Kiyonari Shinichi 清成信一

… Alternative Names

KIYONARI Shinichi 清成信一

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Researcher Number	70570836
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 北里大学, 医学部, 講師 2019: 名古屋大学, 医学系研究科, 特任講師 2017: 名古屋大学, 医学系研究科, 特任助教 2016: 名古屋大学, 医学系研究科, 助教 2016: 名古屋大学, 大学院医学(系)研究科(研究院), 助教 2015: 名古屋大学, 医学(系)研究科(研究院), 助教 2012 – 2013: 名古屋大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Clinical oncology Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 神経芽腫 / 代謝拮抗剤 / MYCN / 合成致死 / 葉酸代謝 / 葉酸代謝拮抗剤 / 化学療法 / 大腸癌 / 併用化学療法 / 5-フルオロウラシル / オキサリプラチン … More Except Principal Investigator … More 発生・分化 / 分化 / 発生 / 癌 Less

Elucidation of the folate metabolic pathway unique to neuroblastoma cellsPrincipal Investigator
- Principal Investigator
  
  清成信一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kitasato University
Utilization of antimetabolite drugs for the treatment of high-risk neuroblastomaPrincipal Investigator
- Principal Investigator
  
  Kiyonari Shinichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kitasato University
  Nagoya University
Development of new treatments for neuroblastoma based on the synthetic lethalityPrincipal Investigator
- Principal Investigator
  
  KIYONARI Shinichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagoya University
Mechanisms of carcinogenesis through deviation from normal development
- Principal Investigator
  
  Kadomatsu Kenji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Mechanisms of dUTPase downregulation by oxaliplatin and its applications to combination chemotherapyPrincipal Investigator
- Principal Investigator
  
  KIYONARI Shinichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Nagoya University

All 2021 2020 2017 2015 2013 2012

All Journal Article Presentation

[Journal Article] Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN ‐amplified neuroblastoma cells2020
- Author(s)
  Yamashita Ken、Kiyonari Shinichi、Tsubota Shoma、Kishida Satoshi、Sakai Ryuichi、Kadomatsu Kenji
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 7 Pages: 2431-2439
- DOI
  10.1111/cas.14485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-19K07711, KAKENHI-PROJECT-19H03415
[Journal Article] Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes.2017
- Author(s)
  1.Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 63 Pages: 106296-106310
- DOI
  10.18632/oncotarget.22435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08617, KAKENHI-PROJECT-17K10131, KAKENHI-PROJECT-16H05139, KAKENHI-PROJECT-15K18442, KAKENHI-PROJECT-16K19049, KAKENHI-PROJECT-17K19623
[Journal Article] PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma2017
- Author(s)
  2.Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K.
- Journal Title
  
  Cancer Res.
  
  Volume: 77 Issue: 19 Pages: 5259-5271
- DOI
  10.1158/0008-5472.can-16-3144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08617, KAKENHI-PROJECT-17K10131, KAKENHI-PROJECT-16H05139, KAKENHI-PROJECT-15K12139, KAKENHI-PROJECT-15K18442
[Journal Article] The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis.2015
- Author(s)
  Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, Niimi S, Saeki H, Tokunaga E, Oki E, Morita M, Kadomatsu K, Maehara Y, Kitao H
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 14 Pages: 2332-2342
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15079
[Journal Article] Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance2013
- Author(s)
  Tuul M
- Journal Title
  
  PLoS One
  
  Volume: 8巻(2号) Issue: 2 Pages: 55361-55361
- DOI
  10.1371/journal.pone.0055361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390321, KAKENHI-PROJECT-24701028, KAKENHI-PROJECT-25460390
[Journal Article] CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.2012
- Author(s)
  Sakasai R., Sakai A., Iimori M., Kiyonari S., Matsuoka K., Kakeji Y., Kitao H., Maehara Y.
- Journal Title
  
  Genes Cells
  
  Volume: 17(12) Issue: 12 Pages: 962-70
- DOI
  10.1111/gtc.12011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591964, KAKENHI-PROJECT-24390321, KAKENHI-PROJECT-24701028
[Presentation] The mechanisms underlying the sensitivity to thymidylate synthase inhibitors in MYCN-amplified neuroblastoma cells2021
- Author(s)
  Shinichi Kiyonari, Ryuichi Sakai, Kenji Kadomatsu
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07711
[Presentation] Thymidylate synthase inhibitor can promote endogenous DNA damage in MYCN-amplified neuroblastoma cells2020
- Author(s)
  Kiyonari Shinichi、Sakai Ryuichi、Kadomatsu Kenji
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07711
[Presentation] Genome-wide RNAi screen identifies new synthetic lethal interactions in MYCN-amplified neuroblastoma cells2017
- Author(s)
  Shinichi Kiyonari、Kenji Kadomatsu
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-15K18442
[Presentation] オキサリプラチンによるdUTPase遺伝子発現抑制の分子メカニズム2013
- Author(s)
  清成信一
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド、神戸市
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-24701028
[Presentation] オキサリプラチンによるdUTPase遺伝子発現抑制の分子メカニズム2013
- Author(s)
  清成信一、飯森真人、松岡和明、Munkhbold Tuul、渡邉すぎ子、北尾洋之、沖英次、前原喜彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Data Source
  KAKENHI-PROJECT-24701028

1. Kadomatsu Kenji (80204519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Takeuchi Ichiro (40335146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Takahashi Yoshiyuki (40432273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西尾信博 (00586430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKAMOTO Kazuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 掛地吉弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 北尾洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岸田聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 堺隆一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kiyonari Shinichi 清成 信一

KIYONARI Shinichi 清成 信一

Research Projects

Research Products

Co-Researchers

Elucidation of the folate metabolic pathway unique to neuroblastoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Utilization of antimetabolite drugs for the treatment of high-risk neuroblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatments for neuroblastoma based on the synthetic lethalityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of carcinogenesis through deviation from normal development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of dUTPase downregulation by oxaliplatin and its applications to combination chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN ‐amplified neuroblastoma cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis.2015

Author(s)

Journal Title

Data Source

[Journal Article] Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] The mechanisms underlying the sensitivity to thymidylate synthase inhibitors in MYCN-amplified neuroblastoma cells2021

Author(s)

Organizer

Data Source

[Presentation] Thymidylate synthase inhibitor can promote endogenous DNA damage in MYCN-amplified neuroblastoma cells2020

Author(s)

Organizer

Data Source

[Presentation] Genome-wide RNAi screen identifies new synthetic lethal interactions in MYCN-amplified neuroblastoma cells2017

Author(s)

Organizer

Data Source

[Presentation] オキサリプラチンによるdUTPase遺伝子発現抑制の分子メカニズム2013

Author(s)

Organizer

Place of Presentation

Kiyonari Shinichi 清成信一

KIYONARI Shinichi 清成信一