SUGIURA Tomoko 杉浦智子

Researcher Number	70542190
External Links
Affiliation (based on the past Project Information) *help	2014 – 2015: 金沢大学, 薬学系, 助教 2009 – 2012: Kanazawa University, 薬学系, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy Except Principal Investigator Sports science / Medical pharmacy / Sports science / Physical pharmacy
Keywords	Principal Investigator PDZK1 / 消化管吸収 / トランスポーター / BCRP / アダプター / 薬物動態学 / アダプタータンパク質 / 薬物間相互作用 / 薬物生態学 / OATP1A2 / タンパク質間相互作用 / Oatp1a1 … More Except Principal Investigator … More トランスポーター / 代謝 / 相互作用 / ミトコンドリア / ミオグロビン / 骨格筋 / 生体膜透過 / 薬物動態 / 薬物動態・代謝学 / 抗酸化物質 / 薬物治療 / 慢性臓器疾患 / 膜輸送体 / 呼吸 / 運動 / 筋細胞 / 抗腫瘍薬 / PDZアダプター / ペプチド / 脂肪酸 / カルニチン / NIRS / 臓器灌流 / ヘモグロビン / 共局在 / タンパ質間相互作用 / Rab8 / PDZK1 / PDZドメイン / 薬物代謝 / タンパク質間相互作用 / アダプター Less

Comprehensive analysis for interaction of oxygen binding protein with mitochondrial proteins in skeletal muscle
- Principal Investigator
  
  MASUDA Kazumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Sports science
- Research Institution
  Kanazawa University
小腸排出トランスポーター・アダプター共発現細胞を用いた薬物相互作用評価系の構築Principal Investigator
- Principal Investigator
  
  杉浦智子
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases
- Principal Investigator
  
  Kato Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Role of carnitine transporter in skeletal bioenergetics during muscle contraction
- Principal Investigator
  
  MASUDA Kazumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Sports science
- Research Institution
  Kanazawa University
Development of triple-target antitumor drugs recognized by oligopeptide transporters
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
In vivo analysis of intestinal drug absorption using adaptor/efflux transporter gene deficient micePrincipal Investigator
- Principal Investigator
  
  SUGIURA Tomoko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
アダプター欠損マウスを用いた薬物の消化管吸収機構と疾患発症のインビボ解析Principal Investigator
- Principal Investigator
  
  杉浦智子
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Research of transporter-adaptor network as target of drug effect and toxicity
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Interaction of myoglobin with mitochondria as an effective oxygen transport system
- Principal Investigator
  
  MASUDA Kazumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Sports science
- Research Institution
  Kanazawa University

All 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book Patent Other

[Book] Chapter 10 PEPT (SLC15A) family2013
- Author(s)
  Sugiura T, Umeda S, Tsuji A, Kato Y
- Data Source
  KAKENHI-PROJECT-23659019
[Book] Pharmacogenomics of Human Drug Transporters2013
- Author(s)
  Sugiura T, Umeda S, Tsuji A, Kato Y.
- Total Pages
  20
- Publisher
  PEPT (SLC15A) family
- Data Source
  KAKENHI-PROJECT-23659019
[Book] 細胞工学Vol.31(5)【メタボロミクスによるトランスポーター機能の探索】2012
- Author(s)
  杉浦智子、加藤将夫
- Total Pages
  625
- Publisher
  株式会社学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 遺伝子医学MOOK(19)トランスポートソーム-生体膜輸送機構の全体像に迫る(金井好克編)(低分子量GTP結合タンパク質Rab8によるSLC トランスポーターを介した消化管吸収制御)2011
- Author(s)
  杉浦智子、加藤将夫
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390047
[Book] 遺伝子医学MOOK(19)(遺伝子欠損マウスのメタボローム解析によるOCTN1(SLC22A4)の生体内機能の解明)2011
- Author(s)
  清水卓也、杉浦智子、加藤将夫(金井好克編集)
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 遺伝子欠損マウスのメタボローム解析によるOCTN1(SLC22A4)の生体内機能の解明2011
- Author(s)
  清水卓也、杉浦智子、加藤将夫
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 低分子量GTP結合タンパク質Rab8によるSLCトランスポーターを介した消化管吸収制御2011
- Author(s)
  杉浦智子、加藤将夫
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 遺伝子医学MOOK(19)(低分子量GTP結合タンパク質Rab8によるSLCトランスポーターを介した消化管吸収制御)2011
- Author(s)
  杉浦智子、加藤将夫(金井好克編集)
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 有機カチオントランスポーターOCTN1/SLC22A4によるエルゴチオネイン輸送ビタミン・バイオファクターのトランスポーター2010
- Author(s)
  杉浦智子、加藤将夫
- Data Source
  KAKENHI-PROJECT-22790152
[Book] 医学のあゆみ (メタボロミクス-網羅的代謝物質解析の医学・医療へのあらたな応用)2009
- Author(s)
  杉浦智子, 加藤将夫(曽我朋義編集)
- Total Pages
  72
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21890085
[Book] 遺伝子医学MOOK (12)最新トランスポーター研究2009、杉山雄一・金井好克編(株式会社メディカルドウ)2009
- Author(s)
  杉浦智子, 加藤将去
- Total Pages
  7
- Publisher
  薬物動態関連トランスポーターと相互作用するタンパク質
- Data Source
  KAKENHI-PROJECT-20390047
[Book] 遺伝子医学MOOK(12)最新トランスポーター研究2009(杉山雄一・金井好克編)(薬物動態関連トランスポーターと相互作用するタンパク質)2009
- Author(s)
  杉浦智子、加藤将夫
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Gene ablation of carnitine/organic cation transporter 1 reduces gastrointestinal absorption of 5-aminosalicylate in mice.2015
- Author(s)
  Shimizu T, Kijima A, Masuo Y, Ishimoto T, Sugiura T, Takahashi S, Nakamichi N, Kato Y.
- Journal Title
  
  Chem Pharm Bull
  
  Volume: （印刷中）
- NAID
  130005068086
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390040
[Journal Article] Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons2014
- Author(s)
  IshimotoT, Nakamichi N, Hosotani H, Masuo Y, Sugiura T and Kato Y.
- Journal Title
  
  PLoS One
  
  Volume: 9(2) Issue: 2 Pages: e89434-e89434
- DOI
  10.1371/journal.pone.0089434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] Interaction of Novel Platelet-increasing Agent Eltrombopag with Rosuvastatin via Breast Cancer Resistance Protein in Human2014
- Author(s)
  Takeuchi, et al.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 42 Issue: 4 Pages: 726-734
- DOI
  10.1124/dmd.113.054767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04561, KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans2014
- Author(s)
  Fujita K, Sasaki Y, Kato Y(他9名)
- Journal Title
  
  Pharm Res
  
  Volume: 31 Issue: 1 Pages: 204-15
- DOI
  10.1007/s11095-013-1153-x
- NAID
  120005385991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198, KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin2013
- Author(s)
  Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto KI, Tsuji A, Kato Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 102(9) Issue: 9 Pages: 3407-3417
- DOI
  10.1002/jps.23595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans2013
- Author(s)
  Tomoko Sugiura et al.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 102(1) Issue: 1 Pages: 237-249
- DOI
  10.1002/jps.23337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590081, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-24790150
[Journal Article] Muscle contraction increases carnitine uptake via translocation of OCTN22012
- Author(s)
  Furuichi Y, Sugiura T, KatoY, Takakura H, Hanai Y, Hashimoto T and Masuda K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 418 Pages: 774-779
- NAID
  120003959479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650404
[Journal Article] メタボロミクスによるトランスポーター機能の探索2012
- Author(s)
  杉浦智子、加藤将夫
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 546-547
- URL
  http://gakken-mesh.jp/journal/detail/9784780901306.html
- Data Source
  KAKENHI-PROJECT-23659019
[Journal Article] Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent2011
- Author(s)
  Takeuchi, K., Sugiura, T., Umeda, S.,Matsubara, K., Horikawa, M., Nakamichi, N., Silver, D.L., Ishiwata, N., Kato, Y
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 6 Pages: 1088-1096
- DOI
  10.1124/dmd.110.037960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590081, KAKENHI-PROJECT-22790152, KAKENHI-PROJECT-23659019
[Journal Article] Pharnweokineties and hepatic uptake of eltromhopag, a novel platelet-increasing agent.2011
- Author(s)
  Takcuchi K, Sugiura T, Umeda S, Matsuhara K, Horikawa M, Nakamichi N.Silver DL., Ishiwata N.Kato Y
- Journal Title
  
  Drug ,Mekab Dispos
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] PDZ adaptors : their regulation of epithelial transporters and involvement in human disease2011
- Author(s)
  Sugiura T, Shimizu T, Kijima A, Minakata S, Kato Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(9) Issue: 9 Pages: 3620-3635
- DOI
  10.1002/jps.22575
- NAID
  120003308592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152, KAKENHI-PROJECT-23659019
[Journal Article] PDZ adaptors : Their regulation of epithelial transporters and involvement in human diseases.2011
- Author(s)
  Tomoko Sugiura, et al.
- Journal Title
  
  J Pharm Sci
  
  Volume: (印刷中)
- NAID
  120003308592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152
[Journal Article] 低分子量GTP結合タンパク質Rab8によるSLCトランスポーターを介した消化管吸収制御2011
- Author(s)
  杉浦智子、加藤将夫
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 19 Pages: 265-270
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] 遺伝子欠損マウスのメタボローム解析によるOCTN1(SLC22A4)の生体内機能の解明2011
- Author(s)
  清水卓也、杉浦智子、加藤将夫
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 19 Pages: 77-82
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] DZK1 regulates breast cancer resistance protein in small intestine2011
- Author(s)
  Shimizu, T., Sugiura, T., Wakayama, T.,Kijima, A., Nakamichi, N., Iseki, S.,Silver, D.L., Kato, Y
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 11 Pages: 2148-2154
- DOI
  10.1124/dmd.111.040295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590081, KAKENHI-PROJECT-22790152, KAKENHI-PROJECT-23659019
[Journal Article] Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in mouse small intestine and liver.2010
- Author(s)
  Tomoko Sugiura, et al.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38 Pages: 1665-1672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152
[Journal Article] OCTN2 is associated with earnitine 〓ransport eapaeity of rat skeletal muselds.2010
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K
- Journal Title
  
  Aata Plwsiologiea
  
  Volume: 200(1) Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] OCTN2 is associated with carnitine transport capacity of rat skeletal muscles.2010
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K
- Journal Title
  
  Acta Physiol 200
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20680032
[Journal Article] PDZK1 Regulates Organic Anion Transporting Polypeptide Oatp1a in Mouse Small Intestine2010
- Author(s)
  Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 25 Issue: 6 Pages: 588-598
- DOI
  10.2133/dmpk.DMPK-10-RG-074
- NAID
  10027743926
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152
[Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatpla in mouse small intestine.2010
- Author(s)
  Sugiura T, Otake T, Shinmizu T, Wakayama T, Silver DL, Utsumi R.Nishimura T.Iseki S.Nakamichi N.Kuho Y. Tsuji A.Kato Y
- Journal Title
  
  Drug Metah Pharmaeokinet
  
  Volume: 25(5) Pages: 589-598
- NAID
  10027743926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010
- Author(s)
  Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A.
- Journal Title
  
  Pharm Res 27(5)
  
  Pages: 832-840
- NAID
  120002224385
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] OCTN2 is associated with carnitine transport capacity of rat skeletal muscles2010
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K
- Journal Title
  
  Acta Physiol
  
  Volume: 200 Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20680032
[Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatpla in mouse small intestine.2010
- Author(s)
  Tomoko Sugiura, et al.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 588-598
- NAID
  10027743926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152
[Journal Article] Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.2010
- Author(s)
  Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kubo Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y.
- Journal Title
  
  Drug Metab Dispos 38(10)
  
  Pages: 1665-1672
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.2010
- Author(s)
  Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y.
- Journal Title
  
  Drug Metab Pharmacokinet 25(5)
  
  Pages: 588-598
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Funetional expression of carnitine/organic cation transporter OCTNI/SLC22A4 in mouse small intestine and liver.2010
- Author(s)
  Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kuho Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38(10) Pages: 1665-1672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] OCTN2 is associated with carnitine transport capacity of rat skeletal muscles2010
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K
- Journal Title
  
  Acta Physiol
  
  Volume: 200(1) Issue: 1 Pages: 57-64
- DOI
  10.1111/j.1748-1716.2010.02101.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790152
[Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010
- Author(s)
  Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A.
- Journal Title
  
  Pharm Res. (印刷中)
- NAID
  120002224385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] 有磯カチオントランスポーターOCTN1/SLC22A4によるエルゴチオネイン輸送2010
- Author(s)
  杉浦智子、加藤将夫
- Journal Title
  
  ビタミン
  
  Volume: 84(10) Pages: 465-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol2009
- Author(s)
  Kato Y, Miyazaki T, Kano T, Sugiura T, Kubo Y, Tsuji A.
- Journal Title
  
  J Pharm Sci 98(7)
  
  Pages: 2529-2539
- NAID
  120001451016
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol.2009
- Author(s)
  Kato Y, Miyazaki T, Kano T, Sugiura T, Kubo Y, Tsuji A.
- Journal Title
  
  J Pharn Sci (印刷中)
- NAID
  120001451016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8 null mice.2009
- Author(s)
  Kato Y, Sugiura T, Nakadera Y, Sugiura M, Kubo Y, Sato T, Harada A, Tsuji A.
- Journal Title
  
  Drug Metab Dispos 37(3)
  
  Pages: 602-607
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] メタボロミクスによる orphan SLCトランスポーターの生体内基質探索2009
- Author(s)
  杉浦智子, 加藤将夫
- Journal Title
  
  医薬のあゆみ 231(12, 13)
  
  Pages: 1176-1182
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice.2009
- Author(s)
  Kato S, Kato Y, Nakamura T, Sugiura T, Kubo Y, Deguchi Y, Tsuji A.
- Journal Title
  
  Biopharm Drug Dispos 30(9)
  
  Pages: 495-507
- NAID
  120001856982
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] Cationic Polyrotaxanes effectively inhibit Uptake via Carnitine/Organic Cationic Transporter without cytotoxicity.2008
- Author(s)
  Utsunomiya H, Katoono R, Yui N, Sugiura T, Kubo Y, Kato Y, Tsuji A.
- Journal Title
  
  Macromol Biosci 8(7)
  
  Pages: 665-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice.2008
- Author(s)
  Sugiura T, Kato Y, Wakayama T, Silver DL, Kubo Y, Iseki S, Tsuji A.
- Journal Title
  
  Drug Metab Dispos 36(6)
  
  Pages: 1181-1188
- Data Source
  KAKENHI-PROJECT-20390047
[Journal Article] PDZK1 regulates two intestinal solute carriers (Slcl5al and Slc22a5) in mice.2008
- Author(s)
  Sugiura T, Kato Y, Wakayama T, Silver DL, Kubo Y, Iseki S, Tsuji A.
- Journal Title
  
  Drug Me tab Dispos 36(6)
  
  Pages: 1181-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390047
[Patent] 抗うつ剤2013
- Inventor(s)
  加藤将夫、中道範隆、杉浦智子、谷口徳之
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2013-039228
- Filing Date
  2013-02-28
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] OCTN1/SLC22A4の生体内基質エルゴチオネインの脳内分布と抗うつ作用2013
- Author(s)
  中山敬悟、中道範隆、石本尚大、杉浦智子、増尾友佑、若山友彦、井関尚一、関口博太、須藤慶太、杉正人、宇住晃治、加藤将夫
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] NASHモデルマウスにおけるトランスポーターOCTN1の発現と局在2013
- Author(s)
  増尾友佑、杉浦智子、酒井佳夫、原田龍一、若山友彦、中道範隆、井関尚一、金子周一、加藤将夫
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] Modulation of proliferation and differentiation activity by solute carrier OCTN1/SLC22A4 in neural progenitor cells2013
- Author(s)
  Noritaka Nakamichi, Takahiro Ishimoto, Hiroshi Hosotani, Tomoko Sugiura and Yukio Kato
- Organizer
  ISN (International Society for Neurochemistry) -ASN (American Society for Neurochemistry) 2013
- Place of Presentation
  Cancun Convention Center, Cancun, Mexico
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] マウス神経系前駆細胞において膜輸送体OCTN1を介したエルゴチオネインの取り込みは神経細胞への分化能を促進する2013
- Author(s)
  石本尚大、中道範隆、細谷拓史、杉浦智子、加藤将夫
- Organizer
  第56回日本神経化学会大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] Potential protective role of OCTN1/SLC22A4 in progression of dimethilnitrosamine (DMN)-induced liver fibrosis2012
- Author(s)
  Tomoko Sugiura, et al
- Organizer
  Past, Present and Future of Moleculr Pharmacokinetics
- Place of Presentation
  Hitotsubashi Hall (Tokyo)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Interaction of breast cancer resistance protein (BCRP/ABCG2) with PDZ adaptor PDZK1 and therapeutic agents in small intestine.2012
- Author(s)
  Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Noritaka Nakamichi, Shoichi Iseki, David L. Silver, and Yukio Kato.
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Meeting 2012
- Place of Presentation
  Monash University (Melbourne, Australia)
- Data Source
  KAKENHI-PROJECT-23659019
[Presentation] Potential protective role of OCTN1/SLC22A4 in progression of dimethylnitrosamine(DMN)-induced liver fibrosis2012
- Author(s)
  Sugiura T, Harada R, Sakai Y, Wakayama T, Kawabata S, Nakamichi N, Iseki S, Kaneko S, Kato Y
- Place of Presentation
  Hitotsubashi Hall(Tokyo, Japan)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Interaction of breast cancer resistance protein (BCRP/ABCG2) with PDZ adaptor PDZK1 and therapeutic agents in small intestine2012
- Author(s)
  Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Noritaka Nakamichi, Shoichi Iseki, David L. Silver and Yukio Kato
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Meeting 2012
- Place of Presentation
  Monash University (Melbourne, Australia)
- Data Source
  KAKENHI-PROJECT-23659019
[Presentation] 新規血小板像多剤Eltrombopagと臨床相互作用薬とのトランスポーターを介した薬物間相互作用2012
- Author(s)
  杉浦智子, 他
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  沖縄コンベンション・センター(沖縄県)
- Data Source
  KAKENHI-PROJECT-24790150
[Presentation] 抗腫瘍薬SN-38のヒト肝への取り込みに及ぼすOATPの関与と尿毒素による阻害2012
- Author(s)
  杉浦智子, 他
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀(東京都)
- Data Source
  KAKENHI-PROJECT-24790150
[Presentation] カルニチン/有機カチオントランスポーターOCTN1の肝臓での機能的発現と肝線維化に及ぼす影響2012
- Author(s)
  杉浦智子, 他
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部(京都府)
- Data Source
  KAKENHI-PROJECT-24790150
[Presentation] PDZ adaptor PDZK1 is a functional regulator of breast cancer resistance protein (BCRP/ABCG2) in small intestine.2012
- Author(s)
  Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Noritaka Nakamichi, Shoichi Iseki, David L. Silver, and Yukio Kato.
- Organizer
  International Symposium on Epithelial Barrier and Transport 2012
- Place of Presentation
  Ritsumeikan University (滋賀県)
- Data Source
  KAKENHI-PROJECT-23659019
[Presentation] カルニチン/有機カチオントランスポーターOCTNIの肝臓での機能的発現と肝線維化に及ぼす影響2012
- Author(s)
  杉浦智子
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学(京都府)
- Data Source
  KAKENHI-PROJECT-24390040
[Presentation] トランスポーターoctn1遺伝子欠損マウスを用いたDMN誘発性肝線維化の解析2011
- Author(s)
  杉浦智子、原田龍一、酒井佳夫、若山友彦、中道範隆、井関尚一、金子周一、加藤将夫
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀(東京)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] PDZK1による消化管排泄トランスポーターBCRPの制御と薬物動態への影響2011
- Author(s)
  杉浦智子、清水卓也、若山友彦、木嶋愛、中道範隆、井関尚一、加藤将夫
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学片平さくらホール(宮城)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Muscle contraction increases carnitine uptake via the cellular redistribution of OCTN22011
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Takakura H, Hanai Y and Masuda K
- Organizer
  American College of Sports Medicine 58th Annual Meeting
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-23650404
[Presentation] PDZK1による消化管排出トランスポーターBCRPの制御と薬物動態への影響2011
- Author(s)
  杉浦智子, 他
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学片平さくらホール(宮城)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1/SLC22A4.2010
- Author(s)
  Sugiura T, Nakamichi N, Kubo Y, Kato S, Soga T, Tsuji A, Kato Y
- Organizer
  The 9the International ISSX Meeting
- Place of Presentation
  Istanbul Lutfi Kirdar Convention and Exhibition Center, Turkey.
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] マウス脳におけるカルニチン/有機カチオントランスポーターの機能的発現2010
- Author(s)
  田口貴之、中道範隆、杉浦智子、若山友彦、井関尚一、加藤将夫
- Organizer
  日本薬物動態学会第25年会
- Place of Presentation
  大宮ソニックシティー(埼玉県)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] 新規血小板増多剤eltrombopagの肝取り込み機構2010
- Author(s)
  松原和貴、竹内和也、梅田沙希、杉浦智子、中道範隆、加藤将夫
- Organizer
  日本薬物動態学会第25年会
- Place of Presentation
  大宮ソニックシティー(埼玉県)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] Localization and function of carnitine/organic cation transporter OCTN2 in the skeletal muscles2010
- Author(s)
  Furuichi Y, Sugiura T, Kato Y, Shimada Y, Hashimoto T, Masuda K
- Organizer
  American College of Sports Medicine 57th Annual Meeting
- Place of Presentation
  Baltimore, MA, USA
- Data Source
  KAKENHI-PROJECT-20680032
[Presentation] PDZアダプターPDZK1による消化管トランスポーターOATPIAの制御2010
- Author(s)
  木嶋愛、杉浦智子、清水卓也、中道範隆、辻彰、加藤将夫
- Organizer
  第5回トランスポーター研究会年会
- Place of Presentation
  東京医科大学病院(東京都)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] アダプターによる消化管トランスポーターの機能・発現制御と薬物動態への影響2010
- Author(s)
  杉浦智子、中道範隆、加藤将夫
- Organizer
  第5回トランスポーター研究会
- Place of Presentation
  東京医科大学病院臨床講堂(東京)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Adaptor protein PDZK1 affects drug absorption by regulating multiple small intestinal transporters2010
- Author(s)
  Sugiura T, Kijima A, Shimizu T, Nakamichi N, Tsuji A, Kato Y
- Organizer
  2010FIP PSWC/AAPS Annual Meeting and Exposition
- Place of Presentation
  New Orleans Ernest N. Morial Convention Center(USA)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] Adaptor protein PDZKI affects drug absorption by regulating multiple small intes tinal transnorters.2010
- Author(s)
  Sugiura T, Kijima A, Shimizu T, Nakamichi N, Tsuji A, Kato Y
- Organizer
  2010 FIP PSWC/AAPS Annual Meeting and Exnosition
- Place of Presentation
  Ernest N.Mortal Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] Adaptor protein PDZK1 affects drug absorption by regulating multiple small intestinal transporters.2010
- Author(s)
  Sugiura T, Kijima A, Shimizu T, Nakamichi N, Tsuji A, Kato Y
- Organizer
  2010 FIP PSWC/AAPS Annual Meeting and Exposition
- Place of Presentation
  Ernest N.Morial Convention Center, New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] Adaptor protein PDZK1 affects drug absorption by regulating multiple small intestinal transporters2010
- Author(s)
  Tomoko Sugiura, et al.
- Organizer
  2010 FIP PSWC/AAPS
- Place of Presentation
  Morial Convention Center (New Orleans)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] 血小板増多剤eltrombopagの肝取り込み機構2010
- Author(s)
  杉浦智子、竹内和也、松原和貴、梅田沙希、中道範隆、加藤将夫
- Place of Presentation
  あわぎんホール徳島県郷土文化会館(徳島)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] カルニチン/有機カチオントランスポーターOCTNs による栄養物吸収と異物排出2010
- Author(s)
  加藤将夫、中道範隆、辻彰、杉浦智子
- Organizer
  日本薬学会第127年会(シンポジウム:「トランスポーター;異物解毒と栄養素供給・利用との境界」)(オーガナイザー:安西尚彦、楠原洋之、3月29日)
- Place of Presentation
  全日空ホテル岡山、(岡山)(招待講演)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1/SLC22A4.2010
- Author(s)
  Sugiura T, Nakamichi N, Kubo Y, Kato S, Soea T, Tsuii A, Kato Y
- Organizer
  The 9the International ISSX Meeting
- Place of Presentation
  Istanbul LGtfi Kirdar Convention and Exhibition Center (Turkey)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] カルニチン/有機カチオントランスポーター0CTNsによる栄養物吸収と異物排出2010
- Author(s)
  加藤将夫, 中道範隆, 辻彰, 杉浦智子
- Organizer
  日本薬学会第127年会 (シンポジウム :「トランスポーター : 異物解毒と栄養素供給・利用との境界」(オーガナイザー : 安西尚彦、楠原洋之、3月29日)
- Place of Presentation
  全日空ホテル岡山 (岡山)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] 新規血小板増多剤eltrombopagの肝取り込み機構2010
- Author(s)
  杉浦智子, 他
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館(徳島県)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] アダプタータンパク質による消化管トランスポーターの機能・発現制御と薬物動態への影響2010
- Author(s)
  杉浦智子, 他
- Organizer
  第5回トランスポーター研究会
- Place of Presentation
  東京医科大学病院臨床講堂(東京都)(招待講演)
- Data Source
  KAKENHI-PROJECT-22790152
[Presentation] 新規血小板増加薬 Eltrombopag の体内動態と肝取り込み機構2010
- Author(s)
  竹内和也, 松原和貴, 梅田沙希, 杉浦智子, 中道範隆, 加藤将夫
- Organizer
  日本薬学会第127年会
- Place of Presentation
  岡山コンベンションセンター (岡山)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] 低分子量GTPタンパク質Rab8によるSLCトランスポーター (PEPT1, SGLT1) を介した消化管吸収制御2009
- Author(s)
  杉浦智子, 中寺康仁, 佐藤隆史, 原田彰宏, 中道範隆, 辻彰, 加藤将夫
- Organizer
  日本薬物動態学会第24年会
- Place of Presentation
  国立京都国際会館 (京都)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] カルニチン・有機カチオントランスポーターOCTN1の小腸および肝臓における機能的発現2009
- Author(s)
  杉浦智子, 他
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター (静岡県)
- Data Source
  KAKENHI-PROJECT-21890085
[Presentation] PDZK1 and Rab8 deficient mice are useful tools for analysis of transporter-mediated intestinal drug absorption in vivo2009
- Author(s)
  杉浦智子, 他
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター (大阪府)
- Data Source
  KAKENHI-PROJECT-21890085
[Presentation] 低分子量GTP結合タンパク質rab8欠損マウスを用いた消化管吸収トランスポーター (PEPT1, SGLT1) の in vivo 評価2009
- Author(s)
  杉浦智子, 他
- Organizer
  第4回トランスポーター研究会
- Place of Presentation
  東京大学弥生講堂 (東京都)
- Data Source
  KAKENHI-PROJECT-21890085
[Presentation] マウス小腸におけるカルニチン/有機カチオントランスポーターOCTN1 (SLC22A4) の機能的発現2009
- Author(s)
  清水卓也, 杉浦智子, 中道範隆, 若山友彦, 井関尚一, 久保義行, 玉井郁巳, 辻彰, 加藤将夫
- Organizer
  日本薬物動態学会第24年会
- Place of Presentation
  国立京都国際会館 (京都)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] 低分子量GTP結合タンパク質Rab8によるSLCトランスポーター (PEPT1, SGLT1) を介した消化管吸収制御2009
- Author(s)
  杉浦智子, 他
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  国立京都国際会館 (京都府)
- Data Source
  KAKENHI-PROJECT-21890085
[Presentation] PDZKI and Rab8 Deficient Mice Are Useful Tools for Analysis of Transporter-mediated Intestinal Drug Absorption in vivo2009
- Author(s)
  Sugiura T, Nakamichi N, Tsuji A, Kato Y
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター (大阪)
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] β遮断薬celiprololの消化管吸収における取り込み・排出トランスポーターの関与2008
- Author(s)
  杉浦智子, 宮崎達也, 叶隆, 久保義行, 加藤将夫, 辻彰
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] アダプタータンパク質(PDZK1, Rab8)による消化管ペプチドトランスポーターPEPT1の機能制御2008
- Author(s)
  杉浦智子, 鳥居恵, 中寺康仁, 久保義行, 辻彰, 加藤将夫
- Organizer
  トランスポーターワークショップin鶴岡
- Place of Presentation
  東北公益文科大学大学院ホール
- Data Source
  KAKENHI-PROJECT-20390047
[Presentation] アダプタータンパクから見えてくる薬物吸収トランスポーター2008
- Author(s)
  加藤将夫, 杉浦智子, 鳥居恵, 辻彰, 玉井郁巳
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20390047
[]
[]

1. KATO Yukio (30251440)

# of Collaborated Projects: 6 results

# of Collaborated Products: 59 results
2. WAKAYAMA Tomohiko (70305100)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. NAKAMICHI Noritaka (10401895)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
4. MASUDA Kazumi (50323283)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. HASHIMOTO Takeshi (70511608)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. HANAI Yoshiteru (50360730)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. IWANAKA Nobumasa (80584002)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KANO Yutaka (90293133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAKURA Hisahi (20631914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAYANO Toshiya (90332303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAI Yoshio (80401925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. MASUO Yusuke (90708140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. SASAKI Yasutsuna

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 藤田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUGIURA Tomoko 杉浦 智子

Research Projects

Research Products

Co-Researchers

Comprehensive analysis for interaction of oxygen binding protein with mitochondrial proteins in skeletal muscle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小腸排出トランスポーター・アダプター共発現細胞を用いた薬物相互作用評価系の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of carnitine transporter in skeletal bioenergetics during muscle contraction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of triple-target antitumor drugs recognized by oligopeptide transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo analysis of intestinal drug absorption using adaptor/efflux transporter gene deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アダプター欠損マウスを用いた薬物の消化管吸収機構と疾患発症のインビボ解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of transporter-adaptor network as target of drug effect and toxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of myoglobin with mitochondria as an effective oxygen transport system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Chapter 10 PEPT (SLC15A) family2013

Author(s)

Data Source

[Book] Pharmacogenomics of Human Drug Transporters2013

Author(s)

Total Pages

Publisher

Data Source

[Book] 細胞工学Vol.31(5)【メタボロミクスによるトランスポーター機能の探索】2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 遺伝子医学MOOK(19)トランスポートソーム-生体膜輸送機構の全体像に迫る(金井好克編)(低分子量GTP結合タンパク質Rab8によるSLC トランスポーターを介した消化管吸収制御)2011

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK(19)(遺伝子欠損マウスのメタボローム解析によるOCTN1(SLC22A4)の生体内機能の解明)2011

Author(s)

Publisher

Data Source

[Book] 遺伝子欠損マウスのメタボローム解析によるOCTN1(SLC22A4)の生体内機能の解明2011

SUGIURA Tomoko 杉浦智子