Murakami Isao 村上功

… Alternative Names

村上功ムラカミイサオ

MURAKAMI Isao 村上功

MURAKAMI ISAO 村上功

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Researcher Number	70445237
Other IDs
Affiliation (Current)	2025: 東邦大学, 医学部, 講師 2025: 慶應義塾大学, 医学部(信濃町), 共同研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 慶應義塾大学, 医学部(信濃町), 共同研究員 2019: 慶應義塾大学, 医学部(信濃町), 助教 2018: 慶應義塾大学, 医学部(信濃町), 共同研究員 2017: 慶應義塾大学, 医学部, 共同研究員 2013: 慶應義塾大学, 医学部, 共同研究員 2011 – 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator ヒトパピローマウイルス / 子宮頸部発癌機構 / raft culture / 維持複製 / 予後因子 / 子宮頸部中等度異形成 / E4 / 抗ウィルス薬 / 初期遺伝子 / HPV … More / MCM / K10 / p53 / E7 / E6 / E1 / 生活環 / E1遺伝子 / 高リスク型ヒトパピローマウイルス / 低リスク型ヒトパピローマウイルス / バイオマーカー / エピジェネティックス / メチル化 Less

HPV維持複製におけるE4の機能解析：癌化メカニズムの解明と臨床応用を目指してPrincipal Investigator
- Principal Investigator
  
  村上功
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Analysis of Early Genes in HPV maintenance replication: The Application to new anti-HPV drugsPrincipal Investigator
- Principal Investigator
  
  MURAKAMI Isao
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
The pathologic clarification of cervical cancer based on epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  MURAKAMI ISAO
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University

All 2024 2023 2021 2020 2019 2018 2017 2013 2012 2011

All Journal Article Presentation

[Journal Article] Roles for E1-independent Replication and E6-mediated p53 Degradation During Low-Risk and High-Risk Human Papillomavirus Genome Maintenance2019
- Author(s)
  Isao Murakami, Nagayasu Egawa, Heather Griffin, Wen Yin, Christian Kranjec, Tomomi Nakahara, Tohru Kiyono , John Doorbar
- Journal Title
  
  PLOS Pathogens
  
  Volume: 15 Issue: 5 Pages: e1007755-e1007755
- DOI
  10.1371/journal.ppat.1007755
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09307, KAKENHI-PROJECT-17K16869
[Journal Article] HPV検査の活用法2018
- Author(s)
  村上功、岩田卓、森定徹、青木大輔
- Journal Title
  
  臨床婦人科産科
  
  Volume: 72 Pages: 150-157
- Data Source
  KAKENHI-PROJECT-17K16869
[Journal Article] Methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia2013
- Author(s)
  Murakami I, Fujii T, Dan K, Saito M, Ohno A, Iwata T, Aoki D
- Journal Title
  
  J Clin Virol
  
  Volume: 58 Issue: 1 Pages: 149-154
- DOI
  10.1016/j.jcv.2013.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592462, KAKENHI-PROJECT-23791855
[Journal Article] Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix2012
- Author(s)
  Murakami I, Fujii T, Kameyama K, Iwata T, Saito M, Kubushiro K, Aoki D
- Journal Title
  
  J Gynecol Oncol
  
  Volume: 23 Issue: 3 Pages: 153-158
- DOI
  10.3802/jgo.2012.23.3.153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592462, KAKENHI-PROJECT-23791855
[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22024
- Author(s)
  Isao Murakami, Ryoko Chiyokura, Sayaki Shimada, Ryoko Oomura, Kyoko Tanaka
- Organizer
  ESGO 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09454
[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22023
- Author(s)
  Isao Murakami, Ryoko Chiyokura, Sayaki Shimada, Ryoko Oomura, Kyoko Tanaka
- Organizer
  IGCS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09454
[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22021
- Author(s)
  Murakami I, Takahashi R, Kugimiya T, Tanaka K.
- Organizer
  The 73rd Annual Congress of the Japan Society of Obstetrics and Gynecology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09454
[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22020
- Author(s)
  Murakami I, Iwata T, Egawa N, Saito M, Nakamura M, Morisada T, Tanaka K, Griffin H, Doorbar J, Aoki D
- Organizer
  The 33rd International Papillomavirus Conference and Clinical Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] HPV E1 is dispensable for low and high-risk HPV maintenance and latent replication in keratinocytes but is necessary for genome amplification.2018
- Author(s)
  Murakami I, Iwata T, Nakamura M, Morisada T, Tanaka K, Tanaka M, Aoki D
- Organizer
  第70回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] E1 is dispensable for maintenance replication in keratinocytes, but necessary for sustenance of viral genome in confluent keratinocytes mediated by p53 degradation by E6.2018
- Author(s)
  Egawa N, Murakami I, Griffin H, Doorbar J
- Organizer
  he 32nd International Papillomavirus Conference and Clinical Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] Nucleosome positioning on episomal human papillomavirus DNA in cultured cells.2018
- Author(s)
  Murakami I, Iwata T, Egawa N, Nakamura M, Morisada T, Tanaka K, Doorbar J, Aoki D
- Organizer
  The 32nd International Papillomavirus Conference and Clinical Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] HPV11 (low-risk) E6 directs p53 degradation in confluent keratinocytes and acts to sustain episomal copy number2017
- Author(s)
  Murakami I, Nakamura M, Morisada T, Iwata T, Tanaka K, Tanaka M, Aoki D
- Organizer
  The 69th Annual Congress of the Japan Society of Obstetrics and Gynecology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] HPV11 (Low-risk) E6 directs p53 degradation in confluent keratinocytes, and like HPV16 (high-risk) E6, acts to sustain episomal copy number2017
- Author(s)
  Murakami I, Egawa N, Griffin H, Doorbar J
- Organizer
  2017 DNA Tumor Virus Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] E1 is dispensable for low-risk and high-risk maintenance and latent replication in keratinocytes but is necessary for viral genome amplification2017
- Author(s)
  Murakami I, Egawa N, Griffin H, Doorbar J
- Organizer
  2017 DNA Tumor Virus Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] Expression of difucosylated H-antigen in human uterine cervical carcinoma tissues detected by monoclonal antibody HMMC-12017
- Author(s)
  Tanaka K, Murakami I, Iwata T, Aoki D, Iwamori M
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K16869
[Presentation] 子宮頸部上皮内病変に対する新規バイオマーカーの開発～ヒトパピローマウイルス 52型・58型メチル化頻度の解析～2013
- Author(s)
  村上功、藤井多久磨、齋藤深雪、杉山重里、西尾浩、大野暁子、森定徹、岩田卓、田中京子、青木大輔
- Organizer
  第12回日本婦人科がん分子標的研究会
- Place of Presentation
  東大寺総合文化センター（奈良県）
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] 子宮頸部上皮内病変に対する新規バイオマーカーの開発2013
- Author(s)
  村上功　藤井多久磨　齋藤深雪　杉山重里　西尾浩　大野暁子　森定徹　岩田卓　田中京子　青木大輔
- Organizer
  第12回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] 子宮頸部上皮内病変に対する新規バイオマーカーの開発～ヒトパピローマウイルス52型・58型メチル化頻度の解析～2013
- Author(s)
  村上功,藤井多久磨,齋藤深雪,杉山重里,西尾浩,大野暁子,森定徹,岩田卓,田中京子,青木大輔
- Organizer
  第12回日本婦人科がん分子標的研究会
- Place of Presentation
  奈良
- Year and Date
  2013-07-16
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] Methylation frequencies of human papillomavirus-58 in cervical neoplasia2012
- Author(s)
  Murakami I, Fujii T, Dan K, Ohno A, Saito M, Iwata T, Aoki D
- Organizer
  28^<th> International Papillomavirus Conference and Clinical Workshop
- Place of Presentation
  San Juan, Puerto Rico
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] Methylation frequencies of human papillomavirus-58 in cervical neoplasia2012
- Author(s)
  Isao Murakami, Takuma Fujii, Katsuaki Dan, Miyuki Saito, Akiko Ohno, Takashi Iwata, Daisuke Aoki
- Organizer
  28th International Papillomavirus Conference and Workshops
- Place of Presentation
  Puerto Rico
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] 子宮頸部上皮内病変における局所免疫応答の解析2011
- Author(s)
  村上功,岩田卓,藤井多久磨,杉山重里,西尾咲子,西尾浩,大野暁子,平尾薫丸,青木大輔,吉村泰典
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] HPV52 genome methylation in asymptomatic infection and cervical neoplasia2011
- Author(s)
  Murakami I, Fujii T, Ohno A, Saito M, Iwata T, Aoki D
- Organizer
  27^<th> International papillomavirus conference and clinical workshop
- Place of Presentation
  Berlin
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-23791855
[Presentation] HPV52 genome methylation in asymptomatic infection and cervical neoplasia2011
- Author(s)
  Isao Murakami, Takuma Fujii, Akiko Ohno, Miyuki Saito, Takashi Iwata, Daisuke Aoki
- Organizer
  27th International papillomavirus conference and clinical workshop
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23791855

1. 藤井多久磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 岩田卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 中原知美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murakami Isao 村上 功

村上 功 ムラカミ イサオ

MURAKAMI Isao 村上 功

MURAKAMI ISAO 村上 功

Research Projects

Research Products

Co-Researchers

HPV維持複製におけるE4の機能解析：癌化メカニズムの解明と臨床応用を目指してPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Early Genes in HPV maintenance replication: The Application to new anti-HPV drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathologic clarification of cervical cancer based on epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Roles for E1-independent Replication and E6-mediated p53 Degradation During Low-Risk and High-Risk Human Papillomavirus Genome Maintenance2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HPV検査の活用法2018

Author(s)

Journal Title

Data Source

[Journal Article] Methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22024

Author(s)

Organizer

Data Source

[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22023

Author(s)

Organizer

Data Source

[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22021

Author(s)

Organizer

Data Source

[Presentation] The HPV E4 is a candidate biomarker in cervical intraepithelial neoplasia grade 22020

Author(s)

Organizer

Data Source

[Presentation] HPV E1 is dispensable for low and high-risk HPV maintenance and latent replication in keratinocytes but is necessary for genome amplification.2018

Author(s)

Organizer

Data Source

[Presentation] E1 is dispensable for maintenance replication in keratinocytes, but necessary for sustenance of viral genome in confluent keratinocytes mediated by p53 degradation by E6.2018

Author(s)

Organizer

Data Source

[Presentation] Nucleosome positioning on episomal human papillomavirus DNA in cultured cells.2018

Author(s)

Organizer

Data Source

[Presentation] HPV11 (low-risk) E6 directs p53 degradation in confluent keratinocytes and acts to sustain episomal copy number2017

Author(s)

Organizer

Data Source

[Presentation] HPV11 (Low-risk) E6 directs p53 degradation in confluent keratinocytes, and like HPV16 (high-risk) E6, acts to sustain episomal copy number2017

Author(s)

Organizer

Data Source

Murakami Isao 村上功

村上功ムラカミイサオ

MURAKAMI Isao 村上功

MURAKAMI ISAO 村上功