Higashi Tomohito 東智仁

… Alternative Names

HIGASHI Tomohito 東智仁

Less

Researcher Number	70515072
Other IDs	https://orcid.org/0000-0001-5616-1477
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 福島県立医科大学, 医学部, 准教授 2018: 福島県立医科大学, 医学部, 講師 2011: Kobe University, 医学(系)研究科(研究院), 研究員 2010: Kobe University, 大学院・医学研究科, グローバルCOE研究員 2009 – 2010: Kobe University, 医学研究科, グローバルCOE研究員
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Cell biology Except Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator タイトジャンクション / 上皮細胞 / アクチン細胞骨格 / 細胞間接着 / トリセルラージャンクション / メカノトランスダクション / メカノセンシング / アドへレンスジャンクション / 三細胞間接着 / バリア機構 … More / プロテアーゼ / 密着結合 / 膜繋留型セリンプロテアーゼ（MASP） / セリンプロテアーゼ / EpCAM / バリア機能 / ZnUMBA / クローディン / 密着結合（タイトジャンクション） / ライブイメージング / 分裂収縮環 / アドヘレンスジャンクション / Rho / アドレヘンスジャンクション / アフリカツメガエル / 細胞質分裂 / フォルミン / RhoA / 裏打ちアクチン / RhoGEF / ArhGEF11 / Rho低分子量Gタンパク質 … More Except Principal Investigator 病理学 / 腸管オルガノイド / ゲノム編集 / クローディン / タイト結合 / 腸上皮幹細胞 / 蠕動 / JAMファミリー / CLMP / 腸管幹細胞 Less

トリセルラーAJをかたちづくる分子の解明Principal Investigator
- Principal Investigator
  
  東智仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Fukushima Medical University
Molecular mechanism of tight junction maintenance by proteasesPrincipal Investigator
- Principal Investigator
  
  Higashi Tomohito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Fukushima Medical University
Mechanisms of actin assembly athte ontractile rings and cell-cell junctionsPrincipal Investigator
- Principal Investigator
  
  Higashi Tomohito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Fukushima Medical University
Fate decision of intestinal stem cells by tight junction molecules
- Principal Investigator
  
  Tanaka Mizuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Fukushima Medical University
密着結合のバリア機能維持機構の解明Principal Investigator
- Principal Investigator
  
  東智仁
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kobe University
Analysis of molecular mechanisms of the formation of the intercellular junction-underlying actin bundle using semi-intact epithelium.Principal Investigator
- Principal Investigator
  
  HIGASHI Tomohito
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kobe University

All 2024 2023 2022 2021 2020 2019 2010 2009

All Journal Article Presentation

[Journal Article] Damage control of epithelial barrier function in dynamic environments2024
- Author(s)
  Higashi Tomohito、Saito Akira C.、Chiba Hideki
- Journal Title
  
  European Journal of Cell Biology
  
  Volume: 103 Issue: 2 Pages: 151410-151410
- DOI
  10.1016/j.ejcb.2024.151410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06156
[Journal Article] ZnUMBA - a live imaging method to detect local barrier breaches2023
- Author(s)
  Higashi Tomohito、Stephenson Rachel E.、Schwayer Cornelia、Huljev Karla、Higashi Atsuko Y.、Heisenberg Carl-Philipp、Chiba Hideki、Miller Ann L.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 136 Issue: 15
- DOI
  10.1242/jcs.260668
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06156
[Journal Article] Tight-junction strand networks and tightness of the epithelial barrier2023
- Author(s)
  Saito Akira C、Higashi Tomohito、Chiba Hideki
- Journal Title
  
  Microscopy
  
  Volume: 72 Issue: 3 Pages: 213-225
- DOI
  10.1093/jmicro/dfad008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06156
[Journal Article] EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier2022
- Author(s)
  Higashi Tomohito、Saito Akira C.、Fukazawa Yugo、Furuse Mikio、Higashi Atsuko Y.、Ono Masahiro、Chiba Hideki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 222 Issue: 1
- DOI
  10.1083/jcb.202204079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06156, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02523
[Journal Article] Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function2021
- Author(s)
  Saito Akira C.、Higashi Tomohito、Fukazawa Yugo、Otani Tetsuhisa、Tauchi Masashi、Higashi Atsuko Y.、Furuse Mikio、Chiba Hideki
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 32 Issue: 8 Pages: 722-738
- DOI
  10.1091/mbc.e20-07-0464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06223, KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-20H05058, KAKENHI-PROJECT-19H03323, KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-21H05286
[Journal Article] Molecular organization, regulation and function of tricellular junctions2020
- Author(s)
  Higashi Tomohito、Chiba Hideki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1862 Issue: 2 Pages: 183143-183143
- DOI
  10.1016/j.bbamem.2019.183143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08699, KAKENHI-PROJECT-18K06223
[Journal Article] Comprehensive analysis of formin localization in Xenopus epithelial cells.2019
- Author(s)
  Tomohito Higashi, Rachel E. Stepheson, Ann L. Miller
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 30 Issue: 1 Pages: 82-95
- DOI
  10.1091/mbc.e18-02-0133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06223
[Journal Article] Horiuchi H Flightless-I (Fli-I) regulates the actin assembly of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperationwith active Rho GTPases.2010
- Author(s)
  Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, Furuse M, Kimura T, Kita T.
- Journal Title
  
  J Biol Chem 285巻
  
  Pages: 16231-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770212
[Presentation] Proteinase-mediated tight junction damage surveillance and repair.2023
- Author(s)
  Higashi T, Saito AC, Fukazawa Y, Furuse M, Higashi AY, Ono M, Chiba H.
- Organizer
  Gordon Research Conference (GRC) on Cell Contact and Adhesion
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06156
[Presentation] Proteinase-mediated tight junction damage surveillance and repair.2023
- Author(s)
  Higashi T.
- Organizer
  Shenyang Brain Science and Disease Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06156
[Presentation] EpCAMの限定分解による密着結合の修復機構2023
- Author(s)
  東智仁
- Organizer
  生理学研究所上皮研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06156
[Presentation] プロテアーゼによる密着結合の破綻の検知・修復の仕組み2022
- Author(s)
  東智仁、齋藤明、深澤有吾、古瀬幹夫、東淳子、小野将寛、千葉英樹
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06156
[Presentation] Dynamic maintenance of tight junction barrier2020
- Author(s)
  Tomohito Higashi
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K06223
[Presentation] Flightless-I (Fli-I) regulates the actin assembly activity of Diaphanous-related formins (DRFs) Daaml and mDial in cooperation with active Rho.2010
- Author(s)
  東智仁
- Organizer
  アメリカ細胞生物学会
- Place of Presentation
  ペンシルベニア会議場(米国・フィラデルフィア)
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-21770212
[Presentation] PDZ-RhoGEFは細胞間接着部位に局在し上皮細胞のアピカル面張力を制御する2010
- Author(s)
  東智仁
- Organizer
  日本細胞生物学会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21770212
[Presentation] ArhGEF11 localizes at intercellular junction of epithelial cells and regulates the actin cytoskeletal organization.2009
- Author(s)
  東智仁
- Organizer
  日本分子生物学会第32回年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21770212

1. Tanaka Mizuko (40583638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 千葉英樹 (00295346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Higashi Tomohito 東 智仁

HIGASHI Tomohito 東 智仁

Research Projects

Research Products

Co-Researchers

トリセルラーAJをかたちづくる分子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of tight junction maintenance by proteasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of actin assembly athte ontractile rings and cell-cell junctionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fate decision of intestinal stem cells by tight junction molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

密着結合のバリア機能維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular mechanisms of the formation of the intercellular junction-underlying actin bundle using semi-intact epithelium.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Damage control of epithelial barrier function in dynamic environments2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZnUMBA - a live imaging method to detect local barrier breaches2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tight-junction strand networks and tightness of the epithelial barrier2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular organization, regulation and function of tricellular junctions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of formin localization in Xenopus epithelial cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Horiuchi H Flightless-I (Fli-I) regulates the actin assembly of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperationwith active Rho GTPases.2010

Author(s)

Journal Title

Data Source

Higashi Tomohito 東智仁

HIGASHI Tomohito 東智仁