KASHIMA Hiroyasu 鹿島大靖

Researcher Number	70464089
Affiliation (based on the past Project Information) *help	2018 – 2020: 信州大学, 学術研究院医学系(医学部附属病院), 講師 2016 – 2017: 信州大学, 学術研究院医学系, 助教 2010 – 2013: 信州大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator アポトーシス / シスプラチン感受性 / 紫外線感受性 / 生存能力 / SLC22A17 / lipocalin2 / 子宮内膜癌 / 発現制御 / タンパク質 / 核酸 / 癌 … More Except Principal Investigator … More 子宮内膜癌 / CD133 / CD44 / 酸化ストレス耐性 / 卵巣明細胞癌 / Lipocalin2 / 婦人科腫瘍学 / 卵巣癌 / 鉄イオン / salinomycin / 鉄運搬 / Sphere形成能 / 抗がん剤耐性 / 合成LCN2 / CD44v / 鉄運搬タンパク / 癌幹細胞性 / LCN2 / がん幹細胞マーカー / CD44 variant / NRF2 / 明細胞癌 / 抗酸化物質 / 酸化ストレス / 卵巣子宮内膜症性嚢胞 / 抗癌剤感受性 / 抗腫瘍薬 / 創薬 / 分子標的薬 / 抗がん剤 / 化合物X / サイクリンA / 低分子化合物 / 細胞周期調節因子 / 子宮体癌 / 診断マーカー / 異所性子宮内膜 / 女性生殖管 / 鑑別診断 / 子宮内膜症 / 婦人科悪性腫瘍 / ケラタン硫酸 Less

Elucidation of the function of LCN2 in stem cell maintenance of gynecologic cancer cells
- Principal Investigator
  
  Miyamoto Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Shinshu University
Elucidation of the mechanism of oxidative stress tolerance by Lipocalin2 in ovarian clear cell carcinoma and development of treatment methods
- Principal Investigator
  
  Kobara Hisanori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Development of novel anti-cancer drugs targeting cyclin A for endometrial carcinoma.
- Principal Investigator
  
  Shiozawa Tanri
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
卵巣明細胞腺癌の発生に関与する遺伝子のcDNA発現ライブラリーを用いた同定Principal Investigator
- Principal Investigator
  
  鹿島大靖
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Study of the expression of keratan sulfate in gynecological malignancies
- Principal Investigator
  
  SHIOZAWA Tanri
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
The functional analysis of lipocalin2 and novel molecular targeted therapy for endometrial carcinomaPrincipal Investigator
- Principal Investigator
  
  KASHIMA Hiroyasu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University

All 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA)2013
- Author(s)
  Takatsu A, Miyamoto T, Fuseya C, Suzuki A, Kashima H, Horiuchi A, Ishii K, Shiozawa T
- Journal Title
  
  Virchows Arch
  
  Volume: 462 Pages: 645-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659725
[Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells2012
- Author(s)
  Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T
- Journal Title
  
  Histopathology
  
  Volume: 60 Pages: 826-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells2012
- Author(s)
  Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T
- Journal Title
  
  Histopathology
  
  Volume: 60 Pages: 826-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659725
[Journal Article] Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma2011
- Author(s)
  Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T
- Journal Title
  
  Exp Mol Pathol.
  
  Volume: 91 Pages: 563-8
- NAID
  120007107372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis : stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance2011
- Author(s)
  Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, Shiozawa T
- Journal Title
  
  Human Pathology
  
  Volume: 42 Pages: 1265-1274
- NAID
  120007107405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Immunohistochemical expression of keratan sulfate : a possible diagnostic marker for carcinomas of the female genital tract2011
- Author(s)
  Miyamoto T, Ishii K, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T
- Journal Title
  
  Journal of clinical pathology
  
  Volume: 64 Pages: 1058-1063
- NAID
  120007107373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance2011
- Author(s)
  Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, Shiozawa T
- Journal Title
  
  Hum Pathol
  
  Volume: 42 Pages: 1265-74
- NAID
  120007107405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract.2011
- Author(s)
  Miyamoto T, Ishii K, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T
- Journal Title
  
  J Clin Pathol.
  
  Volume: 64 Pages: 1058-63
- NAID
  120007107373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings2011
- Author(s)
  Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
- Journal Title
  
  Int J Gynecol Cancer
  
  Volume: 21 Pages: 1287-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma2011
- Author(s)
  Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T
- Journal Title
  
  Experimental and molecular pathology
  
  Volume: 91 Pages: 563-568
- NAID
  120007107372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium.2010
- Author(s)
  Suzuki A, Horiuchi A, Oka K, Miyamoto T, Kashima H, Shiozawa T.
- Journal Title
  
  Virchows Arch.
  
  Volume: 456 Pages: 433-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Journal Article] Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells2010
- Author(s)
  Fakhry H, Miyamoto T, Kashima H, Suzuki A, Ke H, Konishi I, Shiozawa T
- Journal Title
  
  Hum Pathol
  
  Volume: 41 Pages: 848-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2 は紫外線照射後およびシスプラチン処理後の子宮内膜癌細胞の生存を促進する2012
- Author(s)
  宮本強、浅香亮一、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  一般講演神戸
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2は子宮内膜症から発生する卵巣癌で高発現している2012
- Author(s)
  山田靖、宮本強、浅香亮一、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659725
[Presentation] 正常子宮内膜および子宮内膜癌における2012
- Author(s)
  浅香亮一、宮本強、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  sirtuin1 発現の検討
- Place of Presentation
  一般講演神戸
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2は紫外線照射後およびシスプラチン処理後の子宮内膜癌細胞の生存を促進する2012
- Author(s)
  宮本強、浅香亮一、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659725
[Presentation] Lipocalin2 enhances the proliferation of endometrial carcinoma cells in nude mice2012
- Author(s)
  Miyamoto T,Asaka R,Yamada Y,Ishikawa K,Kobara H,Suzuki A,Kashima H,Shiozawa T
- Organizer
  14th International Gynecologic Cancer Society(IGCS)
- Place of Presentation
  Poster Vancouver Canada
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2はヌードマウスでの子宮内膜癌細胞の腫瘍増大を促進する2012
- Author(s)
  宮本強、浅香亮一、山田靖、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659725
[Presentation] 正常子宮内膜および子宮内膜癌におけるsirtuin1発現の検討2012
- Author(s)
  浅香亮一、宮本強、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659725
[Presentation] Lipocalin2 はヌードマウスでの子宮内膜癌細胞の腫瘍増大を促進する2012
- Author(s)
  宮本強、浅香亮一、山田靖、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  口演札幌
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2 は子宮内膜症から発生する卵巣癌で高発現している2012
- Author(s)
  山田靖、宮本強、浅香亮一、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ポスター札幌
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 早期卵巣癌におけるリンパ節郭清不要症例の抽出に Multidetector CT および MRI は有用か2012
- Author(s)
  宮本強、橘涼太、近藤沙織、鹿島大靖、浅香志保、藤永康成、塩沢丹里
- Organizer
  第123回関東連合産科婦人科学会学術集会
- Place of Presentation
  ワークショップ東京
- Year and Date
  2012-06-17
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 子宮内膜癌における lipocalin2 受容体 SLC22A17 発現の検討2011
- Author(s)
  宮本強、浅香亮一、鈴木昭久、高津亜希子、鹿島大靖、塩沢丹里
- Organizer
  第63回日本産科婦人科学会・総会・学術講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 集学的癌治療により腫瘍随伴ネフローゼ症候群が寛解した婦人科癌の2例2011
- Author(s)
  鹿島大靖, 他
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Laser captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis : stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria, and its functional relevance2011
- Author(s)
  Miyamoto T, Asaka R, Imanishi T, Kashima H, Shiozawa T
- Organizer
  2nd Biennial Meeting of Asian Society of Gynecologic Oncology
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 子宮内膜癌におけるlipocalin2受容体SLC22A17発現の検討2011
- Author(s)
  宮本強, 浅香亮一, 鈴木昭久, 高津亜希子, 鹿島大靖, 塩沢丹里
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Immunohistochemical expression of Core2 β1-6 N-acetylglucosaminyl transferase 1 in the endometrial carcinoma;a novel potential prognostic factor.2011
- Author(s)
  Asaka R,Miyamoto T,Suzuki A,Takatsu A, Kashima H,Nakayama J,Shiozawa T
- Organizer
  Asian Society of Gynecologic Oncology
- Place of Presentation
  Poster korea
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lipocalin2は、紫外線照射に対する子宮内膜癌細胞の生存能力を上昇させる.2011
- Author(s)
  宮本強、浅香亮一、鈴木昭久、高津亜希子、鹿島大靖、塩沢丹里
- Organizer
  Lipocalin2は、紫外線照射に対する子宮内膜癌細胞の生存能力を上昇させる.
- Place of Presentation
  ポスター名古屋
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 子宮内膜癌の新規予後因子としての糖転移酵素 C2GnT1 発現2011
- Author(s)
  浅香亮一、宮本強、鈴木昭久、高津亜希子、鹿島大靖、中山淳、塩沢丹里
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  ポスター名古屋
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Lasr captured microdissection-microarray analysis of the genes innolved in endometrial carcinogenesis:stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria,and its functional relevance2011
- Author(s)
  Miyamoto T,Asaka R,Imanishi T,Kashima H,Shiozawa T
- Organizer
  Asian Society of Gynecologic Oncology
- Place of Presentation
  Oral korea
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] Microarray analysis of the genes involved in endometrial carcinogenesis:up-regulation of lipocalin2 in neoplastic endometria,and its functional relevance2010
- Author(s)
  Miyamoto T,Kashima H, Suzuki A,Kikuchi N,Takatsu A,Konishi I, Seki N,Shiozawa T
- Organizer
  International Gynecologic Cancer Society(IGCS 2010)
- Place of Presentation
  Oral presentation Praha Ceska republika
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 子宮内膜腺上皮におけるケラタン硫酸および C2GnT1 発現とその診断への応用2010
- Author(s)
  宮本強、石井恵子、小原久典、浅香亮一、高津亜希子、鈴木昭久、鹿島大靖、中山淳、塩沢丹里
- Organizer
  第49回日本臨床細胞学会秋期大会
- Place of Presentation
  ワークショップ神戸
- Data Source
  KAKENHI-PROJECT-22591852
[Presentation] 子宮内膜腺上皮におけるケラタン硫酸およびC2GnT1発現とその診断への臨床応用2010
- Author(s)
  宮本強、小原久典、浅香亮一、鹿島大靖, 他
- Organizer
  第49回臨床細胞学会秋季大会
- Place of Presentation
  神戸
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-22591852

1. MIYAMOTO Tsutomu (70418721)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
2. SHIOZAWA Tanri (20235493)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
3. Kobara Hisanori (30598818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 浅香亮一 (00623688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小野元紀 (10816432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 竹内穂高 (30816351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山田靖 (60646652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KASHIMA Hiroyasu 鹿島 大靖

Research Projects

Research Products

Co-Researchers

Elucidation of the function of LCN2 in stem cell maintenance of gynecologic cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of oxidative stress tolerance by Lipocalin2 in ovarian clear cell carcinoma and development of treatment methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel anti-cancer drugs targeting cyclin A for endometrial carcinoma.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

卵巣明細胞腺癌の発生に関与する遺伝子のcDNA発現ライブラリーを用いた同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the expression of keratan sulfate in gynecological malignancies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional analysis of lipocalin2 and novel molecular targeted therapy for endometrial carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA)2013

Author(s)

Journal Title

Data Source

[Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis : stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Immunohistochemical expression of keratan sulfate : a possible diagnostic marker for carcinomas of the female genital tract2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings2011

Author(s)

Journal Title

KASHIMA Hiroyasu 鹿島大靖