Kobayashi Masaki 小林正紀

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KOBAYASHI Masaki 小林正紀

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Researcher Number	70431319
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2024: 北海道大学, 薬学研究院, 教授 2020 – 2022: 北海道大学, 薬学研究院, 教授 2019 – 2020: 北海道大学, 薬学研究院, 准教授 2016 – 2018: 北海道大学, 大学病院, 准教授 2015: 北海道大学, 薬学研究科(研究院), 准教授 2012 – 2013: 北海道大学, 薬学研究科(研究院), 助教 2008 – 2009: Hokkaido University, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 52030:Psychiatry-related / Basic Section 47060:Clinical pharmacy-related / Applied pharmacology Except Principal Investigator Eating habits / Medical pharmacy
Keywords	Principal Investigator モノカルボン酸輸送担体（MCT） / 周産期 / 精神神経科系薬剤 / ピルビン酸 / 乳酸 / がん細胞 / 乳酸トランスポーター / 薬剤性筋障害 / 胆汁中排泄 / 肝臓 … More / 高脂血症 / 発現調節 / LXR / ABCトランスポータ / スタチン / トランスポータ / 薬物相互作用 / 臨床 / 薬学 … More Except Principal Investigator ディフェンシン / 免疫学 / 食品 / 経口抗がん剤 / 機能性食品 / 腸管免疫 / 分子標的薬 / 小腸虚血再灌流 / 小腸移植後感染症 Less

周産期の安全な精神神経科系薬剤の服薬支援のためのエビデンス構築Principal Investigator
- Principal Investigator
  
  小林正紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hokkaido University
Functional analysis of MCTs responsible for energy source transport and search for therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
To avoid the side effects of molecularly-targeted agents by functional food and exploration of biomarkers for immune prediction.
- Principal Investigator
  
  Suzuki Natsuko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Hokkaido University of Science
  Hokkaido Pharmaceutical University School of Pharmacy
Prevention strategy for infections after small intestinal transplantation by food ingredient induced alpha defensin secretion
- Principal Investigator
  
  Iseki Ken
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
verification of suppressive effect by MCT inhibition on tumor cell growth and invasionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Masaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University
The strategy to avoid drug-induced skeletal muscle injury involved in monocarboxylate transporterPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Masaki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
The strategy to avoid the side effect of lipid-lowering agentsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Masaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2009 2008

All Journal Article Presentation

[Journal Article] Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line2022
- Author(s)
  Mukai Y, Yamaguchi A, Sakuma T, Nadai T, Furugen A, Narumi K, Kobayashi M
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 43 Issue: 5 Pages: 183-191
- DOI
  10.1002/bdd.2329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07171
[Journal Article] The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes2021
- Author(s)
  Kimura Y, Higuchi I, Kobayashi M, Furugen A, Narumi K, Suzuki Y, Miyoshi H, Nakamura A, Atsumi T, Iseki K.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 37 Pages: 100376-100376
- DOI
  10.1016/j.dmpk.2020.100376
- NAID
  210000167687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07171
[Journal Article] Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin2021
- Author(s)
  Genki Yasuda, Masaki Kobayashi, Atsuhito Kubota, Katsuya Narumi, Ayako Furugen, Yoshitaka Saito, Takashi Satoh, Natsuko Suzuki, Ken Iseki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 2 Pages: 275-278
- DOI
  10.1248/bpb.b20-00644
- NAID
  130007979605
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00871
[Journal Article] Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)2021
- Author(s)
  Kobayashi M, Narumi K, Furugen A, Iseki K
- Journal Title
  
  Pharmacol Ther
  
  Volume: 226 Pages: 107862-107862
- DOI
  10.1016/j.pharmthera.2021.107862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07171
[Journal Article] Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 42020
- Author(s)
  Yamaguchi A, Narumi K, Furugen A, Iseki K, Kobayashi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 529(4) Issue: 4 Pages: 1061-1065
- DOI
  10.1016/j.bbrc.2020.06.068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07171
[Journal Article] Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity2018
- Author(s)
  Kubota A, Kobayashi M, Sarashina S, Takeno R, Yasuda G, Narumi K, Furugen A, Takahashi-Suzuki N, Iseki K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 12 Pages: 1874-1878
- DOI
  10.1248/bpb.b18-00338
- NAID
  130007539553
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08388
[Journal Article] Identification of a selective inhibitor of human monocarboxylate transporter 42018
- Author(s)
  Futagi Yuya、Kobayashi Masaki、Narumi Katsuya、Furugen Ayako、Iseki Ken
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 427-432
- DOI
  10.1016/j.bbrc.2017.10.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J00013, KAKENHI-PROJECT-15K08581
[Journal Article] Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.2018
- Author(s)
  Kubota A, Kobayashi M, Sarashina S, Takeno R, Okamoto K, Narumi K, Furugen A, Suzuki Y, Takahashi N, Iseki K.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 214 Pages: 240-243
- DOI
  10.1016/j.jep.2017.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08388
[Journal Article] The flexible cytoplasmic loop 3 contributes to the substrate affinity of human monocarboxylate transporters2017
- Author(s)
  Futagi Yuya、Sasaki Shotaro、Kobayashi Masaki、Narumi Katsuya、Furugen Ayako、Iseki Ken
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1859 Issue: 10 Pages: 1790-1795
- DOI
  10.1016/j.bbamem.2017.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J00013, KAKENHI-PROJECT-15K08581
[Journal Article] Influence of high glucose state on bromopyruvate-induced cytotoxity by human colon cancer cell lines.2016
- Author(s)
  Ideno M, Sasaki S, Kobayashi M, Futagi Y, Narumi K, Iseki K
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 31 Issue: 1 Pages: 67-72
- DOI
  10.1016/j.dmpk.2015.10.006
- NAID
  50014431243
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08581
[Journal Article] Effect of diclofenac on SLC16A3/MCT4 by the Caco-2 cell line.2016
- Author(s)
  Sasaki S, Futagi Y, Ideno M, Kobayashi M, Narumi K, Furugen A, Iseki K.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 31 Issue: 3 Pages: 218-223
- DOI
  10.1016/j.dmpk.2016.03.004
- NAID
  50014431264
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08581
[Journal Article] Regulation of the Expression and Activity of Glucose and Lactic Acid Metabolism-Related Genes by Protein Kinase C in Skeletal Muscle Cells2013
- Author(s)
  Otake S, Kobayashi M, Narumi K, Sasaki S, Kikutani Y, Furugen A, Watanabe M, Takahashi N, Ogura J, Yamaguchi H, Iseki K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 9 Pages: 1435-1439
- DOI
  10.1248/bpb.b13-00141
- NAID
  130003361512
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790138, KAKENHI-PROJECT-25460184
[Journal Article] Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4)2013
- Author(s)
  Sasaki S, Kobayashi M, Futagi Y, Ogura J, Yamaguchi H, Takahashi N, Iseki K
- Journal Title
  
  PLoS ONE.
  
  Volume: 8 Issue: 7 Pages: 67690-67690
- DOI
  10.1371/journal.pone.0067690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790138, KAKENHI-PROJECT-25460184
[Journal Article] Effects of Acidification and Alkalinization Agent on Statins-induced Muscle Toxicity2012
- Author(s)
  Kobayashi M, Hidaka K, Chisaki I, Takahashi N, Ogura J, Itagaki S, Hirano T, Yamaguchi H, Iseki K
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Issue: 5 Pages: 609-615
- DOI
  10.1248/yakushi.132.609
- NAID
  130001888677
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2012-05-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790138
[Journal Article] Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver2009
- Author(s)
  Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K
- Journal Title
  
  Biochimica et Biophysica Acta 1788(11)
  
  Pages: 2396-2403
- NAID
  120001702428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790126
[Journal Article] receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim.2009
- Author(s)
  Chisaki, I., Kobayashi, M., Itagaki, S., Hirano, T. Iseki, K. Liver X
- Journal Title
  
  Biophys. Acta 1788(11)
  
  Pages: 2396-2403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790126
[Presentation] 分化誘導されたヒト神経芽細胞腫SH-SY5Y細胞における乳酸輸送担体の同定2023
- Author(s)
  佐久間智也、向井悠斗、山口敦史、石川修平、古堅彩子、鳴海克哉、小林正紀
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07171
[Presentation] 肝がん由来細胞において乳酸輸送に寄与する輸送担体の同定に関する研究2022
- Author(s)
  向井悠斗、山口敦史、佐久間智也、古堅彩子、鳴海克哉、小林正紀
- Organizer
  日本薬学会北海道支部第149回例会
- Data Source
  KAKENHI-PROJECT-20K07171
[Presentation] hMCT1, 2, 4の細胞外アスパラギン酸の機能解析2021
- Author(s)
  山口敦史、鳴海克哉、古堅彩子、井関健、小林正紀
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07171
[Presentation] MCT11が2型糖尿病に関与するメカニズムの研究2021
- Author(s)
  鈴木雄也、山口敦史、木村有希、樋口一世、鳴海克哉、古堅彩子、小林正紀
- Organizer
  第34回北海道薬物作用談話会
- Data Source
  KAKENHI-PROJECT-20K07171
[Presentation] 分子標的薬による腸管免疫低下に対するシーベリージュースの効果2019
- Author(s)
  村上えり, 川上莉歩, 保田元気, 窪田篤人, 星幸子, 小林正紀, 井関健, 鈴木夏子
- Organizer
  第8回日本未病システム学会
- Data Source
  KAKENHI-PROJECT-17K00871
[Presentation] エルロチニブによるα-デフェンシンの低下に対するシーベリーの効果2019
- Author(s)
  川上莉歩, 村上えり, 門萌子, 太田沙希, 保田元気, 窪田篤人, 小林正紀, 井関健, 鈴木夏子
- Organizer
  日本薬学会北海道支部第146例会
- Data Source
  KAKENHI-PROJECT-17K00871
[Presentation] 腸管免疫賦活作用を有する食品の探索と機序の解析2018
- Author(s)
  窪田篤人、小林正紀、更科壮太、保田元気、木村有希、鈴木裕治、鈴木夏子、井関健
- Organizer
  第14回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] シーベーリーが抗がん薬による腸管免疫低下に及ぼす影響2018
- Author(s)
  門萌子、窪田篤人、小林正紀、保田元気、更科壮太、井関健、星幸子、鈴木夏子
- Organizer
  日本薬学会第136年会
- Data Source
  KAKENHI-PROJECT-17K00871
[Presentation] GABA はラット小腸 I/R による腸管免疫変動を抑制する2018
- Author(s)
  窪田篤人、小林正紀、更科壮太、保田元気、鳴海克哉、古堅彩子、鈴木夏子、井関健
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] エルロチニブが腸管免疫に及ぼす影響2018
- Author(s)
  宇内優、筑後裕貴、保田元気、小林正紀、井関健、鈴木夏子
- Organizer
  日本薬学会第136年会
- Data Source
  KAKENHI-PROJECT-17K00871
[Presentation] 食品成分による腸管免疫の維持・改善に関する研究2017
- Author(s)
  窪田篤人、小林正紀、竹野礼子、更科壮太、高橋夏子、保田元気、古堅彩子、鳴海克哉、井関健
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] 小腸障害時における腸管免疫の変動に関する研究2016
- Author(s)
  竹野礼子、小林正紀、窪田篤人、更科壮太、高橋夏子、鳴海克哉、古堅彩子、井関健
- Organizer
  第30回北海道薬物作用談話会
- Place of Presentation
  北海道大学大学院獣医学研究科新講義棟講堂(北海道・札幌市）
- Data Source
  KAKENHI-PROJECT-16K08388
[Presentation] hMCT1, 4を介した基質輸送における細胞内ループの役割2016
- Author(s)
  二木悠哉、佐々木将太郎、小林正紀、井関健
- Organizer
  第136回日本薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08581
[Presentation] MCTとがん細胞の生存・運動能との関連性2016
- Author(s)
  関口穂乃佳、小林正紀、佐々木将太郎、木村有希、鳴海克哉、井関健
- Organizer
  日本薬学会北海道支部第143回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-15K08581
[Presentation] MCTの役割に着目した疾患と副作用に関する研究2015
- Author(s)
  小林正紀
- Organizer
  第25回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2015-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-15K08581
[Presentation] 大豆イソフラボンによるモノカルボン酸輸送担体の阻害効果を利用したがん細胞増殖の回避戦略2015
- Author(s)
  小林正紀、佐々木将太郎、二木悠哉、関口穂乃佳、鳴海克哉、高橋夏子、井関健
- Organizer
  第22回日本未病システム学会学術総会
- Place of Presentation
  北海道大学学術交流会館（北海道・札幌市）
- Year and Date
  2015-10-11
- Data Source
  KAKENHI-PROJECT-15K08581
[Presentation] モノカルボン酸輸送担体hMCT4の発現調節機構2013
- Author(s)
  小林正紀、鳴海克哉、大竹翔、佐々木将太郎、井関健
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790138
[Presentation] モノカルボン酸輸送担体 hMCT4 の発現調節機構2013
- Author(s)
  小林正紀, 鳴海克哉, 大竹翔, 佐々木将太郎, 井関健
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  熊本大学薬学部、熊本
- Data Source
  KAKENHI-PROJECT-24790138
[Presentation] Regulation of human monocarboxylate transporter 4 in skeletal muscle cells : the role of AMPactivated protein kinase and protein kinase C2012
- Author(s)
  Kobayashi M, Narumi K, Furugen A, Sasaki S, Iseki K
- Organizer
  AAPS Annual Meeting and Exposition
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-24790138
[Presentation] Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of AMP-activated protein kinase and protein kinase C2012
- Author(s)
  Kobayashi M, Narumi K, Furugen A, Sasaki S, Iseki K
- Organizer
  AAPS Annual Meeting and Exposition
- Place of Presentation
  McCormic Place, Chicago, USA
- Data Source
  KAKENHI-PROJECT-24790138
[Presentation] スタチン系薬物による肝ATP-binding cassette transporter A1 (ABCA1)発現に及ぼす影響2009
- Author(s)
  合田圭佑, 小林正紀, 知嵜郁美, 板垣史郎, 井関健
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20790126
[Presentation] スタチン系薬物による肝ATP-binding cassette transporter A1(ABCA1)発現に及ぼす影響2009
- Author(s)
  合田圭祐、小林正記、知嵜郁美、板垣史郎、井関健
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館, 京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20790126
[Presentation] 肝MRP2発現に与えるスタチン系薬物の影響2008
- Author(s)
  知嵜郁美、小林正紀、板垣史郎、平野剛、井関健
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本交通センターホテル
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20790126
[Presentation] 肝MRP2発現に与えるスタチン系薬物の影響2008
- Author(s)
  知嵜郁美、小林正紀、板垣史郎, 平野剛, 井関健
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20790126

1. Suzuki Natsuko (60535293)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Iseki Ken (40203062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 石川修平 (30880091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 古堅彩子 (90767261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋夏子

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results

Kobayashi Masaki 小林 正紀

KOBAYASHI Masaki 小林 正紀

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周産期の安全な精神神経科系薬剤の服薬支援のためのエビデンス構築Principal Investigator

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Functional analysis of MCTs responsible for energy source transport and search for therapeutic agentsPrincipal Investigator

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To avoid the side effects of molecularly-targeted agents by functional food and exploration of biomarkers for immune prediction.

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Prevention strategy for infections after small intestinal transplantation by food ingredient induced alpha defensin secretion

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verification of suppressive effect by MCT inhibition on tumor cell growth and invasionPrincipal Investigator

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The strategy to avoid drug-induced skeletal muscle injury involved in monocarboxylate transporterPrincipal Investigator

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The strategy to avoid the side effect of lipid-lowering agentsPrincipal Investigator

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[Journal Article] Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line2022

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[Journal Article] The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes2021

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[Journal Article] Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin2021

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[Journal Article] Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)2021

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[Journal Article] Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 42020

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[Journal Article] Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity2018

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Kobayashi Masaki 小林正紀

KOBAYASHI Masaki 小林正紀