Ohnuma Shinobu 大沼忍

… Alternative Names

OHNUMA Shinobu 大沼忍

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Researcher Number	70451565
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 医学系研究科, 准教授 2013 – 2021: 東北大学, 大学病院, 助教 2012: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 大腸癌 / インドール化合物 / ミトコンドリア / 潰瘍性大腸炎 / 炎症性腸疾患 / 腸炎関連大腸癌 / ABC transporter / 胃癌 / 有害事象 / DPD … More / 遺伝子多型 / splicing / 5-FU / TYMS / OPRT / MTHFR / DPYD / スプライシングバリアント / 次世代シーケンサー / βカテニン / Wntシグナル / スプライシング / 多剤耐性 / ABCトランスポーター … More Except Principal Investigator 大腸癌 / 個別化医療 / ERK阻害薬 / MAPK / オルガノイド / Wntシグナル / Wnt5a / Wnt2 / 癌関連線維芽細胞 / マイクロエクソン Less

Development of new treatment for colorectal cancer through improvement of mitochondrial function using indole compoundsPrincipal Investigator
- Principal Investigator
  
  大沼忍
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Organoid Culture for Next Generation Personalized Medicine against Colorectal Cancer
- Principal Investigator
  
  Karasawa Hideaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Discovering the novel indole compound to suppress colitis-associated colorectal cancer and basic research for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Ohnuma Shinobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Mechanisms of metastasis promoted by cancer associated fibroblast via Wnt signal pathway in colorectal cancer
- Principal Investigator
  
  MUSHA Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Identification of novel microexon involved in the regulation of colorectal cancer
- Principal Investigator
  
  Hideaki Karasawa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Pharmacogenomic analysis of biomarker that predict adverse events associated with 5-fluorouracilPrincipal Investigator
- Principal Investigator
  
  Ohnuma Shinobu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Functional analysis of splicing variants of multidrug-resitant ABC transporters expressed in gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  OHNUMA Shinobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and Decreasing Their Accumulation2023
- Author(s)
  Dan-Yang Wang, Shinobu Ohnuma, Hideyuki Suzuki, Masaharu Ishida, Kentaro Ishii, Takashi Hirosawa, Tomoaki Hirashima, Megumi Murakami, Minoru Kobayashi, Katsuyoshi Kudoh, Sho Haneda, Hiroaki Musha, Takeshi Naitoh, Michiaki Unno
- Journal Title
  
  Curr. Issues Mol. Biol.
  
  Volume: 4 Issue: 4 Pages: 2895-2907
- DOI
  10.3390/cimb45040189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09026
[Journal Article] Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression2021
- Author(s)
  Hirashima Tomoaki、Karasawa Hideaki、Aizawa Takashi、Suzuki Takashi、Yamamura Akihiro、Suzuki Hideyuki、Kajiwara Taiki、Musha Hiroaki、Funayama Ryo、Shirota Matsuyuki、Ohnuma Shinobu、Nakayama Keiko、Unno Michiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 568 Pages: 37-42
- DOI
  10.1016/j.bbrc.2021.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-19K09188, KAKENHI-PROJECT-21K08679
[Journal Article] The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer2021
- Author(s)
  Tayama Hodaka、Karasawa Hideaki、Yamamura Akihiro、Okamura Yasunobu、Katsuoka Fumiki、Suzuki Hideyuki、Kajiwara Taiki、Kobayashi Minoru、Hatsuzawa Yuuri、Shiihara Masahiro、Bin Li、Gazi Md Yeashin、Sato Mizuki、Kumada Kazuki、Ito Shigehiro、Shimada Muneaki、Furukawa Toru、Kamei Takashi、Ohnuma Shinobu、Unno Michiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 560 Pages: 59-65
- DOI
  10.1016/j.bbrc.2021.04.130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02996, KAKENHI-PROJECT-21K08679
[Journal Article] Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer2021
- Author(s)
  Mochizuki Y*, Funayama R*, Shirota M, Kikukawa Y, Ohira M, Karasawa H, Kobayashi M, Ohnuma S, Unno M, Nakayama K. *Equal contribution.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 149 Issue: 10 Pages: 1787-1800
- DOI
  10.1002/ijc.33758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07560, KAKENHI-PROJECT-21K08679
[Journal Article] 腸管型ベーチェット病手術例の長期予後の検討2018
- Author(s)
  伊勢一郎、渡辺和宏、長尾宗紀, 大沼忍, 唐澤秀明, 鈴木秀幸, 内藤剛, 海野倫
- Journal Title
  
  日本大腸肛門病学会雑誌
  
  Volume: 71 Pages: 133-138
- NAID
  130006405046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] Endoscopy-Assisted Partial Duodenal Resection for Duodenal Adenoma in a Patient with Familial Adenomatous Polyposis2018
- Author(s)
  Hirashima T, Ohnuma S, Karasawa H, Watanabe K, Imoto H, Aoki T, Kudoh K, Tanaka N, Nagao M, Musha H, Motoi F, Kamei T, Naitoh T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 45 Pages: 518-520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] A Case of Leiomyosarcoma of the Small Intestine with Intestinal Hemorrhage Due to Intraluminal Penetration2017
- Author(s)
  Tsuchiya T, Tanaka N, Nagao M, Watanabe K, Imoto H, Ohnuma S, Musha H, Watanabe M, Murakami K, Fujishima F, Motoi F, Naitoh T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 44 Pages: 1068-1070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.2017
- Author(s)
  Funayama R, Taniguchi H, Mizuma M, Fujishima F, Kobayashi M, Ohnuma S, Unno M, Nakayama K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 4 Pages: 713-718
- DOI
  10.1111/cas.13179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07107, KAKENHI-PROJECT-15K10128
[Journal Article] Multidisciplinary Treatment for Squamous Cell Carcinoma of the Anal Canal2017
- Author(s)
  Karasawa H, Ohnuma S, Watanabe K, Tsuchiya T, Imoto H, Aoki T, Kudoh K, Tanaka N, Nagao M, Abe T, Musha H, Motoi F, Kamei T, Naitoh T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 44 Pages: 2009-2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] Successful Extended Surgery for Mucinous Cystadenocarcinoma of the Appendix with the Right Iliopsoas Muscle Invasion2017
- Author(s)
  金原圭吾, 大沼忍, 唐澤秀明, 渡辺和宏, 工藤克昌, 石田晶玄, 佐藤聡子, 元井冬彦, 内藤剛, 海野倫明
- Journal Title
  
  The Japanese Journal of Gastroenterological Surgery
  
  Volume: 50 Issue: 9 Pages: 754-761
- DOI
  10.5833/jjgs.2016.0158
- NAID
  130006088684
- ISSN
  0386-9768, 1348-9372
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2.2017
- Author(s)
  Murakami M, Ohnuma S, Fukuda M, Chufan EE, Kudoh K, Kanehara K, Sugisawa N, Ishida M, Naitoh T, Shibata H, Iwabuchi Y, Ambudkar SV, Unno M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 11 Pages: 1166-1177
- DOI
  10.1124/dmd.117.076000
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] A Case of Curatively Resected Ascending Colon Cancer with Ovarian Metastasis and Peritoneal Dissemination after Chemotherapy2017
- Author(s)
  Mochizuki Y, Karasawa H, Shimodaira H, Ohnuma S, Watanabe K, Maeda S, Nagao M, Aoki T, Kudo K, Tanaka N, Musha H, Motoi F, Kamei T, Naitoh T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 44 Pages: 1711-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10128
[Journal Article] microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.2017
- Author(s)
  Takahashi, H.，Takahashi, M.，Ohnuma, S.，Unno, M.，Yoshino, Y.，Ouchi, K.，Takahashi, S.，Yamada, Y.，Shimodaira, H.，Ishioka, C.:
- Journal Title
  
  BMC Cancer
  
  Volume: 17 Issue: 1 Pages: 723-727
- DOI
  10.1186/s12885-017-3739-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-15K10128
[Journal Article] Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration.2015
- Author(s)
  Kajiwara T, Miura K, Ohnuma S, Shimada M, Komura T, Toshima M, Kohyama A, Kudoh K, Haneda S, Musha H, Naitoh T, Shirasaka T, Unno M.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: In press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.2015
- Author(s)
  Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 20 (1) Issue: 1 Pages: 117-125
- DOI
  10.1007/s10147-014-0699-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591895, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-25861171
[Journal Article] Two cases of advanced gastric cancer achieved pathological complete response by preoperative chemotherapy with S-1 plus weekly low-dose CDDP2014
- Author(s)
  Kono E, Tanaka N, Kudo K, Musha H, Tsuchiya T, Miyachi T, Nagao M, Kajiwara T, Kimura S, Karasawa H, Aoki T, Abe T, Ohnuma S, Nakagawa K, Morikawa T, Yoshida H, Motoi F, Katayose Y, Naito T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 41 (12) Pages: 2279-2281
- Open Access
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer.2014
- Author(s)
  Fung KL, Pan J, Ohnuma S, Lund PE, Pixley JN, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM.
- Journal Title
  
  Cancer Res.
  
  Volume: 74(2) Issue: 2 Pages: 598-608
- DOI
  10.1158/0008-5472.can-13-2064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] A case report of complete pathological response of a locally advanced rectal cancer after long term chemotherapy2014
- Author(s)
  Kobayashi M, Ohnuma S, Kato S, Karasawa H, Aoki T, Kudo K, Tanaka N, Wat
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 41 (12) Pages: 1755-1757
- Open Access
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] A case of pathological complete response to lt. Lateral lymph node metastasis from lower rectal cancer by s-1 combined neoadjuvant chemoradiotherapy2014
- Author(s)
  Kimura S, Ohnuma S, Karasawa H, Aoki T, Kudoh K, Watanabe K, Tanaka N, Nagao M, Abe T, Musha H, Morikawa T, Motoi F, Katayose Y, Naitoh T, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 41 (12) Pages: 1560-1562
- Open Access
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Therapeutic strategy for neuroendocrine tumor of the rectum2013
- Author(s)
  Ohnuma S, Naitoh T, Haneda S, Kudoh K, Kohyama A, Nagao M, Tanaka N, Sasaki H, Aoki T, Abe T, Musha H, Morikawa T, Yoshida H, Motoi F, Katayose Y, Shibata C, Unno M.
- Journal Title
  
  Gan To Kagaku Ryoho.
  
  Volume: 40(12) Pages: 2077-2079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2.2013
- Author(s)
  Zhao XQ, Dai CL, Ohnuma S, Liang YJ, Deng W, Chen JJ, Zeng MS, Ambudkar SV, Chen ZS, Fu LW.
- Journal Title
  
  Eur J Pharm Sci.
  
  Volume: 49(3) Issue: 3 Pages: 441-450
- DOI
  10.1016/j.ejps.2013.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease.2013
- Author(s)
  Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M.
- Journal Title
  
  Anticancer Res.
  
  Volume: 33(2) Pages: 685-689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Young-onset peri-anorectal leiomyomatosis: report of a case.2012
- Author(s)
  Toshima M, Miura K, Ishida K, Mizoi T, Naitoh T, Ogawa H, Ohnuma S, Sasaki H, Watanabe K, Haneda S, Sase T, Kajiwara T, Matsuda Y, Shibata C, Sasaki I.
- Journal Title
  
  Surg Today
  
  Volume: 43(3) Issue: 3 Pages: 329-334
- DOI
  10.1007/s00595-012-0201-1
- NAID
  10031168013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Journal Article] Runt-related transcription factor 2 in human colon carcinoma: A potent prognostic factor associated with estrogen receptor.2012
- Author(s)
  Sase T
- Journal Title
  
  Int. J. Cancer
  
  Volume: 131 Issue: 10 Pages: 2284-2293
- DOI
  10.1002/ijc.27525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390254, KAKENHI-PROJECT-23650629, KAKENHI-PROJECT-24591895
[Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma.2012
- Author(s)
  Suzuki H, Ogawa H, Miura K, Haneda S, Watanabe K, Ohnuma S, Sasaki H, Sase T, Kimura S, Kajiwara T, Komura T, Toshima M, Matsuda Y, Shibata C, Sasaki I.
- Journal Title
  
  Oncol Lett.
  
  Volume: 4(2) Pages: 199-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 大腸癌切除検体を用いたトランスレーショナル研究～癌関連線維芽細胞とオルガノイド～2022
- Author(s)
  唐澤秀明，相澤卓，平嶋倫亮，田山穂高，市川英孝，小林実，梶原大輝，山村明寛，神山篤史，渡辺和宏，森川孝則，石田孝宣，亀井尚，大沼忍，海野倫明
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] 癌関連繊維芽細胞はWntシグナル経路を介して大腸癌におけるリンパ行性転移に関与する2022
- Author(s)
  唐澤秀明，村上圭吾, 相澤卓, 平嶋倫亮, 三浦康, 佐々木宏之小野智之, 小林実, 梶原大輝, 亀井尚, 大沼忍, 海野倫明
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] 大腸癌におけるERK阻害薬感受性とMAPK経路遺伝子変異の関連性2021
- Author(s)
  田山穂高，唐澤秀明，山村明寛，梶原大輝，小林実，椎原正尋，島田宗昭，古川徹，亀井尚，大沼忍，海野倫明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] 大腸癌同所移植モデルにおける癌関連線維芽細胞のWnt2発現はリンパ節転移と関連する2021
- Author(s)
  唐澤秀明，三浦康，佐々木宏之，小林実，梶原大輝，亀井尚，大沼忍，海野倫明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09188
[Presentation] インドール化合物による炎症性発癌抑制メカニズムの解明2021
- Author(s)
  大沼　忍、金原圭吾、唐澤秀明、市川英孝、小林　実、梶原大輝、神山篤史、渡辺和宏、田山穂高、杉沢徳彦、土屋堯裕、井本博文、山村明寛、田中直樹、森川孝則、亀井　尚、阿部高明、海野倫明
- Organizer
  第76回日本大腸肛門病学会学術集会ワークショップ
- Data Source
  KAKENHI-PROJECT-20K09026
[Presentation] Elucidation of mechanism that an indole compound attenuates colitis associated cancer2020
- Author(s)
  大沼　忍、金原圭吾、海野倫明
- Organizer
  第28回日本消化器病関連週間（神戸）
- Data Source
  KAKENHI-PROJECT-20K09026
[Presentation] Stage IV大腸癌の外科治療戦略2017
- Author(s)
  大沼忍, 唐澤秀明, 渡辺和宏, 工藤克昌, 阿部友哉, 長尾宗紀, 武者宏昭, 元井冬彦, 内藤剛, 海野倫明
- Organizer
  第72回日本消化器外科学会総会（金沢）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] SURGICAL TREATMENTS FOR PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS (FAP); A SINGLE-INSTITUTE EXPERIENCE2017
- Author(s)
  Ohnuma S, Karasawa H, Watanabe K, Suzuki H, Imoto H, Aoki T, Kudoh K, Tanaka N, Nagao M, Musha H, Motoi F, Kamei T, Naitoh T, Unno M.
- Organizer
  IASGO World Congress (Lyon, France)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 規合成クルクミン誘導体における抗癌剤耐性ABCトランスポーターの抑制効果2017
- Author(s)
  村上恵, 大沼忍, 工藤克昌, 石田晶玄, 岩渕好治, 柴田浩行, 林洋毅, 元井冬彦, 内藤剛, 海野倫明
- Organizer
  第76回日本癌学会学術総会（横浜）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 抗癌剤感受性の増強を目指したP-glycoproteinに対する新規抑制剤の開発2017
- Author(s)
  杉沢徳彦, 大沼忍, 村上恵, 海野倫明
- Organizer
  第76回日本癌学会学術総会（横浜）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 直腸神経内分泌腫瘍に対する手術症例の検討2017
- Author(s)
  大沼忍, 唐澤秀明, 渡辺和宏, 鈴木秀幸, 井本博文, 青木豪, 工藤克昌, 田中直樹, 長尾宗紀, 武者宏昭, 内藤剛, 海野倫明
- Organizer
  第72回日本大腸肛門病学会学術集会（福岡）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 原発性小腸癌に対する化学療法の現況2017
- Author(s)
  大沼忍, 唐澤秀明, 渡辺和宏, 鈴木秀幸, 井本博文, 青木豪, 工藤克昌, 田中直樹, 長尾宗紀, 武者宏昭, 元井冬彦, 内藤剛, 海野倫明
- Organizer
  第55回日本癌治療学会学術集会（横浜）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 遠隔転移を有する大腸癌に対する外科治療戦略2017
- Author(s)
  大沼忍, 唐澤秀明, 渡辺和宏, 土屋堯裕, 井本博文, 青木豪, 工藤克昌, 石田晶玄, 田中直樹, 長尾宗紀, 阿部友哉, 武者宏昭, 中川圭, 林洋毅, 森川孝則, 元井冬彦, 内藤剛, 海野倫明
- Organizer
  第117回日本外科学会定期学術集会（横浜）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 家族性大腸腺腫症に対する腹腔鏡下大腸全摘術2017
- Author(s)
  大沼忍, 渡辺和宏, 長尾宗紀, 唐澤秀明, 井本博文, 青木豪, 工藤克昌, 田中直樹, 武者宏昭, 亀井尚, 内藤剛, 海野倫明
- Organizer
  第30回日本内視鏡外科学会総会（京都）
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 大腸癌up-to-date2017
- Author(s)
  大沼忍
- Organizer
  大腸癌東北Webセミナー（仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 局所再発、再発直腸癌に対する外科治療2015
- Author(s)
  大沼　忍
- Organizer
  第13回山形骨盤外科研究会
- Place of Presentation
  山形
- Year and Date
  2015-01-24
- Invited
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Single-nucleotide polymorphisms of DPYD predict adverse events associated with 5-fluorouracil in patients with gastrointestinal cancer2015
- Author(s)
  Shinobu Ohnuma, Masahide Toshima, Koh Miura, Katsuyoshi Kudoh, Masaharu Ishida, Hiroaki Musha, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno
- Organizer
  ESMO-Asia
- Place of Presentation
  Singapore, Singapre
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10128
[Presentation] 進化する大腸がん治療2014
- Author(s)
  大沼　忍
- Organizer
  第6回元気健康フェアinとうほく
- Place of Presentation
  仙台
- Year and Date
  2014-04-06
- Invited
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 直腸GISTの治療戦略2013
- Author(s)
  大沼忍, 内藤剛, 佐々木宏之, 長尾宗紀, 羽根田祥, 工藤克昌, 神山篤史, 柴田近, 海野倫明
- Organizer
  第68日本大腸肛門病学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 大腸癌化学療法　東北大学病院での取り組み2013
- Author(s)
  大沼忍
- Organizer
  第62回日本農村医学会学術総会
- Place of Presentation
  福島
- Invited
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 結腸癌に対する腹腔鏡下結腸切除術における腹部手術既往の影響2013
- Author(s)
  大沼忍, 内藤剛, 阿部友哉, 佐々木宏之, 神山篤史, 羽根田祥, 工藤克昌, 長尾宗紀, 青木豪, 田中直樹, 武者宏昭, 森川孝則, 片寄友, 柴田近, 海野倫明
- Organizer
  第26回日本内視鏡外科学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 直腸神経内分泌腫瘍に対する治療方針2013
- Author(s)
  大沼忍, 内藤剛, 阿部友哉, 長尾宗紀, 羽根田祥, 佐々木宏之, 神山篤史, 森川孝則, 笠島敦子, 片寄友, 柴田近, 海野倫明
- Organizer
  第1回神経内分泌腫瘍研究会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Analysis of the single nucleotide polymorphisms of the DPYD gene that affect adverse events in 5-FU treated patients2013
- Author(s)
  Masahide Toshima, Shinobu Ohnuma, Koh Miura, Michihiro Tanaka, Hiroaki Mush, Sho Haneda, Katsuyoshi Kudo, Atsushi Kohyama, Munenori Nagao, Takeshi Naitoh, Yu Katayose, Chikashi Shibata, Michiaki Unno
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 直腸カルチノイド手術症例の検討2013
- Author(s)
  大沼忍, 三浦康, 内藤剛, 羽根田祥, 工藤克昌, 長尾宗紀, 田中直樹, 佐々木宏之, 鹿郷昌之, 森川孝則, 鈴木秀幸, 梶原大輝, 戸嶋政秀, 小村俊博, 松田泰史, 染谷崇徳, 吉田寛, 元井冬彦, 片寄友, 柴田近, 海野倫明
- Organizer
  第113回日本外科学会定期学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Stage IV大腸癌手術例における長期生存例の特徴2013
- Author(s)
  大沼忍, 内藤剛, 阿部友哉, 長尾宗紀, 羽根田祥, 佐々木宏之, 神山篤史, 片寄友, 柴田近, 海野倫明
- Organizer
  第51日本癌治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] ステージIV大腸癌の細分類および治療戦略 StageIV大腸癌の長期生存例の解析に基づく治療戦略2013
- Author(s)
  大沼忍, 三浦康, 内藤剛, 佐々木宏之, 羽根田祥, 渡辺和宏, 松田泰史, 柴田近, 佐々木巖, 海野倫明
- Organizer
  第67回日本消化器外科学会総会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 直腸神経内分泌腫瘍に対する手術症例の検討2013
- Author(s)
  大沼忍, 内藤剛, 羽根田祥, 工藤克昌, 神山篤史, 長尾宗紀, 田中直樹, 佐々木宏之, 森川孝則, 吉田寛, 鹿郷昌之, 元井冬彦, 小川仁, 片寄友, 三浦康, 柴田近, 海野倫明
- Organizer
  第35回日本癌局所療法研究会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Stemofoline is a potent natural product modulator of the multidrug resistance-linked P-glycoprotein (ABCB1)2013
- Author(s)
  Shinobu Ohnuma, Wisinee Chanmahasathien, Koh Miura, Michiaki Unno, Suresh V. Ambudkar, Pornngarm Limtrakul
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 直腸癌局所再発に対する外科治療の功罪2012
- Author(s)
  大沼忍, 三浦康, 内藤剛, 小川仁, 羽根田祥, 渡辺和宏, 佐々木宏之, 佐瀬友彦, 柴田近, 鹿郷昌之, 森川孝則, 田中直樹, 工藤克昌, 鈴木秀幸, 梶原大輝, 戸嶋政秀, 松田泰史, 小村俊博, 海野倫明, 佐々木巖
- Organizer
  第112回日本外科学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 腹腔鏡補助下直腸切除術42症例の検討2012
- Author(s)
  大沼忍, 内藤剛, 鹿郷昌之, 森川孝則, 田中直樹, 佐々木宏之, 長尾宗紀, 羽根田祥, 工藤克昌, 吉田寛, 元井冬彦, 三浦康, 片寄友, 柴田近, 海野倫明
- Organizer
  第25回日本内視鏡外科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 70歳以上高齢者大腸癌に対する経口フッ化ピリミジン製剤による補助化学療法2012
- Author(s)
  大沼忍, 三浦康, 内藤剛, 長尾宗紀, 羽根田祥, 佐々木宏之, 工藤克昌, 鈴木秀幸, 戸嶋政秀, 梶原大輝, 柴田近, 海野倫明
- Organizer
  第67回日本大腸肛門病学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Stemofoline is a potent natural product modulator of the multidrug resistance-linked P-glycoprotein (ABCB1)2012
- Author(s)
  Ohnuma S, Chanmahasathien W, Miura K, Sasaki H, Kajiwara T, Komura T, Toshima M, Matsuda Y, Katayose Y, Shibata C, Unno M、Ambudkar SV, Limtrakul P.
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Stage IV大腸癌の長期生存例の解析に基づく治療戦略2012
- Author(s)
  大沼忍　三浦康　内藤剛　羽根田祥　渡辺和宏　佐々木宏之　松田泰史　柴田近　佐々木巖　海野倫明
- Organizer
  第67回日本消化器外科学会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] Transcriptome analysis of human ABC-transporters in colorectal cancer cell lines and surgically resected cancer tissues
- Author(s)
  Minoru Kobayashi, Shinobu Ohnuma, Ryo Funayama, Michiaki Unno, Keiko Nakayama
- Organizer
  2nd NIH-Japan-JSPS Symposium
- Place of Presentation
  Bethesda, MD, USA
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24591895
[Presentation] 大腸癌に発現する抗癌剤耐性ABCトランスポーターのスプライスバリアント解析
- Author(s)
  小林　実、大沼　忍、　唐沢秀明、他
- Organizer
  第101回日本消化器病学会
- Place of Presentation
  仙台
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-24591895

1. Hideaki Karasawa (30547401)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 内藤剛 (50291258)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. 山村明寛 (30814678)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 阿部高明 (80292209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. MIURA Koh (40282074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
6. MUSHA Hiroaki (30724322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中山啓子 (60294972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 舟山亮 (20452295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 金澤義丈 (60779726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 黒羽正剛 (70709469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小峰啓吾 (10725807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡村容伸 (00837495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐藤岳哉 (10312696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 村上圭吾 (60742707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TANIGUCHI hajime

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TAKAHASHI Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. TAKAHASHI Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. OUCHI Kota

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鈴木貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 古川徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 海野倫明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 石岡千加史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohnuma Shinobu 大沼 忍

OHNUMA Shinobu 大沼 忍

Research Projects

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Co-Researchers

Development of new treatment for colorectal cancer through improvement of mitochondrial function using indole compoundsPrincipal Investigator

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Organoid Culture for Next Generation Personalized Medicine against Colorectal Cancer

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Discovering the novel indole compound to suppress colitis-associated colorectal cancer and basic research for clinical applicationPrincipal Investigator

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Mechanisms of metastasis promoted by cancer associated fibroblast via Wnt signal pathway in colorectal cancer

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Identification of novel microexon involved in the regulation of colorectal cancer

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Pharmacogenomic analysis of biomarker that predict adverse events associated with 5-fluorouracilPrincipal Investigator

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Functional analysis of splicing variants of multidrug-resitant ABC transporters expressed in gastrointestinal cancerPrincipal Investigator

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[Journal Article] Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and Decreasing Their Accumulation2023

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[Journal Article] Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression2021

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[Journal Article] The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer2021

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[Journal Article] Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer2021

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[Journal Article] 腸管型ベーチェット病手術例の長期予後の検討2018

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NAID

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[Journal Article] Endoscopy-Assisted Partial Duodenal Resection for Duodenal Adenoma in a Patient with Familial Adenomatous Polyposis2018

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[Journal Article] A Case of Leiomyosarcoma of the Small Intestine with Intestinal Hemorrhage Due to Intraluminal Penetration2017

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Ohnuma Shinobu 大沼忍

OHNUMA Shinobu 大沼忍