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Nakamura Akinobu  中村 昭伸

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NAKAMURA Akinobu  中村 昭伸

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Researcher Number 70552420
Other IDs
External Links
Affiliation (Current) 2025: 北海道大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 北海道大学, 医学研究院, 講師
2014 – 2016: 北海道大学, 大学病院, 助教
2013: 横浜市立大学, 医学(系)研究科(研究院), 客員研究員
2013: 横浜市立大学, 医学研究科, 客員研究員
2009 – 2012: Yokohama City University, 附属病院, 助教
2011: 横浜市立大学, 大学病院, 助教
Review Section/Research Field
Principal Investigator
Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Except Principal Investigator
Metabolomics
Keywords
Principal Investigator
グルコキナーゼ / 膵β細胞量 / 糖尿病 / 膵β細胞 / 妊娠
Except Principal Investigator
分化 / アポトーシス / 増殖 / グルコース / グルコースシグナル … More / グルコキナーゼ / 膵β細胞 / ンスリン / ジペプチジルペプチダーゼ / インスリン / インクレチン / 内臓脂肪 / 遊離脂肪酸 / マクロファージ / 膵島 / ジペプチジルペプチダーゼ-4 Less
  • Research Projects

    (7 results)
  • Research Products

    (100 results)
  • Co-Researchers

    (6 People)
  •  Beta cell rest を目指した新たな2型糖尿病治療法の確立Principal Investigator

    • Principal Investigator
      中村 昭伸
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Hokkaido University
  •  Elucidation of pancreatic beta-cell mass regulation mechanism by glucokinasePrincipal Investigator

    • Principal Investigator
      Nakamura Akinobu
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Hokkaido University
  •  The treatment strategy of incresing pancreatic beta cell massPrincipal Investigator

    • Principal Investigator
      Akinobu Nakamura
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Hokkaido University
  •  Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass

    • Principal Investigator
      TERAUCHI Yasuo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  Regulation of adipocyte function by inhibitin of dipeptidyl peptidase-4

    • Principal Investigator
      KIMURA Mari
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  For clinical application of glucokinase activatorPrincipal Investigator

    • Principal Investigator
      NAKAMURA Akinobu
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  Novel treatment strategy of type 2 diabetes focused on beta cell massPrincipal Investigator

    • Principal Investigator
      NAKAMURA Akinobu
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

  • [Book] カレントテラピー2012

    • Author(s)
      中村昭伸
    • Total Pages
      6
    • Publisher
      糖尿病の薬物療法‐最新の治療と将来展望 グルコキナーゼ活性化薬
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] Positive association between proinsulin and fatty liver index in people with type 2 diabetes2024

    • Author(s)
      Nakamura Akinobu、Miya Aika、Suzuki Yuka、Nomoto Hiroshi、Kameda Hiraku、Yong Cho Kyu、Nagai So、Atsumi Tatsuya
    • Journal Title

      Endocr J

      Volume: 71 Issue: 2 Pages: 193-197

    • DOI

      10.1507/endocrj.EJ23-0403

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Journal Article] Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Pancreatic β-Cell Mass and Function2022

    • Author(s)
      Nakamura Akinobu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 9 Pages: 5104-5104

    • DOI

      10.3390/ijms23095104

    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Journal Article] Glucokinase as a therapeutic target based on findings from the analysis of mouse models2022

    • Author(s)
      Nakamura Akinobu
    • Journal Title

      Endocr J

      Volume: 69 Issue: 5 Pages: 479-485

    • DOI

      10.1507/endocrj.EJ21-0742

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Journal Article] Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?2021

    • Author(s)
      Nakamura Akinobu、Omori Kazuno、Terauchi Yasuo
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 23 Issue: 10 Pages: 2199-2206

    • DOI

      10.1111/dom.14459

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Journal Article] Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice2021

    • Author(s)
      Tsuchida Kazuhisa、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Yamauchi Yuki、Kawata Shinichiro、Omori Kazuno、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Seino Yusuke、Terauchi Yasuo、Atsumi Tatsuya
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 9 Pages: 1545-1554

    • DOI

      10.1111/jdi.13532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Journal Article] Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice2021

    • Author(s)
      Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Yamauchi Yuki、Kawata Shinichiro、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
    • Journal Title

      Diabetes

      Volume: 70 Issue: 4 Pages: 917-931

    • DOI

      10.2337/db20-0881

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Journal Article] Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice2021

    • Author(s)
      Kawata Shinichiro、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Shigesawa Ikumi、Yamauchi Yuki、Tsuchida Kazuhisa、Omori Kazuno、Takahashi Kiyohiko、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 24 Issue: 3 Pages: 391-401

    • DOI

      10.1111/dom.14586

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-20K17481
  • [Journal Article] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice2019

    • Author(s)
      Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Takagi Ryo、Hatanaka Kanako C.、Terauchi Yasuo、Atsumi Tatsuya
    • Journal Title

      Metabolism

      Volume: 98 Pages: 27-36

    • DOI

      10.1016/j.metabol.2019.06.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-19K21329
  • [Journal Article] 糖尿病新規治療薬の開発と動向2016

    • Author(s)
      中村昭伸、三好秀明
    • Journal Title

      プラクティス

      Volume: 33 Pages: 39-43

    • Data Source
      KAKENHI-PROJECT-26860683
  • [Journal Article] Present status of clinical deployment of glucokinase activators.2015

    • Author(s)
      Nakamura A, Terauchi Y.
    • Journal Title

      J Diabetes Invest

      Volume: 6 Issue: 2 Pages: 124-132

    • DOI

      10.1111/jdi.12294

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Journal Article] Present status of clinical deployment of glucokinase activators.2015

    • Author(s)
      Nakamura A, Terauchi Y.
    • Journal Title

      J Diabetes Investig

      Volume: 6 Pages: 124-132

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Journal Article] 新たな治療標的と創薬 グルコキナーゼ2015

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      Mebio

      Volume: 32 Pages: 64-68

    • Data Source
      KAKENHI-PROJECT-26860683
  • [Journal Article] βcell proliferation after a partial pancreatectomy is independent of IRS-2 in mice2014

    • Author(s)
      Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014

    • Author(s)
      Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 155(5) Pages: 1643-52

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014

    • Author(s)
      Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 5 Pages: 1643-52

    • DOI

      10.1210/en.2013-1796

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
  • [Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice.2013

    • Author(s)
      Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 305 Issue: 8 Pages: 987-998

    • DOI

      10.1152/ajpendo.00133.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
  • [Journal Article] AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.2013

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 5 Pages: e64633-e64633

    • DOI

      10.1371/journal.pone.0064633

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-24390235, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
  • [Journal Article] Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes.2013

    • Author(s)
      Nakamura A, et al.
    • Journal Title

      Endocr J

      Volume: (In press)

    • NAID

      10031156721

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Journal Article] Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes2013

    • Author(s)
      Nakamura A
    • Journal Title

      Endocrine Journal

      Volume: 60 Pages: 45-49

    • NAID

      10031156721

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice2013

    • Author(s)
      Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 305(8)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Journal Article] Trefoil factor 2 promotes cell proliferation in pancreatic β cells through CXCR-4-mediated ERK1/2 phosphorylation.2013

    • Author(s)
      Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 54-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: (In press) Issue: 6 Pages: 1745-1754

    • DOI

      10.1007/s00125-012-2521-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-09J03269, KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040, KAKENHI-PROJECT-24390232
  • [Journal Article] 糖尿病の薬物療法‐最新の治療と将来展望2012

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      グルコキナーゼ活性化薬 カレントテラピー

      Volume: 30 Pages: 85-90

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A , Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: 55(6) Pages: 1745-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions.2012

    • Author(s)
      Nakamura A, et al.
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 1745-1754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions.2012

    • Author(s)
      Nakamura A
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 1745-1754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Journal Article] Protection from nonalcoholic steatohepatitis and liver tumorigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.2012

    • Author(s)
      Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: 55(12) Issue: 12 Pages: 3382-3391

    • DOI

      10.1007/s00125-012-2703-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590429, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040, KAKENHI-PROJECT-24390232
  • [Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012

    • Author(s)
      Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: 153(3) Pages: 1093-102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012

    • Author(s)
      Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: 153(3) Issue: 3 Pages: 1093-102

    • DOI

      10.1210/en.2011-1712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-09J03269, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040
  • [Journal Article] 次世代の 2 型糖尿病薬物治療 開発中の次世代の治療薬 GK活性化薬、GPR119 受容体アゴニスト2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      月刊Mebio

      Volume: 28 Pages: 104-110

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] Effect of long-term treatment with a small molecule glucokinase activator on glucose metabolism, lipid profiles, and hepatic function2011

    • Author(s)
      Nakamura A, Shimazaki H, Ohyama S, Eiki J, Terauchi Y
    • Journal Title

      J Diabetes Invest

      Volume: 2 Issue: 4 Pages: 276-279

    • DOI

      10.1111/j.2040-1124.2011.00104.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] 次世代の2型糖尿病薬物治療 開発中の次世代の治療薬 GK活性化薬、GPR119受容体アゴニスト2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      Mebio

      Volume: 28 Pages: 104-110

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] 膵β細胞の分化、増殖制御と糖尿病治療 糖代謝を介した膵β 細胞増殖促進薬2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      細胞

      Volume: 43 Pages: 469-472

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] 次世代の2型糖尿病薬物治療 開発中の次世代の治療薬 GK活性化薬、GPR119受容体アゴニスト2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      月刊Mebio 28

      Pages: 104-110

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病治療最前線2011 新しい糖尿病治療薬 9 グルコキナーゼ活性化薬の現状と展望2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      月刊糖尿病

      Volume: 3 Pages: 114-123

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] 糖尿病治療最前線2011 新しい糖尿病治療薬9 グルコキナーゼ活性化薬の現状と展望2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      月刊糖尿病 3

      Pages: 114-123

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 膵β細胞の分化、増殖制御と糖尿病治療 糖代謝を介した膵β細胞増殖促進薬2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      細胞

      Volume: 43 Pages: 469-472

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] Effect of long-term treatment with a small molecule glucokinase activator on glucose metabolism, lipid profiles, and hepatic function.2011

    • Author(s)
      Nakamura A, Shimazaki H, Ohyama S, Eiki J, Terauchi Y
    • Journal Title

      J Diabetes Invest. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病治療最前線2011 新しい糖尿病治療薬9:グルコキナーゼ活性化薬の現状と展望2011

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      月刊糖尿病

      Volume: 3 Pages: 114-123

    • Data Source
      KAKENHI-PROJECT-23791040
  • [Journal Article] グルコキナーゼ活性化薬2010

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      Annual Review 糖尿病・代謝・内分泌2010

      Pages: 49-59

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病診療2010 糖尿病の早期治療 早期治療の意義 膵β細胞の保護から2010

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      日本医師会雑誌 139

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] グルコキナーゼ活性化薬2010

    • Author(s)
      中村昭伸, 寺内康夫
    • Journal Title

      Annual Review 糖尿病・代謝・内分泌2010 1

      Pages: 49-59

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病とその合併症の新薬の現状と未来 グルコキナーゼ活性化薬2010

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      内分泌・糖尿病・代謝内科 31

      Pages: 13-21

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病診療の将来展望 10 Topics経口糖尿病治療薬はこうなる -近未来における治療-2010

    • Author(s)
      中村昭伸、寺内康夫
    • Journal Title

      糖尿病診療マスター 8

      Pages: 581-584

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Journal Article] 糖尿病とその合併症の新薬の現状と未来 グルコキナーゼ活性化薬2010

    • Author(s)
      中村昭伸
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 31 Pages: 13-21

    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] モデル動物から得られたグルコキナーゼに関する新たな知見2024

    • Author(s)
      中村昭伸
    • Organizer
      第37回日本糖尿病・肥満動物学会年次学術集会 研究賞受賞講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Presentation] 高脂肪高スクロース食負荷誘導性膵β細胞機能・量の変化におけるグルコキナーゼの影響2024

    • Author(s)
      中村昭伸、重沢郁美、宮崎あすか、山内裕貴、川田晋一朗、野本博司、亀田啓、寺内康夫、渥美達也
    • Organizer
      第37回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Presentation] 食餌誘導性肥満・糖尿病モデルマウスにおけるグルコキナーゼ抑制が膵β細胞機能・量に与える影響2023

    • Author(s)
      重沢郁美、中村昭伸、山内裕貴、川田晋一朗、宮崎あすか、野本博司、亀田啓、三好秀明、寺内康夫、渥美達也
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Presentation] 膵β細胞機能が2型糖尿病病態に与える影響2023

    • Author(s)
      中村昭伸
    • Organizer
      第57回日本糖尿病学会北海道地方会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Presentation] Effect of glucokinase haploinsufficiency on pancreatic beta-cell function and mass in high-fat, high-sucrose diet-fed mice.2023

    • Author(s)
      Shigesawa I, Nakamura A, Yamauchi Y, Kawata S, Miyazaki A, Nomoto H, Kameda H, Miyoshi H, Terauchi Y, Atsumi T.
    • Organizer
      83rd Scientific Sessions for American Diabetes Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07959
  • [Presentation] グルコキナーゼ活性化薬の長期投与に伴う血糖降下作用の消失機序の解明2022

    • Author(s)
      川田晋一朗、中村昭伸、三好秀明、山内裕貴、土田和久、大森一乃、高橋清彦、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
    • Organizer
      第95回日本内分泌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] 膵β細胞量保持を目指した2型糖尿病の治療戦略2022

    • Author(s)
      大森一乃、中村昭伸
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] グルコキナーゼの抑制が2型糖尿病病態下の膵β細胞量を保持する2022

    • Author(s)
      大森一乃、中村昭伸、三好秀明、山内裕貴、川田晋一朗、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
    • Organizer
      第35回日本糖尿病・肥満動物学会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] 膵β細胞グルコキナーゼの抑制が肥満2型糖尿病モデルマウスの膵β細胞機能・量を保持する2021

    • Author(s)
      中村昭伸、大森一乃、三好秀明、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
    • Organizer
      第41回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] グルコキナーゼの制御が膵β細胞量に与える影響2021

    • Author(s)
      中村昭伸、寺内康夫
    • Organizer
      第64回日本糖尿病学会年次学術集会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] Improved mitochondrial function by luseogliflozin prevents pancreatic beta-cell damage.2021

    • Author(s)
      Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T.
    • Organizer
      81st Scientific Sessions for American Diabetes Association.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] モデル動物を用いた2型糖尿病治療法の確立に向けた研究2021

    • Author(s)
      中村昭伸
    • Organizer
      第94回日本内分泌学会学術総会研究奨励賞受賞講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] db/dbマウスを用いたグルコキナーゼ活性化薬の血糖降下作用消失機序の解明2021

    • Author(s)
      川田晋一朗、中村昭伸、三好秀明、重沢郁美、山内裕貴、関崎知紀、土田和久、大森一乃、高橋清彦、北尾直之、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
    • Organizer
      第64回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] Glucokinase haploinsufficiency ameliorates glucose intolerance by increasing beta-cell mass in db/db mice2020

    • Author(s)
      Kazuno Omori, Akinobu Nakamura, Hideaki Miyoshi, Shinichiro Kawata, Kiyohiko Takahashi, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yasuo Terauchi, Tatsuya Atsumi
    • Organizer
      56th Annual Meeting of the European Association for the Study of Diabetes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] グルコキナーゼ活性化薬の長期投与に伴う血糖降下作用の消失機序の解明2020

    • Author(s)
      川田晋一朗、中村昭伸、土田和久、大森一乃、高橋清彦、野本博司、亀田啓、曺圭龍、寺内 康夫、三好秀明、渥美達也
    • Organizer
      第34回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice.2019

    • Author(s)
      Omori K, Nakamura A, Miyoshi H, Takahashi K, Kitao N, Nomoto H, Kameda H, Cho KY, Terauchi Y, Atsumi T.
    • Organizer
      American Diabetic Association’s 79th Scientific Sessions.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] Reduced hypoglycemic property of glucokinase activator by longitudinal administration in db/db mice.2019

    • Author(s)
      Kawata S, Nakamura A, Miyoshi H, Tsuchida K, Omori K, Takahashi K, Kameda H, Cho KY, Terauchi Y, Atsumi T.
    • Organizer
      55th Annual Meeting of the European Association for the Study of Diabetes.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] SGLT2阻害薬またはインスリンによる血糖降下作用が膵β細胞量および肝脂肪化に与える影響2019

    • Author(s)
      大森一乃、中村昭伸、三好秀明、川田晋一朗、土田和久、高橋清彦、寺内 康夫、渥美達也
    • Organizer
      第56回臨床分子学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] SGLT2阻害薬またはインスリンによる血糖降下作用が肝脂肪化に与える影響2019

    • Author(s)
      大森一乃、中村昭伸、三好秀明、川田晋一朗、土田和久、高橋清彦、寺内 康夫、渥美達也
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08992
  • [Presentation] 高脂肪食負荷誘導性膵β細胞増殖メカニズムの検討2017

    • Author(s)
      中村 昭伸、北尾 直之、三好 秀明、寺内 康夫、渥美 達也
    • Organizer
      第20回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2017-01-13
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 2型糖尿病の新たな治療に向けて~膵β細胞を増やす、守る、復活させる~2016

    • Author(s)
      中村昭伸
    • Organizer
      第34回内分泌代謝学サマーセミナー
    • Place of Presentation
      久山温泉ホテル夢家(福岡県久山町)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] グルコキナーゼ活性化薬による膵β細胞増殖は一過性である2016

    • Author(s)
      高橋清彦、中村昭伸、北尾直之、三好秀明、寺内康夫、渥美達也
    • Organizer
      第53回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-04-15
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] Transient effect of glucokinase activator on beta cell proliferation.2016

    • Author(s)
      1.Nakamura A, Takahashi K, Kitao N, Miyoshi H, Terauchi Y, Atsumi T.
    • Organizer
      52nd Annual Meeting of the European Association for the Study of Diabetes.
    • Place of Presentation
      Munich (Germany)
    • Year and Date
      2016-09-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] マウスへの短期高脂肪食負荷はインスリン抵抗性を伴わず膵β細胞を増殖させる2016

    • Author(s)
      北尾直之、中村昭伸、高橋清彦、山本浩平、三好秀明、寺内康夫、渥美達也
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] グルコキナーゼ活性化薬による膵β細胞増殖機構の解明2016

    • Author(s)
      中村昭伸、高橋清彦、北尾直之、三好秀明、寺内康夫、渥美達也
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] The protective effect of Luseogliflozin on pancreatic beta cell mass.2016

    • Author(s)
      2.Takahashi K, Nakamura A, Kitao N, Cho KY, Miyoshi H, Terauchi Y, Atsumi T.
    • Organizer
      52nd Annual Meeting of the European Association for the Study of Diabetes.
    • Place of Presentation
      Munich (Germany)
    • Year and Date
      2016-09-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] マウスへの短期高脂肪食負荷はインスリン抵抗性を伴わず膵β細胞を増殖させる2016

    • Author(s)
      16.北尾直之、中村昭伸、高橋清彦、山本浩平、三好秀明、寺内康夫、渥美達也.
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 高脂肪食誘導性膵β細胞増殖機構の検討2015

    • Author(s)
      中村昭伸、北尾直之、三好秀明、寺内康夫、渥美達也
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 短期高脂肪食の膵β細胞増殖効果2015

    • Author(s)
      北尾直之、中村昭伸、山本浩平、三好秀明、寺内康夫、渥美達也
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] Partial pancreatectomy facilitated β cell proliferation in glucokinase haploinsufficient mice and IRS-2 deficient mice.2013

    • Author(s)
      Togashi Y, Shirakawa J, Orime K, Inoue H, Nakamura A, Terauchi Y.
    • Organizer
      73rd American Diabetes Association (ADA) meeting
    • Place of Presentation
      Chicago, USA.
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Presentation] メトホルミンは高脂肪食下での肝腫瘍形成を抑制する2013

    • Author(s)
      田島一樹、中村昭伸、白川純、折目和基、富樫優、井上英昭、長嶋洋治、寺内康夫
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2013-04-25
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Presentation] Signaling pathway ofβCell proliferation in pancreatectomy is distinct from that in high-fat diet-loading in Mice2012

    • Author(s)
      Togashi Y, Shirakawa J, Nakamura A, Terauchi Y
    • Organizer
      American Diabetes Association 72^st Scientific Sessions
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Presentation] Trefoil factor 2 (TFF2) induces proliferation of pancreaticβcells2011

    • Author(s)
      Orime K, Shirakawa J, Nakamura A, Togashi Y, Tajima K, Sato K, Terauchi Y
    • Organizer
      71st Scientific Sessions for American Diabetes Association (ADA)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-24
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Presentation] グルコキナーゼ活性化薬が膵β細胞機能・増殖に与える影響2011

    • Author(s)
      中村昭伸
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル(北海道)
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] 膵β細胞の再生を目指して The role of IRS-2 in the regulation of pancreatic beta cell mass in response to small molecule glucokinase activator2011

    • Author(s)
      中村昭伸、寺内康夫
    • Organizer
      第54回日本糖尿病学会年次学術集会シンポジウム(招待講演)
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] Beta Cell Function and Proliferation in Response to Small Molecule Glucokinase Activator under Various Conditions2011

    • Author(s)
      Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Terauchi Y
    • Organizer
      71th Scientific Sessions for American Diabetes Association
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] Impact of vildagliptin on glucose tolerance, and beta cell mass in insulin receptor substrate-2-knockout mice2011

    • Author(s)
      Sato K, Shirakawa J, Muraoka T, Togashi, Orime K, Nakamura A, Terauchi Y
    • Organizer
      71st Scientific Sessions for American Diabetes Association (ADA)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-24
    • Data Source
      KAKENHI-PROJECT-23591316
  • [Presentation] Beta Cell Function and Proliferation in Response to Small Molecule Glucokinase Activator under Various Conditions2011

    • Author(s)
      Akinobu Nakamura
    • Organizer
      71th Scientific Sessions for American Diabetes Association
    • Place of Presentation
      San Diego, California, USA
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] グルコキナーゼ活性化薬が膵β細胞機能・増殖に与える影響2011

    • Author(s)
      中村昭伸、富樫優、折目和基、佐藤光一郎、白川純、田波律子、伊藤譲、寺内康夫
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル(札幌市)
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] 膵β細胞の再生を目指して The role of IRS-2 in the regulation of pancreatic beta cell mass in response to small molecule glucokinase activator2011

    • Author(s)
      中村昭伸
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌(北海道)(招待講演)
    • Data Source
      KAKENHI-PROJECT-23791040
  • [Presentation] β cell fate:β細胞の発生から細胞死The role of glucokinase in the regulation of beta cell proliferation2010

    • Author(s)
      中村昭伸
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山 岡山コンベンションセンター(招待講演)
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] β cell fate:β細胞の発生から細胞死 The role of glucokinase in the regulation of beta cell proliferation2010

    • Author(s)
      中村昭伸
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山 岡山コンベンションセンター(招待講演)
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用におけるIRS-2の役割2010

    • Author(s)
      中村昭伸
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山 岡山コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] A Crucial Role of IRS-2 in the Proliferation of Beta Cells Stimulated by Small Molecule Glucokinase Activator2010

    • Author(s)
      中村昭伸
    • Organizer
      70^<th> Scientific Sessions for American Diabetes Association
    • Place of Presentation
      Orlando, Florida, USA
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用の分子機構2010

    • Author(s)
      中村昭伸
    • Organizer
      第47回日本臨床分子医学会学術集会
    • Place of Presentation
      東京東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用の分子機構2010

    • Author(s)
      中村昭伸
    • Organizer
      第47回日本臨床分子医学会学術集会
    • Place of Presentation
      東京 東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用におけるIRS-2の役割2010

    • Author(s)
      中村昭伸
    • Organizer
      第83回日本内分泌学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] グルコキナーゼ活性化薬による膵β細胞増殖メカニズムの解析2010

    • Author(s)
      中村昭伸
    • Organizer
      第24回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21890213
  • [Presentation] Different effect of short-term and long-term high-fat diet feeding on pancreatic beta cell proliferation

    • Author(s)
      Kitao N, Nakamura A, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
    • Organizer
      6th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre (Suntec, Singapore)
    • Year and Date
      2014-11-21 – 2014-11-24
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] Different effect of short-term and long-term high-fat diet feeding on pancreatic beta cell proliferation.

    • Author(s)
      Kitao N, Nakamura A, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
    • Organizer
      10th IDF-WPR Congress/6th AASD Scientific Meeting
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2014-11-20 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-24390235
  • [Presentation] Different regulation of beta cell proliferation induced by short-term and long-term high-fat diet loading

    • Author(s)
      Nakamura A, Kitao N, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
    • Organizer
      50th Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Reed Messe Vienna (Vienna, Austria)
    • Year and Date
      2014-09-15 – 2014-09-19
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 高脂肪食負荷期間による膵β細胞増殖のメカニズムの差異

    • Author(s)
      北尾直之、中村昭伸、野本博司、亀田啓、近藤琢磨、三好秀明、寺内康夫、渥美達也
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-11 – 2014-04-12
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 短期高脂肪食負荷と長期高脂肪食負荷による膵β細胞増殖機構の差異

    • Author(s)
      中村昭伸、北尾直之、野本博司、三好秀明、寺内康夫、渥美達也
    • Organizer
      第29回日本糖尿病合併症学会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2014-10-03 – 2014-10-04
    • Data Source
      KAKENHI-PROJECT-26860683
  • [Presentation] 短期高脂肪食が膵β細胞増殖に与える影響

    • Author(s)
      北尾直之、中村昭伸、高野善成、一山芽衣、小梁川直秀、宮愛香、三次有奈、山本浩平、山本知穂、野本博司、亀田啓、近藤琢磨、三好秀明、寺内康夫、渥美達也
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-26860683
  • 1.  KIMURA Mari (40363840)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  TERAUCHI Yasuo (40359609)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 3.  SHIRAKAWA Jun (70625532)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  SATO Mikiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  伊藤 讓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  長嶋 洋治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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