Nakamura Akinobu 中村昭伸

… Alternative Names

NAKAMURA Akinobu 中村昭伸

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Researcher Number	70552420
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 北海道大学, 医学研究院, 講師 2014 – 2016: 北海道大学, 大学病院, 助教 2013: 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 2013: 横浜市立大学, 医学研究科, 客員研究員 2009 – 2012: Yokohama City University, 附属病院, 助教 2011: 横浜市立大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics
Keywords	Principal Investigator グルコキナーゼ / 膵β細胞量 / 糖尿病 / 膵β細胞 / 妊娠 Except Principal Investigator 分化 / アポトーシス / 増殖 / グルコース / グルコースシグナル … More / グルコキナーゼ / 膵β細胞 / ンスリン / ジペプチジルペプチダーゼ / インスリン / インクレチン / 内臓脂肪 / 遊離脂肪酸 / マクロファージ / 膵島 / ジペプチジルペプチダーゼ-４ Less

Beta cell rest を目指した新たな2型糖尿病治療法の確立Principal Investigator
- Principal Investigator
  
  中村昭伸
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hokkaido University
Elucidation of pancreatic beta-cell mass regulation mechanism by glucokinasePrincipal Investigator
- Principal Investigator
  
  Nakamura Akinobu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hokkaido University
The treatment strategy of incresing pancreatic beta cell massPrincipal Investigator
- Principal Investigator
  
  Akinobu Nakamura
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hokkaido University
Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass
- Principal Investigator
  
  TERAUCHI Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Regulation of adipocyte function by inhibitin of dipeptidyl peptidase-4
- Principal Investigator
  
  KIMURA Mari
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
For clinical application of glucokinase activatorPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Akinobu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Novel treatment strategy of type 2 diabetes focused on beta cell massPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Akinobu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University

[Book] カレントテラピー2012
- Author(s)
  中村昭伸
- Total Pages
  6
- Publisher
  糖尿病の薬物療法‐最新の治療と将来展望　グルコキナーゼ活性化薬
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] Positive association between proinsulin and fatty liver index in people with type 2 diabetes2024
- Author(s)
  Nakamura Akinobu、Miya Aika、Suzuki Yuka、Nomoto Hiroshi、Kameda Hiraku、Yong Cho Kyu、Nagai So、Atsumi Tatsuya
- Journal Title
  
  Endocr J
  
  Volume: 71 Issue: 2 Pages: 193-197
- DOI
  10.1507/endocrj.EJ23-0403
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07959
[Journal Article] Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Pancreatic β-Cell Mass and Function2022
- Author(s)
  Nakamura Akinobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5104-5104
- DOI
  10.3390/ijms23095104
- Data Source
  KAKENHI-PROJECT-19K08992
[Journal Article] Glucokinase as a therapeutic target based on findings from the analysis of mouse models2022
- Author(s)
  Nakamura Akinobu
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 5 Pages: 479-485
- DOI
  10.1507/endocrj.EJ21-0742
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992
[Journal Article] Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?2021
- Author(s)
  Nakamura Akinobu、Omori Kazuno、Terauchi Yasuo
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 23 Issue: 10 Pages: 2199-2206
- DOI
  10.1111/dom.14459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992
[Journal Article] Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice2021
- Author(s)
  Tsuchida Kazuhisa、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Yamauchi Yuki、Kawata Shinichiro、Omori Kazuno、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Seino Yusuke、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 9 Pages: 1545-1554
- DOI
  10.1111/jdi.13532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992
[Journal Article] Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice2021
- Author(s)
  Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Yamauchi Yuki、Kawata Shinichiro、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Diabetes
  
  Volume: 70 Issue: 4 Pages: 917-931
- DOI
  10.2337/db20-0881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992
[Journal Article] Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice2021
- Author(s)
  Kawata Shinichiro、Nakamura Akinobu、Miyoshi Hideaki、Yang Kelaier、Shigesawa Ikumi、Yamauchi Yuki、Tsuchida Kazuhisa、Omori Kazuno、Takahashi Kiyohiko、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 24 Issue: 3 Pages: 391-401
- DOI
  10.1111/dom.14586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-20K17481
[Journal Article] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice2019
- Author(s)
  Omori Kazuno、Nakamura Akinobu、Miyoshi Hideaki、Takahashi Kiyohiko、Kitao Naoyuki、Nomoto Hiroshi、Kameda Hiraku、Cho Kyu Yong、Takagi Ryo、Hatanaka Kanako C.、Terauchi Yasuo、Atsumi Tatsuya
- Journal Title
  
  Metabolism
  
  Volume: 98 Pages: 27-36
- DOI
  10.1016/j.metabol.2019.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08992, KAKENHI-PROJECT-19K21329
[Journal Article] 糖尿病新規治療薬の開発と動向2016
- Author(s)
  中村昭伸、三好秀明
- Journal Title
  
  プラクティス
  
  Volume: 33 Pages: 39-43
- Data Source
  KAKENHI-PROJECT-26860683
[Journal Article] Present status of clinical deployment of glucokinase activators.2015
- Author(s)
  Nakamura A, Terauchi Y.
- Journal Title
  
  J Diabetes Invest
  
  Volume: 6 Issue: 2 Pages: 124-132
- DOI
  10.1111/jdi.12294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860683
[Journal Article] Present status of clinical deployment of glucokinase activators.2015
- Author(s)
  Nakamura A, Terauchi Y.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 6 Pages: 124-132
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] 新たな治療標的と創薬　グルコキナーゼ2015
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  Mebio
  
  Volume: 32 Pages: 64-68
- Data Source
  KAKENHI-PROJECT-26860683
[Journal Article] βcell proliferation after a partial pancreatectomy is independent of IRS-2 in mice2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y
- Journal Title
  
  Endocrinology
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316
[Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155(5) Pages: 1643-52
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 5 Pages: 1643-52
- DOI
  10.1210/en.2013-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
[Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice.2013
- Author(s)
  Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  Am. J. Physiol. Endocrinol. Metab.
  
  Volume: 305 Issue: 8 Pages: 987-998
- DOI
  10.1152/ajpendo.00133.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
[Journal Article] AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.2013
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 5 Pages: e64633-e64633
- DOI
  10.1371/journal.pone.0064633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-24390235, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25670455, KAKENHI-PROJECT-25860754
[Journal Article] Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes.2013
- Author(s)
  Nakamura A, et al.
- Journal Title
  
  Endocr J
  
  Volume: (In press)
- NAID
  10031156721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes2013
- Author(s)
  Nakamura A
- Journal Title
  
  Endocrine Journal
  
  Volume: 60 Pages: 45-49
- NAID
  10031156721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice2013
- Author(s)
  Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y
- Journal Title
  
  Am. J. Physiol. Endocrinol. Metab.
  
  Volume: 305(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316
[Journal Article] Trefoil factor 2 promotes cell proliferation in pancreatic β cells through CXCR-4-mediated ERK1/2 phosphorylation.2013
- Author(s)
  Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 154 Pages: 54-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012
- Author(s)
  Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
- Journal Title
  
  Diabetologia
  
  Volume: (In press) Issue: 6 Pages: 1745-1754
- DOI
  10.1007/s00125-012-2521-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J03269, KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040, KAKENHI-PROJECT-24390232
[Journal Article] 糖尿病の薬物療法‐最新の治療と将来展望2012
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  グルコキナーゼ活性化薬カレントテラピー
  
  Volume: 30 Pages: 85-90
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions2012
- Author(s)
  Nakamura A , Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
- Journal Title
  
  Diabetologia
  
  Volume: 55(6) Pages: 1745-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316
[Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions.2012
- Author(s)
  Nakamura A, et al.
- Journal Title
  
  Diabetologia
  
  Volume: 55 Pages: 1745-1754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390235
[Journal Article] Control of beta cell function and proliferation in mice stimulated by small molecule glucokinase activator under various conditions.2012
- Author(s)
  Nakamura A
- Journal Title
  
  Diabetologia
  
  Volume: 55 Pages: 1745-1754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316
[Journal Article] Protection from nonalcoholic steatohepatitis and liver tumorigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.2012
- Author(s)
  Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y
- Journal Title
  
  Diabetologia
  
  Volume: 55(12) Issue: 12 Pages: 3382-3391
- DOI
  10.1007/s00125-012-2703-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590429, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040, KAKENHI-PROJECT-24390232
[Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012
- Author(s)
  Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
- Journal Title
  
  Endocrinology
  
  Volume: 153(3) Pages: 1093-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316
[Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012
- Author(s)
  Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
- Journal Title
  
  Endocrinology
  
  Volume: 153(3) Issue: 3 Pages: 1093-102
- DOI
  10.1210/en.2011-1712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J03269, KAKENHI-PROJECT-23591315, KAKENHI-PROJECT-23791040
[Journal Article] 次世代の 2 型糖尿病薬物治療開発中の次世代の治療薬 GK活性化薬、GPR119 受容体アゴニスト2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  月刊Mebio
  
  Volume: 28 Pages: 104-110
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] Effect of long-term treatment with a small molecule glucokinase activator on glucose metabolism, lipid profiles, and hepatic function2011
- Author(s)
  Nakamura A, Shimazaki H, Ohyama S, Eiki J, Terauchi Y
- Journal Title
  
  J Diabetes Invest
  
  Volume: 2 Issue: 4 Pages: 276-279
- DOI
  10.1111/j.2040-1124.2011.00104.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] 次世代の2型糖尿病薬物治療　開発中の次世代の治療薬　GK活性化薬、GPR119受容体アゴニスト2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  Mebio
  
  Volume: 28 Pages: 104-110
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] 膵β細胞の分化、増殖制御と糖尿病治療糖代謝を介した膵β 細胞増殖促進薬2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  細胞
  
  Volume: 43 Pages: 469-472
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] 次世代の2型糖尿病薬物治療開発中の次世代の治療薬 GK活性化薬、GPR119受容体アゴニスト2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  月刊Mebio 28
  
  Pages: 104-110
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病治療最前線2011 新しい糖尿病治療薬 9 グルコキナーゼ活性化薬の現状と展望2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  月刊糖尿病
  
  Volume: 3 Pages: 114-123
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] 糖尿病治療最前線2011 新しい糖尿病治療薬9 グルコキナーゼ活性化薬の現状と展望2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  月刊糖尿病 3
  
  Pages: 114-123
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 膵β細胞の分化、増殖制御と糖尿病治療　糖代謝を介した膵β細胞増殖促進薬2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  細胞
  
  Volume: 43 Pages: 469-472
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] Effect of long-term treatment with a small molecule glucokinase activator on glucose metabolism, lipid profiles, and hepatic function.2011
- Author(s)
  Nakamura A, Shimazaki H, Ohyama S, Eiki J, Terauchi Y
- Journal Title
  
  J Diabetes Invest. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病治療最前線2011　新しい糖尿病治療薬9：グルコキナーゼ活性化薬の現状と展望2011
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  月刊糖尿病
  
  Volume: 3 Pages: 114-123
- Data Source
  KAKENHI-PROJECT-23791040
[Journal Article] グルコキナーゼ活性化薬2010
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  Annual Review 糖尿病・代謝・内分泌2010
  
  Pages: 49-59
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病診療2010 糖尿病の早期治療早期治療の意義膵β細胞の保護から2010
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  日本医師会雑誌 139
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] グルコキナーゼ活性化薬2010
- Author(s)
  中村昭伸, 寺内康夫
- Journal Title
  
  Annual Review 糖尿病・代謝・内分泌2010 1
  
  Pages: 49-59
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病とその合併症の新薬の現状と未来グルコキナーゼ活性化薬2010
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  内分泌・糖尿病・代謝内科 31
  
  Pages: 13-21
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病診療の将来展望 10 Topics経口糖尿病治療薬はこうなる -近未来における治療-2010
- Author(s)
  中村昭伸、寺内康夫
- Journal Title
  
  糖尿病診療マスター 8
  
  Pages: 581-584
- Data Source
  KAKENHI-PROJECT-21890213
[Journal Article] 糖尿病とその合併症の新薬の現状と未来グルコキナーゼ活性化薬2010
- Author(s)
  中村昭伸
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 31 Pages: 13-21
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] モデル動物から得られたグルコキナーゼに関する新たな知見2024
- Author(s)
  中村昭伸
- Organizer
  第37回日本糖尿病・肥満動物学会年次学術集会　研究賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-23K07959
[Presentation] 高脂肪高スクロース食負荷誘導性膵β細胞機能・量の変化におけるグルコキナーゼの影響2024
- Author(s)
  中村昭伸、重沢郁美、宮崎あすか、山内裕貴、川田晋一朗、野本博司、亀田啓、寺内康夫、渥美達也
- Organizer
  第37回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K07959
[Presentation] 食餌誘導性肥満・糖尿病モデルマウスにおけるグルコキナーゼ抑制が膵β細胞機能・量に与える影響2023
- Author(s)
  重沢郁美、中村昭伸、山内裕貴、川田晋一朗、宮崎あすか、野本博司、亀田啓、三好秀明、寺内康夫、渥美達也
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K07959
[Presentation] 膵β細胞機能が2型糖尿病病態に与える影響2023
- Author(s)
  中村昭伸
- Organizer
  第57回日本糖尿病学会北海道地方会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07959
[Presentation] Effect of glucokinase haploinsufficiency on pancreatic beta-cell function and mass in high-fat, high-sucrose diet-fed mice.2023
- Author(s)
  Shigesawa I, Nakamura A, Yamauchi Y, Kawata S, Miyazaki A, Nomoto H, Kameda H, Miyoshi H, Terauchi Y, Atsumi T.
- Organizer
  83rd Scientific Sessions for American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07959
[Presentation] グルコキナーゼ活性化薬の長期投与に伴う血糖降下作用の消失機序の解明2022
- Author(s)
  川田晋一朗、中村昭伸、三好秀明、山内裕貴、土田和久、大森一乃、高橋清彦、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
- Organizer
  第95回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] 膵β細胞量保持を目指した2型糖尿病の治療戦略2022
- Author(s)
  大森一乃、中村昭伸
- Organizer
  第65回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] グルコキナーゼの抑制が2型糖尿病病態下の膵β細胞量を保持する2022
- Author(s)
  大森一乃、中村昭伸、三好秀明、山内裕貴、川田晋一朗、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
- Organizer
  第35回日本糖尿病・肥満動物学会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] 膵β細胞グルコキナーゼの抑制が肥満2型糖尿病モデルマウスの膵β細胞機能・量を保持する2021
- Author(s)
  中村昭伸、大森一乃、三好秀明、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
- Organizer
  第41回日本肥満学会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] グルコキナーゼの制御が膵β細胞量に与える影響2021
- Author(s)
  中村昭伸、寺内康夫
- Organizer
  第64回日本糖尿病学会年次学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] Improved mitochondrial function by luseogliflozin prevents pancreatic beta-cell damage.2021
- Author(s)
  Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T.
- Organizer
  81st Scientific Sessions for American Diabetes Association.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] モデル動物を用いた2型糖尿病治療法の確立に向けた研究2021
- Author(s)
  中村昭伸
- Organizer
  第94回日本内分泌学会学術総会研究奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] db/dbマウスを用いたグルコキナーゼ活性化薬の血糖降下作用消失機序の解明2021
- Author(s)
  川田晋一朗、中村昭伸、三好秀明、重沢郁美、山内裕貴、関崎知紀、土田和久、大森一乃、高橋清彦、北尾直之、野本博司、亀田啓、曺圭龍、寺内康夫、渥美達也
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] Glucokinase haploinsufficiency ameliorates glucose intolerance by increasing beta-cell mass in db/db mice2020
- Author(s)
  Kazuno Omori, Akinobu Nakamura, Hideaki Miyoshi, Shinichiro Kawata, Kiyohiko Takahashi, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yasuo Terauchi, Tatsuya Atsumi
- Organizer
  56th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] グルコキナーゼ活性化薬の長期投与に伴う血糖降下作用の消失機序の解明2020
- Author(s)
  川田晋一朗、中村昭伸、土田和久、大森一乃、高橋清彦、野本博司、亀田啓、曺圭龍、寺内康夫、三好秀明、渥美達也
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice.2019
- Author(s)
  Omori K, Nakamura A, Miyoshi H, Takahashi K, Kitao N, Nomoto H, Kameda H, Cho KY, Terauchi Y, Atsumi T.
- Organizer
  American Diabetic Association’s 79th Scientific Sessions.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] Reduced hypoglycemic property of glucokinase activator by longitudinal administration in db/db mice.2019
- Author(s)
  Kawata S, Nakamura A, Miyoshi H, Tsuchida K, Omori K, Takahashi K, Kameda H, Cho KY, Terauchi Y, Atsumi T.
- Organizer
  55th Annual Meeting of the European Association for the Study of Diabetes.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] SGLT2阻害薬またはインスリンによる血糖降下作用が膵β細胞量および肝脂肪化に与える影響2019
- Author(s)
  大森一乃、中村昭伸、三好秀明、川田晋一朗、土田和久、高橋清彦、寺内康夫、渥美達也
- Organizer
  第56回臨床分子学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] SGLT2阻害薬またはインスリンによる血糖降下作用が肝脂肪化に与える影響2019
- Author(s)
  大森一乃、中村昭伸、三好秀明、川田晋一朗、土田和久、高橋清彦、寺内康夫、渥美達也
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08992
[Presentation] 高脂肪食負荷誘導性膵β細胞増殖メカニズムの検討2017
- Author(s)
  中村昭伸、北尾直之、三好秀明、寺内康夫、渥美達也
- Organizer
  第20回日本病態栄養学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2017-01-13
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 2型糖尿病の新たな治療に向けて～膵β細胞を増やす、守る、復活させる～2016
- Author(s)
  中村昭伸
- Organizer
  第34回内分泌代謝学サマーセミナー
- Place of Presentation
  久山温泉ホテル夢家（福岡県久山町）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] グルコキナーゼ活性化薬による膵β細胞増殖は一過性である2016
- Author(s)
  高橋清彦、中村昭伸、北尾直之、三好秀明、寺内康夫、渥美達也
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] Transient effect of glucokinase activator on beta cell proliferation.2016
- Author(s)
  1．Nakamura A, Takahashi K, Kitao N, Miyoshi H, Terauchi Y, Atsumi T.
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes.
- Place of Presentation
  Munich (Germany)
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] マウスへの短期高脂肪食負荷はインスリン抵抗性を伴わず膵β細胞を増殖させる2016
- Author(s)
  北尾直之、中村昭伸、高橋清彦、山本浩平、三好秀明、寺内康夫、渥美達也
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] グルコキナーゼ活性化薬による膵β細胞増殖機構の解明2016
- Author(s)
  中村昭伸、高橋清彦、北尾直之、三好秀明、寺内康夫、渥美達也
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] The protective effect of Luseogliflozin on pancreatic beta cell mass.2016
- Author(s)
  2．Takahashi K, Nakamura A, Kitao N, Cho KY, Miyoshi H, Terauchi Y, Atsumi T.
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes.
- Place of Presentation
  Munich (Germany)
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] マウスへの短期高脂肪食負荷はインスリン抵抗性を伴わず膵β細胞を増殖させる2016
- Author(s)
  16.北尾直之、中村昭伸、高橋清彦、山本浩平、三好秀明、寺内康夫、渥美達也.
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 高脂肪食誘導性膵β細胞増殖機構の検討2015
- Author(s)
  中村昭伸、北尾直之、三好秀明、寺内康夫、渥美達也
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋国際会議場（名古屋市熱田区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 短期高脂肪食の膵β細胞増殖効果2015
- Author(s)
  北尾直之、中村昭伸、山本浩平、三好秀明、寺内康夫、渥美達也
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] Partial pancreatectomy facilitated β cell proliferation in glucokinase haploinsufficient mice and IRS-2 deficient mice.2013
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Inoue H, Nakamura A, Terauchi Y.
- Organizer
  73rd American Diabetes Association (ADA) meeting
- Place of Presentation
  Chicago, USA.
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] メトホルミンは高脂肪食下での肝腫瘍形成を抑制する2013
- Author(s)
  田島一樹、中村昭伸、白川純、折目和基、富樫優、井上英昭、長嶋洋治、寺内康夫
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23591316
[Presentation] Signaling pathway ofβCell proliferation in pancreatectomy is distinct from that in high-fat diet-loading in Mice2012
- Author(s)
  Togashi Y, Shirakawa J, Nakamura A, Terauchi Y
- Organizer
  American Diabetes Association 72^st Scientific Sessions
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23591316
[Presentation] Trefoil factor 2 (TFF2) induces proliferation of pancreaticβcells2011
- Author(s)
  Orime K, Shirakawa J, Nakamura A, Togashi Y, Tajima K, Sato K, Terauchi Y
- Organizer
  71st Scientific Sessions for American Diabetes Association (ADA)
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23591316
[Presentation] グルコキナーゼ活性化薬が膵β細胞機能・増殖に与える影響2011
- Author(s)
  中村昭伸
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル(北海道)
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] 膵β細胞の再生を目指して　The role of IRS-2 in the regulation of　pancreatic beta cell mass in response to small molecule glucokinase activator2011
- Author(s)
  中村昭伸、寺内康夫
- Organizer
  第54回日本糖尿病学会年次学術集会シンポジウム(招待講演)
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] Beta Cell Function and Proliferation in Response to Small Molecule Glucokinase Activator under Various Conditions2011
- Author(s)
  Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Terauchi Y
- Organizer
  71th Scientific Sessions for American Diabetes Association
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] Impact of vildagliptin on glucose tolerance, and beta cell mass in insulin receptor substrate-2-knockout mice2011
- Author(s)
  Sato K, Shirakawa J, Muraoka T, Togashi, Orime K, Nakamura A, Terauchi Y
- Organizer
  71st Scientific Sessions for American Diabetes Association (ADA)
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23591316
[Presentation] Beta Cell Function and Proliferation in Response to Small Molecule Glucokinase Activator under Various Conditions2011
- Author(s)
  Akinobu Nakamura
- Organizer
  71th Scientific Sessions for American Diabetes Association
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] グルコキナーゼ活性化薬が膵β細胞機能・増殖に与える影響2011
- Author(s)
  中村昭伸、富樫優、折目和基、佐藤光一郎、白川純、田波律子、伊藤譲、寺内康夫
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル（札幌市）
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] 膵β細胞の再生を目指して The role of IRS-2 in the regulation of pancreatic beta cell mass in response to small molecule glucokinase activator2011
- Author(s)
  中村昭伸
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  ロイトン札幌(北海道)(招待講演)
- Data Source
  KAKENHI-PROJECT-23791040
[Presentation] β cell fate:β細胞の発生から細胞死The role of glucokinase in the regulation of beta cell proliferation2010
- Author(s)
  中村昭伸
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山岡山コンベンションセンター(招待講演)
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] β cell fate:β細胞の発生から細胞死 The role of glucokinase in the regulation of beta cell proliferation2010
- Author(s)
  中村昭伸
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山岡山コンベンションセンター(招待講演)
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用におけるIRS-2の役割2010
- Author(s)
  中村昭伸
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] A Crucial Role of IRS-2 in the Proliferation of Beta Cells Stimulated by Small Molecule Glucokinase Activator2010
- Author(s)
  中村昭伸
- Organizer
  70^<th> Scientific Sessions for American Diabetes Association
- Place of Presentation
  Orlando, Florida, USA
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用の分子機構2010
- Author(s)
  中村昭伸
- Organizer
  第47回日本臨床分子医学会学術集会
- Place of Presentation
  東京東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用の分子機構2010
- Author(s)
  中村昭伸
- Organizer
  第47回日本臨床分子医学会学術集会
- Place of Presentation
  東京東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] グルコキナーゼ活性化薬の膵β細胞増殖作用におけるIRS-2の役割2010
- Author(s)
  中村昭伸
- Organizer
  第83回日本内分泌学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] グルコキナーゼ活性化薬による膵β細胞増殖メカニズムの解析2010
- Author(s)
  中村昭伸
- Organizer
  第24回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21890213
[Presentation] Different effect of short-term and long-term high-fat diet feeding on pancreatic beta cell proliferation
- Author(s)
  Kitao N, Nakamura A, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
- Organizer
  6th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Suntec Singapore Convention & Exhibition Centre (Suntec, Singapore)
- Year and Date
  2014-11-21 – 2014-11-24
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] Different effect of short-term and long-term high-fat diet feeding on pancreatic beta cell proliferation.
- Author(s)
  Kitao N, Nakamura A, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
- Organizer
  10th IDF-WPR Congress/6th AASD Scientific Meeting
- Place of Presentation
  Singapore, Singapore
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24390235
[Presentation] Different regulation of beta cell proliferation induced by short-term and long-term high-fat diet loading
- Author(s)
  Nakamura A, Kitao N, Nomoto H, Miyoshi H, Terauchi Y, Atsumi T
- Organizer
  50th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Reed Messe Vienna (Vienna, Austria)
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 高脂肪食負荷期間による膵β細胞増殖のメカニズムの差異
- Author(s)
  北尾直之、中村昭伸、野本博司、亀田啓、近藤琢磨、三好秀明、寺内康夫、渥美達也
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 短期高脂肪食負荷と長期高脂肪食負荷による膵β細胞増殖機構の差異
- Author(s)
  中村昭伸、北尾直之、野本博司、三好秀明、寺内康夫、渥美達也
- Organizer
  第29回日本糖尿病合併症学会
- Place of Presentation
  都市センターホテル（東京都千代田区）
- Year and Date
  2014-10-03 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-26860683
[Presentation] 短期高脂肪食が膵β細胞増殖に与える影響
- Author(s)
  北尾直之、中村昭伸、高野善成、一山芽衣、小梁川直秀、宮愛香、三次有奈、山本浩平、山本知穂、野本博司、亀田啓、近藤琢磨、三好秀明、寺内康夫、渥美達也
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪市北区）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860683

1. KIMURA Mari (40363840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TERAUCHI Yasuo (40359609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. SHIRAKAWA Jun (70625532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. SATO Mikiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 伊藤讓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 長嶋洋治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Akinobu 中村 昭伸

NAKAMURA Akinobu 中村 昭伸

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Beta cell rest を目指した新たな2型糖尿病治療法の確立Principal Investigator

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Elucidation of pancreatic beta-cell mass regulation mechanism by glucokinasePrincipal Investigator

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The treatment strategy of incresing pancreatic beta cell massPrincipal Investigator

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Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass

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Regulation of adipocyte function by inhibitin of dipeptidyl peptidase-4

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For clinical application of glucokinase activatorPrincipal Investigator

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Novel treatment strategy of type 2 diabetes focused on beta cell massPrincipal Investigator

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[Book] カレントテラピー2012

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[Journal Article] Positive association between proinsulin and fatty liver index in people with type 2 diabetes2024

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[Journal Article] Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Pancreatic β-Cell Mass and Function2022

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[Journal Article] Glucokinase as a therapeutic target based on findings from the analysis of mouse models2022

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[Journal Article] Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?2021

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[Journal Article] Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice2021

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Nakamura Akinobu 中村昭伸

NAKAMURA Akinobu 中村昭伸

[Journal Article] 新たな治療標的と創薬　グルコキナーゼ2015