Horikawa Kazuki 堀川一樹

… Alternative Names

HORIKAWA Kazuki 堀川一樹

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Researcher Number	70420247
Other IDs
Affiliation (Current)	2025: 徳島大学, 先端研究推進センター, 教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 徳島大学, 先端研究推進センター, 教授 2018: 徳島大学, 大学院医歯薬学研究部(医学域), 教授 2016 – 2018: 徳島大学, 大学院医歯薬学研究部(医学系), 教授 2015: 徳島大学, 大学院医歯薬学研究部, 教授 2015: 徳島大学, 医歯薬学研究部, 教授 … More 2014: 徳島大学, ヘルスバイオサイエンス研究部, 特任教授 2014: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2013 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2012 – 2013: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任教授 2011 – 2012: 徳島大学, ヘルスバイオサイエンス研究部, 特任教授 2010 – 2011: 国立遺伝学研究所, 新分野創造センター, 准教授 2007 – 2008: Hokkaido University, 電子科学研究所, 特任准教授 2006: 北海道大学, 電子科学研究所, 特任助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biophysics / Complex systems / Cell biology / Developmental biology Except Principal Investigator Biological Sciences / Basic Section 53020:Cardiology-related / Cardiovascular medicine / Developmental biology
Keywords	Principal Investigator 自己組織化 / イメージング / cAMP / 生物物理 / 社会性アメーバ / 光メモリー / 細胞周期 / ゲノム編集 / パターン形成 / 生物 … More / シグナル伝達 / 一分子計測 / バイオメージング / 興奮系 / 離散系 / 生物リズム / 血管平滑筋 / cGMP / 炎症 / マクロファージ / マルチスケール計測 / ライブイメージング / へテロ性 / 細胞個性 / 自已組織化 / BRET / エンハンサーとラップ / ゼブラフィッシュ / エンハンサートラップ / 側線 … More Except Principal Investigator 血管 / 生活習慣病 / マクロファージ / 自然免疫 / 肥満 / インスリン抵抗性 / 慢性炎症 / 動脈硬化 / 協同性 / コヒーレンス / 少数性 / 階層間相互作用 / 共同性 / 分子個性 / 少数分子系 / 可視化 / 自己組織化 / FRET / 顕微鏡 / 骨髄 / Toll様受容体 / STING / アポトーシス / 自己核酸 / 脂質異常症 / 生物物理 / 多階層間相互作用 / エルゴード性 / 協働性 / 個性 / コンストラクト / 脂肪 / 血管周囲脂肪 / サイトカイン / カスパーゼ / インフラマソーム / 脂肪組織 / メタボリックシンドローム / 細胞個性 / 光操作 / 発光タンパク質 / 光スイッチング蛍光タンパク質 / 走化性 / cAMP / 細胞性粘菌 / 光摂動 / 超解像イメージング / 蛍光タンパク質 / 光スイッチング / 1分子 / タンパク質 / イメージング / シグナル伝達 Less

Novel mechanism of chronic inflammation in progression and destabilization of atherosclerotic plaque
- Principal Investigator
  
  SATA Masataka
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokushima
Analysis of the singularity cells controlling the pattern formation of multicellular systemPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Kazuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokushima
Molecular mechanisms translating the pulse information into developmental timePrincipal Investigator
- Principal Investigator
  
  堀川一樹
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Single molecule analysis in the generation of oscillatory circuit for cAMP signalingPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Kazuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokushima
マクロファージの異常な活性化に起因する慢性炎症発症機序の解明Principal Investigator
- Principal Investigator
  
  堀川一樹
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Visualization of chronic inflammation in arterial wall and perivascular adipose tissue
- Principal Investigator
  
  SATA Masataka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokushima
in vivo imaging analysis of cGMP dynamics in the smooth muscle of circulatory systemPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Kazuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokushima
Development of molecular probes and photo manipulation tools - Technologies for visualization and control of small number of biomolecules
- Principal Investigator
  
  Nagai Takeharu
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
多細胞社会の秩序形成を司る細胞個性のマルチスケール定量と操作Principal Investigator
- Principal Investigator
  
  堀川一樹
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
  National Institute of Genetics
Spying minority in biological phenomena -Toward bridging dynamics between individual and ensemble processes-
- Principal Investigator
  
  Nagai Takeharu
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of multi-scale and functional imaging technique to quantify the fluctuation in intercellular signalingPrincipal Investigator
- Principal Investigator
  
  HORIKAWA Kazuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute of Genetics
Elucidation of self-organization process in living organism by small number of molecules using functional imaging
- Principal Investigator
  
  NAGAI Takeharu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  Hokkaido University
エンハンサートラップ法とライブイメージングを軸とした聴覚システム発生機構の研究Principal Investigator
- Principal Investigator
  
  堀川一樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Developmental biology
- Research Institution
  Hokkaido University

[Book] How Low Can You Go? The Numbers of Cells That Make Up Bodies: Large Numbers and Small Numbers, Minorities and Small Numbers from Molecules to Organisms in Biology-Toward a New Understanding of Biological Phenomena2018
- Author(s)
  Kazuki Horikawa
- Total Pages
  7
- Publisher
  Springer
- ISBN
  9789811320835
- Data Source
  KAKENHI-PLANNED-18H05415
[Book] 蛍光タンパク質ⅳ．cAMPプローブ, 生きてるものは全部観る！イメージングの選び方・使い方100＋実験医学増刊 36 No.202018
- Author(s)
  堀川一樹
- Total Pages
  2
- Publisher
  羊土社
- ISBN
  9784758103756
- Data Source
  KAKENHI-PLANNED-18H05415
[Book] 少数性生物学2017
- Author(s)
  永井健治、村越秀治、大場雄介、富樫祐一、小松﨑民樹、城口克之、野地博行、前島一博、粟津暁紀、鈴木宏明、茅　元司、矢島潤一郎、谷口雄一、小嶋誠司、今田勝巳、石島秋彦、福岡　創、蔡　栄淑、堀川一樹、大出晃士
- Total Pages
  178
- Publisher
  日本評論社
- Data Source
  KAKENHI-PROJECT-15K14491
[Book] 実験医学 2017年12月号2017
- Author(s)
  永井健治、堀川一樹、太田裕作、向井あすか、新井由之
- Total Pages
  137
- Publisher
  羊土社
- ISBN
  9784758125024
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Book] CLINICAL CALCIUM Vol.23 No.4 Ca2+イメージングで解き明かすCa2+動態の時空間統御機構2013
- Author(s)
  堀川一樹、永井健治
- Total Pages
  7
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PLANNED-23115003
[Book] 生物の科学、遺伝65 細胞性粘菌の集合流形成における細胞間シグナル伝達2011
- Author(s)
  堀川一樹、永井健治
- Publisher
  (株)エヌ・ティー・エス
- Data Source
  KAKENHI-PLANNED-23115003
[Book] 蛍光イメージング/MRIブローブの開発機能イメージングにおける指示薬感度の重要性 -蛍光タンパク質間FRETを用いたCa^<2+>指示薬開発からの考察-
- Author(s)
  永井健治、堀川一樹
- Publisher
  CMC出版(印刷中)
- Data Source
  KAKENHI-PLANNED-23115003
[Journal Article] Live Imaging of cAMP Signaling in D. discoideum Based on a Bioluminescent Indicator, Nano-lantern (cAMP)2022
- Author(s)
  Horikawa Kazuki、Nagai Takeharu
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2483 Pages: 231-240
- DOI
  10.1007/978-1-0716-2245-2_14
- ISBN
  9781071622445, 9781071622452
- Data Source
  KAKENHI-PLANNED-18H05415
[Journal Article] C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes2022
- Author(s)
  Keisho Hirota, Tsuyoshi Hirashima, Kazuki Horikawa, Akihiro Yasoda, Michiyuki Matsuda
- Journal Title
  
  Endocrinology
  
  Volume: 163(3) Issue: 3 Pages: 1-12
- DOI
  10.1210/endocr/bqac005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17532, KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-19H00993, KAKENHI-PLANNED-20H05898
[Journal Article] Development of a screening system for agents that modulate taste receptor expression with the CRISPR-Cas9 system in medaka2022
- Author(s)
  Beppu Kana、Tsutsumi Rie、Ansai Satoshi、Ochiai Nana、Terakawa Mai、Mori Marie、Kuroda Masashi、Horikawa Kazuki、Tomoi Takumi、Sakamoto Joe、Kamei Yasuhiro、Naruse Kiyoshi、Sakaue Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 601 Pages: 65-72
- DOI
  10.1016/j.bbrc.2022.02.082
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-20H02586, KAKENHI-PROJECT-20K20303, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K24792
[Journal Article] JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes2021
- Author(s)
  Sakane Ayuko、Yano Taka-aki、Uchihashi Takayuki、Horikawa Kazuki、Hara Yusuke、Imoto Issei、Kurisu Shusaku、Yamada Hiroshi、Takei Kohji、Sasaki Takuya
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 551-551
- DOI
  10.1038/s42003-021-02080-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07084, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-18H05415, KAKENHI-PUBLICLY-20H04669, KAKENHI-PUBLICLY-21H00393, KAKENHI-PROJECT-21H01772, KAKENHI-PROJECT-20K08591, KAKENHI-PROJECT-21K06838
[Journal Article] Exploring rare cellular activity in more than one million cells by a transscale scope2021
- Author(s)
  Ichimura T.、Kakizuka T.、Horikawa K.、Seiriki K.、Kasai A.、Hashimoto H.、Fujita K.、Watanabe T. M.、Nagai T.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 16539-16539
- DOI
  10.1038/s41598-021-95930-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03987, KAKENHI-PLANNED-18H05409, KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-21K19225, KAKENHI-PUBLICLY-21H05590, KAKENHI-PROJECT-21H01843, KAKENHI-ORGANIZER-18H05408, KAKENHI-PLANNED-18H05410
[Journal Article] Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity2021
- Author(s)
  Suzuki Akinobu Z.、Sakano Taichi、Sasaki Hirona、Watahiki Rei、Sone Masaki、Horikawa Kazuki、Furuta Toshiaki
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 46 Pages: 5630-5633
- DOI
  10.1039/d1cc01405f
- NAID
  120007175419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05415, KAKENHI-PLANNED-19H05778, KAKENHI-PROJECT-20H02882, KAKENHI-PROJECT-20K06881
[Journal Article] Programmed death (PD)‐1/PD‐ligand 1 blockade mediates antiangiogenic effects by tumor‐derived CXCL10/11 as a potential predictive biomarker2021
- Author(s)
  Mitsuhashi Atsushi、Kondoh Kensuke、Horikawa Kazuki、Koyama Kazuya、Nguyen Na Thi、Afroj Tania、Yoneda Hiroto、Otsuka Kenji、Ogino Hirokazu、Nokihara Hiroshi、Shinohara Tsutomu、Nishioka Yasuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4853-4866
- DOI
  10.1111/cas.15161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-19H03668, KAKENHI-PROJECT-20K08542, KAKENHI-PROJECT-21K15488
[Journal Article] FRET-Based Detection and Quantification of HIV-1 Virion Maturation2021
- Author(s)
  Sarca Anamaria D.、Sardo Luca、Fukuda Hirofumi、Matsui Hiroyuki、Shirakawa Kotaro、Horikawa Kazuki、Takaori-Kondo Akifumi、Izumi Taisuke
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 1-13
- DOI
  10.3389/fmicb.2021.647452
- NAID
  120007180366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07591, KAKENHI-PLANNED-18H05415
[Journal Article] Transfer entropy dependent on distance among agents in quantifying leader-follower relationships2021
- Author(s)
  Basak Udoy S.、Sattari Sulimon、Hossain Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 18 Issue: 0 Pages: 131-144
- DOI
  10.2142/biophysico.bppb-v18.015
- NAID
  130008054076
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02940, KAKENHI-PLANNED-18H05413, KAKENHI-PLANNED-18H05415
[Journal Article] An information-theoretic approach to infer the underlying interaction domain among elements from finite length trajectories in a noisy environment2021
- Author(s)
  Basak Udoy S.、Sattari Sulimon、Hossain Md. Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
- Journal Title
  
  The Journal of Chemical Physics
  
  Volume: 154 Issue: 3 Pages: 034901-034901
- DOI
  10.1063/5.0034467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02940, KAKENHI-PLANNED-18H05413, KAKENHI-PLANNED-18H05415
[Journal Article] Inferring domain of interactions among particles from ensemble of trajectories2020
- Author(s)
  Basak Udoy S.、Sattari Sulimon、Horikawa Kazuki、Komatsuzaki Tamiki
- Journal Title
  
  Physical Review E
  
  Volume: 102 Issue: 1
- DOI
  10.1103/physreve.102.012404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02940, KAKENHI-PLANNED-18H05413, KAKENHI-PLANNED-18H05415
[Journal Article] Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose2018
- Author(s)
  Morishima M, Horikawa K, Funaki M
- Journal Title
  
  PLOS/ONE
  
  Volume: 13(8)
- NAID
  120006871191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05415
[Journal Article] Red fluorescent cAMP indicator with increased affinity and expanded dynamic range2018
- Author(s)
  Ohta Yusaku、Furuta Toshiaki、Nagai Takeharu、Horikawa Kazuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41598-018-20251-1
- NAID
  120006535055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05770, KAKENHI-PROJECT-16H06280
[Journal Article] ardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose2018
- Author(s)
  Masaki Morishima, Kazuki Horikawa, Makoto Funaki
- Journal Title
  
  PLOS One
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Journal Article] Nontrivial Effect of the Color-Exchange of a Donor/Acceptor Pair in the Engineering of Forster Resonance Energy Transfer (FRET)-Based Indicators.2016
- Author(s)
  Yusaku Ohta, Takanori Kamagata, Asuka Mukai, Shinji Takada, Takeharu Nagai, and Kazuki Horikawa
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 11(7) Issue: 7 Pages: 1816-1822
- DOI
  10.1021/acschembio.6b00221
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14491, KAKENHI-PLANNED-24111002
[Journal Article] Reliable handling of highly A/T-rich genomic DNA for efficient generation of knockin strains of Dictyostelium discoideum2016
- Author(s)
  Asuka Mukai, Aya Ichiraku, Kzuki Horikawa
- Journal Title
  
  BMC Biotechnology
  
  Volume: なし Issue: 1 Pages: 37-37
- DOI
  10.1186/s12896-016-0267-8
- NAID
  120006814108
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14491, KAKENHI-PLANNED-23115003
[Journal Article] Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation2015
- Author(s)
  6. Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 32 Pages: 33568-33586
- DOI
  10.18632/oncotarget.5598
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461422, KAKENHI-PROJECT-15K14491, KAKENHI-PLANNED-23115003, KAKENHI-PROJECT-25460389, KAKENHI-PROJECT-25462859
[Journal Article] Recent progress in the development of genetically encoded Ca<sup>2+ </sup>indicators2015
- Author(s)
  Horikawa K
- Journal Title
  
  J. Med. Invest.
  
  Volume: 62 Issue: 1.2 Pages: 24-28
- DOI
  10.2152/jmi.62.24
- NAID
  130005129691
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115003, KAKENHI-PUBLICLY-25113716, KAKENHI-PROJECT-25840050
[Journal Article] Identification of polyethylene glycol-resistant macrophages on stealth imaging in vitro using fluorescent organosilica nanoparticles2015
- Author(s)
  Nakamura M, Hayashi K, Nakano M, Kanadani T, Miyamoto K, Kori T, Horikawa K.
- Journal Title
  
  ACS Nano.
  
  Volume: 9 Issue: 2 Pages: 1058-1071
- DOI
  10.1021/nn502319r
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23115003, KAKENHI-PUBLICLY-25113716, KAKENHI-PROJECT-25350530, KAKENHI-PROJECT-25840050
[Journal Article] Fluorescent probes for bio-imaging of bone2014
- Author(s)
  Kazuki Horikawa
- Journal Title
  
  THE BONE
  
  Volume: Vol.28 No.2
- Data Source
  KAKENHI-PROJECT-25840050
[Journal Article] Spatiotemporal regulation of Ca2＋ dynamics in live cells revealed by Ca2＋ imaging.2014
- Author(s)
  Kazuki Horikawa and Takeharu Nagai
- Journal Title
  
  CLINICAL CALCIUM
  
  Volume: Apr;23(4) Pages: 527-533
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25113716
[Journal Article] Fluorescent probes for bio-imaging of bone2014
- Author(s)
  Kazuki Horikawa
- Journal Title
  
  THE BONE
  
  Volume: Vol.28 No.2
- Data Source
  KAKENHI-PUBLICLY-25113716
[Journal Article] Fluorescent probes for bio-imaging of bone2014
- Author(s)
  Kazuki Horikawa
- Journal Title
  
  THE BONE
  
  Volume: 28
- Data Source
  KAKENHI-PLANNED-23115003
[Journal Article] In vivo visualization of subtle, transient and local activity of astrocytes using an ultrasensitive Ca2+ indicator.2014
- Author(s)
  Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF
- Journal Title
  
  Cell Rep
  
  Volume: 8(1),311 Issue: 1 Pages: 311-318
- DOI
  10.1016/j.celrep.2014.05.056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23115003, KAKENHI-PROJECT-23680042, KAKENHI-PUBLICLY-25113716, KAKENHI-PUBLICLY-25115729, KAKENHI-PUBLICLY-25116523, KAKENHI-PLANNED-25117002, KAKENHI-PLANNED-25117005, KAKENHI-PROJECT-25221304, KAKENHI-PROJECT-25702054, KAKENHI-PROJECT-25840050, KAKENHI-PUBLICLY-26117501, KAKENHI-PROJECT-26460335
[Journal Article] Genetically encoded Ca2+ indicators; expanded affinity range, color hue and compatibility with optogenetics.2014
- Author(s)
  Nagai T, Horikawa K, Saito K, Matsuda T
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 7 Pages: 25-25
- DOI
  10.3389/fnmol.2014.00090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23115003, KAKENHI-PUBLICLY-25113716, KAKENHI-PROJECT-25840050
[Journal Article] Spatiotemporal regulation of Ca2＋ dynamics in live cells revealed by Ca2＋ imaging.2013
- Author(s)
  Kazuki Horikawa and Takeharu Nagai
- Journal Title
  
  CLINICAL CALCIUM
  
  Volume: Apr;23(4) Pages: 527-533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25840050
[Journal Article] Quantitive comparison of genetically encoded Ca^<2+> indicators in cortical pyramidl cells and cerebellar Purkinje cells2011
- Author(s)
  Yamada Y
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 5(18) Pages: 1-10
- DOI
  10.3389/fncel.2011.00018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PLANNED-23115003
[Journal Article] バイオイメージング細胞間シグナルの伝達パターンを捉える2011
- Author(s)
  堀川一樹
- Journal Title
  
  生物の遺伝
  
  Volume: 9月号 Pages: 87-91
- Data Source
  KAKENHI-PROJECT-22770182
[Journal Article] Spontaneous network activity visualized by ultra-sensitive Ca2+ indicators, yellow Cameleon-Nano2010
- Author(s)
  堀川一樹, 永井健治, ほか8名
- Journal Title
  
  Nature Methods
  
  Volume: 7 Pages: 729-732
- NAID
  120002834691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770182
[Journal Article] Spontaneous network activity visualized by ultra-sensitive Ca2+indicators, yellow Cameleon-Nano Nature Methods2010
- Author(s)
  堀川一樹、永井健治, ほか8名
- Volume
  7
- Pages
  729-732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770182
[Journal Article] An ultramarine fluorescent protein with increased photostability and pH insensitivity2009
- Author(s)
  Tomosugi W, Matsuda T, Tani T, Nemoto T, Kotera I, Saito K, Horikawa K & Nagai T
- Journal Title
  
  Nature Methods 6
  
  Pages: 351-353
- NAID
  120001648573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18687014
[Journal Article] An ultramarine fluorescent protein with increased photostability and pH insensitivity2009
- Author(s)
  Tomosugi W., Matsuda T, Tani T, Nemoto T, Kotera I, Saito K, Horikawa K, Nagai T
- Journal Title
  
  Nature Methods (印刷中)
- NAID
  120001648573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18687014
[Presentation] 円順列変異体化による 1 蛍光型プローブの機能改良2022
- Author(s)
  堀川一樹
- Organizer
  物質・デバイス領域キックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] 10万細胞の集団に生じる細胞間信号波の形成機構2022
- Author(s)
  堀川一樹
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] 多細胞システムのパターン形成を駆使するシンギュラリティ細胞の同定と操作2022
- Author(s)
  堀川一樹
- Organizer
  新学術領域「シンギュラリティ生物学」成果報告シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] Onset of the signaling wave at 10,000 cell population2021
- Author(s)
  Kazuki Horikawa
- Organizer
  PacifiChem2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] 興奮性多細胞システムのトランススケールイメージングで明らかになったらせん状信号波の形成機構2021
- Author(s)
  堀川一樹
- Organizer
  第60回日本生体医工学会・第36回日本生体磁気学会合同大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] “Singularity Biology : small elements change the function of the systems”2019
- Author(s)
  Kazuki Horikawa
- Organizer
  ICSB2019
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] 大規模イメージングで明らかになった、cAMP信号波の螺旋コア形成機構2019
- Author(s)
  堀川一樹
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] Red fluorescent cAMP indicator with increased affinity and expanded dynamic range2018
- Author(s)
  堀川一樹
- Organizer
  第１８回タンパク質科学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Presentation] Red fluorescent cAMP indicator with increased affinity and expanded dynamic range2018
- Author(s)
  Kazuki Horikawa
- Organizer
  The 18th Annual Meeting of the Protein Science Society of Japan
- Data Source
  KAKENHI-PLANNED-18H05415
[Presentation] Development of the rhythm in biological self-organization2018
- Author(s)
  堀川一樹
- Organizer
  International Young Scientists Workshop on Neural Development and Stem Cells 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Presentation] 階層横断的イメージングで明らかになったシグナル伝達動態の自発的対称性破れ機構2017
- Author(s)
  堀川一樹
- Organizer
  生命科学系学会合同年次大会（ConBio2017)
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Presentation] 細胞集団に螺旋信号波をもたらす臨界現象2017
- Author(s)
  堀川一樹
- Organizer
  日本生物物理学会第55回年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Presentation] １分子から個体レベルまでの多階層バイオイメージング2017
- Author(s)
  堀川一樹
- Organizer
  日本学術会議公開シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05770
[Presentation] Minority control of synchronized dynamics in biological oscillator2015
- Author(s)
  堀川一樹
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] Minority control of synchronized dynamics in biological oscillator2015
- Author(s)
  堀川一樹
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14491
[Presentation] 自発的発振回路の新規構築原理2015
- Author(s)
  堀川一樹
- Organizer
  日本顕微鏡学会第71回学術講演会
- Place of Presentation
  国立京都国際会館 (京都府京都市)
- Year and Date
  2015-05-13
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] 自発的発振回路の新規構築原理2015
- Author(s)
  堀川一樹
- Organizer
  日本顕微鏡学会第71回学術講演会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2015-05-13
- Data Source
  KAKENHI-PROJECT-15K14491
[Presentation] 生理機能を可視化するFRETプローブの開発2014
- Author(s)
  堀川一樹
- Organizer
  第55回日本生化学会　中国・四国支部例会
- Place of Presentation
  愛媛大学（愛媛県松山市）
- Year and Date
  2014-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-25840050
[Presentation] ライブイメージングを容易にする高機能性指示薬の開発2014
- Author(s)
  堀川一樹
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（　鹿児島県）
- Data Source
  KAKENHI-PUBLICLY-25113716
[Presentation] 生体組織内の任意の細胞での機能イメージングを可能にする光活性化型カルシウムイオンセンサーの開発2014
- Author(s)
  松田知己、堀川一樹、永井健治
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜産貿ホールマリネリア (横浜市)
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] 生理機能を可視化するFRETプローブの開発2014
- Author(s)
  堀川一樹
- Organizer
  第55回日本生化学会　中国・四国支部例会
- Place of Presentation
  愛媛大学 (愛媛県松山市)
- Year and Date
  2014-06-06
- Invited
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] ライブイメージングを容易にする高機能性指示薬の開発2014
- Author(s)
  堀川一樹
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島県）
- Data Source
  KAKENHI-PROJECT-25840050
[Presentation] 生理機能を可視化するFRETプローブの開発2014
- Author(s)
  堀川一樹
- Organizer
  第55回日本生化学会　中国・四国支部例会
- Place of Presentation
  愛媛大学（愛媛県松山市）
- Year and Date
  2014-06-06
- Invited
- Data Source
  KAKENHI-PUBLICLY-25113716
[Presentation] 2個の細胞で多細胞生物は作れるか：細胞性粘菌の多細胞化を可能にする細胞の数2013
- Author(s)
  佐藤朗、堀川一樹
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-25840050
[Presentation] 2個の細胞で多細胞は作れるか：細胞性粘菌の多細胞化を可能にする細胞の数2013
- Author(s)
  佐藤朗、堀川一樹
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際会議場（　兵庫県）
- Data Source
  KAKENHI-PUBLICLY-25113716
[Presentation] シグナル伝達を可視化する改良型プローブの紹介～Ca2+, cAMP, cGMP～2012
- Author(s)
  堀川一樹ら
- Organizer
  第2回日本細胞性粘菌学会年会
- Place of Presentation
  東京大学駒場Iキャンパス(東京都)
- Year and Date
  2012-11-17
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] ライブイメージングのための高性能プローブの開発2012
- Author(s)
  堀川一樹
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] シグナル伝達を可視化する改良型プローブの紹介～Ca2+, cAMP, cGMP～2012
- Author(s)
  堀川一樹
- Organizer
  第2回日本細胞性粘菌学会年会
- Place of Presentation
  東京大学(東京)
- Year and Date
  2012-11-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-23127512
[Presentation] ライブイメージングのための高性能プローブの開発2012
- Author(s)
  堀川一樹
- Organizer
  分子生物学会
- Place of Presentation
  福岡国際会議場 (福岡)
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PUBLICLY-23127512
[Presentation] Spontaneous network activity visualized by ultra-sensitive Ca2+indicators, yellow Cameleon-Nano2011
- Author(s)
  堀川一樹
- Organizer
  日本分子生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22770182
[Presentation] Spontaneous network activity visualized by ultrasensitive Ca^<2+> indicators, yellow Cameleon-Nano2011
- Author(s)
  堀川一樹
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] Spontaneous network activity visualized by ultrasensitive Ca2+ indicators, yellow Cameleon-Nano2011
- Author(s)
  堀川一樹
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22770182
[Presentation] ライブイメージングを容易にする高機能性指示薬の開発
- Author(s)
  堀川一樹
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島市）
- Data Source
  KAKENHI-PLANNED-23115003
[Presentation] 2個の細胞で多細胞生物は作れるか：細胞性粘菌の多細胞化を可能にする細胞の数
- Author(s)
  佐藤朗、堀川一樹
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PLANNED-23115003

1. NAGAI Takeharu (20311350)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. KINNBARA KAZUSHI (30282578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TANI Tomomi (80332378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. SANDO SHINSUKE (20346084)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MATSUDA TOMOKI (50419206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ARAI YOSHIYUKI (20444515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SATA Masataka (80345214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. FUKUDA Daiju (40637568)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. URANO YASUTERU (20292956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OZAWA TAKEAKI (40302806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIGASHIKUNI Yasutomi (10586481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SATOMI Junichi (10304510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAYAMA Taisuke (80582791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UEDA HIROK (20373277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ISHIJIMA AKIHIKO (80301216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IMADA KATSUMI (40346143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAESHIMA KAZUHIRO (00392118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NOJI HIROYUKI (00343111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TOGASHI YUICHI (50456919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YOSHIMURA SHIGEHIRO (90346106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. WATANABE TOMONOBU (00375205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. FUJITA KATSUMASA (80362664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKEUCHI SHOJI (90343110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOMATSUZAKI TAMIKI (30270549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. OKADA YASUSHI (50272430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HARADA YOSHIE (10202269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 竹本龍也 (30443899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 添木武 (60393211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 安部正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 竹居孝二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 山田浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 廣田圭昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 白川康太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horikawa Kazuki 堀川 一樹

HORIKAWA Kazuki 堀川 一樹

Research Projects

Research Products

Co-Researchers

Novel mechanism of chronic inflammation in progression and destabilization of atherosclerotic plaque

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Analysis of the singularity cells controlling the pattern formation of multicellular systemPrincipal Investigator

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Molecular mechanisms translating the pulse information into developmental timePrincipal Investigator

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Single molecule analysis in the generation of oscillatory circuit for cAMP signalingPrincipal Investigator

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マクロファージの異常な活性化に起因する慢性炎症発症機序の解明Principal Investigator

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Visualization of chronic inflammation in arterial wall and perivascular adipose tissue

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in vivo imaging analysis of cGMP dynamics in the smooth muscle of circulatory systemPrincipal Investigator

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Development of molecular probes and photo manipulation tools - Technologies for visualization and control of small number of biomolecules

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多細胞社会の秩序形成を司る細胞個性のマルチスケール定量と操作Principal Investigator

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Spying minority in biological phenomena -Toward bridging dynamics between individual and ensemble processes-

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Development of multi-scale and functional imaging technique to quantify the fluctuation in intercellular signalingPrincipal Investigator

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Elucidation of self-organization process in living organism by small number of molecules using functional imaging

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エンハンサートラップ法とライブイメージングを軸とした聴覚システム発生機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Horikawa Kazuki 堀川一樹

HORIKAWA Kazuki 堀川一樹

[Book] 蛍光タンパク質ⅳ．cAMPプローブ, 生きてるものは全部観る！イメージングの選び方・使い方100＋実験医学増刊 36 No.202018

[Book] 蛍光イメージング/MRIブローブの開発機能イメージングにおける指示薬感度の重要性 -蛍光タンパク質間FRETを用いたCa^<2+>指示薬開発からの考察-