SHIRASU Naoto 白須直人

Researcher Number	70551422
Other IDs
Affiliation (Current)	2025: 福岡大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2012 – 2023: 福岡大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 90130:Medical systems-related / Medical systems / Tumor therapeutics / Applied pharmacology Except Principal Investigator Medical systems / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 光免疫療法 / CCR8 / 制御性T細胞 / 低侵襲治療システム / 免疫チェックポイント治療 / 免疫チェックポイント / 免疫チェックポイント分子 / CTLA-4 / 光線力学療法 / 癌 … More / 抗体療法 / 癌幹細胞 / 抗体 / エクソソーム / ドラッグデリバリー … More Except Principal Investigator 染色体分配 / ポリコーム複合体１ / Geminin / ZFAT / 分化 / 自己複製 / 造血幹細胞 / CEA / 癌胎児性抗原 / 腫瘍関連抗原 / 抗体 / 近赤外線免疫療法 / 低侵襲治療システム / 癌 / がん / マイクロバブル / DDS / ナノリポソーム / 低出力超音波 / 超音波感受性物質 / ナノ粒子製剤 / ドラッグデリバリー / ナノメディシン / ドラッグデリバリーシステム / 超音波力学療法 Less

Efficient anti-tumor immunostimulation by photoimmunotherapy with simultaneous targeting of tumor cells and tumor-infiltrating TregsPrincipal Investigator
- Principal Investigator
  
  白須直人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Fukuoka University
Establishment of cancer photoimmunotherapy allowing simultaneous targeting of tumor-associated antigen and immune checkpoint molecule CTLA-4Principal Investigator
- Principal Investigator
  
  Shirasu Naoto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Fukuoka University
The molecular crosstalk between ZFAT and Geminin in the regulation of hematopoietic stem cell proliferation and differentiation.
- Principal Investigator
  
  Yasunaga Shin'ichiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukuoka University
Study on practical application of non-invasive sonodynamic cancer therapy using ultrasound sensitive substance-loaded nanoliposome
- Principal Investigator
  
  Shibaguchi Hirotomo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Fukuoka University
Establishment of integrative photoimmunotherapy of cancer and its microenvironmentPrincipal Investigator
- Principal Investigator
  
  Shirasu Naoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Fukuoka University
光感受性物質IR700を結合したヒト抗腫瘍抗体を用いる近赤外線免疫療法の確立
- Principal Investigator
  
  黒木政秀
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Fukuoka University
Development of integrative and cooperative photoimmunotherapy targeting cancer and its microenvironmentPrincipal Investigator
- Principal Investigator
  
  Shirasu Naoto
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Fukuoka University
AbEx: a novel drug carrier based on human antibody-displaying exosomePrincipal Investigator
- Principal Investigator
  
  SHIRASU Naoto
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Fukuoka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Physical properties of ultrafine bubbles generated using generator system.2023
- Author(s)
  63.Miyamoto, S., Hirakawa, T., Noguchi, Y., Urushiyama D., Miyata K., Baba T., Yotsumoto, F., Yasunaga, S., Nakabayashi K., Hata K., Nakagawa W., Otsuka T., Nozawa Y., Furuhata I. & Mikasa J.
- Journal Title
  
  In Vivo
  
  Volume: 37(6) Issue: 6 Pages: 2555-2563
- DOI
  10.21873/invivo.13363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08828
[Journal Article] Trophic and immunomodulatory effect of adipose tissue derived stem cells in a preclinical murine model of endometriosis.2022
- Author(s)
  Hirakawa T., Yotsumoto F., Shirasu N., Kiyoshima C., Urushiyama D., Yoshikawa K., Miyata K., Kurakazu M., Azuma Koga K., Aoki M., Nabeshima K., Koga K.S., Osuga Y., Komatsu H., Taniguchi F., Harada T., Yasunaga S., Miyamoto S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 121 Issue: 1 Pages: 8032-8032
- DOI
  10.1038/s41598-022-11891-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08828, KAKENHI-PROJECT-21K06703, KAKENHI-PROJECT-21K07110
[Journal Article] MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis2021
- Author(s)
  Kiyoshima C, Shirasu N, Urushiyama D, Fukagawa S, Hirakawa T, Yoshikawa K, Izuchi D, Miyata K, Kurakazu M, Yotsumoto F, Hiromatsu K, Nomiyama M, Ohta E, Hirose S, Ogura Y, Hayashi T, Hata K, Nabeshima K, Yasunaga S, Miyamoto S
- Journal Title
  
  Future Science OA
  
  Volume: Published online Issue: 5
- DOI
  10.2144/fsoa-2021-0006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16822, KAKENHI-PROJECT-20K12699
[Journal Article] Establishment of human induced pluripotent stem cells derived from skin cells of a patient with Dravet syndrome.2020
- Author(s)
  Kimura Y, Tanaka Y, Shirasu N, Yasunaga S, Higurashi N, Hirose S.
- Journal Title
  
  Stem Cell Res.
  
  Volume: 47 Pages: 101857-101857
- DOI
  10.1016/j.scr.2020.101857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08828, KAKENHI-PROJECT-20H03651, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-18K15735
[Journal Article] 造血幹細胞活性に対する低線量被ばくの影響．2020
- Author(s)
  大野芳典、竹立恭子、郭芸、菅野雅元、白須直人、安永晋一郎、大坪素秋、瀧原義弘．
- Journal Title
  
  広島医学
  
  Volume: 73 Pages: 218-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08828
[Journal Article] Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies.2019
- Author(s)
  Shirasu, N., Shibaguchi H., Yamada H., Kuroki M. & Yasunaga, S
- Journal Title
  
  Cancer Cell Int.
  
  Volume: 19 Issue: 1 Pages: 299-299
- DOI
  10.1186/s12935-019-1034-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08828
[Journal Article] CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5 (carcinoembryonic antigen))2016
- Author(s)
  Naoto Shirasu, Masahide Kuroki
- Journal Title
  
  Atlas Genet. Cytogenet. Oncol. Haematol.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830119
[Journal Article] Novel treatment strategies for cancer and their tumor-targeting approaches using antibodies against tumor-associated antigens.2014
- Author(s)
  Kuroki M, Shirasu N.
- Journal Title
  
  Anticancer Res.
  
  Volume: 34 Pages: 4481-4488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26830119
[Journal Article] Potent and specific antitumor effect of CEA-targeted photoimmunotherapy2014
- Author(s)
  Shirasu N, Yamada H, Shibaguchi H, Kuroki M, Kuroki M
- Journal Title
  
  International Journal of Cancer
  
  Volume: 135 Issue: 11 Pages: 2697-2710
- DOI
  10.1002/ijc.28907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350553, KAKENHI-PROJECT-26830119
[Journal Article] Novel treatment strategies for cancer and their tumor-targeting approaches using antibodies against tumor-associated antigens2014
- Author(s)
  Kuroki M, Shirasu N
- Journal Title
  
  Anticancer Research
  
  Volume: 34 Pages: 4481-4488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350553
[Journal Article] Possible therapeutic targets among the molecules involved in the warburg effect in tumor cells.2013
- Author(s)
  Nam, S O., Yotsumoto, F., Miyata, K., Shirasu, N., Miyamoto, S and Kuroki, Ma.
- Journal Title
  
  Anticancer Res.
  
  Volume: 33 Pages: 2855-2860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Tumor-targeted photodynamic therapy.2013
- Author(s)
  Shirasu, N., Nam, S O. and Kuroki, Ma.
- Journal Title
  
  Anticancer Res.
  
  Volume: 33 Pages: 2823-2831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Tumor-targeted photodynamic therapy2013
- Author(s)
  Shirasu N, Nam SO, Kuroki M
- Journal Title
  
  Anticancer Res.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Possible therapeutic targets among the molecules involved in the warburg effect in tumor cells2013
- Author(s)
  Nam SO, Yotsumoto F, Miyata K, Shirasu N, Miyamoto S, Kuroki Ma
- Journal Title
  
  Anticancer Res
  
  Volume: 33(7) Pages: 2855-2860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Tumor-targeted photodynamic therapy2013
- Author(s)
  Shirasu N, Num SO, Kuroki M
- Journal Title
  
  Anticancer Res
  
  Volume: 33(7) Pages: 2823-2831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Functional design of chimeric T-cell antigen receptors for adoptive immunotherapy of cancer : architecture and outcomes2012
- Author(s)
  Shirasu N, Kuroki M
- Journal Title
  
  Anticancer Res
  
  Volume: 32(6) Pages: 2377-2838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Biological response modifiers used in cancer biotherapy2012
- Author(s)
  Kuroki Ma, Miyamoto S, Morisaki T, Yotsumoto F, Shirasu N, Taniguchi Y, Soma G
- Journal Title
  
  Anticancer Res
  
  Volume: 32(6) Pages: 2229-2233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Journal Article] Biological response modifiers used in cancer biotherapy2012
- Author(s)
  Kuroki M, Miyamoto S, Morisaki T, Yotsumoto F, Shirasu N, Taniguchi Y, Soma G
- Journal Title
  
  Anticancer Res.
  
  Volume: 32(6) Pages: 2229-2233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790542
[Presentation] 光免疫療法の現状とこれから2023
- Author(s)
  白須直人
- Organizer
  第２７回バイオ治療法学会学術集会
- Data Source
  KAKENHI-PROJECT-23K11882
[Presentation] 慢性骨髄性白血病細胞の分化と増殖を標的とした新規白血病治療法の開発2023
- Author(s)
  大野芳典、竹立恭子、白須直人、大坪素秋、瀧原義宏、安永晋一郎
- Organizer
  第２７回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] Low dose rate radiation affects mitochondrial activity in the more undifferentiated hematopoietic cells.2020
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Guo Y., Kanno M., Shirasu N., Yasunaga S., Ohtsubo M., TakiharaY.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] Low dose-rate irradiation preferentially exerts mitochondrial toxicity in hematopoietic stem cells.2020
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Guo Y., Kanno M., Shirasu N., Ohtsubo M., TakiharaY., Yasunaga S.
- Organizer
  第８２回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] Low dose-rate irradiation preferentially affects the stemness of hematopoietic cells.2019
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Guo Y., Kanno M., Shirasu N., Ohtsubo M., Yasunaga S.,Takihara Y.
- Organizer
  The 62th Annual Meeting of the Japanese Radiation Research Society.
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] MolecularLow-dose-rate irradiation preferentially affects hematopoietic stem cell activity.2019
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Guo Y., Kanno M., Shirasu N., Yasunaga S., Ohtsubo M. , Takihara Y.
- Organizer
  The 17th Stem Cell Research Symposium
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] Low dose-rate irradiation promotes down-regulation of hematopoietic stem cell activity.2019
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Guo Y., Kanno M., Shirasu N., Yasunaga S., Ohtsubo M., Takihara Y.
- Organizer
  The 81st Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] 低線量率放射線被ばくは造血幹細胞活性を低下させる2019
- Author(s)
  大野芳典、竹立恭子、郭芸、菅野雅元、白須直人、大坪素秋、瀧原義宏、安永晋一郎
- Organizer
  第６２回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] がん超音波力学療法における超音波感受性物質内封ナノリポソームの取り込みと分布のサイズの違いによる比較2019
- Author(s)
  芝口浩智、白須直人、安永晋一郎
- Organizer
  第７８回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] Analysis of the molecular response for low dose-rate irradiation in the hematopoietic stem cells.2019
- Author(s)
  Suzuki-Takedachi K., Ohno Y., Santo M., Guo Y., Kanno M., Shirasu N., Ohtsubo M., Yasunaga S., Takihara Y.
- Organizer
  The 62th Annual Meeting of the Japanese Radiation Research Society.
- Data Source
  KAKENHI-PROJECT-19K08828
[Presentation] 超音波力学療法における超音波感受性物質ナノ粒子化製剤のEPR効果によるがん組織集積効果の検討2018
- Author(s)
  芝口浩智，白須直人，安永晋一郎
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01428
[Presentation] 腫瘍環境の統括的制御を指向した高汎用性光線免疫療法の開発2017
- Author(s)
  白須直人、山田博美、芝口浩智、黒木求、黒木政秀、安永晋一郎
- Organizer
  バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-16K01427
[Presentation] Integrative control of tumor environment by versatile photoimmunotherapy2017
- Author(s)
  白須直人、山田博美、芝口浩智、黒木求、黒木政秀、安永晋一郎
- Organizer
  生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-16K01427
[Presentation] Integrative and cooperative photoimmunotherapy for cancer using avidin-conjugated near infrared photosensitizer2015
- Author(s)
  Naoto Shirasu, Hiromi Yamada, Hirotomo Shibaguchi, Motomu Kuroki, Masahide Kuroki, and Shin’ichiro Yasunaga
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26830119
[Presentation] In vivo antitumor effect of CEA-targeted photoimmunotherapy
- Author(s)
  Shirasu N, Yamada H, Shibaguchi H, Kuroki M, Kuroki M
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26350553
[Presentation] CEAを標的とした抗腫瘍光免疫療法
- Author(s)
  白須直人，山田博美，芝口浩智，黒木　求，黒木政秀
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  松山
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26350553

1. Yasunaga Shin'ichiro (50336111)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. Shibaguchi Hirotomo (60295061)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 黒木政秀 (40122692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 大野芳典 (10548986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. Yamada Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 漆山大知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRASU Naoto 白須 直人

Research Projects

Research Products

Co-Researchers

Efficient anti-tumor immunostimulation by photoimmunotherapy with simultaneous targeting of tumor cells and tumor-infiltrating TregsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of cancer photoimmunotherapy allowing simultaneous targeting of tumor-associated antigen and immune checkpoint molecule CTLA-4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular crosstalk between ZFAT and Geminin in the regulation of hematopoietic stem cell proliferation and differentiation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on practical application of non-invasive sonodynamic cancer therapy using ultrasound sensitive substance-loaded nanoliposome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of integrative photoimmunotherapy of cancer and its microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

光感受性物質IR700を結合したヒト抗腫瘍抗体を用いる近赤外線免疫療法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of integrative and cooperative photoimmunotherapy targeting cancer and its microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AbEx: a novel drug carrier based on human antibody-displaying exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Physical properties of ultrafine bubbles generated using generator system.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trophic and immunomodulatory effect of adipose tissue derived stem cells in a preclinical murine model of endometriosis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of human induced pluripotent stem cells derived from skin cells of a patient with Dravet syndrome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 造血幹細胞活性に対する低線量被ばくの影響．2020

Author(s)

Journal Title

Data Source

[Journal Article] Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies.2019

Author(s)

Journal Title

DOI

SHIRASU Naoto 白須直人