Ouchi Yasuo 大内靖夫

… Alternative Names

OUCHI Yasuo 大内靖夫

大内靖夫オオウチヤスオ

Less

Researcher Number	70553858
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 特任助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 千葉大学, 大学院医学研究院, 特任助教 2017: 千葉大学, 医学(系)研究科(研究院), 助教 2015: 千葉大学, 大学院医学系研究科, 助教 2014 – 2015: 東京大学, 医科学研究所, 特任助教 2010 – 2012: 中部大学, 実験動物教育研究センター, 助教 2008: The University of Tokyo, 医科学研究所, 特別研究員(PD) 2007: The University of Tokyo, 大学院・医学系研究科, 特別研究員(DC2)
Review Section/Research Field	Principal Investigator Tumor therapeutics / Developmental biology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Experimental pathology / General physiology Except Principal Investigator Experimental pathology
Keywords	Principal Investigator がん免疫療法 / T細胞 / 免疫学 / ゲノム編集 / 免疫細胞療法 / 幹細胞 / 発生生物学 / 網膜 / 老化 / がん免疫細胞療法 … More / 再生 / 部分的初期化 / CRISPR/Cas9 / バイオテクノロジー / COVID-19 / 脂質ナノ粒子 / ゲノム編集技術 / 成体神経幹細胞 / 成体神経化細胞 / 統合失調症 / 認知機能 / 神経新生 / 神経幹細胞 / 成体神経新生 / 認知機能形成 / 幹細胞学 / Lin28 / Let-7 / 腸管系腫瘍 / 腸管上皮幹細胞 / miRNA … More Except Principal Investigator マイクロRNA / アンジオテンシン変換酵素 / マイクロＲＮＡ / 拡張型心筋症 / トランスジェニックマウス / MAS1 / ヘキソキナーゼ２ / 心筋細胞 / 心不全 / p68/p72 / c-Myc / 大腸癌 / 癌 / マイクロ RNA Less

Development of novel T cell rejuvenation approach utilizing partial reprogrammingPrincipal Investigator
- Principal Investigator
  
  Yasuo Ouchi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
Generation of antigen-specific T lymphocytes using genome editing techniquePrincipal Investigator
- Principal Investigator
  
  Ouchi Yasuo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Chiba University
Development of CRISPR/HDR genome editing technology in primary T cells for improved immunotherapyPrincipal Investigator
- Principal Investigator
  
  OUCHI YASUO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Chiba University
Analysis of the molecular basis of neural stem cell maintenance and its role in cognitive functionPrincipal Investigator
- Principal Investigator
  
  OUCHI YASUO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
  The University of Tokyo
Analysis of mechanisms of overexpression of angiotensin converting enzyme and heart failure in transgenic mice of miRNAs
- Principal Investigator
  
  IWAMOTO Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chubu University
Analysis of microRNA function on heart and smooth muscles and itsanti-tumor effect using genetically modified mice
- Principal Investigator
  
  IWAMOTO Takashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chubu University
Analysis of the role of tumor suppressor miRNA in intestinal stem cellsPrincipal Investigator
- Principal Investigator
  
  OUCHI Yasuo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Chubu University
網膜幹細胞未分化維持の分子機構の解明Principal Investigator
- Principal Investigator
  
  大内靖夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Developmental biology
- Research Institution
  The University of Tokyo

[Journal Article] Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice2023
- Author(s)
  Takahashi Yuta、Morales Valencia Mariana、Yu Yang、Ouchi Yasuo、Takahashi Kazuki、Shokhirev Maxim Nikolaievich、Lande Kathryn、Williams April E.、Fresia Chiara、Kurita Masakazu、Hishida Tomoaki、Shojima Kensaku、Hatanaka Fumiyuki、Nu?ez-Delicado Estrella、Esteban Concepcion Rodriguez、Izpisua Belmonte Juan Carlos
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 4 Pages: 715-731.e19
- DOI
  10.1016/j.cell.2022.12.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07651
[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.2022
- Author(s)
  Usui-Ouchi A, Eade K, Giles S, Ideguchi Y, Ouchi Y, Aguilar E, Guoqin W, Marra K, Berlow R, Friedlander M
- Journal Title
  
  GLIA
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0189
[Journal Article] FoxM1 delays senescence and extends lifespan2022
- Author(s)
  Ouchi Y, Sahu S, Belmonte JCI
- Journal Title
  
  Nature Aging
  
  Volume: -
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0189
[Journal Article] FoxM1 delays senescence and extends lifespan2022
- Author(s)
  Ouchi Y, Sahu S, Belmonte JCI
- Journal Title
  
  Nature Aging
  
  Volume: -
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07651
[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.2022
- Author(s)
  Usui-Ouchi A, Eade K, Giles S, Ideguchi Y, Ouchi Y, Aguilar E, Guoqin W, Marra K, Berlow R, Friedlander M
- Journal Title
  
  GLIA
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07651
[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis2022
- Author(s)
  Usui‐Ouchi Ayumi、Eade Kevin、Giles Sarah、Ideguchi Yoichiro、Ouchi Yasuo、Aguilar Edith、Wei Guoqin、Marra Kyle V.、Berlow Rebecca B.、Friedlander Martin
- Journal Title
  
  Glia
  
  Volume: 70 Issue: 9 Pages: 1762-1776
- DOI
  10.1002/glia.24218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09727, KAKENHI-PROJECT-20K07651
[Journal Article] FOXM1 delays senescence and extends lifespan2022
- Author(s)
  Ouchi Yasuo、Sahu Sanjeeb Kumar、Izpisua Belmonte Juan Carlos
- Journal Title
  
  Nature Aging
  
  Volume: 2 Issue: 5 Pages: 373-374
- DOI
  10.1038/s43587-022-00222-y
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07651
[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Communications Biology
  
  Volume: 4(1) Issue: 1 Pages: 820-820
- DOI
  10.1038/s42003-021-02310-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-19H03705, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K07651
[Journal Article] Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome2021
- Author(s)
  Kato H, Maezawa Y, Takayama N, Ouchi Y, Kaneko H, Kinoshita D, Takada-Watanabe A, Oshima M, Koshizaka M, Ogata H, Kubota Y, Mitsukawa N, Eto K, Iwama A, Yokote K.
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 13 Issue: 4 Pages: 4946-4961
- DOI
  10.18632/aging.202696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07651, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-19K23939, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K16542, KAKENHI-PROJECT-18H04164
[Journal Article] Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome2021
- Author(s)
  Kato Hisaya、Maezawa Yoshiro、Ouchi Yasuo、Takayama Naoya、Sone Masamitsu、Sone Kanako、Takada-Watanabe Aki、Tsujimura Kyoko、Koshizaka Masaya、Nagasawa Sayaka、Saitoh Hisako、Ohtaka Manami、Nakanishi Mahito、Tahara Hidetoshi、Shimamoto Akira、Iwama Atsushi、Eto Koji、Yokote Koutaro
- Journal Title
  
  Stem Cell Research
  
  Volume: 53 Pages: 102360-102360
- DOI
  10.1016/j.scr.2021.102360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16542, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-20K07651
[Journal Article] Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair2020
- Author(s)
  Kitamoto Kohdai、Taketani Yukako、Fujii Wataru、Inamochi Aya、Toyono Tetsuya、Miyai Takashi、Yamagami Satoru、Kuroda Masahiko、Usui Tomohiko、Ouchi Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 2000-2000
- DOI
  10.1038/s41598-020-58876-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-17K10564, KAKENHI-PROJECT-17K11446, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-17K07212
[Journal Article] DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells2018
- Author(s)
  Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 4231-4231
- DOI
  10.1038/s41467-018-06468-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-18K07164, KAKENHI-PUBLICLY-18H04665, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-17KK0189
[Journal Article] Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing2018
- Author(s)
  Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 4 Pages: 141-154
- DOI
  10.1093/intimm/dxy006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-16K16144
[Journal Article] Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice2018
- Author(s)
  Usui Yuki、Kimura Yasumasa、Satoh Takeshi、Takemura Naoki、Ouchi Yasuo、Ohmiya Hiroko、Kobayashi Kyosuke、Suzuki Hiromi、Koyama Satomi、Hagiwara Satoko、Tanaka Hirotoshi、Imoto Seiya、Eberl G?rard、Asami Yukio、Fujimoto Kosuke、Uematsu Satoshi
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 7 Pages: 319-331
- DOI
  10.1093/intimm/dxy035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0017, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-16H05330, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-17KK0189
[Journal Article] Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease2016
- Author(s)
  Ayumi Usui-Ouchi, Yasuo Ouchi, Masatoshi Kiyokawa, Toshiro Sakuma, Rei Ito, Nobuyuki Ebihara
- Journal Title
  
  PLOS ONE
  
  Volume: 11 Issue: 6 Pages: e0158043-e0158043
- DOI
  10.1371/journal.pone.0158043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861469, KAKENHI-PROJECT-26870683
[Journal Article] 統合失調症の病態におけるmiRNAの生合成と成体海馬のニューロン新生の役割2015
- Author(s)
  大内靖夫
- Journal Title
  
  神経化学学会誌
  
  Volume: 54 Pages: 20-26
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26870683
[Journal Article] The Heterochronic Genes lin-28a and lin-28b play an Essential and Evolutionarily Conserved Role in Early Zebrafish development.2014
- Author(s)
  Ouchi Y, Yamamoto J, Iwamoto T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 2 Pages: 88086-88086
- DOI
  10.1371/journal.pone.0088086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460506
[Journal Article] Emerging evidence of insulin-like growth factor 2 as a memory enhancer: a unique animal model of cognitive dysfunction with impaired adult neurogenesis2014
- Author(s)
  Iwamoto T, Ouchi Y.
- Journal Title
  
  Rev Neurosci.
  
  Volume: 25 Issue: 4 Pages: 559-574
- DOI
  10.1515/revneuro-2014-0010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460506, KAKENHI-PROJECT-26870683
[Journal Article] Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.2013
- Author(s)
  Ouchi Y, Banno Y, Shimizu Y, Ando S, Hasegawa H, Adachi K, Iwamoto T
- Journal Title
  
  J Neurosci.
  
  Volume: 33 Issue: 22 Pages: 9408-9419
- DOI
  10.1523/jneurosci.2700-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460506
[Journal Article] Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of ApcMin Mice.2012
- Author(s)
  Takaoka Y., Shimizu Y., Hasegawa H., Ouchi Y., Qiao S., Nagahara M., Ichihara M., Lee J.D., Adachi K., Hamaguchi M., Iwamoto T.
- Journal Title
  
  PLoS ONE
  
  Volume: 7(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590369
[Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells.2011
- Author(s)
  大内靖夫
- Journal Title
  
  Mol Cell Neurosci.
  
  Volume: (Epub 印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790221
[Journal Article] Analysis of syndecan-1 gene promoter during mouse tooth development2011
- Author(s)
  Iguchi-Ishiguro H, Ouchi Y, Watanabe S, Numabe Y
- Journal Title
  
  Arch Oral Biol
- Data Source
  KAKENHI-PROJECT-22790221
[Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells2011
- Author(s)
  Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S.
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 46(4) Pages: 770-80
- Data Source
  KAKENHI-PROJECT-22790221
[Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells.2011
- Author(s)
  Yasuo Ouchi
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590369
[Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells2011
- Author(s)
  Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 46 Pages: 770-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790221
[Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinalprogenitor cells2011
- Author(s)
  Yasuo Ouchi
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume: 46 Pages: 770-780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590369
[Journal Article] Sox2 plays a role in the induction of amacrine and Moller glial cells in mouse retinal progenitor cells2009
- Author(s)
  Lin YP, Ouchi Y, Satoh S, Watanabe S.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 50
  
  Pages: 68-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-07J05576
[Journal Article] M6a is expressed in the murine neural retina and regulates neurite extension2008
- Author(s)
  Zhao J, Iida A, Ouchi Y, Satoh S, Watanabe S.
- Journal Title
  
  Mol Vis. 14
  
  Pages: 1623-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-07J05576
[Journal Article] Reduced adult hippocampal neurogenesis and working memory deficits in the DGCR8-deficient mouse model of 22q11 deletion-associated schizophrenia can be rescued by Igf2.
- Author(s)
  Ouchi Y.、 Banno Y., Shimizu Y., Ando S., Hasegawa H., Adachi K., Iwamoto T.
- Journal Title
  
  J.Neuroscience
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590369
[Patent] 老化の評価方法2021
- Inventor(s)
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之、金子ひより、前澤善朗
- Industrial Property Rights Holder
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之、金子ひより、前澤善朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-097552
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07651
[Patent] 老化の評価方法2021
- Inventor(s)
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之、金子ひより、前澤善朗
- Industrial Property Rights Holder
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之、金子ひより、前澤善朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-097552
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-17KK0189
[Patent] アンチセンスオリゴマー2021
- Inventor(s)
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之
- Industrial Property Rights Holder
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-081389
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07651
[Patent] アンチセンスオリゴマー2021
- Inventor(s)
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之
- Industrial Property Rights Holder
  大内靖夫、加藤尚也、横手幸太郎、江藤浩之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-081389
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-17KK0189
[Patent] 神経幹細胞の増殖促進剤及びその用途2013
- Inventor(s)
  大内靖夫,岩本隆司
- Industrial Property Rights Holder
  中部大学
- Industrial Property Number
  2013-000289
- Filing Date
  2013-01-10
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] Generation of tumor-specific CD8+ T-cells via highly efficient CRISPR/Cas9 genome editing2017
- Author(s)
  Yasuo Ouchi, Ashwini Patil, Hiroshi Nishimasu
- Organizer
  XVI KI Cancer-StratCan retreat
- Data Source
  KAKENHI-PROJECT-17K07212
[Presentation] Generation of tumor-specific cytotoxic T cells via highly efficient CRISPR/Cas9 genome editing2017
- Author(s)
  Yasuo Ouchi, Ashwini Patil, Hiroshi Nishimasu, Osamu Nureki, Kenta Nakai, Satoshi Uematsu
- Organizer
  第46回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07212
[Presentation] Generation of tumor-specific cytotoxic T cells via highly efficient CRISPR/Cas9 genome editing2017
- Author(s)
  Yasuo Ouchi, Ashwini Patil, Hiroshi Nishimasu, Osamu Nureki, Kenta Nakai, Satoshi Uematsu
- Organizer
  2017年度生命科学系学会合同年次大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07212
[Presentation] The DGCR8 gene, a candidate gene for 22q11.2 deletion-associated schizophrenia, regulates adult hippocampal neurogenesis and cognition2016
- Author(s)
  Ouchi Y
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県、淡路市)
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870683
[Presentation] 統合失調症の病態におけるmiRNAの生合成と成体海馬のニューロン新生の役割2015
- Author(s)
  大内　靖夫
- Organizer
  厚生労働省ヒト幹細胞情報化推進事(SKIP) セミナー
- Place of Presentation
  慶応義塾大学医学部、東京都新宿区
- Year and Date
  2015-12-11
- Invited
- Data Source
  KAKENHI-PROJECT-26870683
[Presentation] miRNA発現制御因子による組織幹細胞の制御機構2014
- Author(s)
  大内靖夫
- Organizer
  東京大学医科学研究所　学友会セミナー
- Place of Presentation
  東京
- Year and Date
  2014-04-09
- Data Source
  KAKENHI-PROJECT-26870683
[Presentation] The emerging role of microRNA biogenesis and adult neurogenesis in schizophrenia.2014
- Author(s)
  大内靖夫
- Organizer
  第36回日本生物学的精神医学会、第57回日本神経化学会大会合同年会
- Place of Presentation
  奈良
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-26870683
[Presentation] The Lin28/let-7 axis regulates intestinal epithelial cell proliferation and tumor formation2013
- Author(s)
  Ouchi Y, Tsuruda H, Nakashima T, Takaoka Y, Asaeda Y, Iwamoto T
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市)
- Data Source
  KAKENHI-PROJECT-25460506
[Presentation] Reduced adult hippocampal neurogenesis and working memory deficits in the DGCR8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF22013
- Author(s)
  Banno Y, Ouchi Y, Hakumoto Y, Shimizu Y, Andou S, Adachi K, Iwamoto T
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市)
- Data Source
  KAKENHI-PROJECT-25460506
[Presentation] The heterochronic gene Lin-28 regulates cell proliferation and neural expansion during early development in zebrafish2011
- Author(s)
  山本純矢, 大内靖夫, 岩本隆司
- Organizer
  日本分子生物学会年会(BMB2011)
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] DGCR8遺伝子ヘテロ欠損型統合失調症モデルマウス海馬歯状回における神経幹細胞の解析2011
- Author(s)
  大内靖夫, 清水裕子, 安藤章太, 坂野祐哉, 岩本隆司
- Organizer
  第3回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島(広島)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Deficiency of DGCR8 gene, a potential gene for 22q11 deletion syndrome, decreases adult neurogenesis in the mouse hippocampal dentate gyrus2011
- Author(s)
  大内靖夫, 清水裕子, 安藤章太, 坂野祐哉, 岩本隆司
- Organizer
  日本分子生物学会年会(BMB2011)
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Analysis of the Role of Pax6 Targeting miRNA During Mouse Retinal Development2011
- Author(s)
  Ouchi Y, Mano H, Watanabe S
- Organizer
  2011 Association for Research in Vision and Ophthalmology(ARVO) annual meeting
- Place of Presentation
  Fort Lauderdale, Florida, U. S. A.
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Analysis of the Role of Pax6 Targeting miRNA During Mouse Retinal Development2011
- Author(s)
  Ouchi Y, Mano H, Watanabe S
- Organizer
  2011 Association for Research in Vision and Ophth almology (ARVO) annual meeting
- Place of Presentation
  Fort Lauderdale, Florida, U.S.A.
- Year and Date
  2011-05-05
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 癌抑制性マイクロRNAのfeed backネットワーク2011
- Author(s)
  高岡祐司、清水裕子、大内靖夫、岩本隆司
- Organizer
  第3回日本RNAi研究会、グランドプリンスホテル広島
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] 22q11欠損症候群モデルマウスにおけるDGCR8遺伝子の欠損は成体マウス海馬歯状回に内在する神経幹細胞の増殖を低下させる2011
- Author(s)
  大内靖夫
- Organizer
  第34回日本神経科学会大会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] 癌抑制型MicroRNAのフィードバックネットワーク2011
- Author(s)
  高岡祐司, 清水裕子, 大内靖夫, 岩本隆司
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] The heterochrinic gene Lin-28 regulates cell proliferation and neural expansion during early development in zebrafish2011
- Author(s)
  Yamamoto J, Ouchi Y, Iwamoto T
- Organizer
  17th Japanese medaka and zebrafish meeting
- Place of Presentation
  toray human resources development center, mishima
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Deficiency of DGCR8 gene, a potential gene for 22q11 deletion syndrome, decreases adult neurogenesis in the mouse hippocampal dentate gyrus2011
- Author(s)
  大内靖夫
- Organizer
  日本分子生物学会年会(BMB2011)
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] DGCR8遺伝子ヘテロ欠損型統合失調症モデルマウス海馬歯状回における神経幹細胞の解析2011
- Author(s)
  大内靖夫
- Organizer
  第3回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島(広島市)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] 癌抑制型MicroRNAのフィードバックネットワーク"第70回日本癌学会学術総会2011
- Author(s)
  高岡祐司, 清水裕子, 大内靖夫, 岩本隆司
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] miR-143トランスジェニックマウスは内在性miR-145を誘導し・カテニンシグナルを制御することにより腸管腫瘍を抑制する2011
- Author(s)
  高岡祐司、岩本隆司、大内靖夫、濱口道成
- Organizer
  第70回日本癌学会、名古屋国際会議場
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] DGCR8遺伝子へテロ欠損型統合失調症モデルマウス海馬歯状回における神経幹細胞の解析2011
- Author(s)
  大内靖夫, 清水裕子, 安藤章太, 坂野祐哉, 岩本隆司
- Organizer
  第3回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島(広島)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] The heterochrinic gene Lin-28 regulates cell proliferation and neural expansion during early development in zebrafish2011
- Author(s)
  Yamamoto J, Ouchi Y, Iwamoto T
- Organizer
  17th japanese medaka and zebrafish meeting
- Place of Presentation
  toray human resources development center, mishima
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 22q11欠損症候群モデルマウスにおけるDGCR8遺伝子の欠損は成体マウス海馬歯状回に内在する神経幹細胞の増殖を低下させる2011
- Author(s)
  大内靖夫, 清水裕子, 安藤章太, 水野麻衣, 岩本隆司
- Organizer
  第34回日本神経科学会大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Functional analysis of the RNA-binding protein Lin28 gene in mouse intestinal stem cells2010
- Author(s)
  Ouchi Y, Asaeda Y, Mizuno M, Takaoka Y, Iwamoto T
- Organizer
  日本分子生物学会年会(BMB2010)
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 家族性大腸腺腫症モデルマウスにおけるmiR-143 の発がん抑制機能解析2010
- Author(s)
  Shimizu Y., Hasegawa H., Ouchi Y.,Iwamoto T.
- Organizer
  第2回日本RNAi研究会、グランドプリンスホテル広島
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] 腸管上皮細胞におけるRNA結合分子Lin28の機能解析2010
- Author(s)
  大内靖夫
- Organizer
  BMB2010
- Place of Presentation
  神戸国際会議場他(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] Altered brain microRNA biogenesis affects neural stem cell proliferation in mouse hippocampal dentate gyrus.2010
- Author(s)
  Ouchi Y, Simizu Y, Mizuno M, Iwamoto T
- Organizer
  第8回幹細胞シンポジウム2010
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Zebrafishを用いたRNA結合タンパク質Lin28の機能解析2010
- Author(s)
  山本純矢, 大内靖夫, 岩本隆司
- Organizer
  日本分子生物学会年会(BMB2010)
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 腸管上皮細胞におけるRNA結合分子Lin28の機能解析2010
- Author(s)
  大内靖夫
- Organizer
  日本分子生物学会年会(BMB2010)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 家族性大腸腺腫症モデルマウスにおけるmiR-143の発がん抑制機能解析2010
- Author(s)
  大内靖夫
- Organizer
  第2回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Altered brain microRNA biogenesis affects neural stem cell proliferation in mouse hippocampal dentate gyrus.2010
- Author(s)
  大内靖夫
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Altered brain microRNA biogenesis affects neural stem cell proliferation in mouse hippocampal dentate gyrus.2010
- Author(s)
  大内靖夫
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22590369
[Presentation] Zebrafiahを用いたRNA結合タンパク質Lin28の機能解析2010
- Author(s)
  大内靖夫
- Organizer
  日本分子生物学会年会(BMB2010)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] 家族性大腸腺腫症モデルマウスにおけるmiR-143の発がん抑制機能解析2010
- Author(s)
  Shimizu Y, Hasegawa H, Ouchi Y, Iwamoto T
- Organizer
  第2回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島(広島市)
- Data Source
  KAKENHI-PROJECT-22790221
[Presentation] Role of canonical Wnt signaling pathway in mammalian retinal progenitor cells2008
- Author(s)
  Ouchi Y, Watanabe S
- Organizer
  The 23^<rd> Naito conference
- Place of Presentation
  kanagawa, japan
- Data Source
  KAKENHI-PROJECT-07J05576
[Presentation] Chx10遺伝子における進化的に保存された網膜特異的発現制御領域および上流因子の同定2007
- Author(s)
  大内靖夫
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-07J05576
[Presentation] Deficiency of DGCR8 gene, a candidate gene for 22q11.2 deletion-associated schizophrenia, decreases cell proliferation and neurogenesis in the adult mouse dentate gyrus
- Author(s)
  大内靖夫, 坂野祐哉, 清水裕子, 安藤章太, 安達興一, 岩本隆司
- Organizer
  第11回幹細胞シンポジウム
- Place of Presentation
  東京大学（東京）
- Data Source
  KAKENHI-PROJECT-25460506

1. IWAMOTO Takashi (60223426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. ICHIHARA Masatoshi (00314013)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. UEYAMA Tomomi (80379388)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAYAMA Shinsuke (30192230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NODA Akiko (80252287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮井尊史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 加藤尚也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 臼井亜由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 平原潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 武村直紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 田中廣壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ouchi Yasuo 大内 靖夫

OUCHI Yasuo 大内 靖夫

大内 靖夫 オオウチ ヤスオ

Research Projects

Research Products

Co-Researchers

Development of novel T cell rejuvenation approach utilizing partial reprogrammingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of antigen-specific T lymphocytes using genome editing techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of CRISPR/HDR genome editing technology in primary T cells for improved immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular basis of neural stem cell maintenance and its role in cognitive functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanisms of overexpression of angiotensin converting enzyme and heart failure in transgenic mice of miRNAs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of microRNA function on heart and smooth muscles and itsanti-tumor effect using genetically modified mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of tumor suppressor miRNA in intestinal stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

網膜幹細胞未分化維持の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.2022

Author(s)

Journal Title

Data Source

[Journal Article] FoxM1 delays senescence and extends lifespan2022

Author(s)

Journal Title

Data Source

[Journal Article] FoxM1 delays senescence and extends lifespan2022

Author(s)

Journal Title

Data Source

[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.2022

Author(s)

Journal Title

Data Source

[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis2022

Author(s)

Journal Title

DOI

Data Source

Ouchi Yasuo 大内靖夫

OUCHI Yasuo 大内靖夫

大内靖夫オオウチヤスオ