ONO Shinji 小野慎治

Researcher Number	70418820
Other IDs
Affiliation (Current)	2025: 長崎大学, 原爆後障害医療研究所, 客員研究員
Affiliation (based on the past Project Information) *help	2016 – 2023: 長崎大学, 原爆後障害医療研究所, 客員研究員 2015: 長崎大学, 医歯薬学総合研究科(医学系), 講師 2014: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2013: 長崎大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science / Medical genome science Except Principal Investigator Psychiatric science
Keywords	Principal Investigator 臨床精神分子遺伝学 / 臨床精神医学 / 分子遺伝学 / 臨床精神科学 / 精神神経科学 / ゲノム / 遺伝学 / 分子生物学 / 精神遺伝学 / 臨床遺伝学 … More Except Principal Investigator … More ミッシング・ヘリタビリティー / 希少変異仮説 / 精神疾患 / マイクロアレイ / 遺伝子 / ミッシングヘリタビリティー Less

繊毛鞭毛関連タンパク遺伝子変異と水頭症および認知機能低下の関連性についての研究Principal Investigator
- Principal Investigator
  
  小野慎治
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Nagasaki University
The molecular analysis of a candidate gene as a cause of schizophreniaPrincipal Investigator
- Principal Investigator
  
  ONO Shinji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagasaki University
Exome sequencing for monozygotic twins discordant for neuropsychiatric conditions.Principal Investigator
- Principal Investigator
  
  ONO Shinji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Nagasaki University
The molecular analysis of psychiatric disorders focusing missing heritability
- Principal Investigator
  
  KUROTAKI Naohiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagasaki University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models2021
- Author(s)
  Yoshiro Morimoto, Shinji Ono, Shintaro Yoshida, Hiroyuki Mishima, Akira Kinoshita, Takeshi Tanaka, Yoshihiro Komohara, Naohiro Kurotaki, Tatsuya Kishino, Yuji Okazaki, Hiroki Ozawa, Koh-ichiro Yoshiura, Akira Imamura
- Journal Title
  
  Translational Psychiatry
  
  Volume: 11 Issue: 1 Pages: 132-132
- DOI
  10.1038/s41398-021-01258-1
- NAID
  120007000270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08050, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-19K22913, KAKENHI-PROJECT-20K16650, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-18K07850
[Journal Article] Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies.2020
- Author(s)
  Imamura A, Morimoto Y, Ono S, Kurotaki N, Kanegae S, Yamamoto N, Kinoshita H, Tsujita T, Okazaki Y, Ozawa H.
- Journal Title
  
  J Neural Transm
  
  Volume: in press Issue: 11 Pages: 1501-1515
- DOI
  10.1007/s00702-020-02188-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08050, KAKENHI-PROJECT-17K10309
[Journal Article] Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities2019
- Author(s)
  Morimoto Y, Yoshida S, Kinoshita A, Satoh C, Mishima H, Yamaguchi N, Matsuda K, Sakaguchi M, Tanaka T, Komohara Y, Imamura A, Ozawa H, Nakashima M, Kurotaki N, Kishino T, Yoshiura K, Ono S
- Journal Title
  
  Neurology
  
  Volume: 92 Issue: 20
- DOI
  10.1212/wnl.0000000000007505
- NAID
  120006987711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07088, KAKENHI-PROJECT-18K07850, KAKENHI-PROJECT-19K08050, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-19K22913, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-17K10309
[Journal Article] Nonsense mutation in CFAP43 causes normal pressure hydrocephalus with ciliary abnormalities2019
- Author(s)
  Yoshiro Morimoto, Shintaro Yoshida, Akira Kinoshita, Chisei Satoh, Hiroyuki Mishima, Naohiro Yamaguchi, Katsuya Matsuda, Miako Sakaguchi, Takeshi Tanaka, Yoshihiro Komohara, Akira Imamura, Hiroki Ozawa, Masahiro Nakashima, Naohiro Kurotaki, Tatsuya Kishino, Koh-ichiro Yoshiura and Shinji Ono
- Journal Title
  
  Neurology
  
  Volume: 印刷中
- NAID
  120006987711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10190
[Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018
- Author(s)
  Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S.
- Journal Title
  
  Transl Psychiatry
  
  Volume: 8 Issue: 1 Pages: 41-41
- DOI
  10.1038/s41398-017-0088-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-26461721, KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-17K10309, KAKENHI-PROJECT-16K10190, KAKENHI-PROJECT-16K10193
[Journal Article] Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.2017
- Author(s)
  Morimoto Y, Ono S, Imamura A, Okazaki Y, Kinoshita A, Mishima H, Nakane H, Ozawa H, Yoshiura KI, Kurotaki N.
- Journal Title
  
  Hum Genome Var.
  
  Volume: 4 Issue: 1 Pages: 17032-17032
- DOI
  10.1038/hgv.2017.32
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-17K10309, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-26461721, KAKENHI-PROJECT-16K10190
[Journal Article] De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.2017
- Author(s)
  Akira Nishi, Shusuke Numata, Atsushi Tajima, Xiaolei Zhu, Koki Ito, Atsushi Saito, Yusuke Kato, Makoto Kinoshita, Shinji Shimodera, Shinji Ono, Shinichiro Ochi, Akira Imamura, Naohiro Kurotaki, Shu-ichi Ueno, Nakao Iwata, Kiyoshi Fukui, Issei Imoto, Atsushi Kamiya, and Tetsuro Ohmori
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- NAID
  120006309984
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10190
[Journal Article] De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity2017
- Author(s)
  Nishi Akira、Numata Shusuke、Tajima Atsushi、Zhu Xiaolei、Ito Koki、Saito Atsushi、Kato Yusuke、Kinoshita Makoto、Shimodera Shinji、Ono Shinji、Ochi Shinichiro、Imamura Akira、Kurotaki Naohiro、Ueno Shu-ichi、Iwata Nakao、Fukui Kiyoshi、Imoto Issei、Kamiya Atsushi、Ohmori Tetsuro
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 2887-2887
- DOI
  10.1038/s41598-017-02792-z
- NAID
  120006309984
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-15H04320, KAKENHI-PROJECT-15K09809, KAKENHI-PROJECT-26461721, KAKENHI-PROJECT-16K10190
[Journal Article] 精神疾患の原因解明にみる成功が精神疾患では起こっているのかいないのか2015
- Author(s)
  黒滝直弘, 久保達哉, 木下裕久, 小野慎治, 小澤寛樹
- Journal Title
  
  臨床精神医学
  
  Volume: 44(10) Pages: 1333-1339
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461733
[Journal Article] Genomic structural variation in affective, anxiety, and stress-related disorders.2015
- Author(s)
  Ono S, Domschke K, Deckert J
- Journal Title
  
  J Neural Transm.
  
  Volume: 122 Issue: 1 Pages: 69-78
- DOI
  10.1007/s00702-014-1309-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870519
[Journal Article] 発作性運動誘発性舞踏アテトーゼの分子メカニズム2013
- Author(s)
  黒滝直宏, 小野慎治, 小澤寛樹, 吉浦孝一郎
- Journal Title
  
  神経内科
  
  Volume: 79(6) Pages: 719-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461733
[Journal Article] Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1-7.2013
- Author(s)
  Uhal BD, Nguyen H, Dang M, Gopallawa I, Jiang J, Dang V, Ono S, Morimoto K
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 305 Issue: 1 Pages: 33-41
- DOI
  10.1152/ajplung.00001.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870519
[Patent] 正常圧水頭症の発症リスクを試験する方法、及び該方法に用いるキット2019
- Inventor(s)
  吉浦孝一郎、森本芳郎、木住野達也、小野慎治
- Industrial Property Rights Holder
  吉浦孝一郎、森本芳郎、木住野達也、小野慎治
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-19K08050
[Presentation] PLA2G4E遺伝子の希少変異はパニック障害のリスク因子の可能性がある2017
- Author(s)
  森本芳郎、吉田真太朗、木下晃、三嶋博之、山口尚宏、今村明、黒滝直弘、小澤寛樹、吉浦孝一郎、小野慎治
- Organizer
  第62回日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-16K10190
[Presentation] Genetic projects of our department including panic disorder, schizophrenia and gender dysphoria.2016
- Author(s)
  Shinji Ono
- Organizer
  International Alumni Symposium
- Place of Presentation
  Wuerzburg (Germany)
- Invited
- Data Source
  KAKENHI-PROJECT-16K10190
[Presentation] Deep sequencing reveal variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.2016
- Author(s)
  Yoshiro Morimoto, Shinji Ono,Hideyuki Nakane, Hiroki Ozawa, Naohiro Kurotaki, Koh-Ichiro Yoshiura
- Organizer
  ASHG annual meeting 2016
- Place of Presentation
  Vancouver (Canada)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10190
[Presentation] The epidemiological and molecular analysis of Paroxysmal kinesigenic dyskinesia in Japan2015
- Author(s)
  H TANGE, M OHISHI, N KUROTAKI, Y MORIMOTO, S ONO, Y KUSUMOTO, S YAMADA, K SHIROTANI, N IWATA, K YOSHIURA, N MORI, H OZAWA.
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago(USA)
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-25461733
[Presentation] Panic障害多発家族例に対するExome解析2014
- Author(s)
  森本芳郎, 小野慎治, 森貴俊, 黒滝直弘, 吉浦孝一郎, 小澤寛樹
- Organizer
  第59回日本人類遺伝学会
- Place of Presentation
  東京都江戸川区, タワーホール船橋
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25870519
[Presentation] 創始者効果からのアプローチによる統合失調症の遺伝解析2013
- Author(s)
  黒滝直宏, 小野慎治, 小澤寛樹
- Organizer
  第46回精神神経系薬物治療研究報告会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府豊中市)
- Data Source
  KAKENHI-PROJECT-25461733
[Presentation] クロザリル使用の症例報告2013
- Author(s)
  岩永健, 山口尚宏, 鬼塚芙美, 吉田真太郎, 小野慎治, 久保達哉, 黒滝直宏, 小澤寛樹
- Organizer
  第66回九州精神神経学会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-25461733
[Presentation] 発作性運動性舞踏アセトーゼ（PKC）の遺伝解析、そのエピローグ2013
- Author(s)
  黒滝直弘, 小野慎治, 中根允文, 吉浦孝一朗, 小澤寛樹
- Organizer
  第34回てんかん研究会
- Place of Presentation
  サンプリエール長崎（長崎県長崎市）
- Data Source
  KAKENHI-PROJECT-25461733
[Presentation] O15-2. マウスにおける低濃度リチウム長期投与による衝動性の変化の検討
- Author(s)
  山口尚宏, 森本芳郎, 小野慎治, 松本一隆, 松本俊二, 中根秀之, 今村明, 黒滝直弘, 吉本静志, 中根允文, 岡崎祐士, 小澤寛樹
- Organizer
  第36回日本生物学的精神医学会
- Place of Presentation
  奈良文化会館(奈良県奈良市)
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-25461733

1. KUROTAKI Naohiro (20423634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. OZAWA Hiroki (50260766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. IMAMURA Akira (40325642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. YOSHIURA Kouichiro (00304931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ICHINOSE Hitoshi (60404216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 坂口美亜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 吉浦孝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

ONO Shinji 小野 慎治

Research Projects

Research Products

Co-Researchers

繊毛鞭毛関連タンパク遺伝子変異と水頭症および認知機能低下の関連性についての研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular analysis of a candidate gene as a cause of schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exome sequencing for monozygotic twins discordant for neuropsychiatric conditions.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular analysis of psychiatric disorders focusing missing heritability

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nonsense mutation in CFAP43 causes normal pressure hydrocephalus with ciliary abnormalities2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 精神疾患の原因解明にみる成功が精神疾患では起こっているのかいないのか2015

Author(s)

Journal Title

Data Source

[Journal Article] Genomic structural variation in affective, anxiety, and stress-related disorders.2015

Author(s)

Journal Title

DOI

Data Source

ONO Shinji 小野慎治