SONOBE TAKASHI 曽野部崇

… Alternative Names

Sonobe Takashi 曽野部崇

SONOBE Takashi 曽野部崇

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Researcher Number	70548289
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 講師 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 日本医科大学, 医学部, 講師 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 2018 – 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2013: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 2011: 独立行政法人国立循環器病研究センター, 研究員 2010: 独立行政法人国立循環器病研究センター, 心臓生理機能部, 流動研究員 2009: 国立循環器病センター研究所, 心臓生理部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / Sports science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 48020:Physiology-related / Emergency medicine / Environmental physiology (including Physical medicine and Nutritional physiology)
Keywords	Principal Investigator exercise hyperemia / コリンアセチルトランスフェラーゼ / 非神経性コリン作動系 / 血管内皮細胞 / 運動トレーニング / 超音波血流測定 / 微小血管造影 / Goto-Kakizakiラット / EDH / 糖尿病 … More / microangiography / KCaチャネル / 易疲労性 / AICAR / AMPK / アセチルコリン / Ca2+依存性K+チャネル / 内皮依存性過分極 / 骨格筋収縮 / 内皮依存性血管拡張 / EDHF / Exercise hyperemia / Angiography / Exercise / 微小血管障害 / angiography / ZFDMラット / 血管造影 / 微小血管 / 運動 … More Except Principal Investigator 鰹節熱抽出物 / 血液脳関門 / 自律神経系 / 非神経性心臓アセチルコリン産生系 / 非神経性アセチルコリン / ageing / vasodilators / aging / coronary vessels / coronary / nitric oxide / oxidative stress / inflammation / senescence / diabetes / coronary circulation / マイクロダイアリシス法 / 5-HIAA / セロトニン / 虚血・再灌流 / 心臓 / 副腎 / β-アドレナリン受容体 / 低酸素性肺血管収縮 / 肺交感神経 / マウス肺血管造影 / 放射光 / 低酸素性肺高血圧 / 不整脈 / 心臓交感神経 / Rho-kinase / βアドレナリン受容体 / 交感神経 / ムスカリン性アセチルコリン受容体 / グレリン / 心筋梗塞 / 睡眠時無呼吸症候群 / 出血性低血圧 / 肺高血圧 / 低酸素 Less

非神経性コリン作動系活性化制御物質の可能性とその生理機能の解析
- Principal Investigator
  
  柿沼由彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nippon Medical School
内皮由来アセチルコリンは糖尿病における筋収縮依存性血管応答の低下に関与するか？Principal Investigator
- Principal Investigator
  
  曽野部崇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
Investigation of the endothelium-dependent mechanism by which diabetes causes fatigability of skeletal musclePrincipal Investigator
- Principal Investigator
  
  Sonobe Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
  National Cardiovascular Center Research Institute
Influence of non-vascular cells in accelerated coronary aging in diabetes
- Principal Investigator
  
  Pearson James
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Effect of exercise training on endothelium dependent microvascular function in hindlimb of diabetic ratsPrincipal Investigator
- Principal Investigator
  
  Sonobe Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  National Cardiovascular Center Research Institute
myocardial interstitial serotonin and 5-hydroxyindole acetic acid levels during ischemia-reperfusion
- Principal Investigator
  
  AKIYAMA Tsuyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Cardiovascular Center Research Institute
糖尿病に対する運動効果の新規エビデンス取得に向けてPrincipal Investigator
- Principal Investigator
  
  曽野部崇
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Sports science
- Research Institution
  National Cardiovascular Center Research Institute
Neural regulatory mechanisms of cardiopulmonary function in hypoxic conditions.
- Principal Investigator
  
  SHIRAI Mikiyasu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Hiroshima International University

All 2024 2023 2022 2020 2019 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Increased contribution of KCa channels to muscle contraction induced vascular and blood flow responses in sedentary and exercise trained ZFDM rats2022
- Author(s)
  Sonobe T, Tsuchimochi H, Maeda H, Pearson JT.
- Journal Title
  
  J Physiol
  
  Volume: 600 (12) Issue: 12 Pages: 2919-2938
- DOI
  10.1113/jp282981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11358
[Journal Article] Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models2022
- Author(s)
  Waddingham Mark T.、Tsuchimochi Hirotsugu、Sonobe Takashi、Asano Ryotaro、Jin Huiling、Ow Connie P. C.、Schwenke Daryl O.、Katare Rajesh、Aoyama Kohki、Umetani Keiji、Hoshino Masato、Uesugi Kentaro、Shirai Mikiyasu、Ogo Takeshi、Pearson James T.
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 12 Pages: 1-15
- DOI
  10.3389/fphys.2021.766818
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498, KAKENHI-PROJECT-20K17137, KAKENHI-PROJECT-19H03405, KAKENHI-PROJECT-22K16121
[Journal Article] Contribution of calpain to myoglobin efflux from cardiomyocytes during icehemia and after reperfusion in anesthetized rats.2014
- Author(s)
  Sonobe T, Akiyama T, Du CK, Zha n DY, Shirai M.
- Journal Title
  
  Acta Physiol
  
  Volume: 210(4) Issue: 4 Pages: 823-831
- DOI
  10.1111/apha.12205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-24790791
[Journal Article] Contribution of serotonin uptake and degradation to myocardial interstitial seroton in levels during ischaemia-reperfusion in rabbits.2013
- Author(s)
  Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M.
- Journal Title
  
  Acta Physiol (Oxf).
  
  Volume: 207 Issue: 2 Pages: 260-268
- DOI
  10.1111/j.1748-1716.2012.02461.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
[Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice.2013
- Author(s)
  Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shirai M.
- Journal Title
  
  Auton Neurosci
  
  Volume: 176(1-2) Issue: 1-2 Pages: 91-94
- DOI
  10.1016/j.autneu.2013.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
[Journal Article] Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/cmet signaling.2011
- Author(s)
  Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I.
- Journal Title
  
  Circ.Res. 108(6)(Epub)
  
  Pages: 664-675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590242
[Journal Article] Role of Rho kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.2011
- Author(s)
  Schwenke, D.O., Pearson, J.T., Sonobe, T., Ishibashi-Ueda H., Shimouchi, A., Kangawa, K. Umetani, K., Shirai, M.
- Journal Title
  
  J Appl Physiol. 110(4)
  
  Pages: 901-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590242
[Journal Article] Centrally administered ghrelin activates cardiac vasal nerve in anesthetized rabbits2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
- Journal Title
  
  Auton Neurosci
  
  Volume: 162 Issue: 1-2 Pages: 60-65
- DOI
  10.1016/j.autneu.2011.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21591190, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213
[Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits.2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M
- Journal Title
  
  Auton.Neurosci. Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590242
[Journal Article] Imaging on the closed-chest mouse pulmonary circulation using synchrotron radiation micro- angiography.2011
- Author(s)
  Sonobe T, Schwenke DO, Pearson JT, Yoshimoto M, Fujii Y, Umetani K, Shirai M
- Journal Title
  
  J.Appl.Physiol. Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590242
[Presentation] Loss of endothelial cell-derived acetylcholine production causes elevated systemic blood pressure and impaired exercise capacity in mice2024
- Author(s)
  Takashi Sonobe , Yoshihiko Kakinuma
- Organizer
  The 101st Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] Endothelial specific non-neuronal acetylcholine plays an important role in regulation of blood pressure via endothelial cell dependent mechanisms2023
- Author(s)
  Takashi Sonobe , Yoshihiko Kakinuma
- Organizer
  The 7th JCS Council Forum on Basic Cardiovascular Research
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] Effects of AMPK activation on skeletal muscle contraction-induced vasodilation in the hindlimb of non-obese type 2 diabetes Goto-Kakizaki rats2023
- Author(s)
  Sonobe T, Tsuchimochi H, Pearson JT.
- Organizer
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] ラット骨格筋収縮に伴う血管拡張能の可視的機能評価2022
- Author(s)
  曽野部崇，土持裕胤，Pearson James
- Organizer
  第34回呼吸研究会
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] Evaluation of Hindlimb Arteriolar Vasodilation Evoked by Dynamic Muscle Contraction in Goto-Kakizaki Rats Using in vivo X-ray Microangiography2020
- Author(s)
  Sonobe T, Tsuchimochi H, Pearson JT.
- Organizer
  Experimental Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10882
[Presentation] 糖尿病モデルラットにおける運動誘発性血管拡張応答に対する内皮依存性過分極の寄与2019
- Author(s)
  曽野部崇, 土持裕胤, Pearson James.
- Organizer
  第74回日本体力医学会
- Data Source
  KAKENHI-PROJECT-18K10882
[Presentation] 「マウス心臓交感神経終末におけるノルエピネフリン動態の解析」In vivo assessment of norepinephrine kinetics at cardiac sympathetic nerve endings in the anesthetized mice2013
- Author(s)
  戦冬雲、杜成坤、秋山剛、曽野部崇、白井幹康
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] 「腎血管性高血圧ラットモデルでの高血圧発症初期における動脈圧と交感神経活動の変化」Changes in renal sympathetic nerve activity during development of renovascular-hypertension rats2013
- Author(s)
  吉本光佐、秋山剛、曽野部崇、藤井豊、三木健寿、白井幹康
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] In vivo assessment of norepinephrine kinetics at cardiac sympathetic nerve endings in the anesthetized mice2013
- Author(s)
  戦　冬雲、杜　成坤、秋山　剛、曽野部　崇、白井　幹康
- Organizer
  第９０回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Changes in renal sympathetic nerve activity during development of renovascular-hypertension rats2013
- Author(s)
  吉本　光佐、秋山　剛、曽野部　崇、藤井　豊、三木　健寿、白井　幹康
- Organizer
  第９０回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] 「心筋間質5-HTとモノアミンオキシダーゼによる5-HIAAの同時モニタリング」Simultaneous monitoring of myocardial interstitial serotonin (5-HT) and its major metabolite 5-hydroxyindole acetic acid (5-HIAA)2012
- Author(s)
  杜成坤、戦冬雲、秋山剛、曽野部崇、白井幹康
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Contribution of reuptake and enzymatic degradation to myocardial interstitial 5-HT levels during ischemia-reperfusion2012
- Author(s)
  曽野部　崇、秋山　剛、杜　成坤、戦　冬雲、白井　幹康
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市総合体育館（松本市）
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] Simultaneous monitoring of myocardial interstitial serotonin (5-HT) and its major metabolite 5-hydroxyindole acetic acid (5-HIAA)2012
- Author(s)
  杜　成坤、戦　冬雲、秋山　剛、曽野部　崇、白井　幹康
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市総合体育館（松本市）
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] 「心虚血再灌流時の心筋間質中セロトニン動態-再取り込み・代謝の寄与-」Contribution of reuptake and enzymatic degradation to myocardial interstitial 5-HT levels during ischemia-reperfusion2012
- Author(s)
  曽野部崇、秋山剛、杜成坤、戦冬雲、白井幹康
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-23592691
[Presentation] アナフィラキシーショックに対するラット門脈の血管収縮応答2011
- Author(s)
  柳田洋、下内章人、曽野部崇、藤井豊、芝本利重、白井幹康
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20590242
[Presentation] モノクロタリン肺高血圧ラットでの血管内皮とRho-kinaseの機能障害は肺微小血管レベルで起こる2011
- Author(s)
  白井幹康、シュエンキ・ダリル、曽野部崇、藤井豊、吉本光佐、下内章人、寒川賢治、梅谷啓二
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20590242
[Presentation] グレリンノックアウトマウスでは慢性低酸素負荷で怒る換気適応が減弱する2011
- Author(s)
  曽野部崇、シュエンキ・ダリル、徳留健、岸本一郎、寒川賢治、白井幹康
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20590242
[Presentation] マグネシウム静脈内投与の副腎交感神経節伝達に及ぼす影響2010
- Author(s)
  秋山剛、川田徹、清水秀二、曽野部崇、杉町勝、白井幹康
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20590242
[Presentation] In vivo放射光微小血管造影法によるマウス肺循環系の評価2010
- Author(s)
  曽野部崇、シュエンキ・ダリル、ピアーソン・ジェイムズ、梅谷啓二、白井幹康
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20590242

1. 土持裕胤 (60379948)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. AKIYAMA Tsuyoshi (70202554)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. Pearson James (30261390)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 柿沼由彦 (40233944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIRAI Mikiyasu (70162758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. INAMORI Shuji (60412334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMIZU Shuji (80443498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中島正光 (20198097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 清水希功 (40309662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 岩田裕子 (80171908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杜成坤 (90590646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. JAMES T.Pearson

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. DARYL O.Schwenke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 徳留健

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 吉田謙一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 梅谷啓二

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. ワディンガムマーク.トーマス

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SONOBE TAKASHI 曽野部 崇

Sonobe Takashi 曽野部 崇

SONOBE Takashi 曽野部 崇

Research Projects

Research Products

Co-Researchers

非神経性コリン作動系活性化制御物質の可能性とその生理機能の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

内皮由来アセチルコリンは糖尿病における筋収縮依存性血管応答の低下に関与するか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the endothelium-dependent mechanism by which diabetes causes fatigability of skeletal musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Influence of non-vascular cells in accelerated coronary aging in diabetes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of exercise training on endothelium dependent microvascular function in hindlimb of diabetic ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

myocardial interstitial serotonin and 5-hydroxyindole acetic acid levels during ischemia-reperfusion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖尿病に対する運動効果の新規エビデンス取得に向けてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neural regulatory mechanisms of cardiopulmonary function in hypoxic conditions.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Increased contribution of KCa channels to muscle contraction induced vascular and blood flow responses in sedentary and exercise trained ZFDM rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of calpain to myoglobin efflux from cardiomyocytes during icehemia and after reperfusion in anesthetized rats.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of serotonin uptake and degradation to myocardial interstitial seroton in levels during ischaemia-reperfusion in rabbits.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/cmet signaling.2011

SONOBE TAKASHI 曽野部崇

Sonobe Takashi 曽野部崇

SONOBE Takashi 曽野部崇