Kasai Takashi 笠井高士

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KASAI Takashi 笠井高士

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Researcher Number	70516062
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2016 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2013 – 2016: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2009 – 2010: Kyoto Prefectural University of Medicine, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Neurology / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator パーキンソン病 / 解糖系 / Pgk / PGK / 解糖系酵素 / ショウジョウバエ / αsynuclein / リポ蛋白 / 脂質 / α-synuclein … More / アミロイド伝播 / αシヌクレイン / ニューロシン / オリゴマー / α-シヌクレイン … More Except Principal Investigator オリゴマー / パーキンソン病 / α-シヌクレイン / iPS細胞 / ショウジョウバエ / αシヌクレイン / STXBP1 / シヌクレインオリゴマー / 分子篩クロマトグラフィー / リポ蛋白 / エクソソーム / 脂質 / ELISA / アミロイドβ蛋白 / アミロイド前駆蛋白 / Aβモノマー / Aβオリゴマー / アルツハイマー病 / GFP / 小胞体 / 培養細胞 / 蛋白分解 / セリンプロテアーゼ / 蛋白質分解 / 酵素 / ニューロシン Less

A novel disease modification strategy for Parkinson disease by PGK enhancementPrincipal Investigator
- Principal Investigator
  
  Kasai Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Search for targeted therapies for alpha-synuclein-induced neurotoxicity in STXBP1 encephalopathy
- Principal Investigator
  
  Chiyonobu Tomohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
A novel disease modification strategy for Parkinson disease by PGK enhancementPrincipal Investigator
- Principal Investigator
  
  KASAI TAKASHI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of lipid associated alpha-synuclein metabolismPrincipal Investigator
- Principal Investigator
  
  Kasai Takashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Identification of neurotoxic alpha-synuclein oligomers in Parkinson's disease and its application to molecular targeted therapy
- Principal Investigator
  
  Tokuda Takahiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Mutations in the APP in familial Alzheimer's disease increase Abeta oligomer production in cellular models
- Principal Investigator
  
  Yoichi Ohshima
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of the amyloid propagation in alpha-synucleinopathyPrincipal Investigator
- Principal Investigator
  
  KASAI Takashi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine
Exploration of intracellular protease property and control factors of neurosin with α-synuclein degrading activity
- Principal Investigator
  
  TOKUDA Takahiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2010 2009 2008

All Journal Article Presentation

[Journal Article] α-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies2024
- Author(s)
 Matsuoka Taro、Yoshida Hideki、Kasai Takashi、Tozawa Takenori、Iehara Tomoko、Chiyonobu Tomohiro
- Journal Title
 
 Human Molecular Genetics
 
 Volume: - Issue: 15 Pages: 1328-1338
- DOI
 10.1093/hmg/ddae073
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K07855
[Journal Article] Serum leucine-rich α2 glycoprotein as a potential biomarker for systemic inflammation in Parkinson’s disease2023
- Author(s)
  Ohmichi Takuma、Kasai Takashi、Shinomoto Makiko、Kitani-Morii Fukiko、Fujino Yuzo、Menjo Kanako、Mizuno Toshiki
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 2 Pages: e0282153-e0282153
- DOI
  10.1371/journal.pone.0282153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07466, KAKENHI-PROJECT-20K16605
[Journal Article] Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan2021
- Author(s)
  Kitani-Morii Fukiko、Kasai Takashi、Horiguchi Go、Teramukai Satoshi、Ohmichi Takuma、Shinomoto Makiko、Fujino Yuzo、Mizuno Toshiki
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 1 Pages: 0245864-0245864
- DOI
  10.1371/journal.pone.0245864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16605, KAKENHI-PROJECT-18K07506
[Journal Article] Impaired age-dependent increases in phosphoglycerate kinase activity in red blood cells of Parkinson's disease patients2021
- Author(s)
  Fujino Yuzo、Kasai Takashi、Kitani-Morii Fukiko、Ohmichi Takuma、Shinomoto Makiko、Menjo Kanako、Mizuno Toshiki
- Journal Title
  
  Parkinsonism & Related Disorders
  
  Volume: 91 Pages: 128-134
- DOI
  10.1016/j.parkreldis.2021.09.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-21K07466, KAKENHI-PROJECT-20K16605
[Journal Article] Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer’s disease2021
- Author(s)
  Shinomoto Makiko、Kasai Takashi、Tatebe Harutsugu、Kitani-Morii Fukiko、Ohmichi Takuma、Fujino Yuzo、Allsop David、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  Translational Neurodegeneration
  
  Volume: 10 Issue: 1 Pages: 2-2
- DOI
  10.1186/s40035-020-00227-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16605, KAKENHI-PROJECT-18K15461, KAKENHI-PROJECT-18K07506
[Journal Article] Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics2021
- Author(s)
  Kojima Yuta、Kasai Takashi、Noto Yu-ichi、Ohmichi Takuma、Tatebe Harutsugu、Kitaoji Takamasa、Tsuji Yukiko、Kitani-Morii Fukiko、Shinomoto Makiko、Allsop David、Teramukai Satoshi、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 11 Pages: 0260323-0260323
- DOI
  10.1371/journal.pone.0260323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-21K07466
[Journal Article] Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase2020
- Author(s)
  Joe Shimizu, Takashi Kasai, Hideki Yoshida, Anh M Huynh, Yumiko Nakao-Azuma, Makiko Shinomoto, Takahiko Tokuda, Toshiki Mizuno, Masamitsu Yamaguchi
- Journal Title
  
  Neurochemistry Internatinal
  
  Volume: 139 Pages: 104816-104816
- DOI
  10.1016/j.neuint.2020.104816
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07506
[Journal Article] Quantification of Blood Caffeine Levels in Patients With Parkinson's Disease and Multiple System Atrophy by Caffeine ELISA2020
- Author(s)
  Ohmichi Takuma、Kasai Takashi、Shinomoto Makiko、Matsuura Jun、Koizumi Takashi、Kitani-Morii Fukiko、Tatebe Harutsugu、Sasaki Hidenao、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 11 Pages: 580127-580127
- DOI
  10.3389/fneur.2020.580127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-20K16605, KAKENHI-PROJECT-18K15461
[Journal Article] Combined use of CSF NfL and CSF TDP-43 improves diagnostic performance in ALS2019
- Author(s)
  Takashi Kasai, Yuta Kojima, Takuma Ohmichi, Harutsugu Tatebe, Yukiko Tsuji, Yu-Ichi Noto, Fukiko Kitani-Morii, Makiko Shinomoto, David Allsop,Toshiki Mizuno, Takahiko Tokuda
- Journal Title
  
  Annals of Clinical Translational Neurology
  
  Volume: 6 Issue: 12 Pages: 2489-2502
- DOI
  10.1002/acn3.50943
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-18K15461
[Journal Article] Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients2019
- Author(s)
  Shinomoto Makiko、Kasai Takashi、Tatebe Harutsugu、Kondo Masaki、Ohmichi Takuma、Morimoto Masafumi、Chiyonobu Tomohiro、Terada Naoto、Allsop David、Yokota Isao、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 4 Pages: e0211575-e0211575
- DOI
  10.1371/journal.pone.0211575
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-18K15461
[Journal Article] PDの認知機能障害と関連するバイオマーカー2018
- Author(s)
  笠井高士、徳田隆彦
- Journal Title
  
  認知症の最新医療
  
  Volume: 8 Pages: 23-28
- Data Source
  KAKENHI-PROJECT-15K09319
[Journal Article] Increased levels of plasma total tau in adult Down syndrome2018
- Author(s)
  Kasai T, Tatebe H, Kondo M, Ishii R, Ohmichi T, Yeung WTE, Morimoto M, Chiyonobu T, Terada N, Allsop D, Nakagawa M, Mizuno T, Tokuda T.
- Journal Title
  
  Plos One
  
  Volume: 12 Issue: 11 Pages: e0188802-e0188802
- DOI
  10.1371/journal.pone.0188802
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson’s disease2018
- Author(s)
  Ohmichi Takuma、Kasai Takashi、Kosaka Tadashi、Shikata Keisuke、Tatebe Harutsugu、Ishii Ryotaro、Shinomoto Makiko、Mizuno Toshiki、Tokuda Takahiko
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 7 Pages: e0201260-e0201260
- DOI
  10.1371/journal.pone.0201260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07506, KAKENHI-PROJECT-18K15461, KAKENHI-PROJECT-15K09319
[Journal Article] 認知症と糖尿病2018
- Author(s)
  笠井高士
- Journal Title
  
  京都府立医大雑誌
  
  Volume: 126 Pages: 697-784
- Data Source
  KAKENHI-PROJECT-15K09319
[Journal Article] Parkinson病の早期診断2017
- Author(s)
  笠井高士　徳田隆彦
- Journal Title
  
  神経内科
  
  Volume: 86 Pages: 23-29
- Data Source
  KAKENHI-PROJECT-15K09319
[Journal Article] Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: Do PGK-1 mutations contribute to vulnerability to parkinsonism?2017
- Author(s)
  Sakaue S, Kasai T, Osone S, Azuma Y, Imamura T, Mizuta I, Tokuda T, Kanno H, El-Agnaf OM, Morimoto M, Hosoi H, Mizuno T.
- Journal Title
  
  npj Parkinson Disease
  
  Volume: 3 Issue: 1 Pages: 1-3
- DOI
  10.1038/s41531-017-0014-4
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] Parkinson病の生化学的バイオマーカーの標準化2017
- Author(s)
  笠井高士　徳田隆彦
- Journal Title
  
  神経内科
  
  Volume: 86 Pages: 499-507
- Data Source
  KAKENHI-PROJECT-15K09319
[Journal Article] Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome2017
- Author(s)
  Tatebe Harutsugu、Kasai Takashi、Ohmichi Takuma、Kishi Yusuke、Kakeya Tomoshi、Waragai Masaaki、Kondo Masaki、Allsop David、Tokuda Takahiko
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 1-11
- DOI
  10.1186/s13024-017-0206-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K09820
[Journal Article] Abeta levels in the jugular vein and high molecular weight Abeta oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease.2017
- Author(s)
  Kasai T, Kondo M, Ishii R, Tanaka A, Ataka S, Shimada H, Tomiyama T, Mori H, Taylor M, Allsop D, Nakagawa M, Mizuno T, Tokuda T.
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 4 Pages: e0174630-e0174630
- DOI
  10.1371/journal.pone.0174630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study2016
- Author(s)
  Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Miyatani F, Kondo M, Tamura A, Kasai T, Ohshima Y, Yoshida T, Tokuda T, Mizuta I, Mizuno S, Yamada K, Takeda K, Matsumoto S, Nakagawa M, Mizuno T, Watanabe Y
- Journal Title
  
  BMC Neurol
  
  Volume: 16 Pages: 253-253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09322
[Journal Article] Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy.2016
- Author(s)
  Kasai T, Tokuda T, Ohmichi T, Ishii R, Tatebe H, Nakagawa M, Mizuno T
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 1 Pages: e0147574-e0147574
- DOI
  10.1371/journal.pone.0147574
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319, KAKENHI-PROJECT-15K09322
[Journal Article] パーキンソン病およびパーキンソン症候群のバイオマーカー2016
- Author(s)
  笠井高士　徳田隆彦
- Journal Title
  
  内科
  
  Volume: 118 Pages: 251-254
- Data Source
  KAKENHI-PROJECT-15K09319
[Journal Article] Decrease in plasma levels of α-synuclein is evident in patients with parkinson’s disease after elimination of heterophilic antibody interference2015
- Author(s)
  Ishii R, Tokuda T, Tatebe H, Ohmichi T, Kasai T, Nakagawa M, Mizuno T, El-Agnaf OMA
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 4 Pages: e0123162-e0123162
- DOI
  10.1371/journal.pone.0123162
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09322
[Journal Article] Extracellular neurosin degrades alpha-synuclein in cultured cells.2010
- Author(s)
  Tatebe H, Watanabe Y, Kasai T, Mizuno T, Nakagawa M, Tanaka M, Tokuda T.
- Journal Title
  
  Neurosci Res. 67
  
  Pages: 341-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790847
[Journal Article] High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.2010
- Author(s)
  Fukumoto H, Tokuda T, Kasai T, Ishigami N, Hidaka H, Kondo M, Allsop D, Nakagawa M.
- Journal Title
  
  FASEB J. 24
  
  Pages: 2716-2726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790847
[Journal Article] 脳脊髄液および血液中のTDP-43定量とその臨床的有用性2010
- Author(s)
  徳田隆彦, 笠井高士, 中川正法
- Journal Title
  
  最新医学 67巻7号
  
  Pages: 1642-1647
- Data Source
  KAKENHI-PROJECT-21790847
[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : specificity, sensitivity, and a possible prognostic value.2010
- Author(s)
  Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, Mori M, Uchiyama T, Isose S, Nasu S, Sekiguchi Y, Fujimaki Y, Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
- Journal Title
  
  Amyotroph Lateral Scler. 12
  
  Pages: 140-143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790847
[Journal Article] Detection of elevated levels of alpha-synuclein oligomers in CSF from patients with Parkinson disease.2010
- Author(s)
  Tokuda T, Oureshi MM, Ardah MT, Varghese S, Shehab SA, Kasai T, Ishigami N, Tamaoka A, Nakagawa M, El-Agnuf OM.
- Journal Title
  
  Neurology. 75
  
  Pages: 1766-1770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790847
[Journal Article] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.2009
- Author(s)
  Kasai T, Tokuda T, Ishigami N, (他6名)
- Journal Title
  
  Acta Neuropathol 117
  
  Pages: 55-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591007
[Journal Article] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.2009
- Author(s)
  Kasai T, et al.
- Journal Title
  
  Acta Neuropathologica 117
  
  Pages: 55-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591007
[Journal Article] Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.2008
- Author(s)
  Kasai T, Tokuda T, Watanabe Y, (他4名)
- Journal Title
  
  Neurosci Lett 436
  
  Pages: 52-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591007
[Journal Article] Cleavage of normal and pathological forms of alpha-synuclein byneurosin in vitro.2008
- Author(s)
  Kasai T, et al.
- Journal Title
  
  Neuroscience Letters 4362
  
  Pages: 52-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] alpha-Synuclein pathology is exacerbated by haploinsufficiency of Rop, the STXBP1 homolog in Drosophila melanogaster.2023
- Author(s)
  Matsuoka T, Yoshida H, Kasai T, Tozawa T, Chiyonobu T.
- Organizer
  日本人類遺伝学会第68回大会
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] alpha-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: Connecting STXBP1 encephalopathy with alpha-synucleinopathies.2023
- Author(s)
  Matsuoka T, Yoshida H, Kasai T, Tozawa T, Chiyonobu T.
- Organizer
  American Society of Human Genetics Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] The loss of Pgk in Drosophila causes locomotive defects with dopaminergic neuronal degeneration2019
- Author(s)
  Takashi Kasai， Jo Shimizu， Yumiko Azuma， Hideki Yoshida， Masamitsu Yamaguchi， Takahiko　Tokuda， Toshiki Mizuno.
- Organizer
  第60回　日本神経学会
- Data Source
  KAKENHI-PROJECT-18K07506
[Presentation] Analysis of novel Parkinson’s disease (PD)-causing gene using Drosophila melanogaster.2018
- Author(s)
  Shimizu J, Kasai T, Yoshida H, Yamaguchi M.
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K07506
[Presentation] Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: Do PGK-1 mutations contribute to vulnerability to parkinsonism?2017
- Author(s)
  Takashi Kasai, Satoshi Sakaue, Ikuko Mizuta, Masaya Suematsu, Shinya Osone, Yumiko Azuma, Toshihiko Imamura, Takahiko Tokuda, Hitoshi Kanno, Omar M. A. El-Agnaf, Masafumi Morimoto, Masanori Nakagawa, Hajime Hosoi, and Toshiki Mizuno
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319
[Presentation] Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy2017
- Author(s)
  Kasai T.
- Organizer
  Alzheimer's and Parkinson Disease Congress 2017
- Place of Presentation
  ウィーン
- Year and Date
  2017-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09319
[Presentation] Serum levels of coenzyme Q10 in patients with multiple system atrophy2017
- Author(s)
  Kasai T, Tokuda T, Ohmichi T, Ishii R, Tatebe H, Nakagawa M, Mizuno T
- Organizer
  The 13th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09322
[Presentation] Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: Do PGK-1 mutations contribute to vulnerability to parkinsonism?2017
- Author(s)
  Kasai T, Sakaue S, Mizuta I, Suematsu M, Osone S, Azuma Y, Imamura T, Tokuda T, Kanno H, El-Agnaf O, Morimoto M, Nakagawa M, Hosoi H, Mizuno T
- Organizer
  The 23rd World Congress of Neurology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09322
[Presentation] Biomarker changes of plasma and CSF after the treatment of IVIg in patients with AD2015
- Author(s)
  Kasai T, Kondo M, Ishii R, Mizuno T, Tokuda T
- Organizer
  The 8th Clinical Trials on Alzheimer's Disease (CTAD) 2015
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09322
[Presentation] 筋萎縮性側索硬化症と頸椎症性脊髄症における錐体路FA値の比較2010
- Author(s)
  笠井高士
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21790847
[Presentation] α-synuclein 分解酵素であるneurosin の細胞内動態の検討2009
- Author(s)
  笠井高士, 建部陽嗣, 徳田隆彦, 石神紀子, 水野敏樹, 中川正法, 渡邊義久, 田中雅樹
- Organizer
  日本神経学会総会(第50回)
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] Neurosin によるα-synuclein 分解の解析2009
- Author(s)
  建部陽嗣, 渡邊義久, 笠井高士, 徳田隆彦, 水野敏樹, 田中雅樹, 中川正法
- Organizer
  日本神経科学大会(第32回)
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] α-synuclein分解酵素であるneurosinの細胞内動態の検討2009
- Author(s)
  笠井高士, 建部陽嗣, 徳田隆彦, 石神紀子, 水野敏樹, 中川正法, 渡邊義久, 田中雅樹
- Organizer
  日本神経学会総会(第50回)
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21790847
[Presentation] α-Synuclein分解酵素であるneurosinの細胞内動態の検討2009
- Author(s)
  笠井高士, 建部陽嗣, 徳田隆彦, 渡邊義久,田中雅樹
- Organizer
  カテコールアミンと神経疾患研究会(第17回)
- Place of Presentation
  東京
- Year and Date
  2009-04-18
- Data Source
  KAKENHI-PROJECT-21790847
[Presentation] α-synuclein分解酵素であるneurosinの細胞内動態の検討2009
- Author(s)
  笠井高士
- Organizer
  日本神経学会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21790847
[Presentation] α-Synuclein 分解酵素であるneurosin の細胞内動態の検討2009
- Author(s)
  笠井高士, 建部陽嗣, 徳田隆彦, 渡邊義久, 田中雅樹
- Organizer
  カテコールアミンと神経疾患研究会(第17回)
- Place of Presentation
  東京
- Year and Date
  2009-04-18
- Data Source
  KAKENHI-PROJECT-20591007
[Presentation] Neurosinによるα-synuclein分解の解析2009
- Author(s)
  建部陽嗣, 渡邊義久, 笠井高士, 徳田隆彦, 水野敏樹, 田中雅樹, 中川正法
- Organizer
  日本神経科学大会(第32回)
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21790847
[Presentation] CJD 患者髄液中ではα-synuclein の断片ペプチドが増加している2008
- Author(s)
  笠井高士, 徳田隆彦, 石神紀子, 中川正法, 坪井義夫
- Organizer
  日本認知症学会学術集会(第27回)
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591007

1. TOKUDA Takahiko (80242692)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. WATANABE Yoshihisa (50363990)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. 吉田英樹 (30570600)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. MIZUNO Toshiki (30264782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. Yoichi Ohshima (50516060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKAGAWA Masanori (50198040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. Chiyonobu Tomohiro (40571659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 建部陽嗣 (00637027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 山口政光 (00182460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 中雄裕美子 (00453093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大道卓摩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 東裕美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kasai Takashi 笠井 高士

KASAI Takashi 笠井 高士

Research Projects

Research Products

Co-Researchers

A novel disease modification strategy for Parkinson disease by PGK enhancementPrincipal Investigator

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Search for targeted therapies for alpha-synuclein-induced neurotoxicity in STXBP1 encephalopathy

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A novel disease modification strategy for Parkinson disease by PGK enhancementPrincipal Investigator

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Investigation of lipid associated alpha-synuclein metabolismPrincipal Investigator

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Identification of neurotoxic alpha-synuclein oligomers in Parkinson's disease and its application to molecular targeted therapy

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Mutations in the APP in familial Alzheimer's disease increase Abeta oligomer production in cellular models

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Investigation of the amyloid propagation in alpha-synucleinopathyPrincipal Investigator

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Exploration of intracellular protease property and control factors of neurosin with α-synuclein degrading activity

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[Journal Article] α-Synuclein pathology in <i>Drosophila melanogaster</i> is exacerbated by haploinsufficiency of <i>Rop</i>: connecting <i>STXBP1</i> encephalopathy with α-synucleinopathies2024

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[Journal Article] Serum leucine-rich α2 glycoprotein as a potential biomarker for systemic inflammation in Parkinson’s disease2023

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[Journal Article] Risk factors for neuropsychiatric symptoms in patients with Parkinson’s disease during COVID-19 pandemic in Japan2021

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[Journal Article] Impaired age-dependent increases in phosphoglycerate kinase activity in red blood cells of Parkinson's disease patients2021

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[Journal Article] Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer’s disease2021

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[Journal Article] Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics2021

Author(s)

Kasai Takashi 笠井高士

KASAI Takashi 笠井高士