of Presentation
  ニューオリンズ、アメリカ
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] Notchを標的とするsiRNAを用いた白血病細胞の増殖に対する効果の検討2013
- Author(s)
  奥橋佑基、高橋祐介、伊藤真以、東田修二
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] 白血病細胞の生存に対するHIF蛋白の役割2013
- Author(s)
  伊藤真以、奥橋佑基、高橋祐介、東田修二
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] 白血病細胞におけるEph/ephrin系とNotch系との相互作用2013
- Author(s)
  高橋祐介、奥橋佑基、伊藤真以、東田修二
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860404
[Presentation] チロシンキナーゼ阻害薬投与中の慢性骨髄性白血病患者における微少残存病変検出の3種の遺伝子検査法の比較2012
- Author(s)
  東田修二、大野彩、高橋祐介、奥橋佑基、伊藤真以
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 白血病細胞におけるNotchシグナルのmTORシグナルへの作用2012
- Author(s)
  奥橋佑基、大野彩、高橋祐介、伊藤真以、東田修二
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 白血病細胞の増殖に対するmTOR阻害剤の作用2012
- Author(s)
  大野彩、奥橋佑基、高橋祐介、伊藤真以、東田修二
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 骨髄微小環境を再現した低酸素培養が白血病細胞に及ぼす影響2012
- Author(s)
  伊藤真以、奥橋佑基、高橋祐介、大野彩、東田修二
- Organizer
  第59回日本臨床検査医学会学術集会.
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] Eph/ephrinの白血病細胞の増殖に対する作用2012
- Author(s)
  高橋祐介、奥橋佑基、大野彩、伊藤真以、東田修二
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 骨髄増殖性腫瘍におけるJAK2V617F変異の種々の検出法の解析2011
- Author(s)
  大野彩、高橋祐介、奥橋佑基、伊藤真以、東田修二
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] BMP4の白血病細胞の増殖に対する作用2011
- Author(s)
  高橋祐介、石垣智寛、奥橋佑基、大野彩、伊藤真以、東田修二
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 骨髄増殖性腫瘍におけるJAK2V617F変異の種々の検査法の比較2011
- Author(s)
  大野彩、高橋祐介、奥橋佑基、伊藤真以、東田修二
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 白血病細胞の増殖におけるHedgehogシグナルとNotchシグナルの相互作用2011
- Author(s)
  奥橋佑基、大野彩、高橋祐介、伊藤真以、東田修二
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 白血病細胞の増殖におけるNotchシグナルとWnt、Hedgehogシグナルとの相互作用2010
- Author(s)
  奥橋佑基、石垣知寛、伊藤真以、東田修二
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22790523
[Presentation] 骨髄微小環境を再現した低酸素培養が白血病細胞に及ぼす影響
- Author(s)
  伊藤真以、奥橋佑基、高橋祐介、大野彩、東田修二
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790523

Itoh Mai 伊藤 真以

ITOH Mai 伊藤 真以

大澤 真以 オオサワ マイ

Research Projects

Research Products

Molecular target treatment based on the pathological analysis of leukemia stem cells under mimicking bone marrow microenviroment in hypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New drug sensitivity test for leukemia mimicking bone marrow microenvironment in hypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖鎖機能を利用した組換えリソソーム酵素の開発および治療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of a quenching probe method for detection of NPM1 mutations in acute myeloid leukemia cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of EPH-Ephrin signaling on the growth of human leukemia cells.2014

Author(s)

Journal Title

Data Source

[Journal Article] Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells2013

Author(s)

Journal Title

URL

Data Source

[Journal Article] NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Comparative Effects of PP242 and Rapamycin on mTOR Signalling and NOTCH Signalling in Leukemia Cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Effects of the HIF1 inhibitor, echinomycin, on growth and NOTCH signalling in leukaemia cells.2013

Author(s)

Journal Title

Data Source

[Journal Article] Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells.2012

Author(s)

Journal Title

Data Source

[Journal Article] Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Advantages of the quenching probe method over otherPCR-based methods for detection of theJAK2 V617F mutation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells.2012

Author(s)

Journal Title

Data Source

[Journal Article] Effects of BMP4 on the growth and clonogenicity of human leukemia and lymphoma cells2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] Advantage of quenching probe method over other PCR-based methods for detection of JAK2 V617F mutation2012

Author(s)

Journal Title

Data Source

[Journal Article] Effects of combination of Notch inhibitor plus Hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells2011

Author(s)

Journal Title

URL

Itoh Mai 伊藤真以

ITOH Mai 伊藤真以

大澤真以オオサワマイ