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Yagi Mikako  八木 美佳子

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yagi mikako  八木 美佳子

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Researcher Number 70536135
Other IDs
Affiliation (Current) 2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 九州大学, 医学研究院, 助教
2017 – 2018: 九州大学, 大学病院, 学術研究員
2016: 九州大学, ARO次世代医療センター, 学術研究員
2015: 九州大学, 学内共同利用施設等, 研究員
2014: 九州大学, 大学病院, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 52010:General internal medicine-related / Laboratory medicine
Except Principal Investigator
Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 59040:Nutrition science and health science-related / Laboratory medicine
Keywords
Principal Investigator
ミトコンドリア / HIF1α / NAD合成 / 老化 / NAD / p32 / NAD+ / Hif1α / NMN / リソソーム … More / ノックアウトマウス / オートファジー / knockout mouse / autophagy / lysosome / HIF1 / mitochondria / GAPDH / 心筋症 / C1qbp / 大脳白質脳症 / メタボローム解析 / 白質脳症 / p32/C1qbp … More
Except Principal Investigator
ミトコンドリア / リボソーム / 品質管理 / UNR / 肝臓 / リボソーム品質管理機構 / 肝臓特異的 / サイレント変異 / 心不全 / 心不全モデルマウス / フェロトーシス / NMN / 慢性心不全 / リソソーム / 抗老化 / ストレス応答 / TFAM / 代謝物 / stress応答 / 老化 Less
  • Research Projects

    (7 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (12 People)
  •  Elucidation of new molecular mechanisms of mitochondria-related aging diseases and ferroptosis and their treatmentPrincipal Investigator

    • Principal Investigator
      八木 美佳子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kyushu University
  •  肝臓組織特異的発現遺伝子のサイレント変異で翻訳が停止する新規分子機序

    • Principal Investigator
      内海 健
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Kyushu University
  •  Elucidation of the molecular pathogenesis of ageing diseases caused by mitochondrial dysfunction and therapeutic effects of NMN.

    • Principal Investigator
      内海 健
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kyushu University
  •  Functional Analysis and Preventive Treatment of Aging Mitochondrial DiseasePrincipal Investigator

    • Principal Investigator
      Yagi Mikako
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kyushu University
  •  Search for new mechanisms by which mitochondria control autophagy and metabolites of aging-related diseasesPrincipal Investigator

    • Principal Investigator
      Yagi Mikako
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kyushu University
  •  Elucidation of mitochondrial stress response mechanism leading to anti aging and searching for diagnostic molecule, efficacy

    • Principal Investigator
      Uchiumi Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyushu University
  •  pathophysiological analysis of a mouse model of cerebral leukoencephalopathy and search for pathogenesis-related metabolitesPrincipal Investigator

    • Principal Investigator
      yagi mikako
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A?>?G mutation2023

    • Author(s)
      Ueda Saori、Yagi Mikako、Tomoda Ena、Matsumoto Shinya、Ueyanagi Yasushi、Do Yura、Setoyama Daiki、Matsushima Yuichi、Nagao Asuteka、Suzuki Tsutomu、Ide Tomomi、Mori Yusuke、Oyama Noriko、Kang Dongchon、Uchiumi Takeshi
    • Journal Title

      Nucleic Acids Research

      Volume: 51 Issue: 14 Pages: 7480-7495

    • DOI

      10.1093/nar/gkad591

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-23K24794
  • [Journal Article] Induction of glioblastoma cell ferroptosis using combined treatment with chloramphenicol and 2-deoxy-d-glucose2023

    • Author(s)
      Miki Kenji、Yagi Mikako、Noguchi Naoki、Do Yura、Otsuji Ryosuke、Kuga Daisuke、Kang Dongchon、Yoshimoto Koji、Uchiumi Takeshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 10497-10497

    • DOI

      10.1038/s41598-023-37483-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-23K24794
  • [Journal Article] Improving lysosomal ferroptosis with NMN administration protects against heart failure2023

    • Author(s)
      Yagi Mikako、Do Yura、Hirai Haruka、Miki Kenji、Toshima Takahiro、Fukahori Yukina、Setoyama Daiki、Abe Chiaki、Nabeshima Yo-Ichi、Kang Dongchon、Uchiumi Takeshi
    • Journal Title

      Life Science Alliance

      Volume: 6 Issue: 12 Pages: e202302116-e202302116

    • DOI

      10.26508/lsa.202302116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-23K24794
  • [Journal Article] Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation2022

    • Author(s)
      Miki Kenji、Yagi Mikako、Yoshimoto Koji、Kang Dongchon、Uchiumi Takeshi
    • Journal Title

      Oncogenesis

      Volume: 11 Issue: 1 Pages: 64-64

    • DOI

      10.1038/s41389-022-00443-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-20H00530
  • [Journal Article] Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation2022

    • Author(s)
      Miki Kenji、Yagi Mikako、Yoshimoto Koji、Kang Dongchon、Uchiumi Takeshi
    • Journal Title

      Oncogenesis

      Volume: 11 Issue: 1 Pages: 59-59

    • DOI

      10.1038/s41389-022-00437-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678
  • [Journal Article] TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation2022

    • Author(s)
      Fujii Masakazu、Setoyama Daiki、Gotoh Kazuhito、Dozono Yushi、Yagi Mikako、Ikeda Masataka、Ide Tomomi、Uchiumi Takeshi、Kang Dongchon
    • Journal Title

      iScience

      Volume: 25 Issue: 9 Pages: 104889-104889

    • DOI

      10.1016/j.isci.2022.104889

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-21K16090, KAKENHI-PROJECT-20H00530
  • [Journal Article] Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine2022

    • Author(s)
      Tsukahara Shigehiro、Shiota Masaki、Takamatsu Dai、Nagakawa Shohei、Matsumoto Takashi、Kiyokoba Ryo、Yagi Mikako、Setoyama Daiki、Noda Nozomi、Matsumoto Shinya、Hayashi Tetsutaro、Contreras-Sanz Alberto、Black Peter C.、Inokuchi Junichi、Kohashi Kenichi、Oda Yoshinao、Uchiumi Takeshi、Eto Masatoshi、Kang Dongchon
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 8535-8535

    • DOI

      10.1038/s41598-022-12528-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-23K25230
  • [Journal Article] Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction2022

    • Author(s)
      Kiyokoba Ryo、Uchiumi Takeshi、Yagi Mikako、Toshima Takahiro、Tsukahara Shigehiro、Fujita Yasuyuki、Kato Kiyoko、Kang Dongchon
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4056-4056

    • DOI

      10.1038/s41598-022-07893-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-20H00530
  • [Journal Article] Mitochondrial translation deficiency impairs NAD+ -mediated lysosomal acidification.2021

    • Author(s)
      Yagi M, Toshima T, Amamoto R, Do Y, Hirai H, Setoyama D, Kang D, Uchiumi T.
    • Journal Title

      EMBO J.

      Volume: e105268 Issue: 8 Pages: 1-17

    • DOI

      10.15252/embj.2020105268

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K15421
  • [Journal Article] Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response2020

    • Author(s)
      Sasaki K, Uchiumi T, Toshima T, Yagi M, Do Y, Hirai H, Igami K, Gotoh K, Kang D.
    • Journal Title

      Biosci Rep.

      Volume: 40(11) Issue: 11 Pages: 1-12

    • DOI

      10.1042/bsr20201289

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-18K15421
  • [Journal Article] Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies2017

    • Author(s)
      Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H et al
    • Journal Title

      The American Journal of Human Genetics

      Volume: 101 Issue: 4 Pages: 525-538

    • DOI

      10.1016/j.ajhg.2017.08.015

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09973, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764
  • [Journal Article] Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses2017

    • Author(s)
      Saito Toshiro、Uchiumi Takeshi、Yagi Mikako、Amamoto Rie、Setoyama Daiki、Matsushima Yuichi、Kang Dongchon
    • Journal Title

      Cardiovascular Research

      Volume: 113 Issue: 10 Pages: 1173-1185

    • DOI

      10.1093/cvr/cvx095

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00905, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
  • [Journal Article] p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock2017

    • Author(s)
      Sasaki Katsuhiko、Gotoh Kazuhito、Miake Sho、Setoyama Daiki、Yagi Mikako、Igami Ko、Uchiumi Takeshi、Kang Dongchon
    • Journal Title

      EBioMedicine

      Volume: 20 Pages: 161-172

    • DOI

      10.1016/j.ebiom.2017.05.018

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764, KAKENHI-PROJECT-16K19196
  • [Journal Article] Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity2017

    • Author(s)
      Matsumoto Takashi、Uchiumi Takeshi、Monji Keisuke、Yagi Mikako、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Shiota Masaki、Eto Masatoshi、Kang Dongchon
    • Journal Title

      Oncogenesis

      Volume: 6 Issue: 11 Pages: 1-11

    • DOI

      10.1038/s41389-017-0009-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
  • [Journal Article] Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration2017

    • Author(s)
      Yagi Mikako、Uchiumi Takeshi、Sagata Noriaki、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Kang Dongchon
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-15414-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00905, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764
  • [Journal Article] Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells2016

    • Author(s)
      Keisuke Monji,Takeshi Uchiumi, Saki Hoshizawa, Mikako Yagi, Takashi Matsumoto, Daiki Setoyama, Yuichi Matsushima, Kazuhito Gotoh, Rie Amamoto, Donchon Kang
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 75221-7523

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860371
  • [Journal Article] Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells.2016

    • Author(s)
      Monji, K., Uchiumi, T., Hoshizawa, S., Yagi, M., Matsumoto, T, Y., Setoyama, D., Matsushima, Y., Gotoh, K., Amamoto, R., and Kang, D.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 46 Pages: 75221-75234

    • DOI

      10.18632/oncotarget.12117

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
  • [Journal Article] The expression of ubiquitous mitochondrial creatine kinase is downregulated as prostate cancer progression2016

    • Author(s)
      Amamoto, R. Uchiumi, T. Yagi, M. Monji,K. Song, Y. Oda, Y. Shiota,M. Yokomizo, A. Naito, S. Kang, D.
    • Journal Title

      Journal of Cancer

      Volume: 7 Issue: 1 Pages: 50-59

    • DOI

      10.7150/jca.13207

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04764
  • [Journal Article] Melanin pigment interrupts the fluorescence staining of mitochondria in melanocytes.2016

    • Author(s)
      Hideya Ando, Yoshiaki Ohagi, Moemi Yoshida, Satoshi Yoshimoto, Yusuke Higashi, Masayuki Yagi, Keisuke Monji, Mikako Yagi, Takeshi Uchiumi, Dongchon Kang
    • Journal Title

      Journal of Dermatological Science

      Volume: 84 Pages: 346-360

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860371
  • [Presentation] ミトコンドリア翻訳障害による心筋症発症メカニズムとその治療2023

    • Author(s)
      八木美佳子
    • Organizer
      日本ミトコンドリア学会
    • Data Source
      KAKENHI-PROJECT-21K11678
  • [Presentation] ミトコンドリア機能障害による心不全の 病態解析と治療戦略2022

    • Author(s)
      八木美佳子
    • Organizer
      日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K11678
  • [Presentation] ミトコンドリア翻訳阻害マウスの病態解析2022

    • Author(s)
      八木美佳子 内海健
    • Organizer
      日本ミトコンドリア学会
    • Data Source
      KAKENHI-PROJECT-23K24794
  • [Presentation] ミトコンドリアとリソソームの新分子機序2021

    • Author(s)
      八木美佳子
    • Organizer
      日本臨床化学会
    • Data Source
      KAKENHI-PROJECT-21K11678
  • [Presentation] ミトコンドリアを介したリソソーム機能制御のメカニズム2020

    • Author(s)
      八木美佳子 内海健 康東天
    • Organizer
      生化学会
    • Data Source
      KAKENHI-PROJECT-18K15421
  • [Presentation] ミトコンドリアを介したNAD+合成系がリソソームを制御する機構2019

    • Author(s)
      八木 美佳子
    • Organizer
      生化学会
    • Data Source
      KAKENHI-PROJECT-18K15421
  • [Presentation] ミトコンドリア機能障害でみられたオートファジー抑制の分子機序2018

    • Author(s)
      八木 美佳子
    • Organizer
      日本ミトコンドリア学会
    • Data Source
      KAKENHI-PROJECT-18K15421
  • [Presentation] ミトコンドリアがオートファジーを制御する新機構2018

    • Author(s)
      八木 美佳子
    • Organizer
      日本生化学会
    • Data Source
      KAKENHI-PROJECT-18K15421
  • [Presentation] ミトコンドリア機能低下がオートファジー障害を司る新規分子機構2018

    • Author(s)
      八木 美佳子
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K15421
  • [Presentation] ミトコンドリア蛋白p32の心筋、脳 特異的ノックアウトマウスにおける遺伝子発現とミトコンドリア機能解析の相違2017

    • Author(s)
      八木美佳子 内海健 康東天
    • Organizer
      第40回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-15H04764
  • [Presentation] ミトコンドリアシャペロン蛋白p32の変異解析と心筋特異的p32KOマウス機能解析2017

    • Author(s)
      内海 健 八木美佳子 康東天
    • Organizer
      第17回日本ミトコンドリア学会
    • Data Source
      KAKENHI-PROJECT-15H04764
  • [Presentation] ミトコンドリアタンパク質p32の心筋特異的ノックアウトマウスは拡張型心筋症を呈する2016

    • Author(s)
      八木 美佳子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26860371
  • [Presentation] ミトコンドリアタンパクp32の脳特異的ノックアウトマウスの分子基盤と新規診断マーカーの探索2015

    • Author(s)
      内海健、八木美佳子、康東天
    • Organizer
      第55回 日本臨床化学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-15H04764
  • [Presentation] 白質脳症を示す神経特異的C1qbp/p32ノックアウトマウスの遺伝子発現、メタボローム解析2015

    • Author(s)
      内海健、八木美佳子、康東天
    • Organizer
      分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H04764
  • [Presentation] ミトコンドリアp32の個体・細胞レベルでの機能解析

    • Author(s)
      八木 美佳子
    • Organizer
      第二回YoungMito 2014
    • Place of Presentation
      大阪府箕面みのお山荘
    • Year and Date
      2014-05-22 – 2014-05-23
    • Data Source
      KAKENHI-PROJECT-26860371
  • [Presentation] 神経特異的p32ノックアウトマウスはオリゴデンドロサイト分化異常によって白質脳症になる

    • Author(s)
      八木 美佳子
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-22 – 2014-11-25
    • Data Source
      KAKENHI-PROJECT-26860371
  • [Presentation] 神経特異的p32ノックアウトマウスはオリゴデンドロサイト分化異常によって白質脳症になる

    • Author(s)
      八木 美佳子
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      九州大学百年講堂
    • Year and Date
      2014-12-03 – 2014-12-05
    • Data Source
      KAKENHI-PROJECT-26860371
  • 1.  Uchiumi Takeshi (80253798)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  松島 雄一 (20571342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  瀬戸山 大樹 (30550850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  外園 栄作 (60404042)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  塩津 弘倫 (90625766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OKAZAKI Yasushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  OHTAKE Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  MURAYAMA Kei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  GOTO Yu-ichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  木下 善仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  天本 理恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 12.  康 東天
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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