YAMAZAKI Yuri 山崎有理

Researcher Number	70459725
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2012: 東京薬科大学, 薬学部, 助教 2008 – 2011: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 薬学 / 生体分子 / 医薬品化学 / 分子認識 / がん / チューブリン / 癌 Except Principal Investigator 薬学 / プロドラッグ / 有機合成化学 … More / 抗がん剤 / ペプチド創薬 / システインプロテーアゼ阻害剤 / 固相ジスルフィド縮合法 / システインプロテアーゼ阻害剤 / 遺伝子疾患治療薬 / リードスルー薬 / 難治性疾患 / 有機化学 / ペプチド化学 / 生体分子 / 創薬化学 / ネガマイシン / 遺伝子読み飛ばし / ネガマシン / 筋ジストロフィー / 遺伝病 / チューブリン / 血管内皮細胞障害 / 抗がん剤癌 / 化学プローブ / 化学薬剤学 / ケミカルバイオロジー / チューブリン作用薬 / 医薬品開発 Less

Integrated medicinal chemistry research of intractable diseases based on peptidic small molecules
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
新規微小管作用薬Plinabulinの創薬指向型分子機能研究Principal Investigator
- Principal Investigator
  
  山崎有理
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Chenical biology research using diketopiperazine-based anti-microtubule agent.Principal Investigator
- Principal Investigator
  
  YAMAZAKI Yuri
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Study on Medicinal Chemistry, Chemical Biology and Chemical Pharmaceutics of Anticancer Drug Based on the Microtubule Targeting Agents
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
化学療法による遺伝病克服への挑戦:デュシェンヌ型筋ジストロフィーの治療薬の開発
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book Patent

[Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」2012
- Author(s)
  山崎有理、林良雄
- Total Pages
  7
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Prodrug Study of Plinabulin Using a Click Strategy Focused on the Effects of a Replaceable Water-Solubilizing Moiety2012
- Author(s)
  Fumika Yakushiji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 7 Pages: 877-881
- DOI
  10.1248/cpb.c12-00216
- NAID
  130001852497
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790143
[Journal Article] Synthesis and Structure-Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure2012
- Author(s)
  Y.Yamazaki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Issue: 3 Pages: 1056-1071
- DOI
  10.1021/jm2009088
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy2012
- Author(s)
  Akihiro Taguchi, Masataka Shiozuka, Ryoichi Matsuda, Yoshiaki Nonomura, Yoshiaki Kiso, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi et al.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 3 Issue: 2 Pages: 118-122
- DOI
  10.1021/ml200245t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Development of a solidsupported biotinylation reagent for efficient biotin labeling of SH groups on small molecules2012
- Author(s)
  Kentarou Fukumoto, Kumi Adachi, Akihiro Kajiyama, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 5 Pages: 535-538
- DOI
  10.1016/j.tetlet.2011.11.089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Synthesis and structure activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents2012
- Author(s)
  Yamazaki Y, Sumikura M, Masuda Y, Hayashi Y, Yasui H, Kiso Y, Chinen T, Usui T, Yakushiji F, Potts B, Neuteboom S, Palladino M, Lloyd GK, Hayashi Y.
- Journal Title
  
  Bioorganic Medicinal Chemisty
  
  Volume: 20 Issue: 14 Pages: 4279-4289
- DOI
  10.1016/j.bmc.2012.05.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J01199, KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790143
[Journal Article] 環状ジペプチド型抗がん剤の創薬研究とケミカルバイオロジー展開2012
- Author(s)
  山崎有理，林良雄
- Journal Title
  
  遺伝子医学MOOK 21号「最新ペプチド合成技術とその創薬研究への応用」株式会社メディカルドゥ
  
  Volume: 21 Pages: 260-266
- Data Source
  KAKENHI-PROJECT-23790143
[Journal Article] Tubulin Photoaffinity Labeling Study with a Plinabulin Chemical Probe Possessing a Biotin Tag at the Oxazole2011
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他5人
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 19 Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.2011
- Author(s)
  Yuri Yamazaki, Yui Kido, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 19
  
  Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole2011
- Author(s)
  Yuri Yamazaki, 他6人
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19(1) Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a bitin tag at the oxazole.2011
- Author(s)
  Yamazaki, Y., Kido, Y., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin: Effective Strategy with Click Chemistry2011
- Author(s)
  Fumika Yakushiji, Hironari Tanaka, Kyohei Muguruma, Takahiro Iwahashi, Yuri Yamazaki, Yoshio Hayashi
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 17 Pages: 12587-12590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790143
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a bitin tag at the oxazole2011
- Author(s)
  Yamazaki, Y., Kido, Y., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Anti-microtubule "plinabulin" chemical probe KPU-244-B3 labeled both a-and b-tubulin.2010
- Author(s)
  Yamazaki, Y., Sumikura, M., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure.2010
- Author(s)
  Makiko Sumikura, Yuri Yamazaki, Tomoko Yoshida, Yuki Mori, Hiroyuki Yasui, Yoshiaki Kiso, Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, Yoshio Hayashi
- Journal Title
  
  Peptide Science 46
  
  Pages: 315-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Anti-microtubule "plinabulin" chemical probe KPU-244-B3 labeled both α- and β-tubulin2010
- Author(s)
  Yuri Yamazaki, 他6人
- Journal Title
  
  Bioorganic & Medicinal Chemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Synthesis and antimicrobial activity of (+)-negamycin derivatives focused on the hydrazine amide moiety.2010
- Author(s)
  Akihiro Taguchi, Mayuko Ina, Yuri Yamazaki, Fumika Yakushiji, Yoshikazu Takahashi, Yoshiaki Kiso, Yoshio Hayashi
- Journal Title
  
  Peptide Science 46
  
  Pages: 317-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Anti-microtubule "plinabulin" chemical probe KPU-244-B3 labeled both a-and b-tubulin2010
- Author(s)
  Yamazaki, Y., Sumikura, M., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis and antimicrobial activity of (+)-negamycin derivatives focused on the hydrazine amide moiety2010
- Author(s)
  Akihiro Taguchi, Yuri Yamazaki, Yoshio Hayashi, 他6人
- Journal Title
  
  Peptide Science
  
  Volume: 46 Pages: 317-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2010
- Author(s)
  Makiko Sumikura, Yuri Yamazaki, Yoshio Hayashi, 他8人
- Journal Title
  
  Peptide Science
  
  Volume: 46 Pages: 315-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Total synthesis of (+)-neganycin and its 5-epi-derivatives.2010
- Author(s)
  Shigenobu Nishiguchi, Magne O.Sydnes, Akihiro Taguchi, Thomas Regnier, Tetsuya Kajimoto, Manabu Node, Yuri Yamazaki, Fumika Yakushiji, Yoshiaki Kiso, Yoshio Hayashi
- Journal Title
  
  Tetrahedron 66
  
  Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Anti-microtubule 'Plinabulin' Chemical Probe KPU-244-B3 Labeled Both α- and β-Tubulin2010
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他5人
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both α- and β-tubulin2010
- Author(s)
  Yuri Yamazaki, Makiko Sumikura, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 18
  
  Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Total synthesis of(+)-neganycin and its 5-epi-derivatives2010
- Author(s)
  Yoshio Hayashi, Yuri Yamazaki, 他8人
- Journal Title
  
  Tetrahedron 66(1)
  
  Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis2009
- Author(s)
  Yuri Yamazaki, 他5人
- Journal Title
  
  Peptides Breaking Away : Proc. 21st Amer. Peptide Symp.(Ed. Michal Lebl)
  
  Pages: 54-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Okuno.Y., Kiso, Y., Havashi, Y.
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides2009
- Author(s)
  Yuri Yamazaki, 他5人
- Journal Title
  
  Tetrahedron 65(18)
  
  Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Acid catalyzed mono-dehydro-2, 5-diketopiperazine formation from N-α-ketoacyl amino acid amides2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Okuno, Y., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Tetra-hedron
  
  Volume: 65 Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2009
- Author(s)
  Sumikura, M., Yamazaki, Y., Yoshida, T., Mori, Y., Yasui, H., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Journal Title
  
  Peptide Science 2009 2009(in press)
  
  Pages: 315-316
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural productsynthesis.2009
- Author(s)
  Yuri Yamazaki, Yuki Mori, Akiko Oda, Yoshiaki Kiso, Yoshio Hayashi
- Journal Title
  
  Peptides Breaking Away Proc.21st Amer.Peptide Symp.(Ed.Michal Lebl)
  
  Pages: 54-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides.2009
- Author(s)
  Yuri Yamazaki, Yuki Mori, Akiko Oda, Yuka Okuno, Yoshiaki Kiso, Yoshio Hayashi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790118
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Peptides 2009
  
  Pages: 54-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Acid catalyzed monodehydro-2, 5-diketopiperazine formation from N-α-ketoacyl amino acid amides.2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Okuno, Y., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents.2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他9人
- Journal Title
  
  ChemBioChem 9(18)
  
  Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents.2008
- Author(s)
  Yamazaki, Y., Kohno, K., Yasui, H., Kiso, Y., Akamatsu, M., Nicholson, B., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Journal Title
  
  ChemBioChem 9
  
  Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents2008
- Author(s)
  Yamazaki, Y., Kohno, K., Yasui, H., Kiso, Y., Akamatsu, M., Nicholson, B., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G. K., Hayashi, Y.
- Journal Title
  
  Chem Bio Chem
  
  Volume: 9 Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Preparation of dehydrophenylahistin analogs for treating vascular proliferatio2011
- Inventor(s)
  Yamazaki, Yuri; Hayashi, Yoshio
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc., USA
- Filing Date
  2011-07-14
- Overseas
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] Preparation of dehydrophenylahistin analogus for treating vascular proliferation2011
- Inventor(s)
  Yuri Yamazaki, Yoshio Hayashi
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc.
- Filing Date
  2011
- Overseas
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管作用薬の機能評価とそれら利用した結合様式解析研究2012
- Author(s)
  山崎有理、薬師寺文華、臼井健郎、林良雄
- Organizer
  日本がん分子標的治療学会第16回学術集会
- Place of Presentation
  北九州市小倉
- Year and Date
  2012-06-28
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管重合阻害剤plinabulinの構造活性相関研究2012
- Author(s)
  山崎有理、林良雄, 他8名
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] 微小管作用薬Plinabulinの光親和性ビオチン化プローブの開発とそれらを利用した結合様式解析2012
- Author(s)
  山崎有理、林良雄, 他6名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管作用薬の構造活性相関研究2012
- Author(s)
  山崎有理, 林良雄, 他8名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of biotin-tagged plinabulin chemical probes towards the elucidation of binding mechanism of a diketopiperazine based anti-microtubule agent.2011
- Author(s)
  Yuri Yamazaki, Yui Kido, Yurika Masuda, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji and Yoshio Hayashi
- Organizer
  21st American Peptide Symposium: Breaking Away
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] Development of biotin-tagged plinabulin chemical probes towards the elucidation of binding mechanism of a diketopiperazine based anti-microtubule agent2011
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他6人
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管作用薬Plinabulinのケミカルプローブの開発とそれらを利用した結合様式解析2011
- Author(s)
  山崎有理、林良雄, 他6人
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal chemistry of small peptidic natural products against intractable diseases.2011
- Author(s)
  Yoshio Hayashi, Akihiro Taguchi, Yuri Yamazaki, Fumika Yakushiji
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] ジケトピペラジン型微小管重合阻害剤Plinabulinの水溶性プロドラッグ開発研究2011
- Author(s)
  薬師寺文華、山崎有理、林良雄
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管作用薬Plinabulinのケミカルプローブの開発とそれらを利用した結合様式解析2011
- Author(s)
  山崎有理, 城戸結衣,増田優里香,日高興士,安井裕之,木曽良明,薬師寺文華,林良雄
- Organizer
  日本ケミカルバイオロジー学会第６回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] ジケトピペラジン型微小管作用薬Plinabulinを基盤としたケミカルプローブの開発2010
- Author(s)
  山崎有理、角倉真紀子、河野享子、日高興士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  東京
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Development of chemical probes towards the elucidation of binding mechanism of plinabulin, a cyclicdipeptide based anti-microtubule agent2010
- Author(s)
  Yuri Yamazaki
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 微小管作用薬Plinabulinの作用様式解明を目指したケミカルプローブの開発2010
- Author(s)
  山崎有理、城戸結衣、日高輿士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Development of chemical probes towards the elucidation of binding mechanism of plinabulin, a cyclicdipeptide based anti-microtubule agent.2010
- Author(s)
  Yuri Yamazaki, Yui Kido, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 分子平面性を強化したTryprostatin誘導体の合成研究2010
- Author(s)
  篠崎雄希、山本美彦、嶽野遥、山崎有理、薬師寺文華、林良雄
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ジケトピペラジン型微小管作用薬Plinabulinを基盤としたケミカルプローブの開発2010
- Author(s)
  山崎有理、角倉真紀子、河野享子、日高興士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  東京
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 微小管重合阻害剤Plinabulinにおける水溶性プロドラッグの創製2010
- Author(s)
  薬師寺文華、岡本玲子、山崎有理、林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] "Plinabulin" a diketopiperazine-type vascular targeting anti-cancer agent based on microtubule depolymerization activity2010
- Author(s)
  Hayashi, Y., Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K.
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-03-21
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulin' a diketopiperazine-type vascular targeting anti-cancer agent based on microtubule depolymerization activity.2010
- Author(s)
  Yoshio Hayashi, Yuri Yamazaki, Makiko Sumikura, Tomoko Yoshida, Yuki Mori, Hiroyuki Yasui, Kyoko Kohno, Yoshiaki Kiso, Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 'Plinabulin' a diketopiperazine-type vascular targeting anti-cancer agent based on microtubule depolvmerization activity2010
- Author(s)
  Yoshio Hayashi, Yuri Yamazaki, 他9人
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Development of chemical probes towards the elucidation of binding mechanism of plinabulin, a cyclicdipeptide based anti-microtubule agent2010
- Author(s)
  Yuri Yamazaki
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  Kyoto(口頭発表)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulinケミカルプローブの開発とプローブの機能評価2010
- Author(s)
  山崎有理、林良雄
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 微小管作用薬Plinabulinの作用様式解明を目指したケミカルプローブの開発2010
- Author(s)
  山崎有理、城戸結衣、日高興士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 酸触媒環化反応を用いたモノデヒドロ-2,5-ジケトピペラジン化合物の合成研究2010
- Author(s)
  山崎有理、森雄樹、小田暁子、奥野友香、木曽良明、林良雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 新生血管内皮細胞を障害するジケトピペラジン型微小管脱重合剤の創製2010
- Author(s)
  林良雄、山崎有理
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] 新生血管内皮細胞を障害するジケトピペラジン型微小管脱重合剤の創製2010
- Author(s)
  林良雄、山崎有理
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 酸触媒環化反応を用いたモノデヒドロ-2,5-ジケトピペラジン化合物の合成研究2010
- Author(s)
  山崎有理、森雄樹、小田暁子、奥野友香、木曽良明、林良雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Development of chemical probes towards the elucidation of binding mechanism of plinabulin, a cyclicdipeptide based anti-microtubule agent2010
- Author(s)
  Yuri Yamazaki, 他6人
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Plinabulinケミカルプローブの開発とプローブの機能評価2010
- Author(s)
  林良雄、山崎有理
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis of (+)-Negamycin and Derivatives2009
- Author(s)
  Yakushiji, F., Nishiguchi, S., Sydnes, M.O., Taguchi, A., Regnier, T., Kajimoto, T., Node, M., Kiso, Y., Yamazaki, Y., Hayashi, Y.
- Organizer
  3rd Asia-Pacific International Peptide Symposium / 13th Korean Peptide and Protein Symposium : "Peptides at Cutting Edge"
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] Plinabulin a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity.2009
- Author(s)
  Yoshio Hayashi, Yuri Yamazaki, 他9人
- Organizer
  3rd Asia-Pacific International Peptide Symposium/13th Korean Peptide and Protein Symposium
- Place of Presentation
  Jeju Island, Korea
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2009
- Author(s)
  Sumikura, M., Yamazaki, Y., Yoshida, T., Mori, Y., Yasui, H., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  Kitakyushu, Japan
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Cyclic dipeptide-based microtubule depolymerization agents as vascular targetinganti-cancer drugs2009
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他10人
- Organizer
  7th AFMC International Medicinal Chemistry Congress
- Place of Presentation
  Chains, Australia
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Cyclic dipeptide-based microtubule depolymerization agents as vascular targeting anti-cancer drugs2009
- Author(s)
  Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Organizer
  7th AFMC International Medicinal Chemistry Congress
- Place of Presentation
  Cairns, Australia
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis and Antimicrobial Activity of (+)-Negamycin Derivatives Focused on the Hydrazine Amide Moiety2009
- Author(s)
  Taguchi, A., Ina, M., Yamazaki, Y., Yakushiji, F., Takahashi, Y., Kiso, Y., Hayashi, Y.
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管脱重合剤の開発2009
- Author(s)
  角倉真紀子、山崎有理、吉田智子、森雄樹、安井裕之、木曽良明、Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, 林良雄
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Plinabulin" a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity.2009
- Author(s)
  Yoshio Hayashi, Yuri Yamazaki, Makiko Sumikura, Tomoko Yoshida, Yuki Mori, Hiroyuki Yasui, Kyoko Kohno, Yoshiaki Kiso, Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd
- Organizer
  3rd Asia-Pacific International Peptide Symposium/13th Korean Peptide and Protein Symposium
- Place of Presentation
  Jeju Island, Korea
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure.2009
- Author(s)
  Makiko Sumikura, Yuri Yamazaki, Tomoko Yoshida, Yuki Mori, Hiroyuki Yasui, Yoshiaki Kiso, Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, Yoshio Hayashi
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  Kitakyusyu
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] Cyclic dipeptide-based microtubule depolymerization agents as vascular targeting anti-cancer drugs2009
- Author(s)
  Yuri Yamazaki, Makiko Sumikura, Tomoko Yoshida, Yuki Mori, Hiroyuki Yasui, Kyoko Kohno, Yoshiaki Kiso, Gordafaried Deyanat-Yazdi, Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, Yoshio Hayashi
- Place of Presentation
  Chains, Australia
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] ジケトピペラジン型光応答性プローブの開発とチューブリン認識能評価2009
- Author(s)
  山崎有理, 林良雄, 他9人
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Kiso, Y., Hayashi, Y.
- Organizer
  21st American Peptide Symposium
- Place of Presentation
  Bloomington, IN, USA
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2009
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他8人
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] "Plinabulin" a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity2009
- Author(s)
  Hayashi, Y., Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K.
- Organizer
  3rd Asia-Pacific International Peptide Symposium / 13th Korean Peptide and Protein Symposium
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis.2009
- Author(s)
  Yuri Yamazaki, Yuki Mori, Akiko Oda, Yoshiaki Kiso, Yoshio Hayashi
- Organizer
  21st American Peptide Symposium : Breaking Away
- Place of Presentation
  Bloomington, USA
- Data Source
  KAKENHI-PROJECT-21790118
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管脱重合剤の開発2009
- Author(s)
  角倉真紀子、山崎有理、吉田智子、森雄樹、安井裕之、木曽良明、Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, 林良雄
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ジケトピペラジン型微小管作用薬を基盤としたビオチン導入型光応答性分子プローブの開発2008
- Author(s)
  山崎有理, 林良雄, 他6人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Development of biotin-tagged cyclicdipeptied based anti-microtubuleagents and tubulin photoaffinity labeling2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他6人
- Organizer
  32nd European Peptide Symposium (30EPS)
- Place of Presentation
  Helsinki, Finland
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis of biotin-tagged photoaffinity probes for diketopiperazine-basedanti-microtubule agents.2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他9名
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  Kyoto
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 酸触媒を用いるモノデヒドロ-2, 5-ジケトピペラジン類の合成研究2008
- Author(s)
  山崎有理, 林良雄, 他5名
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管作用薬の構造活性相関研究
- Author(s)
  山崎有理，角倉真紀子，林良樹，知念拓実，臼井健郎，安井裕之，薬師寺文華，木曽良明，G. Kenneth Lloyd，林良雄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790143
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管重合阻害剤plinabulinの構造活性相関研究
- Author(s)
  山崎　有理
- Organizer
  日本ケミカルバイオロジー学会第７回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管作用薬の機能評価とそれらを利用した結合様式解析研究
- Author(s)
  山崎　有理
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管作用薬Plinabulinの光親和性ビオチン化プローブの開発とそれらを利用した結合様式解析
- Author(s)
  山崎有理、城戸結衣、増田優里香、日高興士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790143

1. HAYASHI Yoshio (10322562)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
2. YAKUSHIJI Fumika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAZAKI Yuri 山崎 有理

Research Projects

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Co-Researchers

Integrated medicinal chemistry research of intractable diseases based on peptidic small molecules

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新規微小管作用薬Plinabulinの創薬指向型分子機能研究Principal Investigator

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Chenical biology research using diketopiperazine-based anti-microtubule agent.Principal Investigator

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Study on Medicinal Chemistry, Chemical Biology and Chemical Pharmaceutics of Anticancer Drug Based on the Microtubule Targeting Agents

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化学療法による遺伝病克服への挑戦:デュシェンヌ型筋ジストロフィーの治療薬の開発

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[Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」2012

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[Journal Article] Prodrug Study of Plinabulin Using a Click Strategy Focused on the Effects of a Replaceable Water-Solubilizing Moiety2012

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[Journal Article] Synthesis and Structure-Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure2012

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[Journal Article] Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy2012

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[Journal Article] Development of a solidsupported biotinylation reagent for efficient biotin labeling of SH groups on small molecules2012

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[Journal Article] Synthesis and structure activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents2012

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[Journal Article] 環状ジペプチド型抗がん剤の創薬研究とケミカルバイオロジー展開2012

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[Journal Article] Tubulin Photoaffinity Labeling Study with a Plinabulin Chemical Probe Possessing a Biotin Tag at the Oxazole2011

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[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.2011

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[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole2011

YAMAZAKI Yuri 山崎有理