Kurosu Takeshi 黒須剛

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KUROSU Takeshi 黒須剛

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Researcher Number	70432432
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ウイルス第一部, 主任研究員
Affiliation (based on the past Project Information) *help	2015 – 2024: 国立感染症研究所, ウイルス第一部, 主任研究官 2015: 国立感染症研究所, その他部局等, 研究員 2014: 大阪大学, 微生物病研究所, 招へい教員 2009 – 2013: Osaka University, 微生物病研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Integrative animal science / Virology Except Principal Investigator Medical genome science / Laboratory medicine / Infectious disease medicine
Keywords	Principal Investigator デングウイルス / 出血熱 / サイトカインストーム / マウスモデル / 血漿漏出 / 多臓器不全 / 感染症 / フラビウイルス / 感染動物モデル / 全身性感染症 … More / IL-6 / ウイルス性出血熱 / デング熱 / 重症化 / 重症感染症 / デング出血熱 / 動物モデル / 蚊媒介性疾患 / ウイルス感染症 / 免疫異常 / マイクロアレイ / 免疫学 / 病理学 / ウィルス / 骨髄抑制 / 好中球 / RNAウイルス / IL-17 / ガンマ・デルタＴ細胞 / 感染 / 感染モデル / 感染病態 / 血症漏出 / 振興・再興感染症 / ウイルス / 新興・再興感染症 / 熱帯感染症 / ウイルス性熱性疾患 / 感染性クローン / 多様性 / 熱帯病 / ウイルス疑似種 … More Except Principal Investigator デングウイルス / ペプチド核酸 / 遺伝子診断 / 蛋白質 / 核酸 / 遺伝子 / バイオテクノロジー / ウイルス / 国際研究者交流 / 単クローン抗体 / 蚊媒介性 / イムノクロマトキット / 熱帯感染症 / タイ / マウス単クローン抗体 / ヒト単クローン抗体 / イミュノクロマト法 / 迅速診断キット / チクングンヤウイルス / 迅速診断 / 臨床微生物学 / フィリピン / 血小板減少症 / アポトーシス血小板クリアランス / アポトーシス / 二次感染 / デング / インターフェロンレセプター欠損マウス / 骨髄系細胞 / 巨核球 / 血小板 / 血小板アポトーシス / 血小板減少 Less

Elucidation of the mechanism of induction of severe dengue hemorrhagic fever using a novel myeloid cell-infected mouse modelPrincipal Investigator
- Principal Investigator
  
  黒須剛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Institute of Infectious Diseases
Complete elucidation of pathogenic mechanism of severe dengue in mouse model, developing the symptoms of vascular leakage induced by cytokine storm.Principal Investigator
- Principal Investigator
  
  黒須剛
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Institute of Infectious Diseases
Analysis of severe disease mechanism using mouse model infected with dengue virus, developing the symptoms of vascular leakage and bone marrow suppression.Principal Investigator
- Principal Investigator
  
  KUROSU Takeshi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  National Institute of Infectious Diseases
The elucidation of pathogenic mechanisms of vascular leakage and bone marrow suppression in dengue virus mouse modelPrincipal Investigator
- Principal Investigator
  
  KUROSU TAKESHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Integrative animal science
- Research Institution
  National Institute of Infectious Diseases
Development of a highly sensitive RNA virus detection method by artificial nucleoproteins
- Principal Investigator
  
  KAIHATSU KUNIHIRO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  Osaka University
Development of murine model for dengue virus infectionPrincipal Investigator
- Principal Investigator
  
  KUROSU TAKESHI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Osaka University
Development of diagnosis test kits with high specificity, high sensitivity, and low cost against tropical infectious diseases.
- Principal Investigator
  
  IKUTA Kazuyoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka University
A mechanism of platelet phagocytosis in dengue virus infection
- Principal Investigator
  
  OISHI Kazunori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Institute of Infectious Diseases
  Osaka University
Analysis of dengue virus quasispecies and their cell tropism.Principal Investigator
- Principal Investigator
  
  KUROSU Takeshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Osaka University

[Journal Article] Mice, myeloid cells, and dengue: a new model for unraveling vascular leakage mysteries2024
- Author(s)
  Kurosu T, Sakai Y, Ami Y, Shimojima M, Yoshikawa T, Fukushi S, Nagata N, Suzuki T, Ebihara H, Saijo M.
- Journal Title
  
  Front Microbiol .
  
  Volume: 15 Pages: 1367672-1367672
- DOI
  10.3389/fmicb.2024.1367672
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05981
[Journal Article] Dengue virus infection induces selective expansion of Vγ4 and Vγ6TCR γδ T cells in the small intestine and a cytokine storm driving vascular leakage in mice2023
- Author(s)
  Kurosu T, Okuzaki D, Sakai Y, Kadi MA, Phanthanawiboon S, Ami Y, Shimojima M, Yoshikawa T, Fukushi S, Nagata N, Suzuki T, Kamimura D, Murakami M, Ebihara H, Saijo M.
- Journal Title
  
  LoS Negl Trop Dis .
  
  Volume: 17 Issue: 11 Pages: 11743-11743
- DOI
  10.1371/journal.pntd.0011743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05981, KAKENHI-PROJECT-23K27671
[Journal Article] Chimeric flavivirus causes vascular leakage and bone marrow suppression in a mouse model2023
- Author(s)
  Takeshi Kurosu, Keiko Hanabara, Azusa Asai, Sabar Pambudi, Supranee Phanthanawiboon, Magot Diata Omokoko, Yusuke Sakai, Tadaki Suzuki, Kazuyoshi Ikuta
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 659 Pages: 54-61
- DOI
  10.1016/j.bbrc.2023.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05981, KAKENHI-PROJECT-17K08145
[Journal Article] Chimeric flavivirus enables evaluation of antibodies against dengue virus envelope protein in vitro and in vivo.2020
- Author(s)
  Kurosu T, Hanabara K, Asai A, Pambudi A, Phanthanawiboon A, Omokoko MD, Ono K, Saijo M, Ramasoota P, Ikuta K.
- Journal Title
  
  Scientific Report
  
  Volume: 10 Issue: 1 Pages: 21561-21561
- DOI
  10.1038/s41598-020-78639-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08145
[Journal Article] Construction of a high-yield dengue virus by replacing nonstructural proteins 3?4B without increasing virulence2018
- Author(s)
  Phanthanawiboon Supranee、Pambudi Sabar、Omokoko Magot Diata、Hanabara Keiko、A-nuegoonpipat Atchareeya、Kamitani Wataru、Ikuta Kazuyoshi、Kurosu Takeshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 1221-1226
- DOI
  10.1016/j.bbrc.2017.11.137
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14885, KAKENHI-PROJECT-17K08145
[Journal Article] Construction of a high-yield dengue virus by replacing nonstructural proteins 3-4B without increasing virulence2018
- Author(s)
  Phanthanawiboon S, Pambudi S, Omokoko MD, Hanabara K, A-Nuegoonpipat A, Kamitani W, Ikuta K, Kurosu T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Pages: 1221-1226
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08145
[Journal Article] Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor KO mice: implications for dengue virulence.2016
- Author(s)
  1.Dhole P, Nakayama EE, Saito A, Limkittikul K, Phanthanawiboon S, Shioda T, Kurosu T.
- Journal Title
  
  Virology Journal
  
  Volume: 13 Issue: 1 Pages: 199-199
- DOI
  10.1186/s12985-016-0658-4
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14885
[Journal Article] Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors2016
- Author(s)
  Supranee Phanthanawiboon, Kriengsak Limkittikul, Yusuke Sakai, Nobuyuki Takakura, Masayuki Saijo and Takeshi Kurosu
- Journal Title
  
  PLOSOne
  
  Volume: 4 Issue: 2 Pages: e0148564-e0148564
- DOI
  10.1371/journal.pone.0148564
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14885, KAKENHI-PROJECT-24300330
[Journal Article] Antibody with an engineered Fc region as a therapeutic agent against dengue virus infection.2015
- Author(s)
  Ririn Ramadhany, Itaru Hirai, Tadahiro Sasaki, Ken-ichiro Ono, Pongrama Ramasoota, Kazuyoshi Ikuta, and Takeshi Kurosu
- Journal Title
  
  Antiviral Research
  
  Volume: 124 Pages: 61-68
- DOI
  10.1016/j.antiviral.2015.10.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14885
[Journal Article] A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.2014
- Author(s)
  Omokoko MD, Pambudi S, Phanthanawiboon S, Masrinoul P, Setthapramote C, Sasaki T, Kuhara M, Ramasoota P, Yamashita A, Hirai I, Ikuta K, Kurosu T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 91 Issue: 1 Pages: 146-155
- DOI
  10.4269/ajtmh.13-0624
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Isolation and propagation of Dengue virus in Vero and BHK-21 cells expressing human DC-SIGN stably.2014
- Author(s)
  Phanthanawiboon S, A-nuegoonpipat A, Panngarm N, Limkittikul K, Ikuta K, Anantapreecha S, Kurosu T.
- Journal Title
  
  J Virol Methods.
  
  Volume: 209 Pages: 55-61
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Sequence Variation of Dengue Type 2 Virus from clinical cases in Thailand. Japanese Journal of Infectious Diseases.2014
- Author(s)
  Kurosu T, Chaichana P, Phanthanawiboon S, Khamlert C, Yamashita A, A-nuegoonpipat A, Anantapreecha S, Ikuta K.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 67 Pages: 132-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Serotype-specific anti-dengue virus NS1 mouse antibodies cross-react with prM and are potentially involved in virus production2013
- Author(s)
  Masrinoul P., Omokoko M.D., Pambudi S., Ikuta K., and Kurosu T.
- Journal Title
  
  Ｖｉｒａｌ　Ｉｍｍｕｎｏｌｏｇｙ
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.2013
- Author(s)
  Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leaungwutiwong P, Misaki R, Fujiyama K, Ono K, Okuno Y, Ramasoota P, Ikuta K
- Journal Title
  
  Antiviral Res
  
  Volume: 98(3) Pages: 423-31
- Data Source
  KAKENHI-PROJECT-22591106
[Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.2013
- Author(s)
  Sasaki T, Setthapramote C, Kurosu T, et al
- Journal Title
  
  Antiviral Res.
  
  Volume: S0166-3542(13) Issue: 3 Pages: 72-7
- DOI
  10.1016/j.antiviral.2013.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590505, KAKENHI-PROJECT-23659297
[Journal Article] Serotype-Specific Anti-Dengue Virus NS1 Mouse Antibodies Cross-React with prM and Are Potentially Involved in Virus Production.2013
- Author(s)
  Masrinoul P, Omokoko MD, Pambudi S, Ikuta K, Kurosu T
- Journal Title
  
  Viral Immunology
  
  Volume: 26 Issue: 4 Pages: 250-258
- DOI
  10.1089/vim.2012.0102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Chikungunya virus induces a more moderate cytopathic effect in mosquito cells than in mammalian cells.2013
- Author(s)
  Li, Y.G., Siripanyaphinyo, U., Tumkosit, U., Noranate, N., A-Nuegoonpipat, A., Kurosu, T., Ikuta, K., Takeda, N., and Anantapreecha, S.
- Journal Title
  
  Intgervirology
  
  Volume: 56 Issue: 1 Pages: 6-12
- DOI
  10.1159/000339985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659297
[Journal Article] Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection.2012
- Author(s)
  Setthapramote C, Sasaki T, Puiprom O, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 423(4) Issue: 4 Pages: 867-872
- DOI
  10.1016/j.bbrc.2012.06.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590505, KAKENHI-PROJECT-23659297
[Journal Article] Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections.2012
- Author(s)
  Alonzo MTG, Lacuesta TLV, Dimaano EM, Kurosu T, Suarez LC, Mapua CA, Akeda Y, Matias RR, Kuter DJ, Nagata S, Natividad FF, Oishi K
- Journal Title
  
  J Infect Dis
  
  Volume: 205(8) Pages: 1321-9
- Data Source
  KAKENHI-PROJECT-22591106
[Journal Article] Platelet Apoptosis and Apoptotic Platelet Clearance by Macrophages in Secondary Dengue Virus Infections.2012
- Author(s)
  Alonzo, M., Lacuesta, T., Dimaano, EM., Kurosu, T., Suarez, LC., Mapua, CA Akeda, Y., Matias, RR., Kuter, DJ., Nagata, S., Natividad, FF. and Oishi, K.
- Journal Title
  
  J Infect Dis.
  
  Volume: 205 Issue: 8 Pages: 1321-1329
- DOI
  10.1093/infdis/jis180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000013, KAKENHI-PROJECT-22591106, KAKENHI-PROJECT-22790406, KAKENHI-PROJECT-23590542
[Journal Article] Limited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes.2012
- Author(s)
  Noda M, Masrinoul P, Punkum C, Pipattanaboon C, Ramasoota P, Setthapramote C, Sasaki T, Sasayama M, Yamashita A, Kurosu T, Ikuta K, Okabayashi T
- Journal Title
  
  Biologics
  
  Volume: 6 Pages: 409-16
- Data Source
  KAKENHI-PROJECT-22591106
[Journal Article] Limited cross-reactivity of mouse monoclonal antibodies against dengue virus capsid protein among four serotypes.2012
- Author(s)
  Noda, M., Masrinoul, P., Pipattanaboon, C., Ramasoota, P., Setthapramote, C., Sasaki, T., Sasayama, M., Yamashita, A., Kurosu, T., Ikuta, K., and Okabayashi, T.
- Journal Title
  
  Biologics
  
  Volume: 6 Pages: 409-416
- DOI
  10.2147/btt.s37792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659297
[Journal Article] Quasispecies of dengue virus2011
- Author(s)
  TAKESHI KUROSU
- Journal Title
  
  Tropical Medicine and Health, Japanese Society of Tropical Medicine.
  
  Volume: (未定印刷中)
- NAID
  10030727226
- Data Source
  KAKENHI-PROJECT-21790444
[Journal Article] Quasispecies of dengue virus.2011
- Author(s)
  Kurosu T.
- Journal Title
  
  Tropical Medicine and Health, Japanese Society of Tropical Medicine. in press
- NAID
  10030727226
- Data Source
  KAKENHI-PROJECT-21790444
[Journal Article] Quasispecies of dengue virus.2011
- Author(s)
  Kurosu T
- Journal Title
  
  Trop. Med. Health.
  
  Volume: 39 Pages: 1-8
- NAID
  10030727226
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Highly conserved region 141-168 of the NS1 protein is a new common epitope region of dengue virus.2011
- Author(s)
  Masrinoul P, Diata MO, Pambudi S, Limkittikul K, Ikuta K, Kurosu T.
- Journal Title
  
  Jpn J Infect Dis.
  
  Volume: 64 Pages: 109-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590542
[Journal Article] Co-existence of major and minor viral populations from two different origins in patients secondarily infected with dengue virus serotype 2 in Bangkok2011
- Author(s)
  Puiprom O., Yamashita A., Sasayama M., Limkittikul K., Boonha K., Jittmitraphap A., Leaungwutiwong P,. Kurosu T., Ramasoota P., Ikuta K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 413 Issue: 1 Pages: 136-142
- DOI
  10.1016/j.bbrc.2011.08.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590542, KAKENHI-PROJECT-23659297
[Journal Article] Highly conserved region 141-168 of the NS1 protein is a newly identified common epitope region of dengue virus.2011
- Author(s)
  Masrinoul P., Diata MO., Pambudi S., Limkittikul K., Ikuta K., Kurosu T.
- Journal Title
  
  Jpn J Infect Dis. 64
  
  Pages: 109-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790444
[Journal Article] Highly conserved region 141-168 of the NS1 protein is a new common epitope region of dengue virus.2011
- Author(s)
  Masrinoul, P., Diata, M. O., Pambudi, S., Limkittikul, K., Ikuta, K., and Kurosu, T.
- Journal Title
  
  Jpn. J. Infect. Dis.
  
  Volume: 64 Pages: 109-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659297
[Journal Article] Highly Efficient Rescue of Dengue Virus Using a Co-culture System with Mosquito/Mammalian Cells2010
- Author(s)
  TAKESHI KUROSU, et.al.
- Journal Title
  
  Biochemical and Biophysical Research Communications (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790444
[Journal Article] Highly Efficient Rescue of Dengue Virus Using a Co-culture System with Mosquito/Mammalian Cells.2010
- Author(s)
  Kurosu T., Khamlert C, Phanthawiboon S, Ikuta K, Anantapreecha S.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 398-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790444
[Journal Article] Highly Efficient Rescue of Dengue Virus Using a Co-culture System with Mosquito/Mammalian Cells2010
- Author(s)
  TAKESHI KUROSU, et.al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 394 Pages: 398-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] 新規致死性デング出血熱マウスモデルを用いた病原機序解析2023
- Author(s)
  黒須剛、坂井祐介、奥崎大介、Mohamad Al Kadi、網康至、下島昌幸、吉河智城、永田典代、鈴木忠樹、西條政幸、海老原秀喜
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K05981
[Presentation] 馴化デングウイルスを用いた新規致死性デング出血熱マウスモデル2023
- Author(s)
  黒須剛、坂井祐介、奥崎大介、Mohamad Al Kadi、網康至、下島昌幸、吉河智城、永田典代、鈴木忠樹、西條政幸、海老原秀喜
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05981
[Presentation] 致死性デング出血熱マウスモデルを用いたTNF-シグナル阻害による防御効果の分子機序解明2022
- Author(s)
  黒須剛、奥崎大介、坂井祐介、Mohamad Al Kadi、下島昌幸、吉河智城、福士秀悦、永田典代、鈴木忠樹、海老原秀喜、西條政幸
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] Interleukin-17A released from intestinal γδT cells induces cytokine storm in mice with severe dengue2022
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon, Yasusi Ami, Masayuki Shimojima, Tomoki Yoshikawa, Shuetsu Fukushi, Noriyo Nagata, Tadaki Suzuki, Daisuke Kamimura, Masaaki Murakami, Hideki Ebihara, Masayuki Saijo
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05981
[Presentation] Interleukin-17A released from intestinal γδT cells induces cytokine storm in mice with severe dengue2022
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon, Yasusi Ami, Masayuki Shimojima, Tomoki Yoshikawa, Shuetsu Fukushi, Noriyo Nagata, Tadaki Suzuki, Daisuke Kamimura, Masaaki Murakami, Hideki Ebihara, Masayuki Saijo
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] 致死性デング出血熱マウスモデルを用いたTNF-シグナル阻害による防御効果の分子機序解明2022
- Author(s)
  黒須剛、奥崎大介、坂井祐介、Mohamad Al Kadi、下島昌幸、吉河智城、福士秀悦、永田典代、鈴木忠樹、海老原秀喜、西條政幸
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05981
[Presentation] 致死性デング出血熱マウスモデルを用いた高サイトカイン産生誘導による重症化機序の解明2021
- Author(s)
  黒須剛、奥崎大介、下島昌幸、吉河智城、髙松由基、西條政幸
- Organizer
  第６８回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05981
[Presentation] IL-17A produced from gamma/delta T cells plays a critical role in vascular leakage of severe dengue hemorrhagic fever in mice.2019
- Author(s)
  Kurosu T, Phanathanawiboon S, Okuzaki D, Shimojima M, Yoshikawa T, Saijo M.
- Organizer
  第６7回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] Inflammation amplifier plays a critical role in severe dengue hemorrhagic fever2019
- Author(s)
  Kurosu T, Okuzaki D, Shimojima M, Yoshikawa T, Phanthanawiboon S, Kamimura D, Murakami M, Saijo M
- Organizer
  Keystone Symposia Positive-strand RNA Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] IL-17A produced from gamma/delta T cells plays a critical role in vascular leakage of severe dengue hemorrhagic fever in mice2019
- Author(s)
  Kurosu T, Okuzaki D, Shimojima M, Yoshikawa T, Phanathanawiboon S, Kamimura D, Murakami M, Saijo M
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] デング熱重症化マウスモデルでは、γδT細胞から産生されたIL-17AがIL-6産生を増強し、血漿漏出を伴う致死的感染を引き起こしている。2019
- Author(s)
  黒須剛、奥崎大介、Phanthanawiboon S、吉河智城、下島昌幸、村上正晃、上村大、永田典代、岩田奈織子、西條政幸
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] マウスモデルを用いたデング出血熱重症化機序の解明2019
- Author(s)
  黒須剛、奥崎大介、Supranee Phanthanawiboon、吉河智城、下島昌幸、西條政幸
- Organizer
  第162回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] Hematopathogenesis of chimeric dengue mouse model2018
- Author(s)
  Supranee Phanthanawiboon, Takeshi Kurosu, Masayuki Shimojima, Shuetsu Fukushi, Tomoki Yoshikawa, Shumpei Watanabe, Tadaki Suzuki, Naoko Iwata-Yoshikawa, Noriyo Nagata, Masayuki Saijo
- Organizer
  第６６回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] Inflammation amplifier plays a critical role in severe dengue hemorrhagic fever2018
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Masayuki Shimojima, Shuetsu Fukushi, Kamimura, Murakami, Tomoki Yoshikawa, Shunpei Watanabe, Supranee Phanathanawiboon, Masayuki Saijo
- Organizer
  第６６回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu
- Organizer
  Joint International Tropical Medicine Meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Kriengsak Limkittikul, Masayuki Shimojima, Shuetsu Fukushi, Shumpei Watanabe, Masayuki Saijo.
- Organizer
  第58回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu
- Organizer
  Joint International Tropical Medicine Meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Kriengsak Limkittikul, Masayuki Shimojima, Shuetsu Fukushi, Shumpei Watanabe, Masayuki Saijo.
- Organizer
  第58回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Kriengsak Limkittikul, Masayuki Shimojima, Shuetsu Fukushi, Shumpei Watanabe, Masayuki Saijo.
- Organizer
  第６５回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08145
[Presentation] The dynamics of disease progression in severe dengue.2017
- Author(s)
  Takeshi Kurosu, Daisuke Okuzaki, Kriengsak Limkittikul, Masayuki Shimojima, Shuetsu Fukushi, Shumpei Watanabe, Masayuki Saijo.
- Organizer
  第６５回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] 2.Sequence Diversity of Dengue Virus Type 2 in Brain and Thymus of infected Interferon Receptor KO mice: Implications for Dengue Virulence.2016
- Author(s)
  Dhole P, Nakayama EE, Limkittikul K, Phanthanawiboon S, Kazuyoshi I, Shioda T, Kurosu T.
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] Transcriptome analysis using a fatal mouse model for severe dengue.2016
- Author(s)
  Kurosu T, Okuzaki D, Limkittikul K, Shimojima M, Fukushi S, Tani H, Saijo M
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] Acute systemic infection with dengue virus leads vascular leakage and death through TNF-alpha and Tie2/Angiopoietin signaling in mice2015
- Author(s)
  Takeshi Kurosu, Supranee Phanthanawiboon, Yusuke Sakai, Kriengsak Limkittikul, Masayuki Saijo
- Organizer
  第６３回日本ウイルス学会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] デングウイルス感染マウスモデルを用いた重症化機序の解析2015
- Author(s)
  黒須　剛、Supranee Phanthanawiboon、坂井祐介、Kriengsak Limkittikul
- Organizer
  第158回日本獣医学会
- Place of Presentation
  十和田
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15K14885
[Presentation] デング/日本脳炎キメラウイルスを用いたマウスへの感染性の解析2013
- Author(s)
  黒須　剛
- Organizer
  第48回日本脳炎ウイルス生態学研究会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] デング/日本脳炎キメラウイルスを用いたマウスへの感染性の解析2013
- Author(s)
  黒須剛、浅井あづさ、花原景子、Chidchanok Khamlert、Sabar Pambudi、Supranee Phanthanawiboon、Magot Omokoko Diata、 Surapee Anantapreecha、生田和良
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] MOUSE MODEL FOR DENGEU VIRUS INFECTION AND EVALUATION OF THERAPEUTICS2013
- Author(s)
  Takeshi Kurosu
- Organizer
  The Third International Conference on Dengue and Dengue Haemorrhagic Fever
- Place of Presentation
  バンコク
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] Infection of dengue virus and Japanese encephalitis virus in mice.2013
- Author(s)
  黒須　剛
- Organizer
  Ａｓｉａｎ　Ａｆｒｉｃａｎ　Research Forum
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] Development of A New Murine model of Dengue Virus Infection.2013
- Author(s)
  Takeshi Kurosu, Azusa Asai, Keiko Hanabara, Supranee Phanthanawiboon, Sabar Pambudi, Magot D. Omokoko, Tadahiro Sasaki, Motoki Kuhara, Pongraman Ramasoota, Kazuyoshi Ikuta
- Organizer
  The Joint International Tropical Medicine Meeting 2013
- Place of Presentation
  バンコク
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] 哺乳類細胞における高増殖性DENV/JEVキメラウイルス作製の試み2013
- Author(s)
  花原景子、Sabar Pumbudi、Supranee phanthanawiboon、Magot Omokoko、浅井あづさ、生田和良、黒須剛
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] 治療法開発のためのデングウイルス感染マウスモデル2012
- Author(s)
  黒須　剛
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22591106
[Presentation] デングウイルス/日本脳炎ウイルスキメラウイルスを用いたマウスへの感染性の解析2012
- Author(s)
  黒須　剛
- Organizer
  第47回日本脳炎ウイルス生態学研究会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] 治療法開発のためのデングウイルス感染マウスモデル2012
- Author(s)
  黒須　剛
- Organizer
  第６０回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] Infection of mouse cells with dengue virus and Japanese encephalitis virus2012
- Author(s)
  Takeshi Kurosu, Sabar Pambudi, Omokoko Magot, Chidchanok Khamlert, Supranee Phanthanawiboon1, and Kazuyoshi Ikuta
- Organizer
  Asian African Research Forum on Emerging and Reemerging Infections 2012
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] マウスにおけるデングウイルス及び日本脳炎ウイルス感染機序2011
- Author(s)
  黒須剛
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県郷土文化会館(徳島)
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] Infection of mouse cells with dengue virus and Japanese encephalitis virus.2011
- Author(s)
  黒須　剛、Sabar Pambudi, Omokoko　Magot, Chidchanok Khamlert、Supranee Phanthanawiboon、Surapee Anantapreecha, 生田和良
- Organizer
  第59回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] Cross-reasctive antibody responses with host cells by BALB/c mice immunized with BALB/c-derived cells infected with chikungunya virus, but not with those with dengue virus.2011
- Author(s)
  Masrinou, P., Punkum, C., Noda, M., Kurosu, T., Ikuta, K., and Okabayashi, T.
- Organizer
  Joint International Tropical Medicine Meeting 2011
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-23659297
[Presentation] Possible effect of quasispecies to strategy against dengue virus.2010
- Author(s)
  Kurosu T.
- Organizer
  Joint International Tropical Medicine Meeting 2010
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] Possible effect of quasispecies to strategy against dengue virus.2010
- Author(s)
  Kurosu T.
- Organizer
  Joint International Tropical Medicine Meeting 2010
- Place of Presentation
  Bangkok, Thailand(招待講演)
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] マウスにおけるデングウイルス及び日本脳炎ウイルス感染機序2010
- Author(s)
  黒須剛、Chidchanok Khamlert、Supranee Phanthanawiboon、青枝大貴、大畑敬一、Juan F Arias、中村祥子、Surapee Anantapreecha, 石井健、生田和良
- Organizer
  日本ウイルス学会大58回学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] Infection of mouse cells with dengue virus and Japanese encephalitis virus.2010
- Author(s)
  Kurosu T.
- Organizer
  Asia-Africa Research Forum 2010
- Place of Presentation
  Hanoi, Viet Nam
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] タイに流行する2型デングウイルスの多様性2009
- Author(s)
  黒須剛
- Organizer
  第50回日本熱帯医学会大会総会 (招待講演)
- Place of Presentation
  沖縄コンベンションセンター(沖縄)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] Surapee Anantapreecタイに流行する2型デングウイルスの多様性2009
- Author(s)
  黒須剛、Chidchanok Khamlert、Supranee Phanthawiboon、生田和良、
- Organizer
  第50回日本熱帯医学会大会総会
- Place of Presentation
  沖縄
- Year and Date
  2009-12-22
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] タイに流行するデングウイルスの多様性2009
- Author(s)
  黒須剛
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京)
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] タイに流行するデングウイルスの多様性2009
- Author(s)
  黒須剛、Chidchanok Khamlert、Supranee Phanthawiboon、生田和良、Surapee Anantapreecha
- Organizer
  日本ウイルス学会大58回学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21790444
[Presentation] Characterization of dengue virus, the protein responsible for replication and viral pathogenesis in mouse model
- Author(s)
  Supranee Phanthanawiboon, Sabar Pambudi, Magot Omokoko Diata, Panjaporn Chaichana, Chidchanok Khamlert, Surapee Anantapreecha, 生田和良, 黒須　剛
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-09-09 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] デングウイルス/日本脳炎ウイルスによる抗体依存性感染増強効果の解析
- Author(s)
  黒須　剛, 浅井あづさ, 花原景子, Supranee Phanthanawiboon, Surapee Anantapreecha, Kriengsak Limkittikul, 生田和良
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-23590542
[Presentation] Effects of Anti-Dengue Virus Envelope Antibody IgG subclass on Neutralizing, Virus Enhancement Activities and Protection in Mice
- Author(s)
  Ririn Ramadhany, 平井到, 佐々木正大, 小野健一郎, Pongrama Ramasoota, 生田和良, 黒須　剛
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-23590542

1. OISHI Kazunori (80160414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. IKUTA Kazuyoshi (60127181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. SAKUDO Akikazu (10397672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKABAYASHI Tamaki (10359995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SASAKI Tadahiro (20547533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KOSAKA Mieko (70592278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKUZAKI DAISUKE (00346131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. KAIHATSU KUNIHIRO (70419464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAISHI Kazunari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ANANTAPREECHA Surapee

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 長田重一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kurosu Takeshi 黒須 剛

KUROSU Takeshi 黒須 剛

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of induction of severe dengue hemorrhagic fever using a novel myeloid cell-infected mouse modelPrincipal Investigator

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Complete elucidation of pathogenic mechanism of severe dengue in mouse model, developing the symptoms of vascular leakage induced by cytokine storm.Principal Investigator

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Analysis of severe disease mechanism using mouse model infected with dengue virus, developing the symptoms of vascular leakage and bone marrow suppression.Principal Investigator

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The elucidation of pathogenic mechanisms of vascular leakage and bone marrow suppression in dengue virus mouse modelPrincipal Investigator

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Development of a highly sensitive RNA virus detection method by artificial nucleoproteins

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Development of murine model for dengue virus infectionPrincipal Investigator

Principal Investigator

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Development of diagnosis test kits with high specificity, high sensitivity, and low cost against tropical infectious diseases.

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A mechanism of platelet phagocytosis in dengue virus infection

Principal Investigator

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Analysis of dengue virus quasispecies and their cell tropism.Principal Investigator

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[Journal Article] Mice, myeloid cells, and dengue: a new model for unraveling vascular leakage mysteries2024

Author(s)

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Data Source

[Journal Article] Dengue virus infection induces selective expansion of Vγ4 and Vγ6TCR γδ T cells in the small intestine and a cytokine storm driving vascular leakage in mice2023

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DOI

Data Source

[Journal Article] Chimeric flavivirus causes vascular leakage and bone marrow suppression in a mouse model2023

Author(s)

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Data Source

[Journal Article] Chimeric flavivirus enables evaluation of antibodies against dengue virus envelope protein in vitro and in vivo.2020

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[Journal Article] Construction of a high-yield dengue virus by replacing nonstructural proteins 3?4B without increasing virulence2018

Kurosu Takeshi 黒須剛

KUROSU Takeshi 黒須剛