Kusumoto Dai 楠本大

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KUSUMOTO Dai 楠本大

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Researcher Number	70571727
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2023: 慶應義塾大学, 医学部(信濃町), 講師 2019 – 2022: 慶應義塾大学, 医学部(信濃町), 助教 2016: 慶應義塾大学, 医学部(信濃町), 助教 2014 – 2015: 慶應義塾大学, 医学部, 助教 2011 – 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Cardiovascular medicine
Keywords	Principal Investigator 動脈硬化 / 血管内皮細胞 / 血管内皮 / iPS細胞 / 抗老化 / 深層学習 / 薬剤スクリーニング / Deep-SeSMo / 細胞形態 / 新規評価指標 … More / 畳み込みニューラルネットワーク / 人工知能 / 細胞老化 / 血管老化 / 特になし / 分子血管病態学 … More Except Principal Investigator 尿サンプル / 尿中赤血球 / Deep learning / AI / 血尿 / ポドサイト / 慢性腎臓病 / iPS細胞を用いた疾患解析 / 疾患モデル / 疾患解析 / iPS細胞 / ミトコンドリア病 Less

尿中細胞の深層学習・画像解析による腎疾患早期診断方法の開発
- Principal Investigator
  
  林香
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Keio University
Development of anti- atherosclerotic drugs using deep learning- based image analysisPrincipal Investigator
- Principal Investigator
  
  KUSUMOTO Dai
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Keio University
The exploratory research to investigate the novel anti-atherosclerotic factor using iPS cellsPrincipal Investigator
- Principal Investigator
  
  Kusumoto Dai
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Keio University
Disease Modeling for Mitochondrial Disease Using MELAS Specific Induced Pluripotent Stem Cells
- Principal Investigator
  
  KODAIRA Masaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Keio University
Modeling the Idiopathic/Heritable Pulmonary Arterial Hypertensionwith induced pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  KUSUMOTO Dai
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University

All 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness2022
- Author(s)
  Ando T, Tai-Nagara I, Sugiura Y, Kusumoto D, Okabayashi K, Kido Y, Sato Kohji, Saya H, Navankasattusas S, Li DY, Suematsu M, Kitagawa Y, Seiradake E, Yamagishi S, *Kubota Y.
- Journal Title
  
  J Clin Invest
  
  Volume: 132 Issue: 6 Pages: 153626-153626
- DOI
  10.1172/jci153626
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-20K21499, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-23K21369
[Journal Article] Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice2022
- Author(s)
  Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, *Kubota Y.
- Journal Title
  
  J Exp Med
  
  Volume: 219 Issue: 4
- DOI
  10.1084/jem.20211789
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-19H03623
[Journal Article] Anti-senescent drug screening by deep learning-based morphology senescence scoring2021
- Author(s)
  Kusumoto Dai、Seki Tomohisa、Sawada Hiromune、Kunitomi Akira、Katsuki Toshiomi、Kimura Mai、Ito Shogo、Komuro Jin、Hashimoto Hisayuki、Fukuda Keiichi、Yuasa Shinsuke
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 257-257
- DOI
  10.1038/s41467-020-20213-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19K17537
[Journal Article] The application of convolutional neural network to stem cell biology.2019
- Author(s)
  Kusumoto D, Yuasa S
- Journal Title
  
  Inflamm Regen.
  
  Volume: 39 Issue: 1
- DOI
  10.1186/s41232-019-0103-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-16H05304
[Journal Article] Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.2017
- Author(s)
  Shimojima M, Yuasa S, Motoda C, Yozu G, Nagai T, Ito S, Lachmann M, Kashimura S, Takei M, Kusumoto D, Kunitomi A, Hayashiji N, Seki T, Tohyama S, Hashimoto H, Kodaira M, Egashira T, Hayashi K, Nakanishi C, Sakata K, Yamagishi M, Fukuda K.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 44312-44312
- DOI
  10.1038/srep44312
- NAID
  120006325351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860583, KAKENHI-PROJECT-16K15415, KAKENHI-PROJECT-15KK0302, KAKENHI-PUBLICLY-15H01521, KAKENHI-PROJECT-16H05304
[Journal Article] H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells2016
- Author(s)
  Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami K, Tanaka M, Fukuda K.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 6 Issue: 6 Pages: 825-833
- DOI
  10.1016/j.stemcr.2016.04.015
- NAID
  120007135348
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05362, KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-26860583, KAKENHI-PROJECT-15K15478, KAKENHI-PROJECT-16K15415, KAKENHI-PROJECT-16K15536, KAKENHI-PROJECT-16K19429, KAKENHI-PROJECT-16H05304
[Journal Article] G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy2015
- Author(s)
  Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6745-6745
- DOI
  10.1038/ncomms7745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590497, KAKENHI-PROJECT-26290029, KAKENHI-PROJECT-15K19018, KAKENHI-PROJECT-26860583, KAKENHI-PUBLICLY-15H01521, KAKENHI-PROJECT-15J11847, KAKENHI-PROJECT-26670408, KAKENHI-PROJECT-25282202
[Journal Article] Analysis of cardiomyocyte movement in the developing murine heart.2015
- Author(s)
  Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 464 Issue: 4 Pages: 1000-1007
- DOI
  10.1016/j.bbrc.2015.07.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430046, KAKENHI-PROJECT-26860583, KAKENHI-PUBLICLY-25123727, KAKENHI-PUBLICLY-15H01521, KAKENHI-ORGANIZER-22111001, KAKENHI-PROJECT-15J07407, KAKENHI-PROJECT-13J30005, KAKENHI-PROJECT-26670408, KAKENHI-PROJECT-15H02355
[Journal Article] Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels2015
- Author(s)
  Masaki Kodaira, Hideyuki Hatakeyama, Shinsuke Yuasa, Tomohisa Seki, Toru Egashira, Shugo Tohyama, Yusuke Kuroda, Atsushi Tanaka, Shinichiro Okata, Hisayuki Hashimoto, Dai Kusumoto, Akira Kunitomi, Makoto Takei, Shin Kashimura, Tomoyuki Suzuki, Nozomi Hayashiji, Yuki Saito, Yu-ichi Goto, Keiichi Fukuda
- Journal Title
  
  FEBS Open Bio
  
  Volume: 5 Issue: 1 Pages: 219-225
- DOI
  10.1016/j.fob.2015.03.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860623
[Journal Article] Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes2014
- Author(s)
  Tanaka A, Yuasa S, Mearini G, Egashira T, Seki T, Kodaira M, Kusumoto D, Kuroda Y, Okata S, Suzuki T, Inohara T, Arimura T, Makino S, Kimura K, Kimura A, Furukawa T, Carrier L, Node K, Fukuda K
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860583
[Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via noncanonical　pathway2012
- Author(s)
  Onizuka T, Yuasa S, Kusumoto D, Shimoji K,Egashira T, Ohno Y, Kageyama T, Tanaka T,Hattori F, Fujita J, Ieda M, Kimura K, Makino S,Sano M, Kudo A, Fukuda K.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 52 Pages: 650-659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790876
[Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway2012
- Author(s)
  Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, Kageyama T, Tanaka T, Hattori F, Fujita J, Ieda M, Kimura K, Makino S, Sano M, Kudo A, Fukuda K
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 52(3) Pages: 650-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790876
[Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway2012
- Author(s)
  Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, Kageyama T, Tanaka T, Hattori F, Fujita J, Ieda M, Kimura K, Makino S, Sano M, Kudo A, Fukuda K.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 52 Pages: 650-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790876
[Patent] プログラム、スクリーニング方法、至適濃度の特定方法、薬剤剤造方法、モデル生成方法、情報処理方法、及び情報処理装置2022
- Inventor(s)
  楠本　大
- Industrial Property Rights Holder
  株式会社Heartseed社
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] Artificial Intelligence for Vascular biology2022
- Author(s)
  楠本　大
- Organizer
  血管生物若手研究会
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] Deep learning-based drug screening system to develop novel cardiovascular treatment2020
- Author(s)
  Dai Kusumoto
- Organizer
  第４回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] Anti-senescent drug screening by deep learning-based morphology senescence scoring2020
- Author(s)
  Dai Kusumoto, Tomohisa Seki, Hiromune Sawada, Toshiomi Katsuki, Mai Kimura, Shogo Itoh, Jin Komuro, Hisayuki Hashimoto, Keiichi Fukuda, and Shinsuke Yuasa
- Organizer
  American Heart Association Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] 深層学習を用いた画像解析による抗血管老化薬スクリーニングと新規抗老化薬の同定2019
- Author(s)
  楠本　大、澤田　拓宗、関　倫久、勝木　俊臣木村　舞、小室　仁、橋本　寿之、湯浅　慎介、福田　恵一
- Organizer
  日本血管生物医学会学術集会.
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] 深層学習を用いた画像認識システムの疾患創薬への応用.2019
- Author(s)
  楠本　大、湯浅　慎介、福田　恵一
- Organizer
  日本循環制御医学会.
- Data Source
  KAKENHI-PROJECT-19K08549
[Presentation] Primate specific gene, POTEE has a protective role against vascular injury 1 in endothelial cells2017
- Author(s)
  Dai Kusumoto, Shinsuke Yuasa, Tomohisa Seki, Makoto Takei, Akira Kunitomi, Shin Kashimura, Shugo Tohyama, Chikaaki Motoda, Yoshikazu Kishino, Nozomi Hayashiji, Sarasa Isobe, Toshiya Tanaka, Koichiro Homma, Hiroshi Itoh, Keiichi Fukuda.
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  石川県金沢市第4会場（ANAクラウンプラザヴィサージュ会議室 11F）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26860583
[Presentation] Novel model of diabetic vascular complication using induced pluripotent stem cell2013
- Author(s)
  Kusumoto D, Yuasa S, Fukuda K
- Organizer
  Keystone symposia J6:Dabbetes - New Insights into Mechanism of Disease and its Treatment
- Place of Presentation
  Keystone, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23790876
[Presentation] Novel model of diabetic vascular complication using induced pluripotent stem cell2013
- Author(s)
  Kusumoto D
- Organizer
  Keystone symposia: Diabetes-New Insights into Mechanism of Disease and its Treatment
- Place of Presentation
  Keystone, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23790876
[Presentation] Modeling the anti-atherosclerosis by patient-specific induced pluripotent stem cells2013
- Author(s)
  Kusumoto D
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23790876
[Presentation] Modeling the anti-atherosclerosis by patient-specific induced pluripotent stem cells2013
- Author(s)
  Dai Kusumoto, Shinsuke Yuasa , Tomohisa Seki , Toru Egashira , Masaki Kodaira , Hisayuki Hashimoto, Makoto Takei, Atsushi Tanaka, Yusuke Kuroda, Kouichiro Homma, Taichi Sugisaki, Junnichiro Irie, Keiichi Fukuda.
- Organizer
  第77回日本循環器学会学術集会(The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790876

1. KODAIRA Masaki (70464865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. YUASA Shinsuke (90398628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. EGASHIRA Toru (10465023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. HASHIMOTO Hisayuki (90528390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KUNITOMI Akira (30570882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KASHIMURA Shin (90571125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 林香 (60445294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 伊藤裕 (40252457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 菱川彰人 (50867489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUZUKI Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. YAMAZAWA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 武田伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 伊藤章吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 田畑秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田井育江

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kusumoto Dai 楠本 大

KUSUMOTO Dai 楠本 大

Research Projects

Research Products

Co-Researchers

尿中細胞の深層学習・画像解析による腎疾患早期診断方法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti- atherosclerotic drugs using deep learning- based image analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The exploratory research to investigate the novel anti-atherosclerotic factor using iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Disease Modeling for Mitochondrial Disease Using MELAS Specific Induced Pluripotent Stem Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modeling the Idiopathic/Heritable Pulmonary Arterial Hypertensionwith induced pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-senescent drug screening by deep learning-based morphology senescence scoring2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The application of convolutional neural network to stem cell biology.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of cardiomyocyte movement in the developing murine heart.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels2015

Author(s)

Journal Title

Kusumoto Dai 楠本大

KUSUMOTO Dai 楠本大

[Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via noncanonical　pathway2012