Hara Ryotaro 原良太郎

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HARA Ryotaro 原良太郎

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Researcher Number	70553535
Other IDs	https://orcid.org/0000-0003-0553-3837
Affiliation (Current)	2024: 京都大学, 農学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2024: 京都大学, 農学研究科, 特定准教授 2018 – 2022: 京都大学, 農学研究科, 特定准教授 2016: 早稲田大学, 理工学術院総合研究所(理工学研究所), 次席研究員(研究院講師) 2015: 早稲田大学, 理工学術院, 講師
Review Section/Research Field	Principal Investigator Basic Section 38020:Applied microbiology-related / Applied microbiology Except Principal Investigator Basic Section 38020:Applied microbiology-related / Medium-sized Section 38:Agricultural chemistry and related fields
Keywords	Principal Investigator ラセミ化酵素 / 酸化酵素 / 合成酵素 / S-置換システイン誘導体 / 含硫アミノ酸 / バイオ生産 / 微生物酵素 / アミド化 / 高度不飽和脂肪酸 / 物質生産 … More / スクリーニング / 探索 / 酵素 / Mycobacterium / serine protease / 酵素精製 / アミド結合 / 酵素法 / 脂質メディエーター / アミド化合物 / 脂肪酸アミド / hydroxylase / bioproduction / Escherichia coli / hydroxy amino acid / 3-hydroxyglutamine / 3-hydroxyhistidine / trans-3-hydroxyproline / hydroxylation / 2-oxoglutarate / amino acid / screening / dioxygenase / Broken TCA cycle / 3-Hydroxyhisitidine / Insufficient TCA-cycle / 3-Hydroxyglutamine / 3-Hydroxyhistidine / Dioxygenase / Hydroxy amino acid / Enzyme / Hydroxylase / Screening / 2-オキソグルタル酸依存型ジオキシゲナーゼ / エクトイン水酸化酵素 / アミノ酸水酸化酵素 / ヒドロキシエクトイン / trans-3-ヒドロキシ-L-プロリン / 微生物変換 / 水酸化酵素 / エクトイン / ヒドロキシプロリン / プロリン … More Except Principal Investigator plasmalogen / fatty acid / dehydroxylase / oxidoreduction / aldehyde / 転移反応 / 微生物変換 / アノマー / グルコシダーゼ / 微生物 / 糖転移反応 / β-グルコシダーゼ / 配糖体 / (+)-アリイン / S-アリルシステインスルフォキシド / バイオプロセス / ファイトケミカル Less

Development of production process for sulfer containing amino acids using microbial enzymesPrincipal Investigator
- Principal Investigator
  
  原良太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Kyoto University
Analysis of aldehyde chemistry in gut
- Principal Investigator
  
  小川順
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyoto University
Screening of microbial amide-bond forming enzyme for stabilization and functionalization of bioactive fatty acidsPrincipal Investigator
- Principal Investigator
  
  原良太郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Kyoto University
Exploring novel glucosidase for glucoside synthesis and the characterization.
- Principal Investigator
  
  上田誠
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Oyama National College of Technology
Production of (+)-alliin by tandem enzymatic reactions
- Principal Investigator
  
  Hibi Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Toyama Prefectural University
Development of screening tool for amino acid hydroxylase using insufficient TCA-cycle complementation test and its applicationPrincipal Investigator
- Principal Investigator
  
  Hara Ryotaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Kyoto University
Enzymatic synthesis of useful hydroxyproline derivatives by regio- and stereo-selective hydroxylationPrincipal Investigator
- Principal Investigator
  
  HARA Ryotaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Waseda University

All 2022 2021 2020 2019 2016 2015

All Journal Article Presentation

[Journal Article] <scp>l</scp>-Tryptophan-starved cultivation enhances <i>S</i>-allyl-<scp>l</scp>-cysteine synthesis in various food-borne microorganisms2022
- Author(s)
  Mizutani Taku、Hara Ryotaro、Takeuchi Michiki、Yamagishi Kazuo、Hirao Yoshinori、Mori Kenichi、Hibi Makoto、Ueda Makoto、Ogawa Jun
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: in press Issue: 6 Pages: 792-799
- DOI
  10.1093/bbb/zbac044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05794
[Journal Article] 微生物酵素の探索を基盤とした有用化合物生産プロセスの開発2021
- Author(s)
  原良太郎
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 2 Pages: 166-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05400
[Journal Article] A three-component monooxygenase from Rhodococcus wratislaviensis may expand industrial applications of bacterial enzymes2021
- Author(s)
  Hibi Makoto、Fukuda Dai、Kenchu Chihiro、Nojiri Masutoshi、Hara Ryotaro、Takeuchi Michiki、Aburaya Shunsuke、Aoki Wataru、Mizutani Kimihiko、Yasohara Yoshihiko、Ueda Mitsuyoshi、Mikami Bunzo、Takahashi Satomi、Ogawa Jun
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-1
- DOI
  10.1038/s42003-020-01555-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J00905, KAKENHI-PROJECT-18K05400
[Journal Article] Enzymatic reactions and microorganisms producing the various isomers of hydroxyproline2020
- Author(s)
  Hara Ryotaro、Kino Kuniki
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: 104 Issue: 11 Pages: 4771-4779
- DOI
  10.1007/s00253-020-10603-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H01802, KAKENHI-PROJECT-18K05400
[Journal Article] Cloning and characterization of a recombinant α-glucosidase from Ensifer adhaerens NBRC 100388 and evaluation of its glucosyl transfer activity2020
- Author(s)
  Suzuki Tatsuya、Fukaya Miyu、Takahashi Kazuki、Takeuchi Michiki、Hara Ryotaro、Ogawa Jun、Ueda Makoto
- Journal Title
  
  Biocatalysis and Agricultural Biotechnology
  
  Volume: 30 Pages: 101837-101837
- DOI
  10.1016/j.bcab.2020.101837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05400
[Journal Article] Screening, gene cloning, and characterization of orsellinic acid decarboxylase from Arthrobacter sp. K8 for regio-selective carboxylation of resorcinol derivatives2020
- Author(s)
  Kino Kuniki、Hirokawa Yasutaka、Gawasawa Ryo、Murase Ryota、Tsuchihashi Ryohei、Hara Ryotaro
- Journal Title
  
  Journal of Biotechnology
  
  Volume: 323 Pages: 128-135
- DOI
  10.1016/j.jbiotec.2020.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H01802, KAKENHI-PROJECT-18K05400
[Journal Article] Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards L-proline2019
- Author(s)
  Hara R, Nishikawa T, Okuhara T, Koketsu K, Kino K
- Journal Title
  
  Appl. Microbiol. Biotechnol.
  
  Volume: 103 Issue: 14 Pages: 5689-5698
- DOI
  10.1007/s00253-019-09868-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05400, KAKENHI-PROJECT-18H01802
[Journal Article] Development of a multi-enzymatic cascade reaction for the synthesis of trans-3-hydroxy-L-proline from L-arginine2016
- Author(s)
  R. Hara, S. Kitatsuji, K. Yamagata, K. Kino
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: 100 Issue: 1 Pages: 243-253
- DOI
  10.1007/s00253-015-6992-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18677
[Presentation] 微生物酵素を利用したS-置換システインスルフォキシドの立体選択的合成2022
- Author(s)
  水谷拓, 原良太郎, 竹内道樹, 日比慎, 上田誠, 小川順
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-19K05794
[Presentation] Development of biocatalytic tandem process to produce (+)-alliin2021
- Author(s)
  Taku Mizutani, Takayuki Iihoshi, Michiki Takeuchi, Ryotaro Hara, Makoto Hibi, Satomi Takahashi, Jun Ogawa
- Organizer
  EFB 2021 virtual conference
- Data Source
  KAKENHI-PROJECT-19K05794
[Presentation] 微生物酵素の探索と有用化合物生産への応用2020
- Author(s)
  原良太郎
- Organizer
  2020年度酵素工学奨励賞
- Invited
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] 微生物酵素の探索を基盤とした有用化合物生産プロセスの開発2020
- Author(s)
  原良太郎
- Organizer
  2020年度バイオインダストリー奨励賞
- Invited
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] 微生物酵素を利用した(+)-alliin 生産法の構築及び腸内細菌による代謝経路の検討2020
- Author(s)
  水谷拓、飯星貴幸、原良太郎、竹内道樹、日比慎、高橋里美、小川順
- Organizer
  第22回生体触媒化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K05794
[Presentation] 微生物酵素を利用した(+)-alliin 生産法の構築及び腸内細菌による代謝経路の検討2020
- Author(s)
  水谷拓、飯星貴幸、原良太郎、竹内道樹、日比慎、高橋里美、小川順
- Organizer
  第22回生体触媒化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] 微生物由来アミノ酸修飾酵素を利用した有用アミノ酸生産プロセスの開発2020
- Author(s)
  原良太郎
- Organizer
  第21回酵素応用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] Tandem enzymatic reactions for the production of a phytochemical L-(+)-alliin2019
- Author(s)
  Makoto Hibi, Michiki Takeuchi, Ryotaro Hara, Jun Ogawa
- Organizer
  1st Japan-Germany-Switzerland Workshop for Enzyme Technology and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05794
[Presentation] trans-3-ヒドロキシプロリンの実用生産に向けたバイオプロセス開発2019
- Author(s)
  原良太郎、西川健幸、奥原拓也、纐纈健人、木野邦器
- Organizer
  日本生物工学会2019年度大会
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] ヒスチジンおよびグルタミンを基質とする新規水酸化酵素による反応生成物の絶対構造解析2019
- Author(s)
  柳川洋晟、勝又智哉、中島悠太、原良太郎、平沢泉、木野邦器
- Organizer
  酵素工学研究会
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] Enzymatic process for useful amino acid synthesis using microbial Fe(II)/α-ketoglutarate-dependent dioxygenases2019
- Author(s)
  Ryotaro Hara, Makoto Hibi, Takayuki Iihoshi, Shoko Kozono, Satomi Takahashi, Kuniki Kino, Jun Ogawa
- Organizer
  1st Japan-Germany-Switzerland Workshop for Enzyme Technology and Bioprocess Development
- Data Source
  KAKENHI-PROJECT-18K05400
[Presentation] 酵素法によるアルギニンからの3-ヒドロキシオルニチンおよびtrans-3-ヒドロキシプロリンの合成2016
- Author(s)
  原良太郎，北辻早希，山縣海，木野邦器
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-15K18677
[Presentation] アミノ酸水酸化酵素と加水分解酵素の組み合わせによるヒドロキシアミノ酸の合成2015
- Author(s)
  原良太郎, 中野雅至, 北辻早希, 山縣海, 木野邦器
- Organizer
  酵素工学研究会第74回講演会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K18677
[Presentation] 選択的trans-3-ヒドロキシプロリン合成経路の構築と多様なヒドロキシイミノ酸合成への展開2015
- Author(s)
  北辻早希，原良太郎，木野邦器
- Organizer
  第5回CSJ化学フェスタ2015
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-10-13
- Data Source
  KAKENHI-PROJECT-15K18677
[Presentation] エクトイン水酸化酵素発現大腸菌によるヒドロキシプロリン類縁化合物の生産2015
- Author(s)
  西川健幸, 原良太郎, 木野邦器
- Organizer
  酵素工学研究会第74回講演会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K18677

1. 竹内道樹 (40766193)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. Hibi Makoto (30432347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 上田誠 (10615751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小川順 (70281102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安藤晃規 (10537765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岸野重信 (40432348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木野邦器

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hara Ryotaro 原 良太郎

HARA Ryotaro 原 良太郎

Research Projects

Research Products

Co-Researchers

Development of production process for sulfer containing amino acids using microbial enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of aldehyde chemistry in gut

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening of microbial amide-bond forming enzyme for stabilization and functionalization of bioactive fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring novel glucosidase for glucoside synthesis and the characterization.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Production of (+)-alliin by tandem enzymatic reactions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of screening tool for amino acid hydroxylase using insufficient TCA-cycle complementation test and its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enzymatic synthesis of useful hydroxyproline derivatives by regio- and stereo-selective hydroxylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] <scp>l</scp>-Tryptophan-starved cultivation enhances <i>S</i>-allyl-<scp>l</scp>-cysteine synthesis in various food-borne microorganisms2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 微生物酵素の探索を基盤とした有用化合物生産プロセスの開発2021

Author(s)

Journal Title

Data Source

[Journal Article] A three-component monooxygenase from Rhodococcus wratislaviensis may expand industrial applications of bacterial enzymes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatic reactions and microorganisms producing the various isomers of hydroxyproline2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cloning and characterization of a recombinant α-glucosidase from Ensifer adhaerens NBRC 100388 and evaluation of its glucosyl transfer activity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Screening, gene cloning, and characterization of orsellinic acid decarboxylase from Arthrobacter sp. K8 for regio-selective carboxylation of resorcinol derivatives2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards L-proline2019

Author(s)

Journal Title

DOI

Hara Ryotaro 原良太郎

HARA Ryotaro 原良太郎