Yano Masahiko 矢野雅彦

… Alternative Names

YANO Masahiko 矢野雅彦

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Researcher Number	70529693
Affiliation (Current)	2025: 昭和医科大学, 医学部, 兼任講師
Affiliation (based on the past Project Information) *help	2015: 昭和大学, 歯学部, 助教 2011 – 2012: 昭和大学, 医学部, 助教 2010 – 2011: 新潟大学, 医歯学総合病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator ウイルス複製制御機構 / シグナル伝達 / p21細胞内局在 / ウイルス複製抑制機構 / 酸化ストレス / B型肝炎ウイルスX蛋白質 / C型肝炎ウイルス / 肝細胞内シグナル伝達 / 新規ウイルス抑制機構 / 肝炎ウイルス … More Except Principal Investigator … More インターフェロン / 肝脂肪化 / RBP4 / リバビリン / C型慢性肝炎 / Insulin抵抗性 / IFN / インスリン抵抗性 / Peg-IFN / RBP-4 / HCV / トランスジェニックマウス / ATM / HBx遺伝子 / DNA修復機構 / ウイルス発癌 / 肝細胞癌 / DNA修復 / 発癌予防 / IFNβ / 分子機序 / 発がん抑制 / 細胞内局在 / p21 / HBV / 肝癌 / 肝臓学 Less

Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis C
- Principal Investigator
  
  Ohkoshi Shogo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The Nippon Dental University
  Showa University
Development of new IFN-strategy that based on DNA repair mechanism
- Principal Investigator
  
  OHKOSHI Shogo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
  Niigata University
Identification of novel anti-viral mechanism as a therapeutic strategy against intractable hepatitis CPrincipal Investigator
- Principal Investigator
  
  YANO Masahiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Niigata University

All 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy2015
- Author(s)
  Ohkoshi S, Yano M, Matsuda Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 21 Issue: 42 Pages: 12150-6
- DOI
  10.3748/wjg.v21.i42.12150
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Retinol binding protein 4, an insulin- resistance marker, induces interferon resistance in chronic hepatitis C2015
- Author(s)
  Hiromichi Takahashi, Shogo Ohkoshi, Masahiko Yano, Satoshi Yamagiwa, Masanori Ikeda, Nobuyuki Kato, Yasunobu Matsuda, Yutaka Aoyagi
- Journal Title
  
  Hepatogastroenterology
  
  Volume: In Press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.2014
- Author(s)
  Matsuda Y, Sanpei A, Wakai T, Kubota M, Osawa M, Hirose Y, Sakata J, Kobayashi T, Fujimaki S, Takamura M, Yamagiwa S, Yano M, Ohkoshi S, Aoyagi Y
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 7 Pages: 2032-43
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis2013
- Author(s)
  Yano M
- Journal Title
  
  Liv Int
  
  Volume: in press Issue: 8 Pages: 2018-2029
- DOI
  10.1111/liv.12176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590722, KAKENHI-PROJECT-25461012
[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression2013
- Author(s)
  Yano M, Ohkoshi S, Aoki YH, Takahashi H, Kurita S, Yamazaki K, Suzuki K, Yamagiwa S, Sanpei A, Fujimaki S, Wakai T, Kudo SE, Matsuda Y,Aoyagi Y
- Journal Title
  
  Liver Int
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling2012
- Author(s)
  Fujimaki S, Matsuda Y, Wakai T, Sanpei A, Kubota M, Takamura M, Yamagiwa S, Yano M, Ohkoshi S, Aoyagi Y
- Journal Title
  
  Cancer Lett
  
  Volume: 319(1) Pages: 98-108
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] A case with chronic hepatitis C who developed liver cirrhosis due to liver dysfunction caused by pegylated interferon plus ribavirin treatment despite negativity of serum HCV RNA, during therapy2011
- Author(s)
  Ohkoshi S, Morita S, Tanaka Y, Yano M, Takeuchi M, Takahashi H, Ikeda H, Yamagiwa S, Matsuda Y, Nomoto M, Aoyagi Y
- Journal Title
  
  Nihon Shokakibyo Gakkai Zasshi
  
  Volume: 108(2) Pages: 267-74
- NAID
  10029388211
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNalpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response: evaluation of response-guided therapy2011
- Author(s)
  Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Aoki YH, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y,Aoyagi Y.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 58(107-108) Pages: 965-70
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C2011
- Author(s)
  Aoki YH, Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y,(2)Nomoto M, Aoyagi Y
- Journal Title
  
  Hepatol Res
  
  Volume: 41(2) Pages: 118-25
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis2011
- Author(s)
  Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, (4)Kurosaki I, Shirai Y, Okada M, Aoyagi Y
- Journal Title
  
  World J Hepatol
  
  Volume: 3(1) Pages: 15-23
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] C型慢性肝炎とインスリン抵抗性因子RBP4RBP4 はインターフェロン治療抵抗性をもたらす2012
- Author(s)
  高橋弘道, 大越章吾, 矢野雅彦, 山際訓, 松田康伸, 池田正徳, 加藤宣之, 青柳豊
- Organizer
  日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] p21細胞内局在制御によるIFN-βのシスプラチン制癌効果抑制作用2012
- Author(s)
  矢野　雅彦
- Organizer
  日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] p21細胞内局在制御によるIFN-βのシスプラチン制癌効果増強機構2012
- Author(s)
  矢野雅彦, 大越章吾, 高橋弘道, 藤巻隼, 松田康伸, 青柳豊, 工藤進英
- Organizer
  日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] DNA傷害修復因子ATMによる肝癌細胞の細胞死抑制機構の解析2011
- Author(s)
  藤巻隼, 松田康伸, 矢野雅彦, 大越章吾, 若井俊文, 白井良夫, 三瓶歩, 平野茂樹
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] IFN-βprevents HBX-triggered hepatocarcinogenesis by down-regulating cytoplasmic p21 overexpression2011
- Author(s)
  Masahiko Yano
- Organizer
  第46回欧州肝臓学会(EASL)
- Place of Presentation
  ベルリン国際会議場(ドイツ)
- Year and Date
  2011-04-01
- Data Source
  KAKENHI-PROJECT-22790636
[Presentation] IFN-beta prevents HBx-triggered Hepatocarcinogenesis by dowm-regulating cytoplasmic p21 expression2011
- Author(s)
  Yano M, etal.
- Organizer
  全欧肝臓学会
- Place of Presentation
  ベルリン
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] HBx誘導性肝発癌にタイするIFN-βの制御機構の分子学的解析2011
- Author(s)
  矢野雅彦
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] IFN-β prevents HBX-triggered hepatocarcinogenesis by down-regulating cytoplasmic p21 overexpression2011
- Author(s)
  Masahiko Yano
- Organizer
  第46回欧州肝臓学会(EASL)
- Place of Presentation
  ドイツ・ベルリン国際会議場
- Year and Date
  2011-04-01
- Data Source
  KAKENHI-PROJECT-22790636
[Presentation] HBx誘導性肝発癌に対するIFN-βの制御機構の分子学的解析2010
- Author(s)
  矢野雅彦, 大越章吾, 青木洋平, 山崎和秀, 栗田聡, 鈴木健太, 三瓶歩, 松田康伸, 青柳豊
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] Molecular mechanism of IFN-βon prevention of HBx-induced hepatocarcinogenesis2010
- Author(s)
  Masahiko Yano
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790636
[Presentation] Molecular mechanism of IFN-β on prevention of HBx-induced hepatocarcinogenesis2010
- Author(s)
  Masahiko Yano
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790636
[Presentation] HBx誘導性肝発癌に対するIFN-βの制御機構の分子学的解析2010
- Author(s)
  矢野雅彦
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形テルサ(山形県)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22790636

1. OHKOSHI Shogo (70231199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. MATSUDA Yasunobu (40334669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. YAMAGIWA Satoshi (10419327)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results

Yano Masahiko 矢野 雅彦

YANO Masahiko 矢野 雅彦

Research Projects

Research Products

Co-Researchers

Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new IFN-strategy that based on DNA repair mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of novel anti-viral mechanism as a therapeutic strategy against intractable hepatitis CPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinol binding protein 4, an insulin- resistance marker, induces interferon resistance in chronic hepatitis C2015

Author(s)

Journal Title

Data Source

[Journal Article] Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.2014

Author(s)

Journal Title

Data Source

[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression2013

Author(s)

Journal Title

Data Source

[Journal Article] Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling2012

Author(s)

Journal Title

Data Source

[Journal Article] A case with chronic hepatitis C who developed liver cirrhosis due to liver dysfunction caused by pegylated interferon plus ribavirin treatment despite negativity of serum HCV RNA, during therapy2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNalpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response: evaluation of response-guided therapy2011

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C2011

Author(s)

Journal Title

Data Source

[Journal Article] Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis2011

Author(s)

Journal Title

Data Source

[Presentation] C型慢性肝炎とインスリン抵抗性因子RBP4RBP4 はインターフェロン治療抵抗性をもたらす2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] p21細胞内局在制御によるIFN-βのシスプラチン制癌効果抑制作用2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] p21細胞内局在制御によるIFN-βのシスプラチン制癌効果増強機構2012

Author(s)

Organizer

Place of Presentation

Yano Masahiko 矢野雅彦

YANO Masahiko 矢野雅彦