WAKABAYASHI Masaki 若林真樹

Researcher Number	70552024
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 室長 2018 – 2019: 国立研究開発法人国立循環器病研究センター, その他, 室長 2017: 京都大学, 大学院薬学研究科, 連携准教授 2016: 京都大学, 薬学研究科, 助教 2014 – 2015: 京都大学, 薬学研究科(研究院), 助教 … More 2013 – 2015: 京都大学, 大学院薬学研究科, 助教 2012: 京都大学, 大学院・薬学研究科, 助教 2011 – 2012: 京都大学, 薬学研究科(研究院), 助教 2010: 独立行政法人国立循環器病研究センター, 分子薬理部, 研究員 2009: National Cardiovascular Center Research Institute, 薬理部, 室員 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / オミクス計測科学 / Circulatory organs internal medicine / Functional biochemistry Except Principal Investigator Physical pharmacy / Basic Section 53020:Cardiology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Studies on the Super-Aging Society / Genome biology
Keywords	Principal Investigator プロテオミクス / LC-MS / FFPE / リン酸化プロテオミクス / 翻訳後修飾解析 / OCT / 心内膜心筋生検 / 高感度分析 / 高感度LC/MS / HE染色 … More / プロテオーム / 心不全 / LC-MS/MS / シグナルネットワーク / 定量プロテオミクス / 心筋症 / 抗体アフィニティーカラム / C末端アミド化 / ペプチドーム解析 / 生理活性ペプチド … More Except Principal Investigator プロテオーム / 心不全 / 心筋細胞 / 先天性心疾患 / エピジェネティック因子 / 心臓前駆細胞 / 質量分析 / プロテオミクス / トランスクリプトーム / 不均一性 / 転写調節因子 / 内在分子型 / 診断法 / 高精度診断法 / ANP前駆体 / 心筋細胞変性 / 心不全診断法 / 生合成機序 / proANP / β-ANP / ANP分子型測定法 / 心房性ナトリウム利尿ペプチド / エピジェネティック / エピジェネティック変動 / 心臓組織 / 老化 / 分析化学 / タンパク質末端解析 / トリプエヌ / トリプシン / ショットガンプロテオミクス / LC-MS / 血清プロテオーム / 蛋白質 / 分析科学 / 血漿プロテオーム / キナーゼ / リン酸化 / シグナル伝達 Less

心筋細胞のheterogeneityとその特性解明に基づいた心疾患の包括的理解
- Principal Investigator
  
  山口修
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Ehime University
Crosstalk between transcriptional factors and epigenetic factors in cardiac progenitor cell development.
- Principal Investigator
  
  Shirai Manabu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of a high-precision diagnostic method for heart failure utilizing abnormal biosynthesis of beta-atrial natriuretic peptide in the failing heart
- Principal Investigator
  
  Minamino Naoto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Protein Research Foundation
Establishment and application of proteome analysis methods for endomyocardial biopsy samplesPrincipal Investigator
- Principal Investigator
  
  Wakabayashi Masaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of epigenetic disruption in cardiomyocyte senescence and disease.
- Principal Investigator
  
  Manabu Shirai
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  National Cardiovascular Center Research Institute
Epigenetic regulation of cardiac progenitor cells development in lateral plate mesoderm/pharyngeal region.
- Principal Investigator
  
  Shirai Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Shotgun proteomics beyond trypsin
- Principal Investigator
  
  Ishihama Yasushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Development of a platform for proteome analysis of clinical FFPE samplesPrincipal Investigator
- Principal Investigator
  
  Wakabayashi Masaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  オミクス計測科学
- Research Institution
  Kyoto University
Complete Analysis of Human Proteome by Deep Proteomics
- Principal Investigator
  
  Ishihama Yasushi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Elucidation of intracellular phosphorylation network for molecular targeting drug discovery
- Principal Investigator
  
  ISHIHAMA Yasushi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Genome biology
- Research Institution
  Kyoto University
Enrichment of low abundant proteome in plasma
- Principal Investigator
  
  ISHIHAMA Yasushi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Comprehensive analysis of cardiomyopathy-related signaling networks based on quantitative phosphoproteomicsPrincipal Investigator
- Principal Investigator
  
  WAKABAYASHI Masaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Peptidome analysis focusing on C-terminal amidation : Identification and functional analysis of novel bioactive peptides.Principal Investigator
- Principal Investigator
  
  WAKABAYASHI Masaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2021 2018 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] ナノバイオ技術と最新創薬応用研究2012
- Author(s)
  若林真樹、杉山直幸、石濱泰
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23790889
[Journal Article] Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D2023
- Author(s)
  Murakami Yusuke、Nishigori Mitsuhiro、Yagi Hiroaki、Osaki Tsukasa、Wakabayashi Masaki、Shirai Manabu、Son Cheol、Iba Yutaka、Minatoya Kenji、Kusano Kengo、Tomita Tsutomu、Ishibashi-Ueda Hatsue、Matsuda Hitoshi、Minamino Naoto
- Journal Title
  
  Proteome Science
  
  Volume: 21 Issue: 1 Pages: 11-11
- DOI
  10.1186/s12953-023-00212-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06410, KAKENHI-PROJECT-20K08485
[Journal Article] Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosus2023
- Author(s)
  Kitagori Koji、Oku Takuma、Wakabayashi Masaki、Nakajima Tomoya、Nakashima Ran、Murakami Kosaku、Hirayama Yoshitaka、Ishihama Yasushi、Ohmura Koichiro、Morinobu Akio、Mimori Tsuneyo、Yoshifuji Hajime
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 25 Issue: 1 Pages: 76-76
- DOI
  10.1186/s13075-023-03057-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07893, KAKENHI-PROJECT-20K08485
[Journal Article] Maintenance of neural stem‐progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon2021
- Author(s)
  Naoya Yuizumi、Yujin Harada、Takaaki Kuniya、Takehiko Sunabori、Masato Koike、Masaki Wakabayashi、Yasushi Ishihama、Yutaka Suzuki、Daichi Kawaguchi、Yukiko Gotoh
- Journal Title
  
  Stem Cells
  
  Volume: － Issue: 7 Pages: 929-944
- DOI
  10.1002/stem.3359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-20K08485, KAKENHI-PROJECT-19J22938, KAKENHI-PROJECT-18K06477, KAKENHI-PLANNED-16H06481, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H06280
[Journal Article] Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice2021
- Author(s)
  Rabaglino Maria Belen、Wakabayashi Masaki、Pearson James Todd、Jensen Lars J?rn
- Journal Title
  
  Mechanisms of Ageing and Development
  
  Volume: 200 Pages: 111594-111594
- DOI
  10.1016/j.mad.2021.111594
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08485
[Journal Article] A conditional proteomics approach to identify proteins involved in zinc homeostasis2016
- Author(s)
  T. Miki, M. Awa, Y. Nishikawa, S. Kiyonaka, M. Wakabayashi, Y. Ishihama, I. Hamachi
- Journal Title
  
  Nature Methods
  
  Volume: 13 Issue: 11 Pages: 931-937
- DOI
  10.1038/nmeth.3998
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J10316, KAKENHI-PROJECT-26505005
[Journal Article] Extended coverage of singly and multiply phosphorylated peptides from a single titanium dioxide microcolumn2015
- Author(s)
  Masaki Wakabayashi, Yutaka Kyono, Naoyuki Sugiyama, Yasushi Ishihama
- Journal Title
  
  Analytical chemistry
  
  Volume: 87 Issue: 20 Pages: 10213-21
- DOI
  10.1021/acs.analchem.5b01216
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26505005, KAKENHI-PROJECT-26830125
[Journal Article] Hydrophilic Interaction Chromatography Using Meter-scale Monolithic Silica Capillary Column for Proteomics LC-MS.2014
- Author(s)
  Horie K, Kamakura T, Ikegami T, Wakabayashi M, Kato T, Tanaka N, Ishihama Y.
- Journal Title
  
  Anal Chem
  
  Volume: 86 Issue: 8 Pages: 3817-24
- DOI
  10.1021/ac4038625
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-26116717, KAKENHI-PROJECT-26410151, KAKENHI-PROJECT-26505005
[Journal Article] Large-Scale Identification of Phosphorylation Sites for Profiling Protein Kinase Selectivity.2014
- Author(s)
  Imamura H, Sugiyama N, Wakabayashi M, Ishihama Y.
- Journal Title
  
  J Proteome Res.
  
  Volume: 13 Issue: 7 Pages: 3410-19
- DOI
  10.1021/pr500319y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-26505005, KAKENHI-PROJECT-26830125
[Journal Article] Phosphoproteome Analysis of Formalin-Fixed and Paraffin- Embedded Tissue Sections Mounted on Microscope Slides2013
- Author(s)
  Masaki Wakabayashi, Hiroki Yoshihara, Takeshi Masuda, Mai Tsukahara, Naoyuki Sugiyama, and Yasushi Ishihama
- Journal Title
  
  Journal of Proteome research
  
  Volume: 13 Issue: 2 Pages: 915-924
- DOI
  10.1021/pr400960r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08924, KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017
[Journal Article] Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot nanoLC-MS/MS analysis with meter-scale monolithic silica columns2013
- Author(s)
  山名涼太、岩崎未央、若林真樹、中川誠人、山中伸弥、石濱泰
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 12 Issue: 1 Pages: 214-221
- DOI
  10.1021/pr300837u
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04062, KAKENHI-PROJECT-23790889, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24590353, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-24116513
[Journal Article] Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation2012
- Author(s)
  Daisuke Inoue
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Issue: 10 Pages: 1547-54
- DOI
  10.1016/j.febslet.2012.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24590077, KAKENHI-PROJECT-24659017, KAKENHI-PLANNED-20117008, KAKENHI-PUBLICLY-24116513
[Journal Article] Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways2012
- Author(s)
  Koshi Imami, Naoyuki Sugiyama, Haruna Imamura, Masaki Wakabayashi, Masaru Tomita, Masatoshi Taniguchi, Takayuki Ueno, Masakazu Toi, Yasushi Ishihama
- Journal Title
  
  Molecular and Cellular Proteomics
  
  Volume: 11 Issue: 12 Pages: 1741-1757
- DOI
  10.1074/mcp.m112.019919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790889, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24116513
[Journal Article] A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis2012
- Author(s)
  Yoshiaki Nakayama
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 287 Issue: 38 Pages: 32222-32235
- DOI
  10.1074/jbc.m112.370932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770159, KAKENHI-PROJECT-23790889, KAKENHI-PUBLICLY-24110516
[Journal Article] Analytical strategies for shotgun phosphoproteomics : status and prospects2012
- Author(s)
  Haruna Imamura, Masaki Wakabayashi, Yasushi Ishihama
- Journal Title
  
  Seminars in Cell and Developmental Biology
  
  Volume: 23(8) Issue: 8 Pages: 836-42
- DOI
  10.1016/j.semcdb.2012.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04786, KAKENHI-PROJECT-23790889, KAKENHI-PUBLICLY-24116513
[Patent] 細胞外小胞新規大動脈瘤マーカー2022
- Inventor(s)
  若林真樹
- Industrial Property Rights Holder
  国立研究開発法人国立循環器病研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-058302
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K08485
[Presentation] プロテオミクス試料調製用タンパク質固定化StageTipの開発2018
- Author(s)
  西田紘士・若林真樹・杉山直幸・石濱泰
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] 腸内細菌叢メタプロテオーム解析プラットフォームの開発2016
- Author(s)
  伊藤麻里子、若林真樹、杉山直幸、園村和弘、松田文彦、石濱泰
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター(宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] 1細胞解析を指向した超高感度プロテオーム解析プラットフォームの開発2016
- Author(s)
  若林　真樹、杉山　直幸、石濱　泰
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都大学桂キャンパス（京都）
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] メートル長HILICモノリス型シリカカラムを用いた高分離能nanoLC/MS/MSプロテオミクス2016
- Author(s)
  阿知波弘憲, 鎌倉健雄, 市原駿, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  第27回クロマトグラフィー科学会議
- Place of Presentation
  慶應義塾大学芝共立キャンパス(東京都港区）
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] Single cell proteome profiling using highly sensitive LC-MS system and In-capillary sample preparation method2016
- Author(s)
  Masaki Wakabayashi, Yasushi Ishihama
- Organizer
  AOHUPO 2016
- Place of Presentation
  Nantou (Taiwan)
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] 極微量プロテオーム解析手法の開発～1細胞プロテオーム解析への挑戦～2016
- Author(s)
  若林真樹
- Organizer
  北里疾患プロテオーム研究会
- Place of Presentation
  北里大学理学部（神奈川）
- Year and Date
  2016-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] 極微量試料のプロテオーム解析手法の開発～1細胞プロテオーム解析プラットフォームの構築を目指して～2016
- Author(s)
  若林　真樹
- Organizer
  日本プロテオーム学会2016年大会
- Place of Presentation
  北里大学薬学部（東京）
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] Single-cell proteome profiling: Innovations in sample preparation2016
- Author(s)
  Masaki Wakabayashi, Yasushi Ishihama
- Organizer
  15th Human Proteome Organization World Congress
- Place of Presentation
  Taipei (Taiwan)
- Year and Date
  2016-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] Acetyl proteomics using a novel enrichment strategy for lysine acetylated peptides2016
- Author(s)
  Kazuya Tsumagari, Takayuki Hashimoto, Masaki Wakabayashi, Naoyuki Sugiyama, Yasushi Ishihama
- Organizer
  HUPO2016
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2016-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] DIAスライスモードを用いたLC/MS/MSによる大規模定量プロテオミクス2016
- Author(s)
  阿知波弘憲、若林真樹、杉山直幸、石濱泰
- Organizer
  日本プロテオーム学会2016年大会
- Place of Presentation
  北里大学薬学部（東京都港区）
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] High sensitivity and high throughput phosphoproteomics with micro-scale TMT labeling2016
- Author(s)
  Kosuke Ogata, Chia-Feng Tsai, Masaki Wakabayashi, Naoyuki Sugiyama, Yasushi Ishihama
- Organizer
  21st International Mass Spectrometry Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2016-08-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15107
[Presentation] ヒトショットガンプロテオーム解析のための高分離能二次元ナノLC2015
- Author(s)
  鎌倉健雄, 市原駿, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  第26回クロマトグラフィー科学会議
- Place of Presentation
  九州大学医系キャンパス（福岡）
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] Single-cell proteome profiling: Innovations in sample preparation2015
- Author(s)
  Masaki Wakabayashi, Jordan T Aerts, Stanislav S Rubakhin, Yasushi Ishihama, Jonathan V Sweedler
- Organizer
  日本プロテオーム学会2015年会
- Place of Presentation
  くまもと森都心プラザ（熊本）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] Single cell proteome profiling using highly sensitive LC-MS system and In-capillary sample preparation2015
- Author(s)
  Masaki Wakabayashi, Jordan T Aerts, Elena V romanova, Stanislav S Rubakhin, Yasushi Ishihama, Jonathan V Sweedler
- Organizer
  63rd American society for mass spectrometry conference
- Place of Presentation
  St. Louis, United States
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] 単一細胞プロテオーム解析技術の開発2015
- Author(s)
  若林真樹
- Organizer
  BMAS2015
- Place of Presentation
  長崎大学（長崎）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] メートル長モノリスシリカカラムを用いたLC-MS/MSシステムの開発とヒトプロテオーム一斉解析への挑戦2014
- Author(s)
  鎌倉健雄, 市原駿, 堀江勘太, 岩崎未央, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] 定量的リン酸化プロテオミクスによる標的パスウェイのリン酸化動態解析2014
- Author(s)
  矢崎達也, 高木俊輔, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] メートル長モノリスシリカカラムを用いたLC-MS/MSシステムの開発とヒトプロテオーム一斉解析への挑戦2014
- Author(s)
  鎌倉健雄, 市原駿, 堀江勘太, 岩崎未央, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] In Vitro Phosphorylation-Assisted In-Depth Human Serum Proteome Analysis2013
- Author(s)
  Takagi, S.; Imamura, H.; Wakabayashi, M.; Sugiyama, N.; Ishihama, Y.
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] In vitro リン酸化修飾を用いた標的キナーゼ基質の定量的リン酸化プロテオミクス2013
- Author(s)
  高木俊輔, 吉田繁治, 今村春菜, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] Unveiling Phosphoproteome by pY-Enhanced Phosphopeptide Enrichment Coupled with High Resolution Capillary LC-MS2013
- Author(s)
  N. Sugiyama, S. Yoshida, M. Iwasaki, M. Wakabayashi, and Y. Ishihama
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  パシフィコ横浜（神奈川）
- Invited
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] 25ミクロン径のメートル長モノリス型シリカキャピラリーによるプロテオミクスLC-MSシステムの高感度化2013
- Author(s)
  市原駿;岩崎未央;若林真樹;杉山直幸;石濱泰
- Organizer
  第24回クロマトグラフィー科学会議
- Place of Presentation
  東京大学工学部2号館, 東京
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] リン酸化プロテオミクスを用いた分子標的薬プロファイリング2013
- Author(s)
  若林真樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜, 神奈川
- Invited
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 定量的リン酸化プロテオミクスを用いた分子標的薬プロファイリング2013
- Author(s)
  林侑生, 市原駿, 小椋麻由, 吉田繁治, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] リン酸化プロテオミクスを用いた分子標的薬プロファイリング2013
- Author(s)
  若林真樹
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 25ミクロン径のメートル長モノリス型シリカキャピラリーによるプロテオミクスLC-MSシステムの高感度化2013
- Author(s)
  市原駿, 岩崎未央, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  第24回クロマトグラフィー科学会議
- Place of Presentation
  東京大学工学部（東京）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] Deep Profiling of Molecular-Targeted Drugs by One-Shot Quantitative Phosphoproteomics2013
- Author(s)
  Y. Hayashi, S. Ichihara, M. Wakabayashi, N. Sugiyama, and Y. Ishihama
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] In Vitro Phosphorylaton-Assisted In-Depth Human Serum Proteome Analysis2013
- Author(s)
  S. Takagi, H. Imamura, M. Wakabayashi, N. Sugiyama, and Y. Ishihama
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] Enhanced identification of phosphopeptides by peptide dimethylation coupled with titania chromatography2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  Asia Oceania Human Proteome Organization 6th Congress
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 人工リン酸化プロテオーム解析によるヒト血清中低発現量タンパク質同定法の開発2012
- Author(s)
  高木俊輔, 今村春菜, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  第23回クロマトグラフィー科学会議
- Place of Presentation
  長良川国際会議場, 岐阜
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] In-depth pharmaco-phosphoproteomics using meter-long monolithic columns to evaluate molecular-targeting drug2012
- Author(s)
  M. Wakabayashi, A. Sato, M. Iwasaki, N. Sugiyama, and Y. Ishihama
- Organizer
  19th International Mass Spectrometry Conference
- Place of Presentation
  京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] Enhanced identification of phosphopeptides by peptide dimethylation coupled with titania chromatography2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  Asia Oceania Human Proteome Organization 6th Congress
- Place of Presentation
  Beijing (China)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] In-depth pharmaco-phosphoproteomics using meter-long monolithic columns to evaluate molecular-targeting drugs2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  19th International Mass Spectrometry Conference
- Place of Presentation
  京都国際会館, 京都
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] ジメチル標識ペプチドのRP-LCにおける保持挙動評価と定量プロテオミクスの高効率化2012
- Author(s)
  若林真樹
- Organizer
  第23回クロマトグラフィー科学会議
- Place of Presentation
  長良川国際会議場, 岐阜
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] Enhanced identification of phosphopeptides by peptide dimethylation coupled with titania chromatography2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  60th American Society for Mass Spectrometry Conference
- Place of Presentation
  Vancouver (Canada)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] リン酸化プロテオーム計測システムの高感度化と極微量組織試料への応用2012
- Author(s)
  若林真樹
- Organizer
  第11回次世代を担う若手のためのフィジカルファーマフォーラム
- Place of Presentation
  ホテル平安の森京都, 京都
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 人工的リン酸化プロテオーム調製に基づく低発現量タンパク質同定法の開発2012
- Author(s)
  高木俊輔;今村春菜;若林真樹;杉山直幸;石濱泰
- Organizer
  日本プロテオーム学会2012年会
- Place of Presentation
  日本科学未来館、東京
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] リン酸化プロテオーム計測システムの高感度化と極微量組織試料への応用2012
- Author(s)
  若林真樹
- Organizer
  第11回次世代を担う若手のためのフィジカルファマフォラム
- Place of Presentation
  ホテル平安の森京都(京都)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] Highly sensitive phosphoproteome profiling of various human cancers from minuscule amount of formalin-fixed and paraffin-embedded tissue sections on slides2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  HUPO 2012 11th Annual World Congress
- Place of Presentation
  Boston (USA)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] In-depth pharmaco-phosphoproteomics using meter-long monolithic columns to evaluate molecular-targeting drugs2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  19th International Mass Spectrometry Conference
- Place of Presentation
  京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] リン酸化修飾シグナル病の解明に向けた極微量臨床試料解析法の構築2012
- Author(s)
  若林真樹
- Organizer
  第25回バイオメディカル分析化学シンポジウム
- Place of Presentation
  慶応大学薬学部(東京)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] In vitro phosphorylation to manipulate the abundance profiles in proteomic samples2012
- Author(s)
  Takagi, S.; Imamura, H.; Wakabayashi, M.; Sugiyama, N.; Ishihama, Y
- Organizer
  19th International Mass Spectrometry Conference
- Place of Presentation
  京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] 人工リン酸化プロテオーム解析によるヒト血清中低発現量タンパク質同定法の開発2012
- Author(s)
  高木俊輔; 今村春菜; 若林真樹; 杉山直幸; 石濱泰
- Organizer
  第23回クロマトグラフィー科学会議
- Place of Presentation
  長良川国際会議場（岐阜）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] 微量組織試料のリン酸化プロテオーム解析法2012
- Author(s)
  若林真樹
- Organizer
  日本プロテオーム学会2012年大会
- Place of Presentation
  日本科学未来館, 東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] Highly sensitive phosphoproteome profiling of various human cancers from minuscule amount of formalin-fixed and paraffin-embedded tissue sections on slides.2012
- Author(s)
  Masaki Wakabayashi
- Organizer
  HUPO 2012 11th Annual World Congress
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 人工的リン酸化プロテオーム調製に基づく低発現量タンパク質同定法の開発2012
- Author(s)
  高木俊輔; 今村春菜; 若林真樹; 杉山直幸; 石濱泰
- Organizer
  日本プロテオーム学会2012年会
- Place of Presentation
  日本科学未来館（東京）
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] リン酸化修飾シグナル病の病態解明に向けた極微量臨床試料解析法の構築2012
- Author(s)
  若林真樹
- Organizer
  第25回バイオメディカル分析化学シンポジウム
- Place of Presentation
  慶応大学薬学部, 東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] In vitro phosphorylation to manipulate the abundance profiles in proteomic samples2012
- Author(s)
  Takagi, S.; Imamura, H.; Wakabayashi, M.; Sugiyama, N.; Ishihama, Y.
- Organizer
  19th International Mass Spectrometry Conference
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24659017
[Presentation] 微量組織試料のリン酸化プロテオーム解析法2012
- Author(s)
  若林真樹
- Organizer
  日本プロテオーム学会2012 年大会
- Place of Presentation
  日本科学未来館(東京)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] ジメチル標識ペプチドのRP-LC における保持共同評価と定量プロテオミクスの高効率化2012
- Author(s)
  若林真樹
- Organizer
  第23回クロマトグラフィー科学会議
- Place of Presentation
  長良川国際会議場(岐阜)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 高感度LC-MS/MSシステムを用いた極微量組織試料のプロテオーム解析技術の確立2011
- Author(s)
  若林真樹、増田豪、石濱泰
- Organizer
  第２２回クロマトグラフィー科学会
- Place of Presentation
  東北大学（宮城県）
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 微量組織試料に対する定量的リン酸化プロテオーム解析法の確立2011
- Author(s)
  若林真樹、塚原麻伊、吉原宏樹、増田豪、石濱泰
- Organizer
  日本プロテオーム学会 2011 年大会
- Place of Presentation
  朱鷺メッセ(新潟)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 微量組織試料に対する定量的リン酸化プロテオーム解析法の確立2011
- Author(s)
  若林真樹、塚原麻伊、吉原宏樹、増田豪、石濱泰
- Organizer
  日本プロテオーム学会２０１１年大会
- Place of Presentation
  朱鷺メッセ（新潟県）
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] 高感度LC-MS/MS システムを用いた極微量組織試料のプロテオーム解析技術の確立2011
- Author(s)
  若林真樹、増田豪、石濱泰
- Organizer
  第22回クロマトグラフィー科学会
- Place of Presentation
  東北大学(宮城)
- Data Source
  KAKENHI-PROJECT-23790889
[Presentation] Global Identification of peptide processing sites implicated in the regulated secretory pathway2010
- Author(s)
  Masaki Wakabayashi, Kazuki Sasaki, Tsukasa Osaki, Yoshinori Satomi, Toshifumi Takao, Naoto Minamino
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21870055
[Presentation] Global Identification of peptide processing sites implicated in the regulated secretory pathway2010
- Author(s)
  Masaki Wakabayashi
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都国際会館
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21870055
[Presentation] 定量的リン酸化プロテオミクスを用いたプロテインキナーゼのリン酸化修飾と活性に関する研究
- Author(s)
  敷田奈都紀、佐藤綾香、若林真樹、杉山直幸、石濱泰
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホールエリア(兵庫）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] メートル長モノリス型シリカカラムを用いたLC-MS/MSシステムによるヒトプロテオーム解析
- Author(s)
  鎌倉健雄、市原駿、堀江勘太、若林真樹、杉山直幸、石濱泰
- Organizer
  日本プロテオーム学会2014年会
- Place of Presentation
  つくば国際会議場（茨城）
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] 定量的リン酸化プロテオミクスを用いた分子標的薬プロファイリング
- Author(s)
  林侑生、若林真樹、杉山直幸、石濱泰
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] 定量的リン酸化プロテオミクスを用いた分子標的薬プロファイリング
- Author(s)
  林侑生、若林真樹、杉山直幸、石濱泰
- Organizer
  日本プロテオーム学会2014年会
- Place of Presentation
  つくば国際会議場 (茨城）
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] Motif-targeting phosphopeptide enrichment for quantitative phosphoproteome analysis
- Author(s)
  Shunsuke Takagi, Tatsuya Yazaki, Kosuke Ogata, Masaki Wakabayashi, Naoyuki Sugiyama, Yasushi Ishihama
- Organizer
  13th Human Proteome Organization World Congress
- Place of Presentation
  Centro de Conventiones Norte, IFEMA (Madrid, Spain)
- Year and Date
  2014-10-05 – 2014-10-08
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] 超高感度LC-MSシステムを用いた単一細胞プロテオーム解析
- Author(s)
  若林真樹、Jordan T Aerts、Stanislav S Rubakhin、石濱泰、Jonathan V Sweedler
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] メートル長C18モノリス型シリカカラムを用いた高分離能二次元ナノLCMSプロテオミクス
- Author(s)
  鎌倉健雄、市原駿、堀江勘太、若林真樹、杉山直幸、石濱泰
- Organizer
  第25回クロマトグラフィー科学会議
- Place of Presentation
  京都大学桂キャンパス（京都）
- Year and Date
  2014-12-07 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] 単一細胞プロテオーム解析への挑戦
- Author(s)
  若林真樹、Jordan T Aerts、 Stanislav S Rubakhin、石濱泰、Jonathan V Sweedler
- Organizer
  BMAS2014 第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  帝京大学　板橋キャンパス
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] 1細胞プロテオーム解析への挑戦
- Author(s)
  若林真樹、Jordan T Aerts、Stanislav S Rubakhin、石濱泰、Jonathan V Sweedler
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] モチーフターゲットリン酸化プロテオミクスによる分子標的薬の評価
- Author(s)
  小形公亮、矢崎達也、林侑生、若林真樹、杉山直幸、石濱泰
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホールエリア(兵庫）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] Downscaling proteome profiling: toward single cell proteomics
- Author(s)
  Masaki Wakabayashi, Jordan T Aerts, Stanislav S Rubakhin, Yasushi Ishihama, Jonathan V Sweedler
- Organizer
  14th Asia-Pacific International Symposium on Microscale Separations and Analysis
- Place of Presentation
  京大桂キャンパス
- Year and Date
  2014-12-07 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26505005
[Presentation] 定量リン酸化プロテオミクスによる標的パスウェイのリン酸化動態解析
- Author(s)
  矢崎達也、高木俊輔、若林真樹、杉山直幸、石濱泰
- Organizer
  第62回質量分析総合討論会
- Place of Presentation
  ホテル阪急エキスポパーク (大阪）
- Year and Date
  2014-05-14 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] ナローボアメートル長モノリス型シリカカラムを用いたプロテオミクスLC-MS高感度システムの構築
- Author(s)
  市原駿、鎌倉健雄、堀江勘太、若林真樹、杉山直幸、石濱泰
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス（東京）
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] ホルマリン固定パラフィン包埋検体等の組織試料に対する定量的リン酸化プロテオーム解析法の開発
- Author(s)
  小椋麻由、若林真樹、杉山直幸、石濱泰
- Organizer
  日本プロテオーム学会2014年会
- Place of Presentation
  つくば国際会議場 (茨城）
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] タンパク質のN末端大規模解析に向けた新規Ｎ末端ペプチド濃縮法の開発
- Author(s)
  木村迪子 , 橋本貴行, 若林真樹, 杉山直幸, 石濱泰
- Organizer
  日本分析化学会第63年会
- Place of Presentation
  広島大学東広島キャンパス（広島）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] 単一細胞プロテオーム解析への挑戦
- Author(s)
  若林真樹、Jordan T Aerts、 Stanislav S Rubakhin、石濱泰、Jonathan V Sweedler
- Organizer
  BMAS2014 第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス(東京）
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24241062
[Presentation] High Resolution HILIC for Proteomic LC-MS
- Author(s)
  Kanta Horie, Takeo Kamakura, Suguru Ichihara, Masaki Wakabayashi, Nobuo Tanaka, Yasushi Ishihama
- Organizer
  62nd ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Baltimore Convention Center(Baltimore, MD, USA)
- Year and Date
  2014-06-15 – 2014-06-19
- Data Source
  KAKENHI-PROJECT-26670015
[Presentation] Monitoring Kinome Activities Using the Highly Specific and Sensitive Substrate Peptides
- Author(s)
  Naoyuki Sugiyama, Haruna Imamura, Pasrawin Taechawattananant, Dai Sakamoto, Masaki Wakabayashi, Yasushi Ishihama
- Organizer
  13th Human Proteome Organization World Congress
- Place of Presentation
  Centro de Conventiones Norte, IFEMA (Madrid, Spain)
- Year and Date
  2014-10-05 – 2014-10-08
- Data Source
  KAKENHI-PROJECT-24241062

1. Shirai Manabu (70294121)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 4 results

# of Collaborated Products: 41 results
3. SUGIYAMA Naoyuki (50545704)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
4. 笹井紀明 (80391960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TOYOSHIMA Fumiko (40397576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Minamino Naoto (50124839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 海谷啓之 (40300975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 奥崎大介 (00346131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 劉祐誠 (50894698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口修 (90467580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 莖田昌敬 (00709602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OSAKI Tsukasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NAKAYAMA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 吉藤元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岩崎未央

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

WAKABAYASHI Masaki 若林 真樹

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Establishment and application of proteome analysis methods for endomyocardial biopsy samplesPrincipal Investigator

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Development of a platform for proteome analysis of clinical FFPE samplesPrincipal Investigator

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Comprehensive analysis of cardiomyopathy-related signaling networks based on quantitative phosphoproteomicsPrincipal Investigator

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Peptidome analysis focusing on C-terminal amidation : Identification and functional analysis of novel bioactive peptides.Principal Investigator

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[Book] ナノバイオ技術と最新創薬応用研究2012

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[Journal Article] Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D2023

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WAKABAYASHI Masaki 若林真樹