HORISAWA Kenichi 堀澤健一

… Alternative Names

堀澤健一ホリサワケンイチ

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Researcher Number	70424207
Other IDs
Affiliation (Current)	2025: 九州大学, 生体防御医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2023: 九州大学, 生体防御医学研究所, 准教授 2016 – 2018: 九州大学, 生体防御医学研究所, 助教 2013 – 2014: 九州大学, 生体防御医学研究所, 助教 2011 – 2012: 慶應義塾大学, 理工学部, 助教 2009: Keio University, 理工学研究科, 助教 2008: Keio University, 大学院・理工学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / General medical chemistry / Neurochemistry/Neuropharmacology / Biological Sciences / Applied genomics Except Principal Investigator Applied molecular and cellular biology
Keywords	Principal Investigator 転写因子 / ダイレクトリプログラミング / 翻訳後修飾 / NGS解析 / 安定性制御配列 / degron / エピゲノム / Foxa / 核内局在 / ベータ酸化 … More / アセチルCoA / 転写制御 / ヒストン修飾 / アセチル化 / 肝細胞様細胞 / 脂質代謝 / クロマチン / 転写 / 肝細胞 / ベータ酸化 / 脂肪酸 / 代謝 / 再生医学 / 幹細胞 / 分化 / Dcx / Dcc / Musashi / 神経分化 / 転写後制御 / 翻訳制御 / 未分化維持 / 神経回路 / 神経発生 / RNA結合タンパク質 / Musashi1 / プロテオミクス / クリックケミストリー / ケミカルプローブ / 酵素反応 / メチル化 / ケミカルバイオロジー / ハデスプレイ技術 / 翻訳後就職 / 蛋白 / 分子ディスプレイ技術 / 試験管内スクリーニング / アルギニンメチル化 / 酵素 / プロテオーム / 蛋白質 / バイオテクノロジー … More Except Principal Investigator 発現制御 / バイオテクノロジー / 遺伝子 / 蛋白質 / プロテオーム Less

Development of a remarkably reproduceble direct programming methodology founded on stringent regulation of transcription factor expression.Principal Investigator
- Principal Investigator
  
  堀澤健一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyushu University
Analysis of the cooperation between transcription activity and lipid metabolism in direct reprogrammingPrincipal Investigator
- Principal Investigator
  
  HORISAWA Kenichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyushu University
ケミカルプローブによるメチル化標的転写因子のプロテオミクス解析Principal Investigator
- Principal Investigator
  
  堀澤健一
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Keio University
Analysis for a neural differentiation regulatory factor, Musashi1Principal Investigator
- Principal Investigator
  
  HORISAWA Kenichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
  Keio University
On-Chip Co-expression Microarrays for Precise Analysis of Transcriptional Regulatory Networks
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Keio University
Construction of a screening method for target proteins of protein arginine methyltransferasesPrincipal Investigator
- Principal Investigator
  
  HORISAWA Kenichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied genomics
- Research Institution
  Keio University

All 2024 2023 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] 生体の科学特集クロマチンによる転写制御機構の最前線 Ⅳ.転写制御と生命現象「ダイレクトリプログラミングと転写制御」2023
- Author(s)
  堀澤健一、鈴木淳史
- Total Pages
  5
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23K11851
[Book] 細胞工学別冊ダイレクトリプログラミング：目的細胞別　遺伝子導入・培養条件・機能解析リファレンス2015
- Author(s)
  堀澤健一、鈴木淳史（鈴木淳史・監修）
- Total Pages
  119
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-24500447
[Book] "Specific and Quantitative Protein Labeling using Click Chemistry" in Quantitative Biology: Dynamics of living systems2014
- Author(s)
  Horisawa K.
- Publisher
  Frontiers
- Data Source
  KAKENHI-PUBLICLY-24116523
[Book] “Applications of the In Vitro Virus (IVV) Method for Various Protein Functional Analyses” in Protein Engineering - Technology and Application2013
- Author(s)
  Tabata N., Horisawa K., and Yanagawa H.
- Total Pages
  25
- Publisher
  InTech
- Data Source
  KAKENHI-PUBLICLY-24116523
[Book] Neural Stem Cells and Therapy2012
- Author(s)
  Horisawa K. and Yanagawa H.
- Total Pages
  17
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer2024
- Author(s)
  Yamamoto T、Hayashida T、Masugi Y、Oshikawa K、Hayakawa N、Itoh M、Nishime C、Suzuki M、Nagayama A、Kawai Y、Hishiki T、Suematsu M、et al.
- Journal Title
  
  Cancer Research
  
  Volume: 84 Issue: 7 Pages: 1065-1083
- DOI
  10.1158/0008-5472.can-23-2266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-23K11851, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K06845
[Journal Article] The role of pioneer transcription factors in the induction of direct cellular reprogramming2023
- Author(s)
  Horisawa K & Suzuki A
- Journal Title
  
  Regenerative Therapy
  
  Volume: 24 Pages: 112-116
- DOI
  10.1016/j.reth.2023.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11851
[Journal Article] Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature2023
- Author(s)
  Horisawa K, Miura S, Araki H, Miura F, Ito T, & Suzuki A
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22317-22317
- DOI
  10.1038/s41598-023-49546-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11851
[Journal Article] Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors2018
- Author(s)
  Takashima Yasuo、Horisawa Kenichi、Udono Miyako、Ohkawa Yasuyuki、Suzuki Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 11 Pages: 3543-3553
- DOI
  10.1111/cas.13798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09001, KAKENHI-PROJECT-17K19603, KAKENHI-PROJECT-18K18369, KAKENHI-PUBLICLY-18H04802, KAKENHI-PROJECT-16H01850, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-16K08592, KAKENHI-PROJECT-17K19356, KAKENHI-PUBLICLY-18H05102
[Journal Article] In vitro selection of bispecific diabody fragments using covalent bicistronic DNA display.2016
- Author(s)
  Nakayama, M., Komiya, S., Fujiwara, K., Horisawa, K., Doi, N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 478 Issue: 2 Pages: 606-611
- DOI
  10.1016/j.bbrc.2016.07.113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-16K08592
[Journal Article] Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma2016
- Author(s)
  Terada M., Horisawa K., Miura S., Takashima Y., Ohkawa Y., Sekiya S., Matsuda-Ito K., Suzuki A.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 34691-34691
- DOI
  10.1038/srep34691
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01850, KAKENHI-PROJECT-16J02459, KAKENHI-PROJECT-25713014, KAKENHI-PROJECT-15K19025, KAKENHI-PROJECT-16K08592
[Journal Article] Specific and quantitative labeling of biomolecules using click chemistry.2014
- Author(s)
  Horisawa K.
- Journal Title
  
  Front Physiol.
  
  Volume: 5 Pages: 457-457
- DOI
  10.3389/fphys.2014.00457
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation.2013
- Author(s)
  Tokunaga M, Shiheido H, Tabata N, Sakuma-Yonemura Y, Takashima H, Horisawa K, Doi N, Yanagawa H.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 9 Pages: e76774-e76774
- DOI
  10.1371/journal.pone.0076774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display.2013
- Author(s)
  Tokunaga M, Shiheido H, Hayakawa I, Utsumi A, Takashima H, Doi N, Horisawa K, Sakuma-Yonemura Y, Tabata N, Yanagawa H.
- Journal Title
  
  Chemistry & Biology
  
  Volume: 20 Issue: 7 Pages: 935-942
- DOI
  10.1016/j.chembiol.2013.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012
- Author(s)
  Doi, N., Yamakawa, N., Matsumoto, H., Yamamoto, Y., Nagano, T., Matsumura, N., Horisawa, K., Yanagawa, H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22658111
[Journal Article] 3'-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein.2009
- Author(s)
  Horisawa K, Imai T, Okano H, Yanagawa H.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 2429-2434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710153
[Journal Article] 3'-Untranslated region of doublecortin mRNA is a binding target of the Musashil RNA-binding protien2009
- Author(s)
  Horisawa K., et al., (他3名)
- Journal Title
  
  FEBS Letters 583
  
  Pages: 2429-2434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710153
[Presentation] 転写因子の組み合わせによる細胞の運命決定機構の解明2023
- Author(s)
  鈴木陵雅、堀澤健一、三浦静、大川恭行、鈴木淳史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K11851
[Presentation] 細胞運命の直接転換と形質維持における転写因子の機能2023
- Author(s)
  堀澤健一、鈴木淳史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K11851
[Presentation] ダイレクトリプログラミング誘導転写因子の発現量と相関する3次元ゲノム構造変化の解析2023
- Author(s)
  堀澤健一
- Organizer
  先進ゲノム支援拡大班会議
- Data Source
  KAKENHI-PROJECT-23K11851
[Presentation] 細胞運命の直接転換と形質維持に関する転写因子の役割2023
- Author(s)
  堀澤健一、鈴木淳史
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K11851
[Presentation] 翻訳調節による遺伝子発現制御の研究と解析技術の開発2013
- Author(s)
  堀澤健一
- Organizer
  筑波大学大学院生命環境科学研究科セミナー　動物細胞バイオテクノロジー
- Place of Presentation
  筑波大学（つくば市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24116523
[Presentation] A novel chemical tool for proteomic analysis of translational control2013
- Author(s)
  Horisawa K., Miyazawa T., Ohkawa K., Oka K. and Doi N.
- Organizer
  The 12th Human Proteome Organisation World Congress
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] タンパク質の試験管内探索技術の開発　-幹細胞システム研究への応用に向けて-2013
- Author(s)
  堀澤健一
- Organizer
  第30回配偶子制御セミナー
- Place of Presentation
  横浜市立大学（横浜）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24116523
[Presentation] 翻訳調節による遺伝子発現制御の研究と解析技術の開発2013
- Author(s)
  堀澤健一
- Organizer
  筑波大学大学院生命環境科学研究科セミナー　動物細胞バイオテクノロジー
- Place of Presentation
  筑波大学（つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] Development of a chemical probe for protein methylation in living cells2013
- Author(s)
  Momose Y. & Horisawa K.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場（淡路市）
- Data Source
  KAKENHI-PUBLICLY-24116523
[Presentation] RNA-binding protein Msi1 regulates the expression of an axon guidance receptor through translational repression2012
- Author(s)
  Hara H., Horisawa K., Yanagawa H., Doi N.
- Organizer
  Translational Control
- Place of Presentation
  NewYork
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] ケミカルプローブによるメチルプロテオーム解析に向けて2012
- Author(s)
  堀澤健一
- Organizer
  平成24年度「転写代謝システム」領域班会議
- Place of Presentation
  つくばグランドホテル（つくば）
- Year and Date
  2012-07-02
- Data Source
  KAKENHI-PUBLICLY-24116523
[Presentation] 神経発生におけるRNA結合タンパク質Msi1による翻訳制御2012
- Author(s)
  原裕恵、堀澤健一、松尾薫、柳川弘志、土居信英
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] Translationally-regulated proteomics using biotinylated puromycin2011
- Author(s)
  大川皓司, 堀澤健一, 柳川弘志, 土居信英
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22658111
[Presentation] オンチップ共発現マイクロアレイによる転写制御ネットワーク解析2010
- Author(s)
  早坂俊二, 井上鈴代, 堀澤健一, 柳川弘志, 土居信英
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22658111
[Presentation] In vitro virus法によるアルギニンメチル化酵素標的タンパク質の網羅的探索法の開発2009
- Author(s)
  佐保山友加里、堀澤健一、高野直治、山本雄広、末松誠、土居信英、柳川弘志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20710153
[Presentation] In vitro virus法とタイリングアレイを用いた蛋白質相互作用解析技術2008
- Author(s)
  堀澤健一
- Organizer
  BMB2008(第31回日本分子生物学会年会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20710153

1. DOI Nobuhide (50327673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. YANAGAWA Hiroshi (40327672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 今井貴雄 (10383712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 芝田晋介 (70407089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岡野栄之 (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴木淳史 (30415195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAKAYAMA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Ohkawa Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Takashima Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. Miura Shizuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 菱木貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HORISAWA Kenichi 堀澤 健一

堀澤 健一 ホリサワ ケンイチ

Research Projects

Research Products

Co-Researchers

Development of a remarkably reproduceble direct programming methodology founded on stringent regulation of transcription factor expression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the cooperation between transcription activity and lipid metabolism in direct reprogrammingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ケミカルプローブによるメチル化標的転写因子のプロテオミクス解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis for a neural differentiation regulatory factor, Musashi1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

On-Chip Co-expression Microarrays for Precise Analysis of Transcriptional Regulatory Networks

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of a screening method for target proteins of protein arginine methyltransferasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生体の科学 特集 クロマチンによる転写制御機構の最前線 Ⅳ.転写制御と生命現象 「ダイレクトリプログラミングと転写制御」2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 細胞工学別冊 ダイレクトリプログラミング ：目的細胞別 遺伝子導入・培養条件・機能解析リファレンス2015

Author(s)

Total Pages

Publisher

Data Source

[Book] "Specific and Quantitative Protein Labeling using Click Chemistry" in Quantitative Biology: Dynamics of living systems2014

Author(s)

Publisher

Data Source

[Book] “Applications of the In Vitro Virus (IVV) Method for Various Protein Functional Analyses” in Protein Engineering - Technology and Application2013

Author(s)

Total Pages

Publisher

Data Source

[Book] Neural Stem Cells and Therapy2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of pioneer transcription factors in the induction of direct cellular reprogramming2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature2023

Author(s)

Journal Title

DOI

Data Source

HORISAWA Kenichi 堀澤健一

堀澤健一ホリサワケンイチ

[Book] 生体の科学特集クロマチンによる転写制御機構の最前線 Ⅳ.転写制御と生命現象「ダイレクトリプログラミングと転写制御」2023

[Book] 細胞工学別冊ダイレクトリプログラミング：目的細胞別　遺伝子導入・培養条件・機能解析リファレンス2015

[Presentation] タンパク質の試験管内探索技術の開発　-幹細胞システム研究への応用に向けて-2013