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Kadoya Hiroyuki  角谷 裕之

ORCIDConnect your ORCID iD *help
Researcher Number 70509265
Other IDs
Affiliation (Current) 2025: 川崎医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 川崎医科大学, 医学部, 准教授
2022: 川崎医科大学, 腎臓・高血圧内科学, 講師
2019 – 2022: 川崎医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related
Except Principal Investigator
Basic Section 53040:Nephrology-related
Keywords
Principal Investigator
内皮機能障害 / 糖尿病性腎臓病 / CD44 / 糖尿病関連腎臓病 / ヒアルロン酸 / glycocalyx / wnt/beta-catenin経路 / 一酸化窒素(NO) / Wnt/β-catenin / sGC活性化薬 … More / eNOS / wnt/β-catenin / 可溶性グアニル酸シクラーゼ(sGC) / 一酸化窒素(NO) / 腎間質線維化 … More
Except Principal Investigator
TRPC / PKG / ポドサイト / NO / 活性酸素種 / Calcium dynamics / Oxidative stress / GFR / Keap1/Nrf2 / Keap1-Nrf2 / 細胞内カルシウム / GFR制御 / Keap1-Nrf2機構 / 内皮細胞 / 繊維化 / 線維化 / 酸化ストレス / 血行動態変化 / 内皮障害 / 慢性腎臓病 Less
  • Research Projects

    (5 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (5 People)
  •  Unraveling the pathophysiology of kidney disease and developing treatments based on the endothelial/epithelial pathomechanical linkage and ROS/NO imbalance.

    • Principal Investigator
      柏原 直樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kawasaki Medical School
  •  Elucidation of the role of the Keap1-Nrf2 mechanism in the regulation of glomerular filtration rate (GFR)

    • Principal Investigator
      城所 研吾
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kawasaki Medical School
  •  Development of a comprehensive spatio-temporal understanding of the pathogenesis and progression of chronic kidney disease and the development of therapeutic strategies

    • Principal Investigator
      Kashihara Naoki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kawasaki Medical School
  •  Elucidation of Molecular Mechanisms of Glomerular Endothelial Glycocalyx Homeostasis Disruption in Diabetic Kidney DiseasePrincipal Investigator

    • Principal Investigator
      Kadoya Hiroyuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kawasaki Medical School
  •  Nitric oxide attenuates renal interstitial fibrosisPrincipal Investigator

    • Principal Investigator
      Kadoya Hiroyuki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kawasaki Medical School

All 2023 2022 2021 2020

All Journal Article Presentation

  • [Journal Article] 生体イメージングを用いた腎疾患の病態解析2023

    • Author(s)
      角谷 裕之
    • Journal Title

      医学のあゆみ

      Volume: 286巻5号

    • Data Source
      KAKENHI-PROJECT-21K16199
  • [Journal Article] IL-1β may be an indicator of peritoneal deterioration after healing of peritoneal dialysis-associated peritonitis.2023

    • Author(s)
      Hirano A, Kadoya H, Yamanouchi Y, Kishi S, Sasaki T, Kashihara N.
    • Journal Title

      BMC Nephrol.

      Volume: 24 Issue: 1 Pages: 374-374

    • DOI

      10.1186/s12882-023-03431-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Journal Article] Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis2023

    • Author(s)
      Kadoya Hiroyuki、Hirano Akira、Umeno Reina、Kajimoto Eriko、Iwakura Tsukasa、Kondo Megumi、Wada Yoshihisa、Kidokoro Kengo、Kishi Seiji、Nagasu Hajime、Sasaki Tamaki、Taniguchi Shun’ichiro、Takahashi Masafumi、Kashihara Naoki
    • Journal Title

      The FASEB Journal

      Volume: 37 Issue: 9

    • DOI

      10.1096/fj.202201777rrr

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06613, KAKENHI-PROJECT-21K08114, KAKENHI-PROJECT-21K16199, KAKENHI-PROJECT-21H02937
  • [Journal Article] Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.2023

    • Author(s)
      Kidokoro K, Kadoya H, Cherney DZI, Kondo M, Wada Y, Umeno R, Kishi S, Nagasu H, Nagai K, Suzuki T, Sasaki T, Yamamoto M, Kanwar YS, Kashihara N.
    • Journal Title

      Kidney360.

      Volume: 4 Issue: 10 Pages: 1454-1466

    • DOI

      10.34067/kid.0000000000000171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Journal Article] Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation2021

    • Author(s)
      Wada Y、Umeno R、Nagasu H、Kondo M、Tokuyama A、Kadoya H、Kidokoro K、Taniguchi S、Takahashi M、Sasaki T、Kashihara N
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 17 Pages: 9269-9269

    • DOI

      10.3390/ijms22179269

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-20K08602, KAKENHI-PROJECT-21K06613
  • [Journal Article] Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function2021

    • Author(s)
      Kondo M, Kidokoro K, Uchida A, Kadoya H, Umeno R, Tokuyama A, Wada Y, Nagasu H, Kanda E, Sasaki T, Kashihara N
    • Journal Title

      Kawasaki Medical Journal

      Volume: 47 Pages: 131-141

    • DOI

      10.11482/KMJ-E202147131

    • ISSN
      0385-0234, 2434-3404
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] 可溶性グアニル酸シクラーゼ刺激薬による腎保護作用の可能性2023

    • Author(s)
      角谷 裕之, 長洲 一
    • Organizer
      第53回日本腎臓学会西部学術大会
    • Data Source
      KAKENHI-PROJECT-21K16199
  • [Presentation] 腎不全モデルマウスにおけるプロスタサイクリン誘導体の腸管微小血流及びバリア機能に対する作用の検討.2023

    • Author(s)
      平野 憲、角谷裕之、松浦 巧、車谷 元、城所研吾、柏原直樹.
    • Organizer
      第66回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] 内皮機能障害はβカテニンの活性化によるM1/ M2マクロファージ分化誘導を介して、AKI to CKD transition を促進する.2023

    • Author(s)
      高須将伸、岸 誠司、長洲 一、立川理絵、梶本恵莉子、平野 憲、岩倉 主、梅野怜奈、角谷裕之、城所研吾、佐々木 環、柏原直樹.
    • Organizer
      第13回腎不全研究会
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] Endothelial dysfunction exacerbates kidney dysfunction in ageing kidney via activation of inflammasome2022

    • Author(s)
      Yoshihisa Wada, Hajime Nagasu, Hiroyuki Kadoya, Naoki Kashihara
    • Organizer
      the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] eNOS-NO pathway modulates AKI to CKD transition in IRI model mice via regulation of βCatenin translocation2022

    • Author(s)
      Masanobu Takasu, Megumi Kondo, Hajime Nagasu, Hiroyuki Kadoya, Seiji Kishi, Kengo Kidokoro, Naoki Kashihara
    • Organizer
      the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] eNOS/NO signaling regulates renal interstitial fibrosis by increasing cytoplasmic beta-catenin degradation2022

    • Author(s)
      Masanobu Takasu, Hiroyuki Kadoya, Hajime Nagasu, Seiji Kishi, Tamaki Sasaki, Naoki Kashihara
    • Organizer
      the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] 腎疾患進展におけるインフラマソーム活性化の意義2022

    • Author(s)
      角谷裕之、長洲一、岸誠司、佐々木環、柏原直樹
    • Organizer
      第65回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] 糖尿病性腎臓病の進展にはインフラマソームの活性化が関与する2022

    • Author(s)
      梅野怜奈、長洲一、角谷裕之、城所研吾、岸 誠司、柏原直樹
    • Organizer
      第33回日本糖尿病性腎症研究会
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] eNOS-NO pathway regulates inflammasome activation in diabetic mice via modulation of CEBP translocation2022

    • Author(s)
      Hajime Nagasu, Reiko Umeno, Hiroyuki Kadoya, Naoki Kashihara
    • Organizer
      the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] Regulatory mechanism of glomerular filtration rate by the Keap1/Nrf2 pathway2022

    • Author(s)
      Kengo Kidokoro, Hiroyuki Kadoya, Naoki Kashihara
    • Organizer
      the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] SGLT2阻害薬による内皮NOS機能異常改善を介した腎保護効果の検証2021

    • Author(s)
      近藤恵、城所研吾、角谷裕之、和田佳久、長洲一、佐々木環、柏原直樹
    • Organizer
      第21回日本NO学会
    • Data Source
      KAKENHI-PROJECT-21H02937
  • [Presentation] eNOS/sGC/PKG経路活性化はWnt/beta-catenin経路抑制効果を介して腎間質線維化を抑制する2020

    • Author(s)
      角谷 裕之, 長洲 一, 佐々木 環, 柏原 直樹
    • Organizer
      第63回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17726
  • [Presentation] eNOS/sGC/PKG経路活性化はWnt/β-catenin経路抑制効果を介して腎間質線維化 を抑制する2020

    • Author(s)
      角谷裕之
    • Organizer
      第63回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17726
  • 1.  Kashihara Naoki (10233701)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  長洲 一 (40412176)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 3.  城所 研吾 (50435020)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 4.  岸 誠司 (10519507)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  谷口 俊一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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