TAKAHASHI Hirotaka 高橋宏隆

… Alternative Names

Takahashi Hirotaka 高橋宏隆

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Researcher Number	70432804
Other IDs
Affiliation (Current)	2025: 愛媛大学, プロテオサイエンスセンター, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 愛媛大学, プロテオサイエンスセンター, 准教授 2016 – 2020: 愛媛大学, プロテオサイエンスセンター, 講師 2015: 愛媛大学, プロテオサイエンスセンター, 助教
Review Section/Research Field	Principal Investigator Complex systems / System genome science / Basic Section 43060:System genome science-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 43030:Functional biochemistry-related / Basic Section 55030:Cardiovascular surgery-related / Basic Section 49060:Virology-related / Basic Section 43020:Structural biochemistry-related / Complex systems
Keywords	Principal Investigator 脱ユビキチン化酵素 / コムギ無細胞系 / DUB阻害剤 / タンパク質アレイ / コムギ無細胞タンパク質合成系 / ユビキチン / NF-kBシグナル / タンパク質量制御 / タンパク質ノックダウン / 阻害剤 … More / USPファミリー脱ユビキチン化酵素 / タンパク質量制御化合物 / 低分子阻害剤 / USP15 / コムギ無細胞蛋白質合成系 / ユビキチン結合蛋白質 / 直鎖状ユビキチン鎖 / NF-κB / ユビキチン鎖 / ユビキチン鎖結合タンパク質 / NF-kB / 直鎖ユビキチン鎖 / ZFAND / ユビキチン結合タンパク質 / 脱ユビキチン化酵素タンパク質アレイ / 低分子化合物阻害剤 / USPファミリー / コムギ無細胞タンパク質合成 / 脱ユビキチン化酵素阻害剤 / DUBタンパク質アレイ / ユビキチン鎖特異性 / ポリユビキチン鎖 / ケミカルプローブ / NF-κB活性化経路 / 低分子化合物スクリーニング / NF-κB経路 / Subquinocin / 低分子阻害剤探索 / CYLD … More Except Principal Investigator ユビキチン / 骨髄系腫瘍 / ユビキチンリガーゼ / タンパク質品質管理 / トランスレーショナルリサーチ / シングルセル / 弁膜症 / 心血管 / 血管内皮細胞 / トランスクリプトミクス / 間質細胞 / 石灰化 / 心臓 / 骨芽細胞 / 大動脈弁 / 心血管系 / Split-GFP / Cas13 / NONO / 核酸医薬 / CRISPR/Cas13 / NEAT1 / lncRNA / 膜タンパク質 / 小胞体品質管理 / retrotranslocation / 逆輸送 / ERAD / 細胞性因子 / 翻訳終結 / RNA / フラビウイルス / RyDEN / 無細胞タンパク質合成 / ピロリン酸依存性リン酸化酵素 / 結晶構造解析 / リン酸化酵素 / ピロリン酸 / 結晶構造 / ASXL1 / EVI1 / CBFB / RUNX1 / エピゲノム因子 / タンパク質間相互作用 / エピゲノム制御因子 / 転写因子 / 形質膜 / CFTR / 嚢胞性線維症 / DUB / ユビキチン化 / 数理シグナル / NF-kB / プロテオミクス / TGF-β / データベース構築 / マイクロアレイ / プロテオーム / シグナル伝達 / バイオテクノロジー / 蛋白質 / 数理解析 / シグナル伝達経路 / 無細胞プロテオミクス / AirID / 近位依存性ビオチン化酵素 / ジベレリン / 炎症 / サリドマイド / 無細胞 / プロテインアレイ Less

Molecular characterisation of the RyDEN-based translation termination complex in the flavivirus RNA dysfunction
- Principal Investigator
  
  鈴木陽一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
哺乳類 ERAD における逆輸送機構の包括的理解
- Principal Investigator
  
  沖米田司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kwansei Gakuin University
Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapies
- Principal Investigator
  
  合山進
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Understanding the molecular mechanism of aortic valve calcification at the single-cell level
- Principal Investigator
  
  坂上倫久
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Ehime University
Development of the chemical compounds targeting deubiquitinating enzyme for protein regulationPrincipal Investigator
- Principal Investigator
  
  高橋宏隆
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Ehime University
Mass identification and modification of pyrophosphate-dependent kinases based on their three-dimensional structures
- Principal Investigator
  
  藤橋雅宏
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Clarification of the molecular mechanism of NF-kB regulation by novel family of linear ubiquitin binding proteinPrincipal Investigator
- Principal Investigator
  
  Takahashi Hirotaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Ehime University
Development of small chemical compounds that specifically inhibit USP-family deubiquitinating enzymes.Principal Investigator
- Principal Investigator
  
  高橋宏隆
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Ehime University
Elucidation and therapeutic application of ubiquitination mechanisms in the PMQC
- Principal Investigator
  
  Okiyoneda Tsukasa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kwansei Gakuin University
Targeting transcription and epigenetic factors through modulation of protein-protein interactions
- Principal Investigator
  
  Goyama Susumu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Establishment of an wheat cell-free based protein array of deubiquitinating enzyme and determination of specificity of polyubiquitinPrincipal Investigator
- Principal Investigator
  
  Takahashi Hirotaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Ehime University
Development of cell-free proteome technology for analysis of the signal transduction based on protein molecule interaction
- Principal Investigator
  
  SAWASAKI TATSUYA
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Ehime University
Development of specific inhibitors targeting a deubiquitinating enzyme CYLD and application of these inhibitors for chemical probe.Principal Investigator
- Principal Investigator
  
  Takahashi Hirotaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  Ehime University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Methods of Mathematical Oncology, Fusion of Mathematics and Biology2021
- Author(s)
  Morishita R, Takahashi H, Sawasaki T
- Total Pages
  10
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20K06611
[Book] Methods of Mathematical Oncology, Fusion of Mathematics and Biology2021
- Author(s)
  Morishita R, Takahashi H, Sawasaki T
- Total Pages
  10
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Book] Cellular control pf dengue virus replication: Role of interferon-inducible genes. in Dengue2017
- Author(s)
  Takahashi H, Suzuki Y
- Total Pages
  23
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-15K18468
[Book] Technology of wheat cell-free based protein array for biochemical analyses of protein kinases and ubiquitin E3 ligases. in Protein Modifications in Pathogenic Dysregulation of Signaling.2015
- Author(s)
  Takahashi H, Nemoto K, Ramadan A, Sawasaki T
- Total Pages
  18
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15K18468
[Journal Article] HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains2024
- Author(s)
  Yuka Kamada, Yuko Ohnishi, Chikako Nakashima, Aika Fujii, Mana Terakawa, Ikuto Hamano, Uta Nakayamada, Saori Katoh, Noriaki Hirata, Hazuki Tateishi, Ryosuke Fukuda, Hirotaka Takahashi, Gergely L. Lukacs, Tsukasa Okiyoneda
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223(7) Issue: 7
- DOI
  10.1083/jcb.202308003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23840
[Journal Article] The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1‐dependent leukemia cells2023
- Author(s)
  Yonezawa Taishi、Takahashi Hirotaka、Hao Yangying、Furukawa Chie、Tsuchiya Akiho、Zhang Wenyu、Fukushima Tsuyoshi、Fukuyama Tomofusa、Sawasaki Tatsuya、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  The FEBS Journal
  
  Volume: 290 Issue: 21 Pages: 5141-5157
- DOI
  10.1111/febs.16914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24360
[Journal Article] Protein?protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain2022
- Author(s)
  Takaoka Yousuke、Suzuki Kaho、Nozawa Akira、Takahashi Hirotaka、Sawasaki Tatsuya、Ueda Minoru
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 1 Pages: 101504-101504
- DOI
  10.1016/j.jbc.2021.101504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00885, KAKENHI-PROJECT-18KK0162, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H02951, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-20H00402, KAKENHI-PLANNED-17H06407, KAKENHI-PUBLICLY-21H00270, KAKENHI-PROJECT-18H02101
[Journal Article] OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways2022
- Author(s)
  Oikawa Daisuke、Gi Min、Kosako Hidetaka、Shimizu Kouhei、Takahashi Hirotaka、Shiota Masayuki、Hosomi Shuhei、Komakura Keidai、Wanibuchi Hideki、Tsuruta Daisuke、Sawasaki Tatsuya、Tokunaga Fuminori
- Journal Title
  
  Cell Death & Disease
  
  Volume: 13 Issue: 8 Pages: 694-694
- DOI
  10.1038/s41419-022-05145-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H02951, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K19230, KAKENHI-PUBLICLY-21H00287, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-20K10431
[Journal Article] A simple method for labeling proteins and antibodies with biotin using the proximity biotinylation enzyme TurboID2022
- Author(s)
  Shioya Ryouhei、Yamada Kohdai、Kido Kohki、Takahashi Hirotaka、Nozawa Akira、Kosako Hidetaka、Sawasaki Tatsuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 592 Pages: 54-59
- DOI
  10.1016/j.bbrc.2021.12.109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H02951, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K19230
[Journal Article] Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF2021
- Author(s)
  Yamanaka Satoshi、Murai Hidetaka、Saito Daisuke、Abe Gembu、Tokunaga Etsuko、Iwasaki Takahiro、Takahashi Hirotaka、Takeda Hiroyuki、Suzuki Takayuki、Shibata Norio、Tamura Koji、Sawasaki Tatsuya
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 4 Pages: 1-1
- DOI
  10.15252/embj.2020105375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-18H02446, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PUBLICLY-20H04867, KAKENHI-PUBLICLY-20H05024, KAKENHI-PROJECT-18H02445, KAKENHI-PROJECT-19H03218
[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021
- Author(s)
  Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 80-80
- DOI
  10.1038/s42003-020-01603-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K11589, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20K09231, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-18H02619, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-16H06276
[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021
- Author(s)
  Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-Ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 102303-102303
- DOI
  10.1016/j.isci.2021.102303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-19K19947, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K21587
[Journal Article] A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors2020
- Author(s)
  Takahashi Hirotaka、Yamanaka Satoshi、Kuwada Shohei、Higaki Kana、Kido Kohki、Sato Yusuke、Fukai Shuya、Tokunaga Fuminori、Sawasaki Tatsuya
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 6 Pages: 152-152
- DOI
  10.3390/biomedicines8060152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06611, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-16H06276
[Journal Article] Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling2020
- Author(s)
  Yamanaka Satoshi、Sato Yusuke、Oikawa Daisuke、Goto Eiji、Fukai Shuya、Tokunaga Fuminori、Takahashi Hirotaka、Sawasaki Tatsuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2019.12.049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-18H05501, KAKENHI-PUBLICLY-19H05292, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-16H06276
[Journal Article] コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用2020
- Author(s)
  高橋宏隆、山中聡士
- Journal Title
  
  ファルマシア
  
  Volume: 56 Pages: 51-55
- NAID
  130007779025
- Data Source
  KAKENHI-PROJECT-17K07261
[Journal Article] Raf-like kinases CBC1 and CBC2 negatively regulate stomatal opening by negatively regulating plasma membrane H+-ATPase phosphorylation in Arabidopsis2020
- Author(s)
  Hayashi Maki、Sugimoto Hodaka、Takahashi Hirotaka、Seki Motoaki、Shinozaki Kazuo、Sawasaki Tatsuya、Kinoshita Toshinori、Inoue Shin-ichiro
- Journal Title
  
  Photochemical & Photobiological Sciences
  
  Volume: 19 Issue: 1 Pages: 88-98
- DOI
  10.1039/c9pp00329k
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06579
[Journal Article] コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用2020
- Author(s)
  高橋宏隆、山中聡士
- Journal Title
  
  Farumashia
  
  Volume: 56 Issue: 1 Pages: 51-55
- DOI
  10.14894/faruawpsj.56.1_51
- NAID
  130007779025
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-16H06579
[Journal Article] CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.2020
- Author(s)
  1.Inoue S, Kaiserli E, Zhao X, Waksman T, Takemiya A, Okumura M, Takahashi H, Seki M, Shinozaki K, Endo Y, Sawasaki T, Kinoshita T, Zhang X, Christie JM, Shimazaki K
- Journal Title
  
  The Plant Journal
  
  Volume: 104 Issue: 3 Pages: 679-692
- DOI
  10.1111/tpj.14955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06703, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-20H05420, KAKENHI-PLANNED-20H05910, KAKENHI-PROJECT-20H05687, KAKENHI-PROJECT-20H00468, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-18H02468
[Journal Article] Development and application of a protein array of human deubiquitinating enzyme2020
- Author(s)
  高橋宏隆、山中聡士、徳永文稔、澤崎達也
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 64-74
- DOI
  10.14952/SEIKAGAKU.2020.920064
- ISSN
  0037-1017
- Year and Date
  2020-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K07261, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-19H03218
[Journal Article] コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用2020
- Author(s)
  高橋宏隆、山中聡士
- Journal Title
  
  ファルマシア
  
  Volume: 56 Pages: 51-55
- NAID
  130007779025
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Journal Article] Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro2019
- Author(s)
  Nomura Shunsuke、Takahashi Hirotaka、Suzuki Junpei、Kuwahara Makoto、Yamashita Masakatsu、Sawasaki Tatsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 17335-17335
- DOI
  10.1038/s41598-019-53856-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08409, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-18H05036, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-18J12730, KAKENHI-PROJECT-17K07261
[Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD2019
- Author(s)
  Uematsu Atsushi、Kido Kohki、Takahashi Hirotaka、Takahashi Chikako、Yanagihara Yuta、Saeki Noritaka、Yoshida Shuhei、Maekawa Masashi、Honda Mamoru、Kai Tsutomu、Shimizu Kouhei、Higashiyama Shigeki、Imai Yuuki、Tokunaga Fuminori、Sawasaki Tatsuya
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 38 Pages: 14135-14148
- DOI
  10.1074/jbc.ra119.010119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16015, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-17K07261
[Journal Article] The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program2018
- Author(s)
  Yonezawa Taishi、Takahashi Hirotaka、Shikata Shiori、Sawasaki Tatsuya、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Issue: 3 Pages: 905-909
- DOI
  10.1016/j.bbrc.2018.10.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-18J22111, KAKENHI-PLANNED-16H06579
[Journal Article] DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma2018
- Author(s)
  Uematsu Atsushi、Kido Kohki、Manabe Erika、Takeda Hiroyuki、Takahashi Hirotaka、Hayashi Minoru、Imai Yuuki、Sawasaki Tatsuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 3 Pages: 2289-2295
- DOI
  10.1016/j.bbrc.2017.12.142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-17K19728, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15J03774
[Journal Article] The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1?RUNX1T12017
- Author(s)
  Yonezawa Taishi、Takahashi Hirotaka、Shikata Shiori、Liu Xiaoxiao、Tamura Moe、Asada Shuhei、Fukushima Tsuyoshi、Fukuyama Tomofusa、Tanaka Yosuke、Sawasaki Tatsuya、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 30 Pages: 12528-12541
- DOI
  10.1074/jbc.m117.785675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07261, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-16H04729
[Journal Article] Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.2017
- Author(s)
  Krug SM, Hayaishi T, Iguchi D, Watari A,Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y,Sawasaki T, Doi T, Yagi K, Kondoh M
- Journal Title
  
  J. Control. Release.
  
  Volume: 260 Pages: 1-11
- DOI
  10.1016/j.jconrel.2017.05.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08794, KAKENHI-PROJECT-17K19487, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-16K08370
[Journal Article] Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression2017
- Author(s)
  Sun Suofeng、Nakashima Kenji、Ito Masahiko、Li Yuan、Chida Takeshi、Takahashi Hirotaka、Watashi Koichi、Sawasaki Tatsuya、Wakita Takaji、Suzuki Tetsuro
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12874-12874
- DOI
  10.1038/s41598-017-12497-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-16K19137, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 12 Pages: e1006162-e1006162
- DOI
  10.1371/journal.ppat.1006162
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014
[Journal Article] Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.2016
- Author(s)
  Takahashi H, Uematsu A, Yamanaka S, Imamura M, Nakajima T, Doi K, Yasuoka S, Takahashi C, Takeda H, Sawasaki T.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 6 Pages: e0156718-e0156718
- DOI
  10.1371/journal.pone.0156718
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15J03774, KAKENHI-PROJECT-15K18468
[Journal Article] Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage2016
- Author(s)
  Sakamaki K, Ishii TM, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita R, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung SK, Matsuoka S, Koyamada K, Sawasaki T, Nagai T, Ueno N
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1863 Issue: 11 Pages: 2766-2783
- DOI
  10.1016/j.bbamcr.2016.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04674, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26291019, KAKENHI-PROJECT-15K18468, KAKENHI-PUBLICLY-16H01278
[Journal Article] AGIA Tag System Based on a High Affinity Rabbit Monoclonal Antibody against Human Dopamine Receptor D1 for Protein Analysis.2016
- Author(s)
  Yano T, Takeda H, Uematsu A, Yamanaka S, Nomura S, Nemoto K, Iwasaki T, Takahashi H, Sawasaki T.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 6 Pages: e0156716-e0156716
- DOI
  10.1371/journal.pone.0156716
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15J03774, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-16K18570
[Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.2016
- Author(s)
  Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
- Journal Title
  
  Nat. Commun.
  
  Volume: 7 Issue: 1 Pages: 12547-12547
- DOI
  10.1038/ncomms12547
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K18383
[Journal Article] MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.2016
- Author(s)
  Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 44 Issue: 18 Pages: 8621-8640
- DOI
  10.1093/nar/gkw512
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15K18468
[Journal Article] Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication.2016
- Author(s)
  Suzuki Y, Chin WX, Han Q, Ichiyama K, Lee CH, Eyo ZW, Ebina H, Takahashi H, Takahashi C, Tan BH, Hishiki T, Ohba K, Matsuyama T, Koyanagi Y, Tan YJ, Sawasaki T, Chu1 JJ, Vasudevan SG, Sano K, Yamamoto N.
- Journal Title
  
  PLoS Pathogen
  
  Volume: 12 Issue: 1 Pages: 275-275
- DOI
  10.1186/s12870-015-0660-9
- NAID
  120005763386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-26640130, KAKENHI-PROJECT-25290077
[Presentation] タンパク質アレイ技術を基盤とした脱ユビキチン化酵素の機能解析2022
- Author(s)
  高橋宏隆，檜垣佳奈，山中聡士，佐藤裕介，平野港，好井健太朗，髙谷大輔，本間光貴，及川大輔，徳永文稔，澤崎達也
- Organizer
  第27回病態プロテアーゼ学会　ワークショップ「タンパク質修飾プロテアーゼによる生体機能調節」
- Invited
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] Development of small chemical compounds that specifically inhibit the deubiquitinating enzyme USP152022
- Author(s)
  Kana Higaki, Kazuma Iwata, Yusuke Sato, Yangying Hao, Susumu Goyama, Daisuke Takaya, Teruki Honma, Fuminori Tokunaga, Hirotaka Takahashi, Tatsuya Sawasaki
- Organizer
  Ubiquitin New Frontier from Neo-Biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] 細胞内ウイルス受容体MDA5を制御するDUBの探索と機能解析2022
- Author(s)
  高橋宏隆，坂口詩穏，西野耕平, 小迫英尊, 及川大輔，徳永文稔，澤崎達也
- Organizer
  第95回日本生化学会大会・シンポジウムユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] In vitroおよび細胞レベルの２つの相互作用解析を基盤としたウイルスRNA受容体MDA5の新規結合タンパク質の網羅的同定2022
- Author(s)
  高橋宏隆、坂口詩穏、林徳宙、入江崇、小迫英尊、澤崎達也
- Organizer
  第44回日本分子生物学会年会・シンポジウム　生体分子の物性変化が操る生命現象―ストレス顆粒形成から神経変性疾患まで
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] 細胞内ウイルス受容体MDA5を制御するDUBの探索と機能解析2022
- Author(s)
  高橋宏隆，坂口詩穏，西野耕平, 小迫英尊, 及川大輔，徳永文稔，澤崎達也
- Organizer
  第95回日本生化学会大会・シンポジウムユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性
- Invited
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] 脱ユビキチン化酵素USP15を特異的に阻害する低分子化合物の開発2022
- Author(s)
  檜垣佳奈, 岩田和真, 佐藤裕介, 郝楊穎, 合山進, 髙谷大輔, 本間光貴, 徳永文稔, 高橋宏隆, 澤崎達也
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] Development of small-molecule inhibitors for a deubiquitinating enzyme of Crimean-Congo hemorrhagic fever virus.2022
- Author(s)
  Hirotaka Takahashi, Kana Higaki, Minato Hirano, Kentaro Yoshii and Tatsuya Sawasaki
- Organizer
  Ubiquitin New Frontier from Neo-Biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] タンパク質アレイ技術を基盤とした脱ユビキチン化酵素の機能解析2022
- Author(s)
  高橋宏隆，檜垣佳奈，山中聡士，佐藤裕介，平野港，好井健太朗，髙谷大輔，本間光貴，及川大輔，徳永文稔，澤崎達也
- Organizer
  第27回病態プロテアーゼ学会　ワークショップ「タンパク質修飾プロテアーゼによる生体機能調節」
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] デングウイルスNS3に結合する新規宿主因子SIGIRRの機能解析2021
- Author(s)
  高橋宏隆,　重松裕樹，鈴木陽一，Vasudevan G. Subhash，澤崎達也
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] デングウイルスNS3に結合する新規宿主因子SIGIRRの同定と機能解析2021
- Author(s)
  高橋宏隆, 重松裕樹，鈴木康嗣, 渡辺幸三, 鈴木陽一，Subhash G. Vasudevan, 澤崎達也
- Organizer
  第27回トガ・フラビ・ペスチウイルス研究会
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] デングウイルスNS3に結合する新規宿主因子SIGIRRの同定と機能解析2021
- Author(s)
  高橋宏隆,　重松裕樹，鈴木康嗣, 渡辺幸三, 鈴木陽一，Subhash G. Vasudevan, 澤崎達也
- Organizer
  第27回トガ・フラビ・ペスチウイルス研究会
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] デングウイルスNS3に結合する新規宿主因子SIGIRRの機能解析2021
- Author(s)
  高橋宏隆, 重松裕樹，鈴木陽一，Vasudevan G. Subhash，澤崎達也
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] In vitroおよび細胞レベルの2つの相互作用解析を基盤としたウイルスRNA受容体MDA5の新規結合タンパク質の網羅的同定2021
- Author(s)
  高橋宏隆，坂口詩穏，林徳宙，入江崇，小迫英尊，澤崎達也
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] Development of small chemical compounds that specifically inhibit the deubiquitinating enzyme USP152021
- Author(s)
  Higaki K, Yamanaka S, Iwata K, Sato Y, Takaya D, Honma T, Tokunaga F, Takahashi H, Sawasaki T
- Organizer
  The 19th Protein Island Matsuyama International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] In vitroおよび細胞レベルの２つの相互作用解析を基盤としたウイルスRNA受容体MDA5の新規結合タンパク質の網羅的同定2021
- Author(s)
  高橋宏隆，坂口詩穏，林徳宙，入江崇，小迫英尊，澤崎達也
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] 無細胞蛋白合成系を用いた、ユビキチン化によって制御されるNF-kBおよびIFNシグナル伝達経路の分子機構解明2021
- Author(s)
  高橋宏隆
- Organizer
  第17回感染症サイトカイン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] 無細胞蛋白合成系を用いた、ユビキチン化によって制御されるNF-kBおよびIFNシグナル伝達経路の分子機構解明2021
- Author(s)
  高橋宏隆
- Organizer
  第17回感染症サイトカイン研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] Development of small chemical compounds that specifically inhibit the deubiquitinating enzyme USP152021
- Author(s)
  Higaki K, Yamanaka S, Iwata K, Sato Y, Takaya D, Honma T, Tokunaga F, Takahashi H, Sawasaki T
- Organizer
  The 19th Protein Island Matsuyama International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00287
[Presentation] Development of USP-DUB specific inhibitor using human DUB protein array2020
- Author(s)
  Takahashi H, Yamanaka S, Kuwada S, Higaki K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] コムギ無細胞タンパク質アレイ技術を用いたユビキチンシグナル解析2020
- Author(s)
  高橋宏隆
- Organizer
  第6回日本血管生物学会若手研究会
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] コムギ無細胞タンパク質アレイ技術を用いたユビキチンシグナル解析2020
- Author(s)
  高橋宏隆
- Organizer
  第6回日本血管生物学会若手研究会
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] USPファミリーの脱ユビキチン化酵素を特異的に阻害する低分子化合物の開発。2020
- Author(s)
  高橋宏隆，山中聡士，桒田翔平，檜垣佳奈，佐藤裕介，深井周也，徳永文稔，澤崎達也。
- Organizer
  第93回生化学会。シンポジウム「ケモテクノロジーが拓くユビキチンニューフロンティア」。
- Invited
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] コムギ無細胞系を用いた直鎖状ユビキチン鎖の新規デコーダー分子の網羅的探索と機能解析2020
- Author(s)
  高橋宏隆, 長尾和哉, 岩崎誠, 佐藤裕介，及川大輔, 徳永文稔, 澤崎達也
- Organizer
  第43回日本分子生物学会年会ワークショップ「多彩な生理機能を発揮するユビキチンコードのバイオロジー」
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] コムギ無細胞系を用いた直鎖状ユビキチン鎖の新規デコーダー分子の網羅的探索と機能解析。2020
- Author(s)
  高橋宏隆, 長尾和哉, 岩崎誠, 佐藤裕介，及川大輔, 徳永文稔, 澤崎達也
- Organizer
  第43回日本分子生物学会年会　ワークショップ「多彩な生理機能を発揮するユビキチンコードのバイオロジー」
- Data Source
  KAKENHI-PROJECT-20K06611
[Presentation] USPファミリーの脱ユビキチン化酵素を特異的に阻害する低分子化合物の開発。2020
- Author(s)
  高橋宏隆，山中聡士，桒田翔平，檜垣佳奈，佐藤裕介，深井周也，徳永文稔，澤崎達也。
- Organizer
  第93回生化学会。シンポジウム「ケモテクノロジーが拓くユビキチンニューフロンティア」
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] ウイルスRNA受容体MDA5に結合し、IFN産生シグナルを抑制する脱ユビキチン化酵素の同定と機能解析2019
- Author(s)
  林徳宙，高橋宏隆，竹田浩之，入江崇，澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] Establishment of a protein array system consisted of 90 human recombinant deubiquitinating enzymes (DUBs) proteins for assessment of linkage specificity of each DUB and evaluation of the selectivity of DUB inhibitors.2019
- Author(s)
  Takahashi H, Kuwada S, Yamanaka S, Goto E, Tokunaga F, Sawasaki T.
- Organizer
  EMBO meeting. The ubiquitin system: Biology, mechanisms and roles in disease.
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-kB抑制機構の解明2019
- Author(s)
  高橋宏隆, 及川大輔, 長尾和哉, 岩崎誠, 今井祐記, 徳永文稔, 澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] コムギ無細胞タンパク質合成系を用いた脱ユビキチン化酵素タンパク質アレイの作製と応用2019
- Author(s)
  高橋宏隆, 山中聡士, 桑田翔平, 後藤栄二, 今井賢一郎, 富井健太郎, 佐藤裕介, 深井周也, 徳永文稔, 澤崎達也
- Organizer
  第二回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Development of RUNX1 inhibitor2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  第三回乳癌転移若手研究会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] The ubiquitin ligase DTX2 promotes nuclear export of RUNX1 and inhibits RUNX1-dependent leukemogenesis2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  The 61st American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Development of RUNX1-CBFB interaction inhibitor for RUNX1-dependent leukemias2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] コムギ無細胞タンパク質合成系を基盤としたヒト脱ユビキチン化酵素タンパク質アレイの作製と応用。2019
- Author(s)
  高橋宏隆，山中聡士，後藤栄治，及川大輔，佐藤裕介，深井周也，徳永文稔，澤崎達也
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] Establishment of a protein array system consisted of 90 human recombinant deubiquitinating enzymes (DUBs) proteins for assessment of linkage specificity of each DUB and evaluation of the selectivity of DUB inhibitors.2019
- Author(s)
  Takahashi H, Yamanaka S, Sato Y, Goto E, Oikawa D, Fukai S, Tokunaga F, Sawasaki T.
- Organizer
  EMBO workshop. The ubiquitin system: Biology, mechanisms and roles in disease
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] RNF26 is a novel host E3 ligase targeting dengue virus nonstructural protein 4B.2019
- Author(s)
  Takahashi H, Suzuki Y, Sameshima Y, Kato F, Hishiki T, Vasudevan SG, Sawasaki T
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] ウイルスRNA受容体MDA5に結合し、IFN産生シグナルを抑制する脱ユビキチン化酵素の同定と機能解析2019
- Author(s)
  高橋宏隆，林徳宙，竹田浩之，入江崇，澤崎達也
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] ウイルスRNA受容体MDA5に結合し、IFN産生シグナルを抑制する脱ユビキチン化酵素の同定と機能解析2019
- Author(s)
  高橋宏隆，林徳宙，竹田浩之，入江崇，澤崎達也
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-kB抑制機構の解明2019
- Author(s)
  高橋宏隆, 及川大輔, 長尾和哉, 岩崎誠, 今井祐記, 徳永文稔, 澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] IRF3のユビキチン化修飾によりIFNシグナル伝達を制御する新規E3リガーゼの同定2019
- Author(s)
  谷口健，高橋宏隆，入江崇，澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] コムギ無細胞プロテインアレイを用いたサリドマイド依存的なCRBN基質の同定2019
- Author(s)
  山中聡士、村井英隆、齋藤大介、阿部玄武、高橋宏隆、竹田浩之、鈴木孝幸、田村宏治、澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] Development of RUNX1-CBFB interaction inhibitor for RUNX1-dependent leukemias2019
- Author(s)
  米澤大志、高橋弘隆、澤崎達也、北村俊雄、合山進
- Organizer
  プロテインアイランド松山
- Data Source
  KAKENHI-PROJECT-19H03685
[Presentation] Identification and functional analysis of host factor proteins targeting DENV NS3.2019
- Author(s)
  Shigematsu Y, Takahashi H, Takeda H, Suzuki Y, Sawasaki T.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] Development of novel approach to identify HBV receptor proteins based on in vitro protein-protein interaction assay.2019
- Author(s)
  Takahashi H, Shioya R, Matake S, Takeda H, Ono C, Fukuhara T, Matsuura Y, Sawasaki T
- Organizer
  2019 international HBV meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] Biochemical analysis of DENV non-structural proteins using a wheat cell-free protein synthesis system.2019
- Author(s)
  Takahashi H.
- Organizer
  5th Peptides and Proteins Symposium Singapore (P2S2-2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05292
[Presentation] コムギ無細胞タンパク質合成系を基盤としたヒト脱ユビキチン化酵素タンパク質アレイの作製と応用。2019
- Author(s)
  高橋宏隆，山中聡士，後藤栄治，及川大輔，佐藤裕介，深井周也，徳永文稔，澤崎達也
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Establishment of a protein array system consisted of 90 human recombinant deubiquitinating enzymes (DUBs) proteins for assessment of linkage specificity of each DUB and evaluation of the selectivity of DUB inhibitors.2019
- Author(s)
  Takahashi H, Kuwada S, Yamanaka S, Goto E, Tokunaga F, Sawasaki T.
- Organizer
  The ubiquitin system: Biology, mechanisms and roles in disease.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Biochemical analysis of DENV non-structural proteins using a wheat cell-free protein synthesis system.2019
- Author(s)
  Takahashi H.
- Organizer
  5th Peptides and Proteins Symposium Singapore (P2S2-2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-kB抑制機構の解明2019
- Author(s)
  高橋宏隆, 及川大輔, 長尾和哉, 岩崎誠, 今井祐記, 徳永文稔, 澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Establishment of a protein array system consisted of 85 human recombinant deubiquitinating enzymes (DUBs) proteins for assessment of linkage specificity and evaluation of the selectivity of DUB inhibitors.2018
- Author(s)
  Takahashi H, Kuwada S, Yamanaka S, Goto E, Tokunaga F, Sawasaki T
- Organizer
  Keystone Symposia, Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Development of CYLD inhibitor using wheat cell-free based drug screening system.2018
- Author(s)
  Yamanaka S, Tokunaga F, Sato Y, Fukai S, Takahashi H, Sawasaki T
- Organizer
  Keystone Symposia, Ubiquitin Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Comprehensive in vitro screening to identify the host proteins that binds to HBs protein using wheat cell-free technology.2018
- Author(s)
  Takahashi H, Iwasaki T, Takeda T, Fukuhara T, Suzuki T, Matsuura Y, Sawasaki T.
- Organizer
  2018 International HBV meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Functional analysis of a novel host E3 ligase targeting dengue virus nonstructural protein 4B.2018
- Author(s)
  Takahashi H, Suzuki Y, Sameshima Y, Kato F, Hishiki T, Vasudevan SG, Sawasaki T.
- Organizer
  25th International Symposium on Hepatitis C Virus and Related Viruses.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] 85種類のヒト脱ユビキチン化酵素（DUB）の完全長組換えタンパク質を用いたポリユビキチン鎖特異性決定とDUB阻害剤評価系の構築2017
- Author(s)
  桑田翔平、山中聡士、岡田健吾、後藤英治、徳永文稔、高橋宏隆、澤崎達也
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Functional analysis of a novel host E3 ligase targeting dengue virus nonstructural protein 4B2017
- Author(s)
  Takahashi H, Sameshima Y, Mitsumori R, Imamura M, Suzuki Y, Vasudevan SG, Suzuki T, Takaji W, Sawasaki T.
- Organizer
  24th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] Identification of host E3 ligases targeting dengue virus nonstructural protein 4B using wheat cell-free based-E3 protein array technology2017
- Author(s)
  Takahashi H, Suzuki Y, Sameshima Y, Vasudevan SG, Yamamoto N, Sawasaki T.
- Organizer
  International Union of Microbiological Societies 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] GTP結合タンパク質PI5P4Kbによって制御される、PI(5)Pの標的タンパク質の網羅的探索系の構築2017
- Author(s)
  高橋宏隆、壽美田一貴、河口理紗、小藤智史、笠原亜希子、井上竜也、櫻井秀敬、和田直也、久保田一石、佐々木敦朗、澤崎達也
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Invited
- Data Source
  KAKENHI-PROJECT-17K07261
[Presentation] 無細胞プロテオミクス2017
- Author(s)
  澤崎達也、高橋宏隆
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Invited
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NF-kB活性を抑制する新規DUBの機能解析2016
- Author(s)
  高橋宏隆, 桒田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] コムギ無細胞タンパク質合成系を用いたフラビウイルスタンパク質の宿主相互作用タンパク質の探索2016
- Author(s)
  高橋宏隆
- Organizer
  関西ウイルスクラブ
- Place of Presentation
  大阪大学微生物病研究所（大阪府吹田市）
- Year and Date
  2016-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] Establishment of deubiquitinating enzyme (DUB) protein array based on wheat cell-free system for a novel biochemical tool.2016
- Author(s)
  Takahashi H, Doi K, Yamanaka S, Kuwada S, Goto E, Tokunaga F, Sawasaki T.
- Organizer
  Ubiquitin signaling joint with the meeting on NF-kB and MAP kinase signaling in inflammation, Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  Whistler, British Columbia, Canada
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] プロテオーム大規模解析が切り開く新たな生化学研究：コムギ無細胞系を基盤とした２つの大規模生化学的解析法：ヒト２万種プロテインアレイによるインタラクトーム解析とケミカルバイオロジーに向けた薬剤開発2016
- Author(s)
  澤崎達也, 高橋宏隆
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学・仙台国際センター（宮城研仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PLANNED-16H06579
[Presentation] コムギ無細胞系を基盤としたプロテインアレイ技術の開発と応用2016
- Author(s)
  高橋宏隆
- Organizer
  AMED-創薬等支援技術基盤プラットフォーム解析拠点-領域間技術交流会
- Place of Presentation
  名古屋大学・創薬科学研究館（愛知県名古屋市）
- Year and Date
  2016-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] Regulation of the stability of Dengue virus non-structural protein 4B by ubiquitin-proteasome pathway.2016
- Author(s)
  Takahashi H, Sameshima Y, Vasudevan SG, Suzuki Y, Yamamoto N. Sawasaki T.
- Organizer
  23th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2016-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] コムギ無細胞系を用いた287種類のヒトとマウスからなるE3ユビキチンリガーゼプロテインアレイの作製と生化学的解析への応用2015
- Author(s)
  高橋宏隆, 中島達朗, 今村芽依, 高橋千佳子, 澤崎達也
- Organizer
  第38回日本分子生物学会年会, 第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートピアホテルおよび神戸国際会議場他, 兵庫県神戸市中央区港島中町
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] Regulation of the stability of dengue virus non-structural protein 4B by ubiquitin-proteasome pathway.2015
- Author(s)
  Takahashi H, Suzuki Y, Vasudevan SG, Sawasaki T, Yamamoto N.
- Organizer
  第63回ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場, 福岡県福岡市博多区石城町
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K18468
[Presentation] Identification of novel E3 ligase that degrades HCV nonstructural protein 4B and inhibits viral replication in Huh7.5.1 cells using wheat cell-free protein production system.2015
- Author(s)
  Takahashi H, Imamura M, Takeda H, Ito M, Suzuki T, Wakita T, Sawasaki T
- Organizer
  22nd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Strasbourg, France
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18468

1. Okiyoneda Tsukasa (90398248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Goyama Susumu (80431849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 福田亮介 (90825308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 長門石曉 (30550248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SAWASAKI TATSUYA (50314969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
6. 中村照也 (40433015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石黒洋 (90303651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤橋雅宏 (10397581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 鈴木陽一 (40432330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 村川武志 (90445990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 坂上倫久 (20709266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 青野潤 (70512169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 倉田美恵 (80423440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 泉谷裕則 (90419200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. INOUE Shin-ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 及川大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. 桑原誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 上田実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 高岡洋輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 森脇健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 永浜政博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 竹内綾子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 松岡達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Hirotaka 高橋 宏隆

Takahashi Hirotaka 高橋 宏隆

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Development of the chemical compounds targeting deubiquitinating enzyme for protein regulationPrincipal Investigator

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Clarification of the molecular mechanism of NF-kB regulation by novel family of linear ubiquitin binding proteinPrincipal Investigator

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Development of small chemical compounds that specifically inhibit USP-family deubiquitinating enzymes.Principal Investigator

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Establishment of an wheat cell-free based protein array of deubiquitinating enzyme and determination of specificity of polyubiquitinPrincipal Investigator

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Development of specific inhibitors targeting a deubiquitinating enzyme CYLD and application of these inhibitors for chemical probe.Principal Investigator

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[Book] Methods of Mathematical Oncology, Fusion of Mathematics and Biology2021

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TAKAHASHI Hirotaka 高橋宏隆

Takahashi Hirotaka 高橋宏隆