yamaguchi suguru 山口賢

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YAMAGUCHI Suguru 山口賢

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Researcher Number	70451614
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 研究医員
Affiliation (based on the past Project Information) *help	2019: 日本大学, 医学部, 研究医員 2017 – 2018: 日本大学, 医学部, 助教 2011 – 2014: 日本大学, 医学部, 助教 2010: 東北大学, 国際高等研究機構, 助教 2008: Tohoku University, 国際高等研究教育機構, 助教 … More 2008: 東北大学, 国際高等融合領域研究所, 助教授 2007: Tohoku University, 国際高等研究機構, 助教 2007: 東北大学, 国際高等融合領域研究所, 助教 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Metabolomics / Endocrinology Except Principal Investigator Metabolomics / Pathological medical chemistry
Keywords	Principal Investigator 小胞体ストレス / 膵β細胞 / 糖尿病 / 低酸素 / インスリン分泌 / Chrono遺伝子 / 時計遺伝子 / 膵β細胞障害 / DPP-4阻害薬 / ATF6α … More / 4E-BP1 / 翻訳制御機構 / 分子生物学 / 翻訳抑制機構 … More Except Principal Investigator 膵ランゲルハンス島 / シグナル伝達 / 膵島 / 糖尿病 / スルホニル尿素薬 / インスリン / 膵α細胞 / メトホルミン / DPP-4阻害薬 / スルホニル尿素受容体 / インクレチン / グルカゴン / インスリン抵抗性 / 炎症 / 酸化ストレス / 小胞体ストレス / 動脈硬化 Less

Functional analysis of novel ER stress related proteinPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Suguru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
- Principal Investigator
  
  ISHIHARA Hisamitsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Nihon University
the molecular mechanism of ER stress response in pancreatic beta cells : type 2 diabetsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Suguru
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Nihon University
  Tohoku University
Involvement of CHOP in Arteriosclerosis Acceleration with Augmented Biological Stress Responses
- Principal Investigator
  
  ISHIGAKI Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
Molecular mechanisms of pancreaticβ-cell failure and insulin resistance due to impaired ER stress response
- Principal Investigator
  
  ISHIHARA Hisamitsu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Nihon University
The molecular mechanisms of transcriptional and translational control of stress responses in pancreatic β cells
- Principal Investigator
  
  ISHIHARA Hisamitsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
  Tohoku University
stress signaling dysfunction of pancreatic beta-cells caused by insulin resistance in Type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Suguru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University

All 2019 2018 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book Other

[Book] WFS1 Protein (wolframin): Emerging Link between the Emotional Brain and Endocrine Pancreas. (Chapter 3. Role of endoplasmic reticulum stress in pancreatic β cell loss in WFS1-deficient mice) (Koks and Vasar ed.)2009
- Author(s)
  Ishihara H, Yamaguchi S, Yamada T, Tamura A, Oka Y
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-19590300
[Book] WFS1 Protein (wolframin): Emerging Link between the Emotional Brain and Endocrine Pancreas. (Chapter 2. Progressive β cell loss and defective) (Koks and Vasar ed.)2009
- Author(s)
  Ishihara H, Takeda S, Tamura A, Takahashi R, Yamaguchi S, Takei D, Yamada T, Inoue H, Tanizawa Y, Oka Y
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-19590300
[Book] 日本臨床増刊号新時代の糖尿病学(1)巻2008
- Author(s)
  山口賢、石原寿光、岡芳知
- Total Pages
  5
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-19890018
[Book] 糖尿病カレントライブラリー(7) 脂肪細胞と脂肪組織2007
- Author(s)
  山口賢、石原寿光、岡芳知
- Total Pages
  4
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19890018
[Journal Article] Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control <i>via</i> different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes2015
- Author(s)
  Otsuka Y, Yamaguchi S, Furukawa A, Kosuda M, Nakazaki M, Ishihara H.
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 2 Pages: 133-143
- DOI
  10.1507/endocrj.EJ14-0148
- NAID
  130004699224
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591343
[Journal Article] Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy With Islet Autotransplantation.2013
- Author(s)
  Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
- Journal Title
  
  Transplantation
  
  Volume: 96(5) Issue: 5 Pages: e38-e40
- DOI
  10.1097/tp.0b013e3182a01333
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-23390310, KAKENHI-PROJECT-24591107, KAKENHI-PROJECT-24591343, KAKENHI-PROJECT-24659439, KAKENHI-PROJECT-24659582, KAKENHI-PROJECT-25253067
[Journal Article] Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance2012
- Author(s)
  M.Usui, S.Yamaguchi, Y.Tanji, R.Tominaga, Y.Ishigaki, M.Fukumoto, H.Katagiri, K.Mori, Y.Oka, H.Ishihara
- Journal Title
  
  Metabol
  
  Volume: (in press) Issue: 8 Pages: 1118-28
- DOI
  10.1016/j.metabol.2012.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058009, KAKENHI-PROJECT-21591147, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-24591343, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659439
[Journal Article] Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance2012
- Author(s)
  Masahiro Usui, Suguru Yamaguchi, Yasuhiro Tanji, Ryu Tominaga, Yasushi Ishigaki, Manabu Fukumoto, Hideki Katagiri, Kazutoshi Mori, Yoshitomo Oka, Hisamitsu Ishihara
- Journal Title
  
  Metabolism
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22790842
[Journal Article] Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses2011
- Author(s)
  Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
- Journal Title
  
  Circulation
  
  Volume: 124(7) Pages: 830-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591122
[Journal Article] The JNK pathway modulates expression and phosphorylation of the translational suppressor 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions2010
- Author(s)
  Tominaga R, Yamaguchi S, Satake C, Usui M, Tanji Y, Kondo K, Katagiri H, Oka Y, Ishihara H
- Journal Title
  
  Cell Biochem Funct
  
  Volume: 28 Issue: 5 Pages: 387-393
- DOI
  10.1002/cbf.1667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591147, KAKENHI-PROJECT-22790842
[Journal Article] The JNK pathway modulates expression and phosphorylation of the translational suppressor 4E-BP1 in MIN6 pancreatic β-cells under oxidative stress conditions2010
- Author(s)
  Ryu Tominaga, Suguru Yamaguchi, Chihiro Satake, Masahiro Usui, Yasuhiro Tanji, Keiichi Kondo, Hideki Katagiri, Yoshitomo Oka, Hisamitsu Ishihara
- Journal Title
  
  cell biochemistry and function
  
  Volume: 28(5) Pages: 387-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790842
[Journal Article] ATF4-mediated induction of 4E-BP1 contributes to pancreatic β cell survival under endoplasmic reticulum stress2008
- Author(s)
  山口賢, 石原寿光, 山田高広, 田村明, 薄井正寛, 富永竜, 宗像佑一郎, 佐竹千尋, 片桐秀樹, 田代文, 油谷浩幸, 小原恭子, 宮崎純一, Nahum Sonenberg, 岡芳知
- Journal Title
  
  Cell Metabolism 7
  
  Pages: 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590300
[Journal Article] The Translational Repressor 4E-BP1 is Induced by ATF4 and Plays a Role in Maintaining Pancreatic β Cell Homeostasis under Endoplasmic Reticulum Stress2008
- Author(s)
  Suguru Yamaguchi, Hisamitsu Ishihara, Takahiro Yamada, Akira Tamura, Masahiro Usui, Ryu Tominaga, Yuichiro Munakata, Chihiro Satake, Hideki Katagiri, Fumi Tashiro, Hiroyuki Aburatani, Kyoko Tsukiyama-Kohara, Jun-ichi Miyazaki, Nahum Sonenberg and Yoshitom Oka
- Journal Title
  
  Cell Metabolism 7(3)
  
  Pages: 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890018
[Journal Article] ATF4-mediated induction of 4E-BP1 contributes to pancreatic β cell survival under endoplasmic reticulum stress2008
- Author(s)
  Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y
- Journal Title
  
  Cell Metab 7
  
  Pages: 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590300
[Journal Article] Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
- Author(s)
  Masahiro Usui, Suguru Yamaguchi Yasuhiro Tanji, Ryu Tominaga, Yasushi Ishigaki, Manabu Fukumoto, Hideki Katagiri, Kazutoshi Mori, Yoshitomo Oka, Hisamitsu Ishihara
- Journal Title
  
  Metabolism
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] 膵β細胞におけるChrono遺伝子の機能解析2019
- Author(s)
  山口賢、石原寿光
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08673
[Presentation] 膵β細胞におけるChrono遺伝子の機能解析2019
- Author(s)
  山口賢、長澤瑛子、山名碧、小須田南、石原寿光
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08673
[Presentation] インスリン分泌におけるCITED4の機能解析2018
- Author(s)
  山口　賢
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08673
[Presentation] 2型糖尿病患者における血漿グルカゴン値の新規ELISA法と従来型RIA法を用いた測定の比較検討2014
- Author(s)
  山口賢，小須田南，田中彩，古川麻美，大塚雄一郎，中崎満浩，石原寿光
- Organizer
  第15回日本内分泌学会関東甲信越支部学術集会
- Place of Presentation
  ラフレさいたま（埼玉県・さいたま市）
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Modulation of glucagon and insulin secretion by DPP-4 and DPP-4 inhibitors2014
- Author(s)
  Yamaguchi S, Otsuka Y, Ishihara H
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Sitagliptin improves blood glucose control by suppressing glucagon secretion in insulin-treated type 2 diabetic patients2013
- Author(s)
  Otsuka Y，Kosuda M，Ueno N，Yamaguchi S，Nakazaki M，Ishihara H
- Organizer
  The 49th European Association for Study of Diabetes Annual Meeting.
- Place of Presentation
  Balcerona, Spain
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] グルコース応答性インスリノーマの一例2013
- Author(s)
  古川麻美，山口賢，江頭富士子，大塚雄一郎，大川原奈々，東海林忍，岡本真由美，中崎満浩，石原寿光
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] グルコース反応性インスリンノーマの一例2013
- Author(s)
  古川麻美，大川原奈々，上野のぶ子，大塚雄一郎，東海林忍，山口賢，江頭富士子，岡本真由美，中崎満浩，武市奈緒美，杉原仁，内田英二，及川眞一，石原寿光
- Organizer
  第56回日本糖尿病学会総会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Zinc regulates insulin secretion through interaction with histidine residues of SUR1.2013
- Author(s)
  Ishihara H，Otsuka Y，Yamaguchi S，Hurukawa A，Nakazaki M.
- Organizer
  The 73nd Scientific sessions of American Diabetes Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Regulation of islet hormone secretion by intracellular and intercellular mechanisms2012
- Author(s)
  Ishihara H, Yamaguchi S, Otsuka Y, Furukawa A, Nakazaki M
- Organizer
  The 9th Iinternational Diabete Fedeation Western Pacific Region Congress
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] WFS1遺伝子欠損マウスにおけるDPP-4阻害薬(vildagliptin)の膵β細胞保護効果の検討2011
- Author(s)
  丹治泰裕、山口賢、薄井正寛、冨永竜、近藤敬一、、石垣泰、岡芳知、片桐秀樹、石原寿光
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] GLP-1 exerts a protective role in pancreatic β-cells with WFS1-deficiency2011
- Author(s)
  Suguru Yamaguchi, Yasuhiro Tanji, Masahiro Usui, Ryu Tominaga, Keiichi Kondo, Yasushi Ishigaki, Hideki Katagiri, Yoshitomo Oka, Hisamitsu Ishihara
- Organizer
  the 47th EASD Annual Meeting
- Place of Presentation
  Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] ATF6α欠損マウスを用いた、ATF6α欠損が耐糖能に与える影響についての検討2011
- Author(s)
  薄井正寛、石原寿光、鈴木千登世、山口賢、、石垣泰、福本学、森和俊、岡芳知、片桐秀樹
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] GLP-1 exerts a protective role in pancreatic β-cells with WFS1-deficiency2011
- Author(s)
  Suguru Yamaguchi, Yasuhiro Tanji, Masahiro Usui, Ryu Tominaga, Keiichi Kondo, Yasushi Ishigaki, Hideki Katagiri, Yoshitomo Oka, Hisamitsu Ishihara
- Organizer
  The 47th EASD Annual Meeting
- Place of Presentation
  Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] ATF6α欠損マウスを用いた、ATF6α欠損が耐糖能に与える影響についての検討2010
- Author(s)
  薄井正寛、石原寿光、鈴木千登世、山口賢、石垣泰、福本学、森和俊、岡芳知、片桐秀樹
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] 新規小胞体ストレス蛋白・CRELD2の蛋白特性についての検討2010
- Author(s)
  山口賢、石原寿光、宗像佑一郎、佐竹千尋、薄井正寛、冨永竜、丹治泰裕、鈴木千登世、石垣泰、山田哲也、檜尾好徳、片桐秀樹、岡芳知
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] WFS1遺伝子欠損マウスに発表演目おけるDPP-4阻害薬(ビルダグリプチン)の膵β細胞保護効果の検討2010
- Author(s)
  丹治泰裕、山口賢、薄井正寛、冨永竜、近藤敬一、石垣泰、片桐秀樹、岡芳知、石原寿光
- Organizer
  第22回分子糖尿病学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] 新規小胞体ストレス蛋白CRELD2の蛋白特性についての検討2010
- Author(s)
  山口賢
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山市
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21591147
[Presentation] 膵β細胞における小胞体ストレス応答と酸化ストレス応答のクロストーク2010
- Author(s)
  冨永竜、石原寿光、山口賢、佐竹千尋、薄井正寛、丹治泰裕、鈴木千登世、石垣泰、山田哲也、檜尾好徳、片桐秀樹、岡芳知
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] 動脈硬化発症・進展におけるWFS1の役割の検討2010
- Author(s)
  高俊弘、片桐秀樹、石垣泰、石原寿光、山田哲也、今井淳太、澤田正二郎、宇野健司、長谷川豊、山口賢、金子慶三、鈴木俊伸、齋藤徳郎、突田壮平、近藤敬一、高橋圭、檜尾好徳、岡芳知
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22790842
[Presentation] 新規小胞体ストレス蛋白・CRELD2の蛋白特性についての検討2010
- Author(s)
  山口賢
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山市
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21591147
[Presentation] 翻訳抑制因子4E-BP1は、慢性的な小胞体ストレス下の膵β細胞において、翻訳抑制を介して細胞を保護する2008
- Author(s)
  山口賢
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-19890018
[Presentation] 膵β細胞小胞体ストレス応答における翻訳抑制因子4E-BP1の役割2008
- Author(s)
  石原寿光、山田高弘、山口賢、冨永竜、宗像佑一郎、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第81回日本内分泌学会学術集会
- Place of Presentation
  青森市
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 膵β細胞量の調節におけるmRNA 翻訳制御の役割2008
- Author(s)
  石原寿光、山口賢、薄井正寛、冨永竜、岡芳知
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 翻訳抑制因子4E-BP1は小胞体ストレス応答転写因子ATF4の直接のターゲットである2008
- Author(s)
  佐竹千尋、石原寿光、田村明、山田高弘山口賢、冨永竜、宗像佑一郎、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 膵β細胞ストレス応答における翻訳制御の役割2008
- Author(s)
  山口賢
- Organizer
  第20回分子糖尿病学シンポジウム
- Place of Presentation
  東京カンファレンスセンター品川
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-19890018
[Presentation] 膵β細胞における小胞体ストレス応答と酸化ストレス応答の特徴2008
- Author(s)
  富永竜、石原寿光、山田高弘、山口賢、宗像佑一郎、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 翻訳抑制因子4E-BP1は、慢性的な小胞体ストレス下の膵β細胞において翻訳抑制を介して細胞を保護する2008
- Author(s)
  山口賢、石原寿光、田村明、山田高弘、冨永竜、宗像佑一郎、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] Transcription factor TFII-I binds to WFS1 protein and dissociates in response to endoplasmic reticulum stress.2007
- Author(s)
  山口賢, 石原寿光, 岡芳知
- Organizer
  The 67th scientific sessions of American Diabetes Association
- Place of Presentation
  Chicago
- Year and Date
  2007-06-23
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] Transcription factor TFII-I binds to WFS1 protein and dissociates in response to endoplasmic reticulum stress2007
- Author(s)
  Yamaguchi S, Ishihara H, Oka Y
- Organizer
  The 67th scientific sessions of American Diabetes Association
- Place of Presentation
  Chicago
- Year and Date
  2007-06-23
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 膵β細胞特異的小胞体ストレス応答の検討2007
- Author(s)
  宗像佑一郎、石原寿光、田村明、山田高弘、山口賢、佐竹千尋、薄井正寛、冨永竜、檜尾好徳、荻原健英、片桐秀樹、岡芳知
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 翻訳抑制因子4E・BP1の欠損は、小胞体ストレスによる細胞障害を悪化させる2007
- Author(s)
  山口賢
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台サンプラザ
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19890018
[Presentation] 翻訳抑制因子4E-BP1の欠損は、小胞体ストレスによる細胞障害を悪化させる2007
- Author(s)
  山口賢
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台サンプラザ
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19890018
[Presentation] 翻訳抑制因子4E-BP1の欠損は、小胞体ストレスによる膵β細胞障害を悪化させる2007
- Author(s)
  山口賢, 石原寿光, 田村明, 山田高弘, 佐竹千尋, 薄井正寛, 冨永竜, 檜尾好徳, 荻原健英, 鈴木進, 片桐秀樹, 岡芳知
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 翻訳抑制因子4E-BP1の欠損は小胞体ストレスによる膵β細胞障害を悪化させる2007
- Author(s)
  山口賢、石原寿光、田村明、山田高弘、佐竹千尋、薄井正寛、冨永竜、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 膵β細胞における小胞体ストレスによる翻訳抑制因子4E-BP1発現誘導機構2007
- Author(s)
  薄井正寛、佐竹千尋、石原寿光、田村明、山田高弘、山口賢、冨永竜、宗像佑一郎、檜尾好徳、荻原健英、鈴木進、片桐秀樹、岡芳知
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PROJECT-19590300
[Presentation] 腹部症状を契機に発症した抗インスリン抗体比較的強陽性の劇症1型糖尿病の1例
- Author(s)
  小須田南，岡本真由美, 荒井秀仁, 東海林忍, 山口賢, 江頭富士子, 石原寿光
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] DPP-4阻害薬とSU薬による遷延性低血糖に対してオクトレオチド投与が奏効した症例
- Author(s)
  古川麻美，山口賢, 池島碧, 田中彩, 上野のぶ子, 東海林忍, 江頭富士子, 岡本真由美, 吉田好徳, 阿部雅紀, 石原寿光
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Modulation of glucagon and insulin secretion by DPP-4 and DPP-4 inhibitors
- Author(s)
  Yamaguchi S, Otsuka Y, Ishihara H
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-24591343
[Presentation] Generation of a MIN6 beta-cell clone horboring platform for introduction of an inducible expression unit by recombinase-mediated cassette exchange
- Author(s)
  Ishihara H, Furukawa A, Tanaka A, Otsuka Y, Yamaguchi S
- Organizer
  The 74th Scientific Sessions of American Diabetes Association
- Place of Presentation
  San Francisco （USA）
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-24591343
[]

1. ISHIHARA Hisamitsu (60361086)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. OKAMOTO Mayumi (80349993)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. ISHIGAKI Yasushi (50375002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. GAO Junhong (70455781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SAWADA Shoujirou (60509420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SAGAWA Chigako (30459896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 片桐秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 森和俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yamaguchi suguru 山口 賢

YAMAGUCHI Suguru 山口 賢

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Functional analysis of novel ER stress related proteinPrincipal Investigator

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Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs

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the molecular mechanism of ER stress response in pancreatic beta cells : type 2 diabetsPrincipal Investigator

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Involvement of CHOP in Arteriosclerosis Acceleration with Augmented Biological Stress Responses

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Molecular mechanisms of pancreaticβ-cell failure and insulin resistance due to impaired ER stress response

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The molecular mechanisms of transcriptional and translational control of stress responses in pancreatic β cells

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stress signaling dysfunction of pancreatic beta-cells caused by insulin resistance in Type 2 diabetesPrincipal Investigator

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[Book] WFS1 Protein (wolframin): Emerging Link between the Emotional Brain and Endocrine Pancreas. (Chapter 3. Role of endoplasmic reticulum stress in pancreatic β cell loss in WFS1-deficient mice) (Koks and Vasar ed.)2009

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[Book] WFS1 Protein (wolframin): Emerging Link between the Emotional Brain and Endocrine Pancreas. (Chapter 2. Progressive β cell loss and defective) (Koks and Vasar ed.)2009

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[Book] 日本臨床増刊号新時代の糖尿病学(1)巻2008

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[Book] 糖尿病カレントライブラリー(7) 脂肪細胞と脂肪組織2007

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[Journal Article] Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control <i>via</i> different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes2015

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[Journal Article] Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy With Islet Autotransplantation.2013

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[Journal Article] Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance2012

Author(s)

yamaguchi suguru 山口賢

YAMAGUCHI Suguru 山口賢