Harada Kenichi 原田研一

… Alternative Names

HARADA Kenichi 原田研一

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Researcher Number	70441590
Affiliation (Current)	2025: 徳島文理大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 徳島文理大学, 薬学部, 講師 2007 – 2011: Tokushima Bunri University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 33020:Synthetic organic chemistry-related
Keywords	Principal Investigator 神経栄養因子 / パラジウム触媒 / 神経突起伸展促進活性 / アルツハイマー病 / ジアジフェニン / 有機合成化学 / 不斉四級炭素 / 有機分子触媒 / 不斉合成 / チェノポデン … More / ビブサン型次テルペン / アルツハイマー病治療薬 / スピロビブサニン / ネオビブサニン / ビブサン型ジテルペン / [3.3.1]-ビシクロ骨格 / スピロビブサニンA / ビブサン型ジテルペエン / 不斉アルドール反応 / 有機化学合成 / 有機触媒 / ジアジフェノリド / Tsuii-Trost反応 / Mizoroki-Heck反応 / イリジウム触媒 / パラシウム触媒 / 神経突起伸展促進 / 構造活性相関 / Tsuji-Trost反応 / 合成化学 Less

Construction of asymmetric carbon using organo-catalyst and systematic synthetic studies on vibsane-type diterpenesPrincipal Investigator
- Principal Investigator
  
  Harada Kenichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 33020:Synthetic organic chemistry-related
- Research Institution
  Tokushima Bunri University
神経栄養因子様活性を有するセコプレジザン型セスキテルペンの系統的合成研究Principal Investigator
- Principal Investigator
  
  原田研一
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokushima Bunri University
Asymmetric synthetic studies on jiadifenin, neurotrophic compoundPrincipal Investigator
- Principal Investigator
  
  HARADA Kenichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokushima Bunri University

All 2022 2021 2020 2019 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Germacrane-type sesquiterpenoids from Illicium lanceolatum2022
- Author(s)
  Kubo Miwa、Nishikawa Yuri、Nakagawa Hiroyuki、Shimada Shiori、Mori Ayana、Harada Kenichi、Huang Jian-Mei、Ohsaki Ayumi、Fukuyama Yoshiyasu
- Journal Title
  
  Tetrahedron
  
  Volume: 109 Pages: 132673-132673
- DOI
  10.1016/j.tet.2022.132673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-20K05736, KAKENHI-PROJECT-22K06689
[Journal Article] Chemistry and Neurotrophic Activities of (?)-Talaumidin and Its Derivatives2020
- Author(s)
  Harada Kenichi、Kubo Miwa、Fukuyama Yoshiyasu
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 8 Pages: 301-301
- DOI
  10.3389/fchem.2020.00301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-18K06727
[Journal Article] Asymmetric Construction of Vicinal Stereocenters Containing Quaternary and Tertiary Carbons: Application to the Formal Synthesis of (-)-Chenopodene2020
- Author(s)
  Harada Kenichi、Ibaragi Daisuke、Edazawa Yui、Sakashita Masanori、Nakata Ayane、Kubo Miwa、Carter Rich G.、Fukuyama Yoshiyasu
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2020 Issue: 4 Pages: 420-423
- DOI
  10.1002/ejoc.201901722
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-20K05736, KAKENHI-PROJECT-16K01921
[Journal Article] Metabolite Profiling of Javanese Ginger Zingiber purpureum and Identification of Antiseizure Metabolites via a Low-Cost Open-Source Zebrafish Bioassay-Guided Isolation2020
- Author(s)
  Brillatz Th?o、Kubo Miwa、Takahashi Shimon、Jozukuri Natsumi、Takechi Kenshi、Queiroz Emerson Ferreira、Marcourt Laurence、Allard Pierre-Marie、Fish Richard、Harada Kenichi、Ishizawa Keisuke、Crawford Alexander D.、Fukuyama Yoshiyasu、Wolfender Jean-Luc
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 68 Issue: 30 Pages: 7904-7915
- DOI
  10.1021/acs.jafc.0c02641
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-18K06727
[Journal Article] Development of New Neurotrophic Compounds Based on Talaumidin2020
- Author(s)
  Harada Kenichi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 2 Pages: 129-137
- DOI
  10.1248/yakushi.19-00167
- NAID
  130007793318
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05488
[Journal Article] The search for, and chemistry and mechanism of, neurotrophic natural products2020
- Author(s)
  Fukuyama Yoshiyasu、Kubo Miwa、Harada Kenichi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Issue: 4 Pages: 648-671
- DOI
  10.1007/s11418-020-01431-8
- NAID
  40022344629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-16K01921
[Journal Article] Serine protease inhibitors and activators from Dalbergia tonkinensis species2020
- Author(s)
  N. T. Son, M. Suenaga, Y. Matsunaga, L. V. Chinh, M. Kubo, K. Harada, N. M. Cuong, Y. Fukuyama 4.巻
- Journal Title
  
  J. Nat. Med.
  
  Volume: 74 Pages: 257-263
- NAID
  40022130337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05488
[Journal Article] Structure of seven new vibsane-type diterpenoids from Viburnum awabuki2019
- Author(s)
  Kubo Miwa, Nakai Megumi, Harada Kenichi, Fukuyama Yoshiyasu
- Journal Title
  
  Tetrahedron
  
  Volume: 75 Issue: 16 Pages: 2379-2384
- DOI
  10.1016/j.tet.2019.02.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-19K05488
[Journal Article] Sucupiranins M-Q, five new furanocassane-type diterpenoids from the seeds of Bowdichia virgilioides2019
- Author(s)
  Endo Yuta, Kasahara Taku, Asakura Kenta, Mori Ayana, Funasaki Mariko, Akisue Gokithi, Etoh Tadahiro, Harada Kenichi, Fukuyama Yoshiyasu, Matsuzaki Keiichi, Ishibashi Masami, Ohsaki Ayumi
- Journal Title
  
  Tetrahedron
  
  Volume: 75 Issue: 37 Pages: 130511-130511
- DOI
  10.1016/j.tet.2019.130511
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-19K05488, KAKENHI-PUBLICLY-19H04640, KAKENHI-PROJECT-17H03992
[Journal Article] Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells2019
- Author(s)
  Shoji Masaki, Ueda Masako, Nishioka Megumi, Minato Hiroki, Seki Masahide, Harada Kenichiubo Miwa, Fukuyama Yoshiyasu, Suzuki Yutaka, Aoyama Eriko, Takigawa Masaharu, Kuzuhara Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 519 Issue: 2 Pages: 309-315
- DOI
  10.1016/j.bbrc.2019.09.003
- NAID
  120006842045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-18K06645, KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-19K10053, KAKENHI-PROJECT-19H03817
[Journal Article] Synthesis of the ABC Ring System of Jiadifenin via Pd-Catalyzed Cyclizations.2011
- Author(s)
  Kenichi Harada
- Journal Title
  
  Organic Letters
  
  Volume: 13 Pages: 988-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790030
[Journal Article] Asymmetric Synthesis of (+)-Machilin F by Unusual Stereoselective Mitsunobu Reaction.2011
- Author(s)
  Kenichi Harada
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 1127-1132
- NAID
  40018702701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790030
[Journal Article] Asymmetric synthesis of (-)-chicanine using a highly regioselective intramolecular Mitsunobu reaction and revision of its absolute configuration.2011
- Author(s)
  Kenichi Harada
- Journal Title
  
  Tetrahedron Letters
  
  Volume: (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790030
[Journal Article] NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii2010
- Author(s)
  M. Kubo, Y. Kishimoto, K. Harada, H. Hioki, Y. Fukuyama
- Journal Title
  
  Bioorg. Med. Chem. Lett. 20
  
  Pages: 2566-2571
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi2009
- Author(s)
  M. Kubo, C. Okada, J. -M. Huang, K. Harada, H. Hioki, Y. Fukuyama
- Journal Title
  
  Org. Lett. 11
  
  Pages: 5190-5193
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis2009
- Author(s)
  H. Hioki, R. Nishimoto, K. Kawaguchi, M. Kubo, K. Harada, Y. Fukuyama
- Journal Title
  
  Chem. Comm.
  
  Pages: 7194-7196
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Total Synthesis of Pseudodehydrothyrsiferol2009
- Author(s)
  H. Hioki, M. Motosue, Y. Mizutani, A. Noda, T. Shimoda, M. Kubo, K. Harada, Y. Fukuyama, M. Kodama
- Journal Title
  
  Org. Lett. 11
  
  Pages: 579-582
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides2009
- Author(s)
  W. Tang, M. Kubo, K. Harada, H. Hioki, Y. Fukyama
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19
  
  Pages: 882-886
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Isolation, synthesis, and outgrowth- promoting activity of illicinin A from the flowers of Illicium anisatum2009
- Author(s)
  S. Takaoka, N. Takaoka, Y. Minoshima, J. -M. Huang, M. Kubo, K. Harada, H. Hioki, Y. Fukuyama
- Journal Title
  
  Tetrahedron 65
  
  Pages: 8354-8361
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXR-agonists2009
- Author(s)
  H. Hioki, N. shima, K. Kawaguchi, K. Harada, M. Kubo, T. Esumi, T. Nishimaki-Mogami, J. Sawada, T. Hashimoto, Y. Asakawa, Y. Fukyama
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19
  
  Pages: 738-741
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Solid-phase combinatorial synthesis of 2-arylquinazolines and 2-arylquinazolinones by an 4-alkoxyaniline linker2008
- Author(s)
  H. Hioki, K. Matsushita, S. Nakamura, H. Horiuchi, M. Kubo, K. Harada, Y.
- Journal Title
  
  Fukuyama, J. Comb. Chem. 10
  
  Pages: 620-623
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Clerodane Diterpenoids with NGF-Potentiating Activity from Ptychopetalum olacoides2008
- Author(s)
  W. Tang, H. Hioki, K. Harada, M. Kubo, Y.
- Journal Title
  
  Fukuyama, J. Nat. Prod. 71
  
  Pages: 1760-1763
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Two New Sesquiterpenoids and Two New Prenylated Phenylpropanoids from Illicium fargesii, and Neuroprotective Activity of Macranthol2008
- Author(s)
  M. Moriyama, J. -M. Huang, C. -S. Yang, M. Kubo, K. Harada, H. Hioki, Y.
- Journal Title
  
  Fukuyama, Chem. Pharm. Bull. 56
  
  Pages: 1201-1204
- NAID
  110006838336
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Synthesis of (-)-talaumidin, a neurotrophic 2, 5-biaryl-3, 4-dimethyltetrahydrofuran lignan, and its stereoisomers2008
- Author(s)
  Y. Fukuyama, K. Harada, T. Esumi, D. Hojyo, Y. Kujime, N. Kubo, M. Kubo, H. Hioki
- Journal Title
  
  Heterocycles. 76
  
  Pages: 551-567
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Antioxidant Phenylpropanoid-Substituted Epi- catechins from Trichilia catigua2007
- Author(s)
  W. Tang, H. Hioki, K. Harada, M. Kubo, Y.
- Journal Title
  
  Fukuyama, J. Nat. Prod. 70
  
  Pages: 2010-2013
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] An efficient synthesis oflhe CD rings model for merrilactone A2007
- Author(s)
  Kenichi Harada
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 6105-6108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] An efficient synthesis of the CD rings model for merrilactone A2007
- Author(s)
  K. Harada, H. Ito, H. Hioki, Y.
- Journal Title
  
  Fukuyama, Tetrahedron Lett. 48
  
  Pages: 6105-6108
- Data Source
  KAKENHI-PROJECT-19790027
[Journal Article] Solid-phase combinatorial synthesis of benzothiazoles, benzimidazoles, and benzoxazoles using a traceless linker2007
- Author(s)
  H. Hioki, K. Matsushita, M. Kubo, K. Harada, M. Kodama, Y. Fukuyama
- Journal Title
  
  Tetrahedron 63
  
  Pages: 11315-11324
- Data Source
  KAKENHI-PROJECT-19790027
[Presentation] エナンチオ選択的アルドール反応を活用したスピロビブサニンAの合成研究2022
- Author(s)
  濵本大、原田研一、板東志乃、久保美和、福山愛保
- Organizer
  日本薬学会第142年会(名古屋)
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] エナンチオ選択的アルドール反応を活用したネオビブサニン類の合成研究2021
- Author(s)
  原田研一、濵本大、板東志乃、茨木大輔、久保美和、福山愛保
- Organizer
  日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] ジャワショウガに含まれる歯周病原菌 Porphyromonas gingivalis に対する増殖抑制活性成分の探索研究2021
- Author(s)
  矢野渚、山内学、原田研一、久保美和、小田真隆、福山愛保
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] Tsuji-Trost反応を活用した二連続四級炭素構築法 (2); フラノピングイサノールの合成研究2021
- Author(s)
  原田研一、大上南波、大西菜月、久保美和、福山愛保
- Organizer
  日本薬学会第141年会（広島）
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] Tsuji-Trost反応を活用した二連続四級炭素構築法 (2); フラノピングイサノールの合成研究2021
- Author(s)
  原田研一、大上南波、大西菜月、久保美和、福山愛保
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] 三成分縮合反応によるカンチン構築法 (2); アマラステリンAの合成研究2021
- Author(s)
  久米貴大、原田研一、高橋賢龍、久保美和、大崎愛弓、福山愛保
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] 二連続四級炭素構築法を利用したフラノピングイサノールの合成研究2020
- Author(s)
  大上南波、原田研一、大西菜月、板東裕大、久保美和、福山愛保
- Organizer
  第140年会日本薬学会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] ジャワショウガBangleの歯周病原菌増殖抑制活性成分の探索研究2020
- Author(s)
  矢野渚、山内学、古江由依、原田研一、久保美和、小田真隆、福山愛保
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] 三成分縮合反応を利用したアマラステリンAの合成研究2020
- Author(s)
  久米貴大、高橋賢龍、原田研一、久保美和、大崎愛弓、福山愛保
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] エナンチオ選択的アルドール反応による不斉四級炭素の構築と (-)-チェノポデンの合成研究2019
- Author(s)
  原田研一、茨木大輔、坂下正倫、中田絢音、枝沢由衣、久保美和、福山愛保
- Organizer
  第63回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] タラウミジンを基盤とする新規神経栄養因子様活性物質の創製とアルツハイマー病モデルマウスに対する認知機能改善効果2019
- Author(s)
  原田研一、板東莉奈、入交諒、久保美和、窪田剛志、岸本泰司、郡山恵樹、松井敦聡、福山愛保
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K05488
[Presentation] Synthetic studies on jiadifenin, a neurotrophic sesquiterpene2010
- Author(s)
  Kenichi Harada
- Organizer
  環太平洋国際化学会議PacifiChem2010
- Place of Presentation
  米国ハワイ州
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-22790030

1. 福山愛保

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 大崎愛弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada Kenichi 原田 研一

HARADA Kenichi 原田 研一

Research Projects

Research Products

Co-Researchers

Construction of asymmetric carbon using organo-catalyst and systematic synthetic studies on vibsane-type diterpenesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経栄養因子様活性を有するセコプレジザン型セスキテルペンの系統的合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Asymmetric synthetic studies on jiadifenin, neurotrophic compoundPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Germacrane-type sesquiterpenoids from Illicium lanceolatum2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemistry and Neurotrophic Activities of (?)-Talaumidin and Its Derivatives2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asymmetric Construction of Vicinal Stereocenters Containing Quaternary and Tertiary Carbons: Application to the Formal Synthesis of (-)-Chenopodene2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolite Profiling of Javanese Ginger Zingiber purpureum and Identification of Antiseizure Metabolites via a Low-Cost Open-Source Zebrafish Bioassay-Guided Isolation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of New Neurotrophic Compounds Based on Talaumidin2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] The search for, and chemistry and mechanism of, neurotrophic natural products2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Serine protease inhibitors and activators from Dalbergia tonkinensis species2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Structure of seven new vibsane-type diterpenoids from Viburnum awabuki2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sucupiranins M-Q, five new furanocassane-type diterpenoids from the seeds of Bowdichia virgilioides2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis of the ABC Ring System of Jiadifenin via Pd-Catalyzed Cyclizations.2011

Harada Kenichi 原田研一

HARADA Kenichi 原田研一