ooguti hiroto 大口裕人

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Ohguchi Hiroto 大口裕人

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Researcher Number	70451557
Other IDs
Affiliation (Current)	2025: 熊本大学, 生命資源研究・支援センター, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 熊本大学, 大学院先導機構, 准教授
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / 0901:Oncology and related fields
Keywords	Principal Investigator 多発性骨髄腫 / エピゲノム / 転写 / 遺伝子 / モデルマウス / 造血 / 細胞増殖 / ヒストン修飾

The mechanisms of myeloma-driving transcriptional programPrincipal Investigator
- Principal Investigator
  
  大口裕人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Establishment of Dis3-deficient myeloma model mousePrincipal Investigator
- Principal Investigator
  
  Ohguchi Hiroto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Mechanism of myeloma cell growth induced by KDM5APrincipal Investigator
- Principal Investigator
  
  Ohguchi Hiroto
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] FOXO1 stimulates tip cell-enriched gene expression in endothelial cells2024
- Author(s)
  Miyamura Yuri、Kamei Shunsuke、Matsuo Misaki、Yamazaki Masaya、Usuki Shingo、Yasunaga Keiichiro、Uemura Akiyoshi、Satou Yorifumi、Ohguchi Hiroto、Minami Takashi
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 3 Pages: 109161-109161
- DOI
  10.1016/j.isci.2024.109161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07862, KAKENHI-PROJECT-22K20716, KAKENHI-PROJECT-23K24094
[Journal Article] Multiple myeloma?associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis2024
- Author(s)
  Ohguchi Hiroto、Ohguchi Yasuyo、Kubota Sho、Etoh Kan、Hamashima Ai、Usuki Shingo、Yokomizo-Nakano Takako、Bai Jie、Masuda Takeshi、Kawano Yawara、Harada Takeshi、Nakao Mitsuyoshi、Minami Takashi、Hideshima Teru、Araki Kimi、Sashida Goro
- Journal Title
  
  Blood Neoplasia
  
  Volume: 1 Issue: 1 Pages: 100005-100005
- DOI
  10.1016/j.bneo.2024.100005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07862, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22H04922
[Journal Article] Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase2023
- Author(s)
  Harada Takeshi、Ohguchi Hiroto、Oda Asuka、Nakao Michiyasu、Teramachi Jumpei、Hiasa Masahiro、Sumitani Ryohei、Oura Masahiro、Sogabe Kimiko、Maruhashi Tomoko、Takahashi Mamiko、Fujii Shiro、Nakamura Shingen、Miki Hirokazu、Kagawa Kumiko、Ozaki Shuji、Sano Shigeki、Hideshima Teru、Abe Masahiro
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 6 Pages: 1019-1032
- DOI
  10.1182/bloodadvances.2022007155
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19626, KAKENHI-PROJECT-20K08734, KAKENHI-PROJECT-23K21485
[Journal Article] DIS3: The Enigmatic Gene in Multiple Myeloma2023
- Author(s)
  Yasuyo Ohguchi, Hiroto Ohguchi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 4079-4079
- DOI
  10.3390/ijms24044079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K08734
[Journal Article] Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator?2022
- Author(s)
  Ohguchi Yasuyo、Ohguchi Hiroto
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 13 Pages: 3270-3270
- DOI
  10.3390/cancers14133270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08734
[Journal Article] Water Droplet-in-Oil Digestion Method for Single-Cell Proteomics2022
- Author(s)
  Masuda Takeshi、Inamori Yuma、Furukawa Arisu、Yamahiro Maki、Momosaki Kazuki、Chang Chih-Hsiang、Kobayashi Daiki、Ohguchi Hiroto、Kawano Yawara、Ito Shingo、Araki Norie、Ong Shao-En、Ohtsuki Sumio
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 29 Pages: 10329-10336
- DOI
  10.1021/acs.analchem.1c05487
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08734, KAKENHI-PROJECT-19H03772, KAKENHI-PROJECT-22F22111
[Journal Article] Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma2021
- Author(s)
  Ohguchi H、Park Paul M.C.、wang t、Gryder B E.、Ogiya D、kurata k、zhang x、Li D、pei c、Masuda T、Johansson C、Wimalasena V K、Kim Y、Hino S、Usuki S、Kawano Y、Samur M K、Tai Yu-Tzu、Munshi N C.、Matsuoka M、Ohtsuki S、Nakao M、Minami T、Lauberth S、Khan J、Oppermann U、Durbin A D.、Anderson K C.、Hideshima T、Qi J
- Journal Title
  
  Blood Cancer Discovery
  
  Volume: in press Issue: 4 Pages: 370-387
- DOI
  10.1158/2643-3230.bcd-20-0108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K05544, KAKENHI-PUBLICLY-19H04972, KAKENHI-PROJECT-20H04108, KAKENHI-PROJECT-21H02686, KAKENHI-PROJECT-21H02917, KAKENHI-PROJECT-20K08734, KAKENHI-PROJECT-21K19513, KAKENHI-PROJECT-20KK0185
[Presentation] Late B cell-specific Dis3-deficient mice do not develop plasma cell neoplasm2023
- Author(s)
  大口裕人、大口康代、久保田翔、横溝貴子、荒木喜美、指田吾郎
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07862
[Presentation] 骨髄腫関連遺伝子DIS3は正常造血に必須である2023
- Author(s)
  大口裕人、大口康代、久保田翔、横溝貴子、荒木喜美、指田吾郎
- Organizer
  第48回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07862
[Presentation] Late B Cell-specific Dis3-knockout Mice Do Not Develop Plasma Cell Neoplasm2023
- Author(s)
  Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Ai Hamashima, Takako Yokomizo, Kimi Araki, Goro Sashida
- Organizer
  65th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07862
[Presentation] 多発性骨髄腫においてIL-6-JAK-STAT3経路により駆動される転写サイン2022
- Author(s)
  Hiroto Ohguchi
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] KDM5AはRNAポリメラーゼIIリン酸化を促進し、MYC駆動性の転写を増強する2022
- Author(s)
  Hiroto Ohguchi, Tingjian Wang, Berkley Gryder, Daisuke Ogiya, Takeshi Masuda, Shinjiro Hino, Mitsuyoshi Nakao, Takashi Minami, Kenneth C Anderson, Teru Hideshima, Jun Qi
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] IL-6-JAK-STAT3経路は骨髄腫を駆動する転写プログラムの頑強性に寄与する2022
- Author(s)
  Hiroto Ohguchi, Mitsuyoshi Nakao, Takashi Minami
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] IL-6-JAK-STAT3経路は骨髄腫を駆動する転写プログラムを支持する2022
- Author(s)
  Hiroto Ohguchi
- Organizer
  第47回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] KDM5Aは多発性骨髄腫においてMYC標的遺伝子の維持に必須な因子である2021
- Author(s)
  大口裕人
- Organizer
  第46回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] KDM5Aは骨髄腫細胞においてRNAポリメラーゼIIリン酸化を制御し、MYC駆動性の転写を促進する2021
- Author(s)
  大口裕人
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K08734
[Presentation] KDM5Aは多発性骨髄腫におけるMYC転写プログラムを補強する2019
- Author(s)
  Hiroto Ohguchi, Daisuke Ogiya, Paul Park, Cheng-Kui Pei, Shinjiro Hino, Shingo Usuki, Mehmet K. Samur, Yu-Tzu Tai, Nikhil C. Munshi, Mitsuyoshi Nakao, Takashi Minami, Jun Qi, Teru Hideshima, Kenneth C. Anderson
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21276
[Presentation] KDM5A reinforces MYC transcriptional program and promotes myeloma cell growth2019
- Author(s)
  Hiroto Ohguchi, Daisuke Ogiya, Paul Park, Shinjiro Hino, Shingo Usuki, Mehmet Samur, Yu-Tzu Tai, Nikhil Munshi, Mitsuyoshi Nakao, Takashi Minami, Jun Qi, Teru Hideshima, Kenneth C. Anderson
- Organizer
  17th International Myeloma Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21276

1. TERAMACHI Jyumpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 南敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ooguti hiroto 大口 裕人

Ohguchi Hiroto 大口 裕人

Research Projects

Research Products

Co-Researchers

The mechanisms of myeloma-driving transcriptional programPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of Dis3-deficient myeloma model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of myeloma cell growth induced by KDM5APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] FOXO1 stimulates tip cell-enriched gene expression in endothelial cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple myeloma?associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DIS3: The Enigmatic Gene in Multiple Myeloma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator?2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Water Droplet-in-Oil Digestion Method for Single-Cell Proteomics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Late B cell-specific Dis3-deficient mice do not develop plasma cell neoplasm2023

Author(s)

Organizer

Data Source

[Presentation] 骨髄腫関連遺伝子DIS3は正常造血に必須である2023

Author(s)

Organizer

Data Source

[Presentation] Late B Cell-specific Dis3-knockout Mice Do Not Develop Plasma Cell Neoplasm2023

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫においてIL-6-JAK-STAT3経路により駆動される転写サイン2022

Author(s)

Organizer

Data Source

[Presentation] KDM5AはRNAポリメラーゼIIリン酸化を促進し、MYC駆動性の転写を増強する2022

Author(s)

Organizer

Data Source

[Presentation] IL-6-JAK-STAT3経路は骨髄腫を駆動する転写プログラムの頑強性に寄与する2022

Author(s)

ooguti hiroto 大口裕人

Ohguchi Hiroto 大口裕人