Ohtawa Masaki 大多和正樹

… Alternative Names

OHTAWA Masaki 大多和正樹

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Researcher Number	70453503
Other IDs
Affiliation (Current)	2025: 立教大学, 理学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 北里大学, 薬学部, 准教授 2018: 北里大学, 薬学部, 講師 2014 – 2015: 北里大学, 薬学部, 講師 2009 – 2013: Kitasato University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry
Keywords	Principal Investigator 天然有機化合物 / 創薬化学 / 有機合成化学 / 構造活性相関 / 全合成 / 天然物合成 / ラジカル / 反応開発 / ブテノリド / ラジカル反応 … More / 活性増強剤 / アムホテリシンB / 活性増強物質 / 天然物合成化学 / 化合物設計 / ACAT2選択的阻害剤 / 合成化学 / 天然物化学 / ACAT / complex II / 天然物 / 生理活性物質 Less

ブテノリド特有の極性/ラジカル反応を駆使した天然物の革新的全合成研究Principal Investigator
- Principal Investigator
  
  大多和正樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Development of new reactions using the properties of butenolide and the synthetic study on gibberellinsPrincipal Investigator
- Principal Investigator
  
  Ohtawa Masaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Development of amphotericin B potenciators based on novel natural productsPrincipal Investigator
- Principal Investigator
  
  Ohtawa Masaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Design, synthesis and biological evaluation of pyripyropene A truncated analogs as ACAT2 selective inhibitorPrincipal Investigator
- Principal Investigator
  
  Ohtawa Masaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Structure-activity relationship of atpenin A5 derivatives as complex II selective inhibitorsPrincipal Investigator
- Principal Investigator
  
  OHTAWA Masaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Synthesis and structure activity relationship of atpenin A5 derivatives as complex II inhibitorsPrincipal Investigator
- Principal Investigator
  
  OHTAWA Masaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University

All 2023 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Concise syntheses of (-)-habiterpenol and (+)-2,3-epi-habiterpenol via redox radical cyclization of alkenylsilane2023
- Author(s)
  Taguchi Haruki、Kawaguchi Mayuko、Nagamitsu Tohru、Ohtawa Masaki
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 21 Issue: 30 Pages: 6129-6133
- DOI
  10.1039/d3ob01062g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06481
[Journal Article] Comprehensive Studies on the Synthetic Organic Chemistry of Unique Bioactive Natural Products; Total Synthesis, Drug Discovery, and Development of New Reactions2022
- Author(s)
  Ohtawa Masaki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 142 Issue: 10 Pages: 1067-1075
- DOI
  10.1248/yakushi.22-00118
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2022-10-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06481
[Journal Article] Synthesis and Evaluation of Habiterpenol Analogs2022
- Author(s)
  Konya Miyuki、Arima Shiho、Lee Daiki、Ohtawa Masaki、Shimoyama Kenta、Fukuda Takashi、Uchida Ryuji、Tomoda Hiroshi、Yamaotsu Noriyuki、Tanaka Nobutada、Nagamitsu Tohru
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 4 Pages: 261-268
- DOI
  10.1248/cpb.c21-00993
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06481
[Journal Article] Concise Syntheses of (−)-11-O-Debenzoyltashironin and (−)-Bilobalide2022
- Author(s)
  Ohtawa Masaki、Shenvi Ryan A.
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 8 Pages: 766-777
- DOI
  10.5059/yukigoseikyokaishi.80.766
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06481
[Journal Article] Mixture of clopidogrel bisulfate and magnesium oxide tablets reduces clopidogrel dose administered through a feeding tube2021
- Author(s)
  Aoki M, Naya M, Arima S, Shinohara K, Kato M, Shibuya K, Ohtawa M, Nagamitsu T, Otori K
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 7:18 Issue: 1 Pages: 1-8
- DOI
  10.1186/s40780-021-00202-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20716, KAKENHI-PROJECT-21K06481
[Journal Article] One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping2021
- Author(s)
  Yamane Daichi、Tanaka Haruna、Hirata Akihiro、Tamura Yumiko、Takahashi Daichi、Takahashi Yusuke、Nagamitsu Tohru、Ohtawa Masaki
- Journal Title
  
  Organic Letters
  
  Volume: 23 Issue: 7 Pages: 2831-2835
- DOI
  10.1021/acs.orglett.1c00840
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06554, KAKENHI-PROJECT-21K06481
[Journal Article] Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (?)-Bilobalide2020
- Author(s)
  Demoret Robert M.、Baker Meghan A.、Ohtawa Masaki、Chen Shuming、Lam Ching Ching、Khom Sophia、Roberto Marisa、Forli Stefano、Houk Kendall N.、Shenvi Ryan A.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 43 Pages: 18599-18618
- DOI
  10.1021/jacs.0c08231
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06554
[Journal Article] Repair of DNA damage induced by the novel nucleoside analogue CNDAG through homologous recombination2020
- Author(s)
  Liu Xiaojun、Jiang Yingjun、Nowak Billie、Ichikawa Satoshi、Ohtawa Masaki、Matsuda Akira、Plunkett William
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 85 Issue: 4 Pages: 661-672
- DOI
  10.1007/s00280-020-04035-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06554
[Journal Article] Total Synthesis and Absolute Configuration of Simpotentin, a Potentiator of Amphotericin B Activity2019
- Author(s)
  Ohtawa Masaki、Shimizu Eri、Saito Atsushi、Sakamoto Sayuri、Waki Ai、Kondo Ariko、Yagi Akiho、Uchida Ryuji、Tomoda Hiroshi、Nagamitsu Tohru
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 14 Pages: 5596-5599
- DOI
  10.1021/acs.orglett.9b01945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06554
[Journal Article] Design and synthesis of A-ring truncated analogs as potent ACAT2 selective inhibitors2015
- Author(s)
  Ohtawa, M.; Omura, S.; Tomoda, H.; Nagamitsu, T
- Journal Title
  
  MEDCHEMNEWS
  
  Volume: 3 Pages: 25-31
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460152
[Journal Article] New pyripyropene derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse model.2015
- Author(s)
  Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 355 Issue: 2 Pages: 299-309
- DOI
  10.1124/jpet.115.227348
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26253009
[Journal Article] Design, synthesis and biological evaluation of air-stable nafuredin-γ analogs as complex II inhibitors.2015
- Author(s)
  Ohtawa, M.; Matsunaga, M.; Fukunaga, K.; Shimizu, R.; Shimizu, E.; Arima, S.; Ohmori, J.; Kita, K.; Shiomi, K.; Omura, S.; Nagamitsu. T.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 5 Pages: 932-943
- DOI
  10.1016/j.bmc.2015.01.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013
[Journal Article] Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives2015
- Author(s)
  D. Yamamuro, R. Uchida, M. Ohtawa, S. Arima, Y. Futamura, M. Katane, H. Homma, T. Nagamitsu, H. Osada, H. Tomoda
- Journal Title
  
  Bioorg. Medic. Chem. Lett.
  
  Volume: 25 Issue: 2 Pages: 313-316
- DOI
  10.1016/j.bmcl.2014.11.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013
[Journal Article] In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.2015
- Author(s)
  Ohshiro, T.; Matsuda, D.; Ohtawa, M.; Yamazaki, H.; Nagamitsu. T.; Tomoda, H.
- Journal Title
  
  J. Antibiot. 2015, 25, 313-316.
  
  Volume: 68 Issue: 1 Pages: 27-34
- DOI
  10.1038/ja.2014.91
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013, KAKENHI-PROJECT-26253009
[Journal Article] Regioselective mono-deprotection of di-tert-butylsilylene acetal derived from 1,3-diol with ammonium fluoride2014
- Author(s)
  Ohtawa, M.; Tomoda, H.; Nagamitsu. T.
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 87 Issue: 1 Pages: 113-118
- DOI
  10.1246/bcsj.20130237
- NAID
  130004153261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152
[Journal Article] Structure-Activity Relationship Study and Total Synthesis of Pyripyropene A as a Potent ACAT2-Selective Inhibitor2013
- Author(s)
  Ohtawa, M.; Omura, S.; Tomoda, H.; Nagamitsu, T.
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 71 Issue: 8 Pages: 830-843
- DOI
  10.5059/yukigoseikyokaishi.71.830
- NAID
  10031191019
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152
[Journal Article] Synthesis and Structure-Activity Relationship of Pyripyropene A Derivatives as Potent and Selective Acyl-CoA:cholesterol Acyltransferase 2 (ACAT2) Inhibitors: Part 22013
- Author(s)
  Ohtawa Masaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 9 Pages: 2659-2662
- DOI
  10.1016/j.bmcl.2013.02.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590011, KAKENHI-PROJECT-25460152
[Journal Article] Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 32013
- Author(s)
  Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L. L.; Omura, S.; Tomoda, H.; Nagamitsu. T
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 13 Pages: 3798-3801
- DOI
  10.1016/j.bmcl.2013.04.075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460152
[Journal Article] Synthesis and Structure-Activity Relationship of Pyripyropene A Derivatives as Potent and Selective Acyl-CoA:cholesterol Acyltransferase 2 (ACAT2) Inhibitors: Part 12013
- Author(s)
  Ohtawa Masaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 5 Pages: 1285-1287
- DOI
  10.1016/j.bmcl.2012.12.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590011, KAKENHI-PROJECT-23790140
[Journal Article] Stereoselective Total Synthesis of Atpenins A4 and B, Harzianopyridone, and NBRI23477 B2012
- Author(s)
  Masaki Ohtawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 7 Pages: 898-906
- DOI
  10.1248/cpb.c12-00266
- NAID
  130001852500
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790140
[Journal Article] Potentiation of Bleomycin in Jurkat Cells by Fungal Pycnidione2012
- Author(s)
  Kaneko M, Matsuda D, Ohtawa M, Fukuda T, Nagamitsu T, Yamori T, Tomoda H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 1 Pages: 18-28
- DOI
  10.1248/bpb.35.18
- NAID
  130001872337
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-23790140
[Journal Article] Total Synthesis of Pyripyropene A2011
- Author(s)
  Odani Atsuki
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 42 Pages: 8195-8203
- DOI
  10.1016/j.tet.2011.06.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590011, KAKENHI-PROJECT-23790140
[Journal Article] Enantioselective total synthesis of atpenin A52009
- Author(s)
  Ohtawa, M., et. al.
- Journal Title
  
  The Journal of Antibiotics 62
  
  Pages: 289-294
- NAID
  10030635353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790117
[Journal Article] Enantioselective total synthesis of atpenin A5.2009
- Author(s)
  Ohtawa, M.; Ogihara, S.; Sugiyama, K.; Shiomi, K.; Harigaya, Y.; Nagamitsu, T.; Omura, S.
- Journal Title
  
  J. Antibiot. 62
  
  Pages: 289-294
- NAID
  10030635353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790117
[Patent] コレステロールアシル転移酵素アイソザイム2 (ACAT2) 阻害活性を有する新規医薬化合物2014
- Inventor(s)
  供田洋、大多和正樹、大村智、長光亨
- Industrial Property Rights Holder
  供田洋、大多和正樹、大村智、長光亨
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-129126
- Filing Date
  2014-06-24
- Data Source
  KAKENHI-PROJECT-25460152
[Patent] ACAT2阻害活性を示すピリピロペンA構造簡略型誘導体2013
- Inventor(s)
  大多和正樹、大村智、供田洋、長光亨
- Industrial Property Rights Holder
  大多和正樹、大村智、供田洋、長光亨
- Filing Date
  2013-01-28
- Data Source
  KAKENHI-PROJECT-23790140
[Patent] ACAT2阻害活性を示す代謝酵素に安定なピリピロペン誘導体2011
- Inventor(s)
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Industrial Property Rights Holder
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Filing Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Gibberellin 類の合成研究2023
- Author(s)
  中平善幸、井上波音、安成範顕、田村歩夢、長光亨、大多和正樹
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 天然物合成を指向したブテノリドラジカルを介する反応開発研究2023
- Author(s)
  小田みづき、内藤真帆、勅使川原壮平、長光亨、大多和正樹
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 天然物合成を指向したブテノリドラジカルを介する反応開発研究2023
- Author(s)
  小田みづき、内藤真帆、勅使川原壮平、長光亨、大多和正樹
- Organizer
  第21回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Lamellolactone 類の全合成2023
- Author(s)
  布施侑叶、長光亨、大多和正樹
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 神経栄養保護作用を有するかご型テルペノイドの全合成2022
- Author(s)
  ○ 大多和正樹
- Organizer
  名古屋大学大学院創薬科学研究科第156回創薬科学セミナー/GTRセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Gibberellin A1 及び A3 の合成研究2022
- Author(s)
  ○ 安成範顕、田村歩夢、中平善幸、長光亨、大多和正樹
- Organizer
  第12回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Shodoamide C の合成研究2022
- Author(s)
  ○ 平田晃大、岩堀雅大、大城太一、供田洋、内田龍児、長光亨、大多和正樹
- Organizer
  第12回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] アルケニルシランに対する MHAT 駆動形レドックス環化反応を鍵とする habiterpenol および 2,3-epi-habiterpenol の全合成2022
- Author(s)
  田口遥規、川口真由子、有馬志保、長光亨、○ 大多和正樹
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] ブテノリドラジカルのダイマー化を鍵とする biatractylolide の全合成研究2022
- Author(s)
  ○ 川口真由子、長光亨、大多和正樹
- Organizer
  第12回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Shodoamide C の合成研究2022
- Author(s)
  ○ 平田晃大、岩堀雅大、大城太一、供田洋、内田龍児、長光亨、大多和正樹
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] ブテノリドラジカルを用いた反応開発研究2022
- Author(s)
  ○ 小田みづき、内藤真帆、勅使川原壮平、長光亨、大多和正樹
- Organizer
  第12回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Gibberellin A1 及び A3 の合成研究2022
- Author(s)
  ○ 安成範顕、田村歩夢、中平善幸、長光亨、大多和正樹
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] ブテノリドラジカルを用いた反応開発研究と天然物合成への応用2022
- Author(s)
  勅使川原, 壮平, 山口茉里絵, 長光亨, 大多和正樹
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] ビニルシランに対する MHAT 駆動形レドックス環化反応を鍵とする habiterpenol および 2,3-epi-habiterpenol の全合成2022
- Author(s)
  田口遥規、川口真由子、有馬志保、長光亨、○ 大多和正樹
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 天然物から広がる有機合成化学-全合成から創薬まで-2021
- Author(s)
  大多和正樹
- Organizer
  第8回慶應有機化学若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 特徴的な生物活性を有する天然有機化合物を中心とした創薬研究、全合成および反応開発研究2021
- Author(s)
  大多和正樹
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] 構造の複雑な天然物の効率的な合成法の構築を目指して2021
- Author(s)
  大多和正樹
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06554
[Presentation] 特徴的な生物活性を有する天然有機化合物を中心とした創薬研究、全合成および反応開発研究2021
- Author(s)
  大多和正樹
- Organizer
  第46回白金シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] ブテノリドラジカルを用いた反応開発研究と天然物合成への応用2021
- Author(s)
  勅使川原, 壮平, 山口茉里絵, 長光亨, 大多和正樹
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06481
[Presentation] Amphotericin B活性増強作用を有するsimpotentinの全合成と絶対立体配置の決定2020
- Author(s)
  大多和正樹、李大葵、内田龍児、供田洋、長光亨
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06554
[Presentation] Total synthesis and absolute configuration of simpotentin, a potentiator of amphotericin B activity2019
- Author(s)
  Masaki Ohtawa, Ryuji Uchida, Hiroshi Tomoda, Tohru Nagamitsu
- Organizer
  258th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06554
[Presentation] Simpotentinの全合成と絶対立体配置の決定2018
- Author(s)
  大多和正樹、長光亨
- Organizer
  第41回白金シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06554
[Presentation] Amphotericin B活性増強作用を有するsimpotentinの全合成と絶対立体配置の決定2018
- Author(s)
  大多和正樹、清水恵里、齋藤淳、李大葵、近藤あり子、八木瑛穂、小林啓介、内田龍児、供田洋、長光亨
- Organizer
  第44回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06554
[Presentation] Structure-activity relationship study and total synthesis of pyripyropene A as a ACAT2-selective inhibitor2015
- Author(s)
  Ohtawa, M.; Ohshiro, T.; Omura, S.; Tomoda. H.; Nagamitsu, T.
- Organizer
  The 13th International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  京都リーガロイヤルホテル
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460152
[Presentation] Structure-activity relationship study and total synthesis of pyripyropene A as a ACAT2-selective inhibitor2015
- Author(s)
  Ohtawa, M.; Ohshiro, T.; Omura, S.; Tomoda. H.; Nagamitsu, T.
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, USA
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460152
[Presentation] ACAT2選択的阻害剤pyripyropene Aの構造簡略型誘導体の創製研究2013
- Author(s)
  大多和正樹，寺山富明，大城太一，福田隆志，大村智，供田洋，長光亨
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島/アステールプラザ
- Data Source
  KAKENHI-PROJECT-25460152
[Presentation] Atpenin A5 の構造活性相関研究2012
- Author(s)
  樋浦徹 (大多和正樹)
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学札幌キャンパス(北海道)
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Nafuredin-γの誘導体合成2012
- Author(s)
  福永恵子、清水理紗、大多和正樹、塩見和郎、大村智、長光亨
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学札幌キャンパス
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Atpenin A5の構造活性相関研究2012
- Author(s)
  大多和正樹
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Atpenin A5の構造活性相関研究2012
- Author(s)
  樋浦徹、杉山晃平、大多和正樹、森美穂子、塩見和朗、大村智、長光亨
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学札幌キャンパス
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Atpenin A5 の構造活性相関研究2012
- Author(s)
  宮尾篤欣 (大多和正樹)
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  タワーホール船堀 (東京)
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Atpenin A5 の構造活性相関研究2011
- Author(s)
  樋浦徹 (大多和正樹)
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス (千葉)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] ACAT2 選択的阻害剤pyripyropene A の構造活性相関研究ならびに全合成2011
- Author(s)
  大多和正樹、松田大介、山崎寛之、大城太一、大村智、長光亨、供田洋
- Organizer
  第53回天然有機化合物討論会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Atpenin A5の構造活性相関研究2011
- Author(s)
  樋浦徹、大多和正樹、森美穂子、塩見和朗、大村智、長光亨
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] Structure-activity relationship of new pyripyropene A derivatives as inhibitors of acyl-CoA:cholesterol acyltransferase 22011
- Author(s)
  Ohtawa, M.;Matsuda, D.; Yamazaki H.; Ohshiro, T.; Omura, S.; Nagamitsu, T.; Tomoda, T.
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル (新宿)
- Data Source
  KAKENHI-PROJECT-23790140
[Presentation] NFRD阻害剤atpenin類の全合成ならびに構造活性相関研究2010
- Author(s)
  杉山晃平(大多和正樹)
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Data Source
  KAKENHI-PROJECT-21790117
[Presentation] Enantioselective total synthesls of atpenins2009
- Author(s)
  Ohtawa, M., et. al.
- Organizer
  The 11^<th> International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  京都リーガロイヤルホテル(京都府)
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-21790117
[Presentation] Enantioselective total synthesis of atpenin A5 and its analogues.2009
- Author(s)
  杉山晃平(大多和正樹)
- Organizer
  The 11^<th> International KYOTO conerence on New Aspects of Organic Chemistry.
- Place of Presentation
  リーガロイヤルホテル京都(京都)
- Data Source
  KAKENHI-PROJECT-21790117
[Presentation] Fumarate reductase阻害剤atpenin類の全合成ならびに構造活性相関研究2009
- Author(s)
  杉山晃平(大多和正樹)
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学安田講堂(東京)
- Data Source
  KAKENHI-PROJECT-21790117
[Presentation] ACAT2選択的阻害剤pyripyropene Aの構造簡略型誘導体の創製研究
- Author(s)
  大多和正樹，寺山富明，大城太一，福田隆志，大村智，供田洋，長光亨
- Organizer
  第8回北里化学シンポジウム
- Place of Presentation
  神奈川/北里大学理学部
- Data Source
  KAKENHI-PROJECT-25460152
[Presentation] ACAT2選択的阻害剤 pyripyropene A の構造簡略型誘導体の創製研究
- Author(s)
  大多和正樹
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場 (神戸)
- Year and Date
  2014-11-26 – 2014-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-25460152

1. 青木学一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 本間浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohtawa Masaki 大多和 正樹

OHTAWA Masaki 大多和 正樹

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ブテノリド特有の極性/ラジカル反応を駆使した天然物の革新的全合成研究Principal Investigator

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Development of new reactions using the properties of butenolide and the synthetic study on gibberellinsPrincipal Investigator

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Development of amphotericin B potenciators based on novel natural productsPrincipal Investigator

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Design, synthesis and biological evaluation of pyripyropene A truncated analogs as ACAT2 selective inhibitorPrincipal Investigator

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Structure-activity relationship of atpenin A5 derivatives as complex II selective inhibitorsPrincipal Investigator

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Synthesis and structure activity relationship of atpenin A5 derivatives as complex II inhibitorsPrincipal Investigator

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[Journal Article] Concise syntheses of (-)-habiterpenol and (+)-2,3-epi-habiterpenol via redox radical cyclization of alkenylsilane2023

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[Journal Article] Comprehensive Studies on the Synthetic Organic Chemistry of Unique Bioactive Natural Products; Total Synthesis, Drug Discovery, and Development of New Reactions2022

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[Journal Article] Synthesis and Evaluation of Habiterpenol Analogs2022

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[Journal Article] Concise Syntheses of (−)-11-O-Debenzoyltashironin and (−)-Bilobalide2022

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[Journal Article] Mixture of clopidogrel bisulfate and magnesium oxide tablets reduces clopidogrel dose administered through a feeding tube2021

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[Journal Article] One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping2021

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Ohtawa Masaki 大多和正樹

OHTAWA Masaki 大多和正樹