Okuno Hironobu 奥野博庸

Researcher Number	70445310
Other IDs	https://orcid.org/0000-0003-1932-9482
Affiliation (Current)	2026: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京医科大学, 医学部, 講師 2016 – 2024: 慶應義塾大学, 医学部(信濃町), 助教 2019: 慶應義塾大学, 医学部, 助教 2017: 慶應義塾大学, 医学部, 助教 2015: 慶應義塾大学, 医学部, 助教 2014: 慶應義塾大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatric surgery
Keywords	Principal Investigator iPS細胞 / PDGFRb / 疾患モデリング / 脳血液関門 / 患者由来iPS細胞 / PDGFRｂ / migration assay / Gain of function / 患者特異的iPS細胞 / 遊走アッセイ … More / pericyte / 小崎過成長症候群 / PDGFRB / プラダー・ウィリー症候群 / プラダーウィリー症候群 / MeCP2 / MeCP2結合領域 / Prader-Willi sydrome / インプリンティング / メチル化維持機能 / Prader-Willi症候群 / 視床下部 / 方向性 / 神経堤細胞 / 遊走 / CHD7 / 神経堤 / CHARGE症候群 … More Except Principal Investigator 神経堤 / CDC42 / 遺伝医学 / 神経堤細胞 / iPS細胞 / 血管障害 / 白質病変 / 小崎過成長症候群 / 血小板由来成長因子受容体 / 脳動脈瘤 / 冠状動脈瘤 / 動脈瘤 / 過成長 / 過成長症候群 / 血小板由来成長因子 / 疾患モデル動物 / PDGFRB / 巨大動脈瘤 / 頭蓋縫合早期癒合症 / 乳歯幹細胞 / ヒルシュスプルング病類縁疾患 / ヒルシュスプルング病 / 指定難病 / 組織工学 / 細胞移植 / 乳歯幹細胞学 / 再生医療学 / 小児外科学 / 歯学 / 細胞・組織 / 再生医学 / 移植・再生医療 / 腸管蠕動不全 / 再生医療 / 幹細胞 Less

CDC42異常症患者iPS細胞由来神経堤および神経細胞を用いた病態解明
- Principal Investigator
  
  中山俊宏
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical University
小崎過成長症候群患者iPS細胞由来脳血液関門モデルを用いた疾患メカニズムの解明Principal Investigator
- Principal Investigator
  
  奥野博庸
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical University
  Keio University
Research on pathogenesis of PDGFRB-related overgrowth syndrome
- Principal Investigator
  
  Takenouchi Toshiki
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Okayama University
  Keio University
Elucidation of the mechanism of methylation maintenance of imprinting region using iPS cellsPrincipal Investigator
- Principal Investigator
  
  OKUNO HIronobu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders
- Principal Investigator
  
  TAGUCHI Tomoaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatric surgery
- Research Institution
  Kyushu University
Neural crest disease model using iPS cells and elucidation of pathophysiology for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Okuno Hironobu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University

All 2023 2021 2019 2017 2016 2015

All Journal Article Presentation

[Journal Article] Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet‐derived growth factor receptor‐beta2019
- Author(s)
  Takenouchi Toshiki、Okuno Hironobu、Kosaki Kenjiro
- Journal Title
  
  American Journal of Medical Genetics Part C: Seminars in Medical Genetics
  
  Volume: 181 Issue: 4 Pages: 650-657
- DOI
  10.1002/ajmg.c.31755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08329
[Journal Article] CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations2017
- Author(s)
  Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.
- Journal Title
  
  elife
  
  Volume: 6 Pages: 23-24
- DOI
  10.7554/elife.21114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07115, KAKENHI-PROJECT-26860823, KAKENHI-PROJECT-16K21360, KAKENHI-PLANNED-16H06482
[Presentation] Disease modeling using induced pluripotent stem cellsfrom patients with Kosaki overgrowth syndrome revealsabnormal migration of myofibroblasts2023
- Author(s)
  Hironobu Okuno, Miki Sato, Naoko Yamamoto Toshiki Takenouchi, Kenjiro Kosaki, Hideyuki Okano
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07922
[Presentation] Modeling Prader-Willi syndrome using hypothalamic neurons from patient-derived induced pluripotent stem cells2021
- Author(s)
  Akisa Nemoto, Hironobu Okuno, Hideyuki Okano
- Organizer
  第64回神経化学会
- Data Source
  KAKENHI-PROJECT-18K15686
[Presentation] Generation of Hypothalamic Cell Model of Prader-Willi Syndrome Using Patient-derived induced Pluripotent Stem Cells2021
- Author(s)
  Akisa Nemoto, Hironobu Okuno, Hideyuki Okano
- Organizer
  The 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15686
[Presentation] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells harboring CHD7 mutations reveals defective migration of CHARGE syndrome2017
- Author(s)
  Hironobu Okuno
- Organizer
  Society for Neuroscience (SfN) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860823
[Presentation] CHARGE症候群患者iPS細胞由来神経堤細胞を用いた病態解析2017
- Author(s)
  奥野博庸
- Organizer
  第一回慶應ライフサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-26860823
[Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in cranial neural crest cell development.2016
- Author(s)
  Hironobu Okuno, Francois Renault Mihara, Shigeki Ohta, Kenji Kurosawa, Wado Akamatsu, Kenjiro Kosaki, Takao Takahashi, Hideyuki Okano
- Organizer
  The 13 th International Congress of Human Genetics
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860823
[Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in the development of the embryonic cranial neural crest cell lineage.2016
- Author(s)
  奥野　博庸
- Organizer
  The 13th International Congress of human Genetics
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860823
[Presentation] Modeling for abnormal neural crest cells migration in CHARGE syndrome using patient-iPSCs derived neural crest cells2015
- Author(s)
  奥野博庸
- Organizer
  The 55th Annual Meeting of the Japanese Teratology Society, The 38th Annual Meeting of the Japan Society of Pediatric Genetics
- Place of Presentation
  神戸国際会議場(兵庫県神戸市中央区)
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860823

1. TAGUCHI Tomoaki (20197247)

# of Collaborated Projects: 1 results

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2. Takenouchi Toshiki (60383741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 松浦俊治 (10532856)

# of Collaborated Projects: 1 results

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4. 吉丸耕一朗 (60711190)

# of Collaborated Projects: 1 results

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5. 桐野浩輔 (00621707)

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6. 山座孝義 (80304814)

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7. 山座治義 (30336151)

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8. 尾崎正雄 (10152472)

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9. 岡暁子 (60452778)

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10. 孝橋賢一 (10529879)

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11. 梶岡俊一 (90274472)

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12. 大賀正一 (60233053)

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13. 黒田達夫 (60170130)

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14. 増本幸二 (20343329)

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15. 田尻達郎 (80304806)

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16. 家入里志 (00363359)

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17. 木下義晶 (80345529)

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18. 柳佑典 (30596664)

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19. 野中和明 (90128067)

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20. 高田英俊 (70294931)

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21. 中畑龍俊 (20110744)

# of Collaborated Projects: 1 results

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22. 中山俊宏 (00991928)

# of Collaborated Projects: 1 results

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23. OHTA Shigeki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuno Hironobu 奥野 博庸

Research Projects

Research Products

Co-Researchers

CDC42異常症患者iPS細胞由来神経堤および神経細胞を用いた病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小崎過成長症候群患者iPS細胞由来脳血液関門モデルを用いた疾患メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on pathogenesis of PDGFRB-related overgrowth syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of methylation maintenance of imprinting region using iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neural crest disease model using iPS cells and elucidation of pathophysiology for drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet‐derived growth factor receptor‐beta2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Disease modeling using induced pluripotent stem cellsfrom patients with Kosaki overgrowth syndrome revealsabnormal migration of myofibroblasts2023

Author(s)

Organizer

Data Source

[Presentation] Modeling Prader-Willi syndrome using hypothalamic neurons from patient-derived induced pluripotent stem cells2021

Author(s)

Organizer

Data Source

[Presentation] Generation of Hypothalamic Cell Model of Prader-Willi Syndrome Using Patient-derived induced Pluripotent Stem Cells2021

Author(s)

Organizer

Data Source

[Presentation] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells harboring CHD7 mutations reveals defective migration of CHARGE syndrome2017

Author(s)

Organizer

Data Source

[Presentation] CHARGE症候群患者iPS細胞由来神経堤細胞を用いた病態解析2017

Author(s)

Organizer

Data Source

[Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in cranial neural crest cell development.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Differentiation of iPS cells into cranial neural crest cells to model congenital disorder that arises from defects in the development of the embryonic cranial neural crest cell lineage.2016

Author(s)

Organizer

Place of Presentation

Okuno Hironobu 奥野博庸