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Osaka Toshifumi  大坂 利文

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OSAKA Toshifumi  大坂 利文

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Researcher Number 70514470
Other IDs
Affiliation (Current) 2025: 東京女子医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 東京女子医科大学, 医学部, 准教授
2015 – 2016: 東京女子医科大学, 医学部, 助教
2014: 早稲田大学, 理工学研究所, 招聘研究員
2013: 早稲田大学, 付置研究所, 助教
2011 – 2012: 早稲田大学, 理工学術院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology
Except Principal Investigator
Biofunction/Bioprocess
Keywords
Principal Investigator
腸内細菌叢 / 口腔病原体 / 腸肝連関 / ヘパトカイン / 創傷治癒 / 腸上皮細胞 / 腸上皮組織 / 腸管炎症 / LECT2 / 生活習慣病 … More / Fusobacterium / AI-2 / シグナル分子 / プロテオーム解析 / 口腔細菌 / Fusobacterium nuleatum / 2D-DIGE / 細菌表面タンパク質 / バイオフィルム形成 / Fusobacterium nucelatum / 大腸がん / クォーラムセンシング / バイオフィルム / Fusobacterium nucleatum / 歯周病 / NAFLD / 炎症 / NAFLD / 非アルコール性脂肪肝疾患 … More
Except Principal Investigator
抗炎症 / 数理モデル / メタボローム / 大腸炎 / 代謝産物 / 炎症性疾患 / プロバイオティクス / 腸内細菌 Less
  • Research Projects

    (4 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (2 People)
  •  腸管粘膜バリア機能の修復・再生機構における腸肝連携の解明Principal Investigator

    • Principal Investigator
      大坂 利文
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Phenotypic plasticity of the microbiota associated with odontogenic infectionsPrincipal Investigator

    • Principal Investigator
      Osaka Toshifumi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Tokyo Women's Medical University
  •  Effect of oral pathogens on the progression of NAFLD in high caloric diet-fed mice.Principal Investigator

    • Principal Investigator
      Osaka Toshifumi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Tokyo Women's Medical University
  •  Systems engineering approach for colitis remission by use of gut commensal bacteria

    • Principal Investigator
      TSUNEDA SATOSHI
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biofunction/Bioprocess
    • Research Institution
      Waseda University

All 2023 2020 2016 2015 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum2015

    • Author(s)
      Chen-Yu Hsieh, Toshifumi Osaka, Eri Moriyama1, Yasuhiro Date, Jun Kikuchi, Satoshi Tsuneda
    • Journal Title

      Physiological Reports

      Volume: 3 Issue: 3 Pages: e12327-e12327

    • DOI

      10.14814/phy2.12327

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23360373, KAKENHI-PROJECT-25513012
  • [Presentation] 細菌間コミュニケーションによるFusobacterium nucleatumの動態変化の解析2023

    • Author(s)
      中川隼輔、塩﨑有彩、常田聡、柳澤直子、大坂利文
    • Organizer
      日本細菌学会関東支部総会
    • Data Source
      KAKENHI-PROJECT-19K10077
  • [Presentation] Biological effects of Fusobacterium nuleatum with different autoinducer-2 productivity2020

    • Author(s)
      Arisa Shiozaki, Toshifumi Osaka, Hidehiro Ueshiba, Satoshi Tsuneda, Junji Yagi, Naoko Yanagisawa
    • Organizer
      弟93回日本細菌学会総会
    • Data Source
      KAKENHI-PROJECT-19K10077
  • [Presentation] 口腔病原体が誘引する腸内細菌叢バランス異常が非アルコール性脂肪肝疾患の病態進展に与える影響2016

    • Author(s)
      大坂利文
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-08-24
    • Data Source
      KAKENHI-PROJECT-15K20392
  • [Presentation] 生活習慣病の病態進展と制御に関する腸内細菌叢の変化2016

    • Author(s)
      大坂利文
    • Organizer
      第92回実験動物コンファレンス
    • Place of Presentation
      日本獣医生命科学大学(東京都、武蔵野市)
    • Year and Date
      2016-06-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K20392
  • [Presentation] Liver senses gut environmental alteration induced by oral pathobionts2016

    • Author(s)
      大坂利文, 阿部義廣、上芝秀博、常田聡、八木淳二
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Data Source
      KAKENHI-PROJECT-15K20392
  • [Presentation] DSS腸炎マウスの病態形成過程における腸内細菌由来TLRs刺激能の動態2012

    • Author(s)
      大坂利文
    • Organizer
      第16回腸内細菌学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] Host-microbes interplay involving in the resolution of intestinal inflammation2012

    • Author(s)
      大坂利文
    • Organizer
      14th International Symposium on Microbial Ecology
    • Place of Presentation
      コペンハーゲン
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸内細菌叢が大腸炎の病態に与える影響解析2011

    • Author(s)
      三木硬介, 大坂利文, 伊達康博, 菊地淳, 常田聡
    • Organizer
      第27回日本微生物生態学会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] Characterization of Colonic Microflora and Innate Immune-Stimulatory Activity during Colitis Progression2011

    • Author(s)
      T.Osaka, J.Hayasaki, K.Miki, S.Tsuneda
    • Organizer
      International Union of Microbiological Societies Congresses 2011
    • Place of Presentation
      札幌国際会議場(北海道)
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸炎の病態形成に寄与する腸内環境因子の探索2011

    • Author(s)
      三木硬介, 大坂利文, 伊達康博, 菊地淳, 常田聡
    • Organizer
      平成23年度日本生物工学会大会
    • Place of Presentation
      東京農工大(東京都)
    • Year and Date
      2011-09-26
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] In vitro Screening of Prospective Bacteria Modulating the Epithelial Inflammatory Response2011

    • Author(s)
      T.Osaka, R.Matsuura, S.Shibata, S.Tsuneda
    • Organizer
      International Union of Microbiological Societies Congresses 2011
    • Place of Presentation
      札幌国際会議場(北海道)
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] The interaction between commensal bacteria and innate immune receptors for modulating the intestinal inflammatory response

    • Author(s)
      Toshifumi Osaka, Chihiro Wayu, Junki Hayasaki, Kosuke Miki, Satoshi Tsuneda
    • Organizer
      Cell Symposia: Microbiome and Host Health (CMIC2013)
    • Place of Presentation
      リスボン
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸内細菌代謝産物を介した大腸上皮細胞の炎症応答抑制

    • Author(s)
      大坂利文,謝鎮宇,森山恵里,伊達康博,菊地淳,常田聡
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-11
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸内細菌代謝産物を介した大腸上皮細胞の炎症応答抑制機構の探索

    • Author(s)
      鎌田瑞翔,大坂 利文,常田聡
    • Organizer
      第18回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-11 – 2014-06-12
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸内細菌代謝産物を介した大腸上皮細胞の炎症応答抑制

    • Author(s)
      大坂利文, 松浦諒, 常田聡
    • Organizer
      第17回腸内細菌学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] The Regulation of the Intestinal Epithelial Tight Junction Protein by Bifidobacterium bifidum

    • Author(s)
      謝鎮宇,大坂利文,常田聡
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸管上皮バリア機能の強化・修復を担う腸内細菌の探索

    • Author(s)
      大坂利文,謝鎮宇,森山恵里, 伊達康博, 菊地淳, 常田聡
    • Organizer
      第19回Hindgut Club Japan
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] 腸内細菌による腸管上皮バリア機能の強化・修復

    • Author(s)
      大坂利文,謝鎮宇,森山恵里,伊達康博,菊地淳,常田聡
    • Organizer
      第18回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-11 – 2014-06-12
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] DSS腸炎の寛解誘導に関わる腸管内細菌代謝物動態の解析

    • Author(s)
      森山恵里, 大坂利文, 伊達康博,  菊地淳, 常田聡
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-11
    • Data Source
      KAKENHI-PROJECT-23360373
  • [Presentation] The physiological importance of commensal Enterobacteriaceae populations in the gut homeostasis

    • Author(s)
      大坂利文, 常田聡
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-23360373
  • 1.  KAGAWA Yuki (90409649)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  TSUNEDA SATOSHI (30281645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results

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