SHIMOGAWA Hiroki 下川浩輝

Researcher Number	70447928
Affiliation (based on the past Project Information) *help	2010 – 2013: 京都大学, 化学研究所, 助教 2007 – 2008: Kyoto University, 化学研究所, 助教
Review Section/Research Field	Principal Investigator Chemistry related to living body
Keywords	Principal Investigator ミトコンドリア / 蛍光色素 / 蛍光化合物 / 塩基性顆粒 / 蛍光染色 / チエノピリジン環 / イメージング / 分子内環化反応 / 塩基感受性 / iPS細胞 … More / アダマンタン / Sur2 / 細胞膜透過性 / 小分子有機化合物 / 転写活性化 / 転写因子 / レンチノロール / 合成化合物 / スクリーニング / 外膜 Less

塩基感受性蛍光色素の開発とその応用Principal Investigator
- Principal Investigator
  
  下川浩輝
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Kyoto University
Development of the artificial transcription factor which promotes endogenous gene expression in cellPrincipal Investigator
- Principal Investigator
  
  SHIMOGAWA Hiroki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Kyoto University
Development of new fluorescent materialPrincipal Investigator
- Principal Investigator
  
  SHIMOGAWA Hiroki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Kyoto University

All 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] ファルマシア第23回化合物推理ゲーム2010
- Author(s)
  下川浩輝, 上杉志成
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion2011
- Author(s)
  Kawazoe Y.; Shimogawa, H.; Sato, A.; Uesugi, M. Angew
- Journal Title
  
  Chem. Int. Ed
  
  Volume: 50 Issue: 24 Pages: 5478-5481
- DOI
  10.1002/anie.201100935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin-Filament Stabilizers.2011
- Author(s)
  Eriko Sumiya, Hiroki Shimogawa, Hiroaki, Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] Chemical library screening identifies a small moleculethat downregulates SOD1 transcription for drugs to treat ALS.2011
- Author(s)
  Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R.
- Journal Title
  
  The Journal of Biomolecular Screening
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] Chemical Library Screening Identifies a Small Molecule That Downregulates SOD1 Transcription for Drugs to Treat Amyotrophic Lateral Sclerosis2011
- Author(s)
  Murakami, G.; Inoue, H.; Tsukita, K.; Asai, Y.; Amagai, Y.; Aiba, K.; Shimogawa, H.; Uesugi, M.; Nakatsuji, N.; Takahashi, R
- Journal Title
  
  Journal of Biomolecular Screening
  
  Volume: 16 Issue: 4 Pages: 405-414
- DOI
  10.1177/1087057110397888
- NAID
  120004225661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151, KAKENHI-PROJECT-23500446
[Journal Article] Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins2011
- Author(s)
  紙透伸治
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 54巻 Issue: 13 Pages: 4923-4927
- DOI
  10.1021/jm200304y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710229, KAKENHI-PROJECT-22750151
[Journal Article] Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers2011
- Author(s)
  Sumiya, E.; Shimogawa, H.; Sasaki, H.; Tsutsumi, M.; Yoshita, K.; Ojika, M.; Suenaga, K.; Uesugi, M
- Journal Title
  
  ACS Chem. Biol
  
  Volume: 6 Issue: 5 Pages: 425-431
- DOI
  10.1021/cb1003459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] Mitochondorial surface-specific fluorescent probe activated by bioconversion.2011
- Author(s)
  Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi.
- Journal Title
  
  Angew.Chem.Int.Ed.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750151
[Journal Article] Wrenchnolol Derivative Optimized for Gene Activation in Cells2009
- Author(s)
  Jung, D.; Shimogawa, H.; Kwon, Y.; Mao, Q.; Sato, S.;Kamisuki, S.; Kigoshi, H.; Uesugi, M.
- Journal Title
  
  J. Am. Chem. Soc. 131
  
  Pages: 4774-4782
- Data Source
  KAKENHI-PROJECT-19850011
[Journal Article] Wrenchnolol Derivative Optimized for Gene Activation in Cells2009
- Author(s)
  Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M
- Journal Title
  
  J. Am. Chem. Soc. 131(13)
  
  Pages: 4774-4782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19850011
[Journal Article] 化合物推理ゲーム2008
- Author(s)
  下川浩輝、上杉志成
- Journal Title
  
  ファルマシア 11月号
  
  Pages: 1108-1111
- Data Source
  KAKENHI-PROJECT-19850011
[Presentation] 海洋天然物Bisebromoamideによるアクチン線維の安定化2010
- Author(s)
  住谷瑛理子・下川浩輝・佐々木宏明・末永聖武・上杉志成
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] 海洋天然物Bisebromoamideによるアクチン線維の安定化2010
- Author(s)
  住谷瑛理子・下川浩輝・佐々木宏明・末永聖武・上杉志成
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜慶応義塾大学
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] 細胞形態変化誘導活性を指標としたアクチン阻害化合物の探索2010
- Author(s)
  住谷瑛理子・下川浩輝・佐々木宏明・小鹿一・末永聖武・上杉志成
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都京都テルサ
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] 転写を制御する小分子有機化合物2010
- Author(s)
  下川浩輝
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山岡山大学
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] Morphology-based screening for the identification of actin-interfering compounds2010
- Author(s)
  Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi
- Organizer
  PACIFICHEM2010
- Place of Presentation
  Hawaii Hawaii convention center
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] 細胞形態変化誘導活性を指標としたアクチン阻害化合物の探索2010
- Author(s)
  住谷瑛理子・下川浩輝・佐々木宏明・小鹿一・末永聖武・上杉志成
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡静岡県コンベンションアーツセンター
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22750151
[Presentation] 細胞接着を促進するダンベル型小分子化合物、アドヘサミンの発見と作用機序2009
- Author(s)
  山添紗有美、下川浩輝、佐藤慎一、上杉志成
- Organizer
  第4回ケミカルバイオロジー学会年会
- Place of Presentation
  神戸市産業振興センター
- Data Source
  KAKENHI-PROJECT-19850011
[Presentation] レンチノロール類縁体による細胞内転写活性化2009
- Author(s)
  下川浩輝, Dongju Jung, Youngjoo Kwon, Qian Mao, 佐藤慎一, 紙透伸治, 木越英夫, 上杉志成
- Organizer
  第4回ケミカルバイオロジー学会年会
- Place of Presentation
  神戸市産業振興センター
- Data Source
  KAKENHI-PROJECT-19850011
[Presentation] 細胞接着を促進するダンベル型小分子化合物、アドヘサミンの発見と作用機序2008
- Author(s)
  山添紗有美、下川浩輝、佐藤慎一、上杉志成
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19850011
[Presentation] Discovery and Mechanism of Adhesamine, a Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion2008
- Author(s)
  Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, and Motonari Uesugi
- Organizer
  10^<th> KAIST-KYOTO Chemical Symposium
- Place of Presentation
  Deajeon、Korea
- Data Source
  KAKENHI-PROJECT-19850011

1. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMOGAWA Hiroki 下川 浩輝

Research Projects

Research Products

Co-Researchers

塩基感受性蛍光色素の開発とその応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the artificial transcription factor which promotes endogenous gene expression in cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new fluorescent materialPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ファルマシア第23回化合物推理ゲーム2010

Author(s)

Data Source

[Journal Article] A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin-Filament Stabilizers.2011

Author(s)

Journal Title

Data Source

[Journal Article] Chemical library screening identifies a small moleculethat downregulates SOD1 transcription for drugs to treat ALS.2011

Author(s)

Journal Title

Data Source

[Journal Article] Chemical Library Screening Identifies a Small Molecule That Downregulates SOD1 Transcription for Drugs to Treat Amyotrophic Lateral Sclerosis2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondorial surface-specific fluorescent probe activated by bioconversion.2011

Author(s)

Journal Title

Data Source

[Journal Article] Wrenchnolol Derivative Optimized for Gene Activation in Cells2009

Author(s)

Journal Title

Data Source

[Journal Article] Wrenchnolol Derivative Optimized for Gene Activation in Cells2009

Author(s)

Journal Title

Data Source

[Journal Article] 化合物推理ゲーム2008

Author(s)

Journal Title

Data Source

[Presentation] 海洋天然物Bisebromoamideによるアクチン線維の安定化2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 海洋天然物Bisebromoamideによるアクチン線維の安定化2010

Author(s)

Organizer

Place of Presentation

SHIMOGAWA Hiroki 下川浩輝