KOYAMA Hironari 小山裕也

Researcher Number	70567718
Affiliation (based on the past Project Information) *help	2010 – 2011: 九州保健福祉大学, 薬学部, 助手
Review Section/Research Field	Except Principal Investigator Environmental pharmacy
Keywords	Except Principal Investigator イメージング / 脳血管性認知症 / プリオン病 / アルツハイマー病 / 小胞体ストレス / 銅 / コンフォメーション / プリオン / カルノシン / アポトーシス … More / カルシウム / 亜鉛 / 無機金属毒性 / 中毒学 Less

Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress
- Principal Investigator
  
  KAWAHARA Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University of Health and Welfare

All 2012 2011 2010

All Journal Article Presentation Book

[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation by β Amyloid Protein In "Neurodegenerative Diseases/Book 2", ISBN 979-953-307-672-9(Ed by Ivana Zach)2011
- Author(s)
  Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21590145
[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation byβAmyloid Protein, In "Neurodegenerative Diseases/Book 2"2011
- Author(s)
  Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M.
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] 神経疾患と微量金属2012
- Author(s)
  川原正博、小山裕也、大河原晋
- Journal Title
  
  金属
  
  Volume: 82 Pages: 19-27
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012
- Author(s)
  Koyama H, Konoha K, Sadakane Y, Ohkawara S, Kawahara M
- Journal Title
  
  J.Clin Toxicol.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012
- Author(s)
  Koyama H, Konoha K, Sadakane Y, Ohkawara S, and Kawahara M
- Journal Title
  
  J. Clin Toxicol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's β-amyloid protein2011
- Author(s)
  Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M., Sadakane Y.
- Journal Title
  
  Int.J.Alzheimer Dis.
  
  Volume: 2011 Pages: 304583-304583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Kawahara M, Koyama H., Nagata T., Sadakane Y.
- Journal Title
  
  Metallomics
  
  Volume: 3 Pages: 726-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011
- Author(s)
  川原正博、小山裕也、定金豊
- Journal Title
  
  Biomed. Res. Trace Elements
  
  Volume: 22 Pages: 7-14
- NAID
  10028117958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011
- Author(s)
  川原正博、小山裕也、定金豊
- Journal Title
  
  Biomed.Res.Trace Elements
  
  Volume: 28 Pages: 49-53
- NAID
  10028117958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's s-amyloid protein2011
- Author(s)
  Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M. and Sadakane Y
- Journal Title
  
  Int. J. Alzheimer Dis.
  
  Pages: 304583-304583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein2010
- Author(s)
  Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 31 Pages: 9-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590145
[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2010
- Author(s)
  Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
- Journal Title
  
  Photomedicine and Photobiology 31(In press)
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] アルツハイマーβペプチドのN末側アミノ酸の構造的変化と線維化への影響2012
- Author(s)
  定金豊,小山裕也,川原正博
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] PrP106-126の高次構造変化に重要な配列2012
- Author(s)
  小山裕也,坂口哲陛,大河原晋,定金豊,川原正博
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] コンフォメーション病に関与するペプチド中のアスanti-stressanti-oxidantanti-glycationanti-painanti-crosslink(Alzheimer, prion) pHbalanceCarnosineCH2CH2CNHOCHCCH2OHONNHH2Nパラギンおよびアスパラギン酸残基の構造変化と生理活性2011
- Author(s)
  定金豊,小山裕也,川原正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] PrP断片ペプチドに対する亜鉛および銅の影響2011
- Author(s)
  小山裕也,永田哲也,定金豊,川原正博
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] アルミニウムの神経毒性と神経疾患との関連2011
- Author(s)
  川原正博、小山裕也
- Organizer
  第22回日本微量元素学会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011
- Author(s)
  Koyama H, Okahara M, Sakaguchi T, Sadakane Y and Kawahara M
- Organizer
  5th International Conference on Metals and Genetics
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白による培養細胞に対する亜鉛および銅の影響2010
- Author(s)
  小山裕也
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオンペプチド断片(106-126)中のアスパラギン残基の自発的構造変化と生理機能2010
- Author(s)
  定金豊,小山裕也、大塚功、川原正博
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白断片ペプチドのコンフォメーション変化と神経毒性に及ぼす微量金属の影響2010
- Author(s)
  川原正博、小山裕也、定金豊
- Organizer
  第2回メタロミクス研究フォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Alterations of gene expressions during neuronal death after zinc exposure : implications of calcium dyshomeostasis2010
- Author(s)
  Kawahara M., Koyama H., Sadakane Y.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオンペプチド断片(106-126)中のAsn残基の構造的変化と生理活性について2010
- Author(s)
  定金豊,小山裕也,大塚功,木葉敬子,川原正博
- Organizer
  第6回D-アミノ酸研究会学術講演会
- Place of Presentation
  富山
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] PrP断片ペプチドの神経毒性に対する亜鉛および銅の影響2010
- Author(s)
  小山裕也、永田哲也、定金豊、川原正博
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide (PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] プリオン蛋白による培養細胞に対する亜鉛および銅の影響2010
- Author(s)
  小山裕也,永田哲也,定金豊,大塚功,戸泉文江,横山祥子,川原正博
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590145
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide(PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590145

1. KAWAHARA Masahiro (40224828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 26 results
2. SADAKANE Yutaka (60293304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results

KOYAMA Hironari 小山 裕也

Research Projects

Research Products

Co-Researchers

Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation by β Amyloid Protein In "Neurodegenerative Diseases/Book 2", ISBN 979-953-307-672-9(Ed by Ivana Zach)2011

Author(s)

Publisher

Data Source

[Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation byβAmyloid Protein, In "Neurodegenerative Diseases/Book 2"2011

Author(s)

Data Source

[Journal Article] 神経疾患と微量金属2012

Author(s)

Journal Title

Data Source

[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012

Author(s)

Journal Title

Data Source

[Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012

Author(s)

Journal Title

Data Source

[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's β-amyloid protein2011

Author(s)

Journal Title

Data Source

[Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011

Author(s)

Journal Title

Data Source

[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's s-amyloid protein2011

Author(s)

Journal Title

Data Source

[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein2010

Author(s)

Journal Title

Data Source

[Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2010

Author(s)

Journal Title

Data Source

[Presentation] アルツハイマーβペプチドのN末側アミノ酸の構造的変化と線維化への影響2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] PrP106-126の高次構造変化に重要な配列2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] コンフォメーション病に関与するペプチド中のアスanti-stressanti-oxidantanti-glycationanti-painanti-crosslink(Alzheimer, prion) pHbalanceCarnosineCH2CH2CNHOCHCCH2OHONNHH2Nパラギンおよびアスパラギン酸残基の構造変化と生理活性2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] PrP断片ペプチドに対する亜鉛および銅の影響2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] アルミニウムの神経毒性と神経疾患との関連2011

KOYAMA Hironari 小山裕也