HIROSE Kinuko 廣瀬衣子

Researcher Number	70436880
Affiliation (based on the past Project Information) *help	2014: 山梨大学, 総合研究部, 医学研究員 2011 – 2012: 山梨大学, 医学工学総合研究部, 医学研究員 2009 – 2011: University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 2008: 山梨大学, 医学部・附属病院, 医員 2007 – 2008: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics
Keywords	Principal Investigator LMO2 / B細胞性白血病 / B 細胞性白血病 / T細胞性リンパ性白血病 / 転写因子 / T細胞性急性白血病 Except Principal Investigator 白血病 / 細胞傷害因子 / 移植片対白血病効果 / 造血幹細胞移植 … More / BCR-ABL / 小胞体ストレス / TRAIL / 17;19転座 / Slug遺伝子 / 17 ; 19転座 / 転写因子 / 細胞死 Less

Research for clinical application of cytotoxic ligands for graft-versus-leukemia effect against childhood leukemia
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Aberrant expression of LMO2 in B-precursor ALPrincipal Investigator
- Principal Investigator
  
  HIROSE Kinuko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Clinical significance of cytotoxic factor-mediated graft-versus-leukemia effect against high-risk childhood leukemia
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Aberrant expression of LMO2 gene in T-ALLPrincipal Investigator
- Principal Investigator
  
  HIROSE Kinuko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Involvement of Slug transcription factor, a human homolog of ces-1 of C. elegans, in the regulation of apoptotic cell death of leukemia cells
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi

All 2012 2011 2010 2009 2007 Other

All Journal Article Presentation

[Journal Article] Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.2012
- Author(s)
  Zhang X
- Journal Title
  
  Leukemia
  
  Volume: 26 Issue: 12 Pages: 2483-2493
- DOI
  10.1038/leu.2012.139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-23390253, KAKENHI-PROJECT-24591544, KAKENHI-PLANNED-22118005
[Journal Article] Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis2011
- Author(s)
  Zhang X, Inukai T, Akahane K, Hirose K, Kuroda I, et al
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19)2010
- Author(s)
  Kinuko Hirose
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 962-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790975
[Journal Article] Resistance of T-cell acute lymphoblastic leukemia totumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis2010
- Author(s)
  Akahane K, Inukai T, Hirose K, Kuroda I, et al
- Journal Title
  
  Exp Hematol
  
  Volume: 38 Pages: 885-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19).2010
- Author(s)
  Hirose K
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 962-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).2010
- Author(s)
  Hirose K, Inukai T, Kikuchi J, et al.
- Journal Title
  
  Blood. 116
  
  Pages: 962-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790975
[Journal Article] Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT2009
- Author(s)
  Inukai T, Goi K, Tezuka T, Uno K, Nemoto A, Takahashi K, Sato H, Akahane K, Hirose K, Honna H, Kuroda I, Kagami K, Nakamoto K, Taniguchi K, Nakazawa S, Sugita K.
- Journal Title
  
  Bone Marrow Transplant 43
  
  Pages: 229-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents2007
- Author(s)
  Furuichi Y, Goi K, Inukai T, Sato H, Nemoto A, Takahashi K, Akahane K, Hirose K, Honna H, Kuroda I, Zhang X, Kagami K, Hayashi Y, Harigaya K, Nakazawa S, Sugita K.
- Journal Title
  
  Cancer Res 67(29)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA22007
- Author(s)
  Inukai T, Uno K, Taniguchi K, Goi K, Tezuka T, Nemoto A, Takahashi K, Sato H, Akahane K, Hirose K, Honna H, Kagami K, Hiraoka A, Tanihiro M, Nakazawa S, Sugita K.
- Journal Title
  
  Br J Haematol 139
  
  Pages: 280-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007
- Author(s)
  Inukai T, Akahane K, Nemoto A, Kuroda I, Noguchi S, Hirose K, Honna H, Goi K, Kondo T, Iwasa S, Murata S, Kato R, Nakazawa S, Sugita K.
- Journal Title
  
  Histopathology 50(7)
  
  Pages: 947-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Oncogenic fusion E2A-HLF sensitize t(17 ; 19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors
- Author(s)
  Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, et al
- Journal Title
  
  Leukemia
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand(TRAIL) in Philadelphia chromosome-positive leukemia
- Author(s)
  Kuroda I, Inukai T, Akahane K, Hirose K, et al
- Journal Title
  
  Oncogene
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] Expression ofLMO2/hHEX pathway in B-precursor ALL2012
- Author(s)
  渡邊敦、犬飼岳史、廣瀬衣子
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23791160
[Presentation] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand(TRAIL) inPhiladelphia chromosome-positive leukemia2011
- Author(s)
  Kuroda I, Inukai T, Akahane K, HiroseK, et al
- Organizer
  53th American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] B前駆細胞型ALLにおけるLMO2の過剰発現2010
- Author(s)
  廣瀬衣子
- Organizer
  日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790975
[Presentation] 犬飼岳史B前駆細胞型ALLにおけるLMO2の過剰発現2010
- Author(s)
  廣瀬衣子
- Organizer
  日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790975
[Presentation] T細胞型急性リンパ性白血病のTRAIL耐性へのTRAIL受容体DR4/DR5遺伝子のメチル化とプロモーター活性の関与2009
- Author(s)
  赤羽弘資,犬飼岳史,廣瀬衣子,黒田格, ほか
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] BCR-ABLはPh1陽性白血病細胞のTRAILに対するdeath受容体の発現に関与する2009
- Author(s)
  黒田格,犬飼岳史,張暁春,廣瀬衣子,赤羽弘資, ほか
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] Philadelphia染色体陽性白血病細胞におけるImatinibによる小胞体ストレス誘導作用とTRAIL感受性の検討2009
- Author(s)
  張暁春,犬飼岳史,黒田格,赤羽弘資,廣瀬衣子, ほか
- Organizer
  第51回日本小児血液学会総会
- Place of Presentation
  幕張
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21591356

1. INUKAI Takeshi (30293450)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. KURODA Itaru (30402051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. GOI Kumiko (70324192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. AKAHANE Koshi (90377531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. NEMOTO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIROSE Kinuko 廣瀬 衣子

Research Projects

Research Products

Co-Researchers

Research for clinical application of cytotoxic ligands for graft-versus-leukemia effect against childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aberrant expression of LMO2 in B-precursor ALPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical significance of cytotoxic factor-mediated graft-versus-leukemia effect against high-risk childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aberrant expression of LMO2 gene in T-ALLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of Slug transcription factor, a human homolog of ces-1 of C. elegans, in the regulation of apoptotic cell death of leukemia cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis2011

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19)2010

Author(s)

Journal Title

Data Source

[Journal Article] Resistance of T-cell acute lymphoblastic leukemia totumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis2010

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19).2010

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).2010

Author(s)

Journal Title

Data Source

[Journal Article] Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT2009

Author(s)

Journal Title

Data Source

[Journal Article] Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents2007

Author(s)

Journal Title

Data Source

[Journal Article] Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA22007

Author(s)

Journal Title

Data Source

[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007

Author(s)

Journal Title

Data Source

[Journal Article] Oncogenic fusion E2A-HLF sensitize t(17 ; 19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors

Author(s)

Journal Title

Data Source

[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand(TRAIL) in Philadelphia chromosome-positive leukemia

HIROSE Kinuko 廣瀬衣子