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Higashi Tomohito  東 智仁

… Alternative Names

HIGASHI Tomohito  東 智仁

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Researcher Number 70515072
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5616-1477
Affiliation (Current) 2025: 福島県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 福島県立医科大学, 医学部, 准教授
2018: 福島県立医科大学, 医学部, 講師
2011: Kobe University, 医学(系)研究科(研究院), 研究員
2010: Kobe University, 大学院・医学研究科, グローバルCOE研究員
2009 – 2010: Kobe University, 医学研究科, グローバルCOE研究員
Review Section/Research Field
Principal Investigator
Basic Section 44010:Cell biology-related / Cell biology
Except Principal Investigator
Basic Section 49020:Human pathology-related
Keywords
Principal Investigator
タイトジャンクション / 上皮細胞 / アクチン細胞骨格 / 細胞間接着 / トリセルラージャンクション / メカノトランスダクション / メカノセンシング / アドへレンスジャンクション / 三細胞間接着 / バリア機構 … More / プロテアーゼ / 密着結合 / 膜繋留型セリンプロテアーゼ(MASP) / セリンプロテアーゼ / EpCAM / バリア機能 / ZnUMBA / クローディン / 密着結合(タイトジャンクション) / ライブイメージング / 分裂収縮環 / アドヘレンスジャンクション / Rho / アドレヘンスジャンクション / アフリカツメガエル / 細胞質分裂 / フォルミン / RhoA / 裏打ちアクチン / RhoGEF / ArhGEF11 / Rho低分子量Gタンパク質 … More
Except Principal Investigator
病理学 / 腸管オルガノイド / ゲノム編集 / クローディン / タイト結合 / 腸上皮幹細胞 / 蠕動 / JAMファミリー / CLMP / 腸管幹細胞 Less
  • Research Projects

    (6 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (2 People)
  •  トリセルラーAJをかたちづくる分子の解明Principal Investigator

    • Principal Investigator
      東 智仁
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Fukushima Medical University
  •  Molecular mechanism of tight junction maintenance by proteasesPrincipal Investigator

    • Principal Investigator
      Higashi Tomohito
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Fukushima Medical University
  •  Mechanisms of actin assembly athte ontractile rings and cell-cell junctionsPrincipal Investigator

    • Principal Investigator
      Higashi Tomohito
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Fukushima Medical University
  •  Fate decision of intestinal stem cells by tight junction molecules

    • Principal Investigator
      Tanaka Mizuko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Fukushima Medical University
  •  密着結合のバリア機能維持機構の解明Principal Investigator

    • Principal Investigator
      東 智仁
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Kobe University
  •  Analysis of molecular mechanisms of the formation of the intercellular junction-underlying actin bundle using semi-intact epithelium.Principal Investigator

    • Principal Investigator
      HIGASHI Tomohito
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Kobe University

All 2024 2023 2022 2021 2020 2019 2010 2009

All Journal Article Presentation

  • [Journal Article] Damage control of epithelial barrier function in dynamic environments2024

    • Author(s)
      Higashi Tomohito、Saito Akira C.、Chiba Hideki
    • Journal Title

      European Journal of Cell Biology

      Volume: 103 Issue: 2 Pages: 151410-151410

    • DOI

      10.1016/j.ejcb.2024.151410

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Journal Article] ZnUMBA - a live imaging method to detect local barrier breaches2023

    • Author(s)
      Higashi Tomohito、Stephenson Rachel E.、Schwayer Cornelia、Huljev Karla、Higashi Atsuko Y.、Heisenberg Carl-Philipp、Chiba Hideki、Miller Ann L.
    • Journal Title

      Journal of Cell Science

      Volume: 136 Issue: 15

    • DOI

      10.1242/jcs.260668

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Journal Article] Tight-junction strand networks and tightness of the epithelial barrier2023

    • Author(s)
      Saito Akira C、Higashi Tomohito、Chiba Hideki
    • Journal Title

      Microscopy

      Volume: 72 Issue: 3 Pages: 213-225

    • DOI

      10.1093/jmicro/dfad008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Journal Article] EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier2022

    • Author(s)
      Higashi Tomohito、Saito Akira C.、Fukazawa Yugo、Furuse Mikio、Higashi Atsuko Y.、Ono Masahiro、Chiba Hideki
    • Journal Title

      Journal of Cell Biology

      Volume: 222 Issue: 1

    • DOI

      10.1083/jcb.202204079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06156, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02523
  • [Journal Article] Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function2021

    • Author(s)
      Saito Akira C.、Higashi Tomohito、Fukazawa Yugo、Otani Tetsuhisa、Tauchi Masashi、Higashi Atsuko Y.、Furuse Mikio、Chiba Hideki
    • Journal Title

      Molecular Biology of the Cell

      Volume: 32 Issue: 8 Pages: 722-738

    • DOI

      10.1091/mbc.e20-07-0464

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06223, KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-20H05058, KAKENHI-PROJECT-19H03323, KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-21H05286
  • [Journal Article] Molecular organization, regulation and function of tricellular junctions2020

    • Author(s)
      Higashi Tomohito、Chiba Hideki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1862 Issue: 2 Pages: 183143-183143

    • DOI

      10.1016/j.bbamem.2019.183143

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08699, KAKENHI-PROJECT-18K06223
  • [Journal Article] Comprehensive analysis of formin localization in Xenopus epithelial cells.2019

    • Author(s)
      Tomohito Higashi, Rachel E. Stepheson, Ann L. Miller
    • Journal Title

      Molecular Biology of the Cell

      Volume: 30 Issue: 1 Pages: 82-95

    • DOI

      10.1091/mbc.e18-02-0133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06223
  • [Journal Article] Horiuchi H Flightless-I (Fli-I) regulates the actin assembly of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperationwith active Rho GTPases.2010

    • Author(s)
      Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, Furuse M, Kimura T, Kita T.
    • Journal Title

      J Biol Chem 285巻

      Pages: 16231-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770212
  • [Presentation] Proteinase-mediated tight junction damage surveillance and repair.2023

    • Author(s)
      Higashi T, Saito AC, Fukazawa Y, Furuse M, Higashi AY, Ono M, Chiba H.
    • Organizer
      Gordon Research Conference (GRC) on Cell Contact and Adhesion
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Presentation] Proteinase-mediated tight junction damage surveillance and repair.2023

    • Author(s)
      Higashi T.
    • Organizer
      Shenyang Brain Science and Disease Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Presentation] EpCAMの限定分解による密着結合の修復機構2023

    • Author(s)
      東 智仁
    • Organizer
      生理学研究所上皮研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Presentation] プロテアーゼによる密着結合の破綻の検知・修復の仕組み2022

    • Author(s)
      東智仁、齋藤明、深澤有吾、古瀬幹夫、東淳子、小野将寛、千葉英樹
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K06156
  • [Presentation] Dynamic maintenance of tight junction barrier2020

    • Author(s)
      Tomohito Higashi
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K06223
  • [Presentation] Flightless-I (Fli-I) regulates the actin assembly activity of Diaphanous-related formins (DRFs) Daaml and mDial in cooperation with active Rho.2010

    • Author(s)
      東智仁
    • Organizer
      アメリカ細胞生物学会
    • Place of Presentation
      ペンシルベニア会議場(米国・フィラデルフィア)
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PROJECT-21770212
  • [Presentation] PDZ-RhoGEFは細胞間接着部位に局在し上皮細胞のアピカル面張力を制御する2010

    • Author(s)
      東智仁
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-21770212
  • [Presentation] ArhGEF11 localizes at intercellular junction of epithelial cells and regulates the actin cytoskeletal organization.2009

    • Author(s)
      東智仁
    • Organizer
      日本分子生物学会第32回年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21770212
  • 1.  Tanaka Mizuko (40583638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  千葉 英樹 (00295346)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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