Kobayashi Kimiko 小林希実子

… Alternative Names

KOBAYASHI Kimiko 小林希実子

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Researcher Number	70418961
Other IDs
Affiliation (Current)	2025: 名古屋学院大学, リハビリテーション学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2023: 兵庫医科大学, 医学部, 講師 2007 – 2014: Hyogo College of Medicine, 医学部, 助教
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Basic Section 55050:Anesthesiology-related / Basic Section 48010:Anatomy-related / Pain science / General anatomy (including Histology/Embryology) Except Principal Investigator 疼痛学 / Basic Section 59010:Rehabilitation science-related / Nerve anatomy/Neuropathology / Pain science
Keywords	Principal Investigator 脊髄後角 / 神経障害性疼痛 / マイクログリア / 炎症性疼痛 / 末梢神経損傷 / MAP kinase / microglia / P2Y受容体 / オピオイド受容体 / NppB/BNP … More / DRG / 多重ISH-IHC法 / 末梢神経障害 / 炎症 / 痛み / 痒み / 一次知覚神経 / BDNF / 腕傍核 / 投射ニューロン / 脳由来神経成長因子 / 血液脳関門 / 脊髄後角neuron / ペリサイト / 血管透過性 / 脊髄後角ニューロン / 血管内皮細胞 / 後根神経節(DRG) / p38 MAPK / ADP / 形態変化 / Rho kinase / ATP受容体 / ロイコリエン / ロイコトリエン合成酵素 / 後根神経節 / ロイコトリエン受容体 / ロイコトリエン / p38 / P2Y receptor / UTP / ATP / 神経因性疼痛 / MAPキナーゼ / アストロサイト / 神経因性痙痛 / プリン受容体 … More Except Principal Investigator 脊髄後角 / マイクログリア / 神経因性疼痛 / 神経障害性疼痛 / 神経傷害性疼痛 / Kv / Nav / DRG / 再生関連因子 / 細胞間接着因子 / シナプス可塑性 / 可塑性 / 形態変化 / L1-CAM / リン酸化 / JNK / GAP-43 / p38 / ROCK / Rho / 合成酵素 / プロスタグランジン / ニューロン / 脂質メディエーター / グリア / P2Y / ATP / P2Y受容体 / TNF受容体 / サイトカイン / TNF alpha / アストロサイト / 末梢神経損傷 / 神経因性疼痛モデル / substance P / BDNF / NPY / A電流 / neuropathic pain / GDNF / Kv(電位依存型カリウムチャネル) / Nav(電位依存型ナトリウムチャネル) / DRG(後根神経節) / 脊髄 / 腰部交感神経節 Less

JNK活性による損傷c-fiber終末の形態的可塑性と疼痛への関与
- Principal Investigator
  
  山中博樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Hyogo Medical University
一次感覚神経から見た痒み-痛みシグナルの相互作用Principal Investigator
- Principal Investigator
  
  小林希実子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hyogo Medical University
BDNF as a modulator of the regulatory system for ascending pathway of painPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kimiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Hyogo Medical University
Peripheral nerve injury induced changes of neuro-glia-vascular unit in the spinal cordPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI KIMIKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Hyogo Medical University
Molecular basis of spinal glia/endothelium/neurons interaction as the mechanisms of development and maintenance of chronic pain
- Principal Investigator
  
  Noguchi Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
RhoA/ROCK pathway mediates morphological changes downstream of P2Y12/13 receptors in spinal microglia following peripheral nerve injuryPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kimiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
Induction of P2Y receptors in the spinal cord following peripheral nerve injury.
- Principal Investigator
  
  YANAMOTO Fujio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Kobe University
Leukotrienes in nociceptive pathway and neuropathic pain.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kimiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
GDNF reverses neuropathic pain through mitigation of nerve injury-induced changes in expression of voltage-gated sodium and potassium channels.
- Principal Investigator
  
  FUKUOKA Tetsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Hyogo Medical University
Involvement of cytokine network in the pathology of neuropathic pain following peripheral nerve injury
- Principal Investigator
  
  KAMIHARA Masahito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Hyogo Medical University
Comparative study of the expression of voltage-gated ion channel mRNAs in a rat neuropathic pain model
- Principal Investigator
  
  FUKUOKA Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Hyogo College of Medicine
The role of purinergic receptor in the spinal microglia following peripheral nerve injuryPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kimiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hyogo College of Medicine

All 2023 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats2016
- Author(s)
  Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Hirosato Kanda, Hideshi Yagi and Koichi Noguchi
- Journal Title
  
  Plos ONE
  
  Volume: 11 Issue: 4 Pages: e0153375-e0153375
- DOI
  10.1371/journal.pone.0153375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15205, KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016, KAKENHI-PROJECT-16K19220
[Journal Article] Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.2016
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Noguchi K.
- Journal Title
  
  Neuroscience
  
  Volume: 314 Pages: 189-199
- DOI
  10.1016/j.neuroscience.2015.11.058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016
[Journal Article] Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons.2015
- Author(s)
  Yasuko Ikeda-Miyagawa, Kimiko Kobayashi, Hiroki Yamanaka, Masamichi Okubo, Shenglan Wang, Yi Dai, Hideshi Yagi, Munetaka Hirose, Koichi Noguchi
- Journal Title
  
  Mol Pain
  
  Volume: 11 Pages: 8-8
- DOI
  10.1186/s12990-015-0004-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290016
[Journal Article] Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury2015
- Author(s)
  Kiyoyuki Y, Taniguchi W, Okubo M, Yamanaka H, Kobayashi K, Nishio N, Nakatsuka T, Noguchi K
- Journal Title
  
  Mol. Pain
  
  Volume: 11 Pages: 53-53
- DOI
  10.1186/s12990-015-0059-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15205, KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016
[Journal Article] RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.2015
- Author(s)
  Tatsumi E1, Yamanaka H, Kobayashi K, Yagi H, Sakagami M, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 63 Issue: 2 Pages: 216-228
- DOI
  10.1002/glia.22745
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500416, KAKENHI-PROJECT-25290016
[Journal Article] COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.2013
- Author(s)
  Kanda H, Kobayashi K, Yamanaka H, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 61 Issue: 6 Pages: 943-956
- DOI
  10.1002/glia.22487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659688, KAKENHI-PROJECT-25290016
[Journal Article] Noguchi K. Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury.2012
- Author(s)
  Kobayashi K, Yamanaka H, Yanamoto F, Okubo M
- Journal Title
  
  Glia
  
  Volume: 60 Issue: 10 Pages: 1529-39
- DOI
  10.1002/glia.22373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22600012, KAKENHI-PROJECT-23500418, KAKENHI-PROJECT-24659688, KAKENHI-PUBLICLY-23116517
[Journal Article] Multiple P2Y Subtypes in Spinal Microglia are Involved in Neuropathic Pain After Peripheral Nerve Injury2012
- Author(s)
  Kobayashi K
- Journal Title
  
  GLIA
  
  Volume: 60 Pages: 1529-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22600012
[Journal Article] Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation2012
- Author(s)
  Fukuoka T, Yamanaka H, Kobayashi K, Okubo M, Miyoshi K, Dai Y, Noguchi K
- Journal Title
  
  Pain
  
  Volume: 153 Issue: 1 Pages: 68-79
- DOI
  10.1016/j.pain.2011.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590798, KAKENHI-PROJECT-21591908, KAKENHI-PROJECT-21600016, KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22790195, KAKENHI-PUBLICLY-23116517, KAKENHI-PROJECT-24590737, KAKENHI-PROJECT-24659688
[Journal Article] Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.2012
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
- Journal Title
  
  Mol Pain
  
  Volume: 8 Pages: 8-8
- DOI
  10.1186/1744-8069-8-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22700371, KAKENHI-PROJECT-23500418, KAKENHI-PROJECT-23590730, KAKENHI-PROJECT-24659688, KAKENHI-PUBLICLY-23116517
[Journal Article] Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain2011
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Fukuoka T, Noguchi K.
- Journal Title
  
  Journal of Comparative Neurology
  
  Volume: 519 Issue: 8 Pages: 1597-615
- DOI
  10.1002/cne.22588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21600016, KAKENHI-PROJECT-22300115, KAKENHI-PUBLICLY-23116517, KAKENHI-PROJECT-23500418
[Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors2010
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K
- Journal Title
  
  Mol Pain
  
  Volume: 17 Pages: 57-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700371
[Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors2010
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K.
- Journal Title
  
  Mol Pain
  
  Volume: 17(57)
- DOI
  10.1186/1744-8069-6-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700371
[Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 58 Issue: 5 Pages: 599-610
- DOI
  10.1002/glia.20948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22700371
[Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Noguchi K
- Journal Title
  
  Glia
  
  Volume: 58 Pages: 599-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700371
[Journal Article] Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons2008
- Author(s)
  Fukuoka T, Kobayashi K, Yamanaka H, Obata K, Dai Y and Noguchi K
- Journal Title
  
  J. Comp. Neurol 10, 510
  
  Pages: 188-206
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.2008
- Author(s)
  Katsura, H., Obata, K., Miyoshi, K., Kondo, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Sakagami, M. and Noguchi, K.
- Journal Title
  
  Glia 56
  
  Pages: 723-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1 : a molecular mechanism of inflammatory pain2008
- Author(s)
  Wang, S., Dai, Y., Fukuoka, T., Yamanaka, H., Kobayashi, K., Obata, K., Cui, X., Tominaga, M. and Noguchi, K.
- Journal Title
  
  Brain. 131(Pt-5)
  
  Pages: 1241-1251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia2008
- Author(s)
  Cui XY, Dai Y, Wang SL, Yamanaka H, Kobayashi K, Obata K, Chen J, Noguchi K.
- Journal Title
  
  Mol Pain 30,4(1)
  
  Pages: 17-17
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008
- Author(s)
  Kobayashi, K., et. al.
- Journal Title
  
  J.Neurosci. 28
  
  Pages: 2892-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008
- Author(s)
  Kobayashi, K., et. al.
- Journal Title
  
  J. Neurosci. 28
  
  Pages: 2892-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008
- Author(s)
  Kobayashi, K., et.al.
- Journal Title
  
  J. Neurosci 28
  
  Pages: 2892-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury.2008
- Author(s)
  Obata, K., Katsura, H., Miyoshi, K., Kondo, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Akira, S. and Noguchi K.
- Journal Title
  
  J. Neurochem. 105
  
  Pages: 2249-2259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.2008
- Author(s)
  Kobayashi, K. et. al.
- Journal Title
  
  J. Neurosci. 28
  
  Pages: 2892-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1 : a molecular mechanism of inflammatory pain2008
- Author(s)
  Wang S, Dai Y, Fukuoka T, Yamanaka H, Kobayashi K, Obata K, Cui X, Tominaga M, Noguchi K.
- Journal Title
  
  Brain 131
  
  Pages: 1241-1251
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008
- Author(s)
  Kobayashi, K., Yamanaka, H., Fukuoka, T., Dai, Y., Obata, K. and Noguchi, K.
- Journal Title
  
  J. Neurosci. 12, 28
  
  Pages: 2892-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008
- Author(s)
  Kobayashi K, Yamanaka H, Fukuoka T, Dai Y, Obata K, Noguchi K
- Journal Title
  
  J. Neurosci 28
  
  Pages: 2892-902
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.2008
- Author(s)
  Fukuoka, T., Kobayashi, K., Yamanaka, H., Obata, K., Dai, Y. and Noguchi, K.
- Journal Title
  
  J. Comp. Neurol. 10, 510
  
  Pages: 188-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.2007
- Author(s)
  Yamanaka, H., Obata, K., Kobayashi, K., Dai, Y., Fukuoka, T. and Noguchi, K.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury2007
- Author(s)
  Kozai, T., Yamanaka, H., Dai, Y., Obata, K., Kobayashi, K., Mashimo, T. and Noguchi, K
- Journal Title
  
  Glia 55
  
  Pages: 595-603
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to the neuropathic pain2007
- Author(s)
  Yamanaka, H., Obata, K., Kobayashi, K., Dai, Y., Fukuoka, T., Noguchi, K.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Alternation of the cell adhesion molecule Ll expression in a specific subset of primary afferent neurons contributes to neuropathic pain2007
- Author(s)
  Yamanaka, H., Obata, K, Kobayashi, K., Dai, Y., Fukuoka, T., Noguchi, K.
- Journal Title
  
  Eur. J. Neurosci 25
  
  Pages: 1097-111
- Data Source
  KAKENHI-PROJECT-19790159
[Journal Article] Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.2007
- Author(s)
  Dai, Y., Wang, S., Tominaga, M., Yamamoto, S., Fukuoka, T., Higashi, T., Kobayashi, K., Obata, K., Yamanaka, H. and Noguchi, K.
- Journal Title
  
  J. Clin. Invest. 117
  
  Pages: 1979-1987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation.2007
- Author(s)
  Katsura, H., Obata, K., Mizushima, T., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Sakagami, M. and Noguchi, K.
- Journal Title
  
  J. Neurochem. 102
  
  Pages: 1614-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603019
[Journal Article] Sensitization of TRPA1 by PAR-2 through PLC/PIP2-dependent mechanisms contributes to inflammatory pain2007
- Author(s)
  Dai, Y., Wang, S., Tominaga, M., Yamamoto, S., Fukuoka, T., Higashi, T., Kobayashi, K., Obata, K., Yamanaka, H., Noguchi, K.
- Journal Title
  
  J. Clin. Invest 117
  
  Pages: 1979-1987
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] 後根神経節・脊髄における高感度多重ISH法の確立を目指して2023
- Author(s)
  小林希実子、大久保正道、山中博樹
- Organizer
  第128回日本解剖学会総会　全国学術集会
- Data Source
  KAKENHI-PROJECT-22K09034
[Presentation] Role of JNK in the morphological changes of injured C-fiber terminal via the phosphorylation of GAP43 in the dorsal horn of a rat neuropathic pain model2023
- Author(s)
  山中博樹,　小林希実子,　神田浩里,　野口光一
- Organizer
  Neuroscience 2023: Society for Neurocience, Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10574
[Presentation] 末梢神経損傷後の脊髄におけるPGE2合成酵素とEP受容体の発現変化2015
- Author(s)
  神田浩里, 小林希実子, 山中博樹, 大久保正道, 野口光一
- Organizer
  第37回日本疼痛学会
- Place of Presentation
  市民会館崇城大学ホール（熊本県熊本市）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Glial TNF alpha induces COX-2 expression and PGI2 synthesis in the spinal endothelial cells in neuropathic pain2014
- Author(s)
  K.Kanda, Kobayashi K, Yamanaka H, Noguchi K.
- Organizer
  15th World Congress on Pain
- Place of Presentation
  Buenos Aires, Argentine
- Year and Date
  2014-10-09
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] 脊髄microgliaに対するRhoキナーゼ阻害剤の影響と神経障害性疼痛への関与2014
- Author(s)
  山中博樹, 巽恵美子, 小林希実子, 阪上雅史, 野口光一
- Organizer
  第119回日本解剖学会総会全国学術集会
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] 末梢神経損傷により誘導される脊髄Cox2/PGIS発言へのTNF alpha の関与2014
- Author(s)
  小林希実子,　神田浩里,　山中博樹,　野口光一.
- Organizer
  第36回日本疼痛学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Leukotriene enhances NMDA induced inward currents in dorsal horn neurons of rat spinal cord after peripheral nerve injury.2013
- Author(s)
  Kiyoyuki Y, Yamanaka H, Kobayashi K, Okubo M, Noguchi K, Taniguchi W, Nishio N, Nakatsuka T.
- Organizer
  The 43nd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] 脊髄microgliaに対するRhoキナーゼ阻害剤の影響と神経障害性疼痛への関与2013
- Author(s)
  巽恵美子, 山中博樹, 小林希実子, 阪上雅史, 野口光一
- Organizer
  第35回日本疼痛学会
- Place of Presentation
  さいたま市大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] Expression of colony-stimulateing factors and their receptors in dorsal root ganglion and spinal cord after peripheral nerve injury.2013
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
- Organizer
  The 43nd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Changes in the expression pattern of P2X receptors in the rat DRG following peripheral nerve injury.2012
- Author(s)
  Kobayashi K, Yamanaka H, Noguchi K.
- Organizer
  The 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] ラット後根神経節におけるロイコトリエン受容体の発現と疼痛行動への関与2011
- Author(s)
  大久保正道, 山中博樹, 小林希実子, 野口光一
- Organizer
  第33回日本疼痛学会
- Place of Presentation
  愛媛
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-22700371
[Presentation] 末梢神経損傷後の脊髄に一過性に増加するTNF alpha2011
- Author(s)
  神原政仁, 小林希実子, 野口光一
- Organizer
  第87会日本解剖学会近畿支部学術集会
- Place of Presentation
  西宮
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] Expression of leukotriene receptors in the rat dorsal root ganglion and the effect on pain behaviors2011
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y Noguchi K
- Organizer
  The 41th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22700371
[Presentation] Induction of P2Y receptors in the spinal cord following peripheral nerve injury.2010
- Author(s)
  K.Kobayashi, et.al.
- Organizer
  13^<th> World Congress on Pain
- Place of Presentation
  (カナダ)モントリオール
- Year and Date
  2010-09-01
- Data Source
  KAKENHI-PROJECT-22600012
[Presentation] 末梢神経損傷後に脊髄で増加する血小板活性化因子(PAF)は神経障害性疼痛に関与する2010
- Author(s)
  大久保正道, 山中博樹, 小林希実子, 野口光一
- Organizer
  第32回日本疼痛学会
- Place of Presentation
  京都
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-22700371
[Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury2010
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
- Organizer
  13th World Congress on Pain(IASP)
- Place of Presentation
  Montreal
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22700371
[Presentation] Transient expression of TNF alpha in the rat spinal cord following peripheral nerve injury2009
- Author(s)
  Kobayashi K., et.al.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21600016
[Presentation] 腰部交感神経節ニューロンにおける電位依存性ナトリウムチャネルの発現と軸索切断後の変化2009
- Author(s)
  福岡哲男, 小林希実子, 山中博樹, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-20
- Data Source
  KAKENHI-PROJECT-21600016
[Presentation] 末梢神経損傷後の脊髄後角マイクログリアで増加するP2受容体2009
- Author(s)
  小林希実子, 他3名
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21600016
[Presentation] 末梢神経損傷後に脊髄マイクログリアで増加するP2Y受容体2009
- Author(s)
  小林希実子, 他3名
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] 末梢神経損傷後に脊髄マイクログリアで増加するP2Y受容体2009
- Author(s)
  小林希実子, 他3名
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21600016
[Presentation] Transient expression of TNF alpha in the rat spinal cord following peripheral nerve injury2009
- Author(s)
  Kobayashi K., et.al.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] 末梢神経損傷後に脊髄で増加するP2Y受容体2009
- Author(s)
  小林希実子, 他2名
- Organizer
  第47回日本生物物理学会
- Place of Presentation
  徳島
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] 末梢神経損傷後の脊髄後角マイクログリアで増加するP2受容体2009
- Author(s)
  小林希実子, 他3名
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] Transient expression of TNF alpha in the rat spinal cord following peripheral nerve iujury2009
- Author(s)
  Kobayashi K, Yamanaka H, Okubo M, Dai Y, Noguchi K.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21600017
[Presentation] 末梢神経損傷後に脊髄で増加するP2Y受容体2009
- Author(s)
  小林希実子, 他2名
- Organizer
  第47回日本生物物理学会
- Place of Presentation
  徳島
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-21600016
[Presentation] Laminae-specific distribution of Nav mRNAs in the rat spinal cord.2008
- Author(s)
  Fukuoka, T., Kobayashi, K., Yamanaka, H., Obata, K., Dai, Y. and Noguchi, K.
- Organizer
  The 38th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington, DC., U.S.A.
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] Induction of P2Y receptor in the spinal cord following peripheral nerve injury2008
- Author(s)
  Kobayashi, K., et.al.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] Induction of P2Y receptor in the spinal cord following peripheral nerve injury2008
- Author(s)
  Kobayashi, K., Yamanaka, H., Fukuoka, T. and Noguchi, K
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U. S. A
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] Induction of P2Y receptor in the spinal cord following peripheral nerve injury.2008
- Author(s)
  Kobayashi, K., Yamanaka, H., Fukuoka, T. and Noguchi, K.
- Organizer
  The 38th Annual Meeting Society for Neuroscience
- Place of Presentation
  Washington, DC., U.S.A.
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] 一次知覚ニューロンにおける電位依存性ナトリウムチャネルサブタイプの発現比較2008
- Author(s)
  福岡哲男, 小林希実子, 山中博樹, 戴毅, 小畑浩一, 野口光一
- Organizer
  第30回日本疼痛学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] 神経因性疼痛における脊髄マイクログリアに発現するP2Y12受容体の関与.2007
- Author(s)
  小林希実子他
- Organizer
  第30回日本神経科学大会,
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] 神経因性疼痛における脊髄マイクログリアに発現するP2Y12受容体の関与.2007
- Author(s)
  小林希実子他
- Organizer
  第29回日本疼痛学会
- Place of Presentation
  横浜
- Year and Date
  2007-07-07
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] 神経因性疼痛における脊髄マイクログリアに発現するP2Y12受容体の関与2007
- Author(s)
  小林希実子
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] 神経因性痺痛における脊髄マイクログリアに発現するP2Y12受容体の関与2007
- Author(s)
  小林希実子,福岡哲男,山中博樹,野口光一
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] P2Y12 receptor expressed in spinal microglia contributes to neuropathic pain.2007
- Author(s)
  Kobayashi, K., Fukuoka, T., Yamanaka, H. and Noguchi, K.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] 神経因性疼痛における脊髄マイクログリアに発現するP2Y12受容体の関与2007
- Author(s)
  小林希実子, 福岡哲男, 山中博樹, 野口光一
- Organizer
  第29回日本疼痛学会
- Place of Presentation
  横浜
- Year and Date
  2007-07-07
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] P2Y12 receptor expressed in spinal microglia contributes to neuropathic pain2007
- Author(s)
  Kobayashi, K., Fukuoka, T., Yamanaka, H. and Noguchi, K
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] 神経因性痺痛における脊髄マイクログリアに発現するP2Y12受容体の関与2007
- Author(s)
  小林希実子,福岡哲男,山中博樹,野口光一
- Organizer
  第29回日本痺痛学会
- Place of Presentation
  横浜
- Year and Date
  2007-07-07
- Data Source
  KAKENHI-PROJECT-19790159
[Presentation] 神経因性疼痛における脊髄マイクログリアに発現するP2Y12 受容体の関与.2007
- Author(s)
  小林希実子, 福岡哲男, 山中博樹, 野口光一
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] P2Y12 receptor expressed in spinal microglia contributes to neuropathic pain2007
- Author(s)
  Kobayashi, K, et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19603019
[Presentation] P2Y12 receptor expressed in spinal microglia contributes to neuropathic pain2007
- Author(s)
  Kobayashi, K., et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-19790159

1. YAMANAKA Hiroki (20340995)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. FUKUOKA Tetsuo (90399147)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. KAMIHARA Masahito (10441312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ARIMURA Yoshinobu (30419824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKANO Susumu (40412019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YANAMOTO Fujio (40368543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORIYAMA Kazuhide (30301659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Noguchi Koichi (10212127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
9. YAGI Hideshi (10303372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. MIYOSHI Kan

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Kimiko 小林 希実子

KOBAYASHI Kimiko 小林 希実子

Research Projects

Research Products

Co-Researchers

JNK活性による損傷c-fiber終末の形態的可塑性と疼痛への関与

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一次感覚神経から見た痒み-痛みシグナルの相互作用Principal Investigator

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BDNF as a modulator of the regulatory system for ascending pathway of painPrincipal Investigator

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Peripheral nerve injury induced changes of neuro-glia-vascular unit in the spinal cordPrincipal Investigator

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Molecular basis of spinal glia/endothelium/neurons interaction as the mechanisms of development and maintenance of chronic pain

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RhoA/ROCK pathway mediates morphological changes downstream of P2Y12/13 receptors in spinal microglia following peripheral nerve injuryPrincipal Investigator

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Induction of P2Y receptors in the spinal cord following peripheral nerve injury.

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Leukotrienes in nociceptive pathway and neuropathic pain.Principal Investigator

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GDNF reverses neuropathic pain through mitigation of nerve injury-induced changes in expression of voltage-gated sodium and potassium channels.

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Involvement of cytokine network in the pathology of neuropathic pain following peripheral nerve injury

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Comparative study of the expression of voltage-gated ion channel mRNAs in a rat neuropathic pain model

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The role of purinergic receptor in the spinal microglia following peripheral nerve injuryPrincipal Investigator

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[Journal Article] Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats2016

Author(s)

Journal Title

Kobayashi Kimiko 小林希実子

KOBAYASHI Kimiko 小林希実子