ooshita kenuske 大下健輔

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Oshita Kensuke 大下健輔

oshita kensuke 大下健輔

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Researcher Number	70529510
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023: 久留米大学, 医学部, 講師 2021 – 2022: 久留米大学, 医学部, 助教 2015 – 2018: 久留米大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology
Keywords	Principal Investigator 脊髄後角 / HCN / HCN４ / 心房細動 / DREADD / 慢性疼痛 / ＨＣＮ / 炎症性疼痛 / 遺伝子治療 / 後根神経節

HCN4をターゲットとした新たな心房細動の治療戦略の開発Principal Investigator
- Principal Investigator
  
  大下健輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kurume University
Development of DREADD-based gene therapy targeting HCN4 in spinal dorsal hornPrincipal Investigator
- Principal Investigator
  
  Oshita Kensuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kurume University
Development of gene therapy in chronic pain targeting HCN channelsPrincipal Investigator
- Principal Investigator
  
  oshita kensuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Kurume University

All 2023 2021 2019 2017 2016 2015

All Journal Article Presentation Book

[Book] まれな疾患の麻酔　A to Z2015
- Author(s)
  大下健輔　牛島一男
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15K20064
[Journal Article] The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression2023
- Author(s)
  Tauchi Miyuki、Oshita Kensuke、Urschel Katharina、Furtmair Roman、Kuhn Constanze、Stumpfe Florian M.、Botos Balazs、Achenbach Stephan、Dietel Barbara
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 2 Pages: 1174-1174
- DOI
  10.3390/ijms24021174
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08395, KAKENHI-PROJECT-18K16465
[Journal Article] Anesthetic management of a patient with methamphetamine-associated pulmonary arterial hypertension undergoing laparoscopic cholecystectomy2023
- Author(s)
  Oshita Kensuke、Tokuyama Shin、Jotaki Shosaburo、Yokomizo Michiko、Hiraki Teruyuki
- Journal Title
  
  JA Clinical Reports
  
  Volume: 9 Issue: 1 Pages: 10-10
- DOI
  10.1186/s40981-023-00601-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16465
[Journal Article] Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia2019
- Author(s)
  Oshita K, Kozasa Y, Nakagawa Y, Kuwabara Y, Kuwahara K, Nakagawa T, Nakashima N, Hiraki T, Takano M
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: in press Issue: 4 Pages: 653-660
- DOI
  10.1007/s12576-019-00684-7
- NAID
  40021916400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05124, KAKENHI-PROJECT-18K16465, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-17H04174
[Journal Article] Clinical Concentrations of Local Anesthetics Bupivacaine and Lidocaine Differentially Inhibit Human Kir2.x Inward Rectifier K+ Channels2016
- Author(s)
  Nakahara Kei, Oshita Kensuke, Itoh Masayuki, Takano Makoto, Ishihara Keiko
- Journal Title
  
  Anesthesia and Analgesia
  
  Volume: 122
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20064
[Presentation] HCN4ノックダウンは心房細動持続時間を延長する2023
- Author(s)
  大下健輔、中島則行、大野聖子、鷹野誠、平木照之
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-23K08395
[Presentation] アロディニア病態モデルマウスにおける脊髄後角HCN4陽性興奮性インターフェロンの機能2021
- Author(s)
  中川拓、大下健輔、八坂敏一、中島則行、鷹野誠、山浦健
- Organizer
  日本麻酔科学会第68回学術集会
- Data Source
  KAKENHI-PROJECT-18K16465
[Presentation] 下肢虚血再灌流障害に対して術中血液浄化療法を行った2症例2017
- Author(s)
  大下健輔、新山修平、有永康一、佐藤晃、渡邉誠之
- Organizer
  日本集中治療医学会
- Place of Presentation
  札幌
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-15K20064
[Presentation] 心臓特異的HCN2過剰発現マウスは低カリウム血症による催不整脈性が上昇する。2017
- Author(s)
  大下健輔、小佐々優子、中島則行、鷹野誠、牛島一男
- Organizer
  日本麻酔科学会　第64回学術集会
- Data Source
  KAKENHI-PROJECT-15K20064
[Presentation] ペースメーカーチャネルHCN４の陰性変時作用における新たな機能2016
- Author(s)
  小佐々優子　武谷三恵　大下健輔　鷹野誠　牛島一男
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-15K20064
[Presentation] 炎症性疼痛による脊髄後角のHCN4発現変化2016
- Author(s)
  大下健輔　中島則行　小佐々優子　鷹野誠　牛島一男
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-15K20064
[Presentation] ペースメーカーチャネルHCN4の発現制御による心機能変化2015
- Author(s)
  小佐々優子　大下健輔　中島則行　鷹野誠　牛島一男
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K20064

1. Takano Makoto (30236252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

ooshita kenuske 大下 健輔

Oshita Kensuke 大下 健輔

oshita kensuke 大下 健輔

Research Projects

Research Products

Co-Researchers

HCN4をターゲットとした新たな心房細動の治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of DREADD-based gene therapy targeting HCN4 in spinal dorsal hornPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene therapy in chronic pain targeting HCN channelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] まれな疾患の麻酔 A to Z2015

Author(s)

Publisher

Data Source

[Journal Article] The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anesthetic management of a patient with methamphetamine-associated pulmonary arterial hypertension undergoing laparoscopic cholecystectomy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Clinical Concentrations of Local Anesthetics Bupivacaine and Lidocaine Differentially Inhibit Human Kir2.x Inward Rectifier K+ Channels2016

Author(s)

Journal Title

Data Source

[Presentation] HCN4ノックダウンは心房細動持続時間を延長する2023

Author(s)

Organizer

Data Source

[Presentation] アロディニア病態モデルマウスにおける脊髄後角HCN4陽性興奮性インターフェロンの機能2021

Author(s)

Organizer

Data Source

[Presentation] 下肢虚血再灌流障害に対して術中血液浄化療法を行った2症例2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 心臓特異的HCN2過剰発現マウスは低カリウム血症による催不整脈性が上昇する。2017

Author(s)

Organizer

Data Source

[Presentation] ペースメーカーチャネルHCN４の陰性変時作用における新たな機能2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 炎症性疼痛による脊髄後角のHCN4発現変化2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ペースメーカーチャネルHCN4の発現制御による心機能変化2015

Author(s)

ooshita kenuske 大下健輔

Oshita Kensuke 大下健輔

oshita kensuke 大下健輔

[Book] まれな疾患の麻酔　A to Z2015