Iwasa Hiroaki 岩佐宏晃

Researcher Number	70582188
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 国際医療福祉大学, 基礎医学研究センター, 講師 2016 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2014 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator General medical chemistry
Keywords	Principal Investigator RASSF / シグナル伝達 / 腫瘍抑制 / Hippo pathway / 攪乱遺伝子 / Hippo / 外分泌消化酵素 / リボソーム生合成 / 糖尿病 / pRB … More / BCL-XL / Ras / RAS / 多面的効果 / 翻訳後修飾 / フェイルセーフ … More Except Principal Investigator ケミカルバイオロジー / 線維症 / 筋委縮 / がん / 腫瘍抑制 / シグナル伝達 Less

膵β細胞のHippoシグナル伝達系に着目した糖尿病発症につながる撹乱遺伝子の解明Principal Investigator
- Principal Investigator
  
  岩佐宏晃
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  International University of Health and Welfare
Study of tumor suppressors RASSF on pleiotropic effectPrincipal Investigator
- Principal Investigator
  
  Iwasa Hiroaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Analysis of tumor suppressors RASSF3 and RASSF6Principal Investigator
- Principal Investigator
  
  Iwasa Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Study on the tumor suppressor Hippo pathway and RASSF proteins
- Principal Investigator
  
  Hata Yutaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] 別冊・医学のあゆみ　広がるHippo pathway研究-癌から各種疾患へ2015
- Author(s)
  岩佐宏晃（共著）
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26460359
[Journal Article] Role of the transcription factor MAFA in the maintenance of pancreatic β-cells.2022
- Author(s)
  Nishimura W, Iwasa H, Tumurkhuu M.
- Journal Title
  
  Int. J. Mol. Sci
  
  Volume: 23 Issue: 9 Pages: 4478-4478
- DOI
  10.3390/ijms23094478
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09843, KAKENHI-PROJECT-20K08915, KAKENHI-PROJECT-22K08677
[Journal Article] UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p532018
- Author(s)
  Iwasa Hiroaki、Sarkar Aradhan、Shimizu Takanobu、Sawada Takeru、Hossain Shakhawoat、Xu Xiaoyin、Maruyama Junichi、Arimoto-Matsuzaki Kyoko、Withanage Kanchanamala、Nakagawa Kentaro、Kurihara Hidetake、Kuroyanagi Hidehito、Hata Yutaka
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 9 Pages: 2767-2780
- DOI
  10.1111/cas.13706
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08624, KAKENHI-PROJECT-18K07830, KAKENHI-PROJECT-18K08221, KAKENHI-PROJECT-16K19029
[Journal Article] Tumor suppressor C-RASSF proteins2018
- Author(s)
  Iwasa Hiroaki、Hossain Shakhawoat、Hata Yutaka
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 75 Issue: 10 Pages: 1773-1787
- DOI
  10.1007/s00018-018-2756-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08624
[Journal Article] The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein2018
- Author(s)
  Hossain Shakhawoat、Iwasa Hiroaki、Sarkar Aradhan、Maruyama Junichi、Arimoto-Matsuzaki Kyoko、Hata Yutaka
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 38 Issue: 17
- DOI
  10.1128/mcb.00046-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08624, KAKENHI-PROJECT-16K19029
[Journal Article] Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability2018
- Author(s)
  Lu Yuxiong、Maruyama Junichi、Kuwata Keiko、Fukuda Hiroyuki、Iwasa Hiroaki、Arimoto-Matsuzaki Kyoko、Sugimura Haruhiko、Hata Yutaka
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 16 Pages: 130-137
- DOI
  10.1016/j.bbrep.2018.10.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08624, KAKENHI-PROJECT-18K15059, KAKENHI-PROJECT-16K19029
[Journal Article] BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression2017
- Author(s)
  Xu Xiaoyin、Iwasa Hiroaki、Hossain Shakhawoat、Sarkar Aradhan、Maruyama Junichi、Arimoto-Matsuzaki Kyoko、Hata Yutaka
- Journal Title
  
  Genes to Cells
  
  Volume: 22 Issue: 12 Pages: 993-1003
- DOI
  10.1111/gtc.12541
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08624, KAKENHI-PROJECT-16K19029
[Journal Article] Domain analysis of Ras-association domain family member 6 upon interaction with MDM2.2017
- Author(s)
  Sarkar A, Iwasa H, Hossain S, Xu X, Sawada T, Shimizu T, Maruyama J, Arimoto-Matsuzaki K, Hata Y.
- Journal Title
  
  FEBS Letters
  
  Volume: 591 Issue: 2 Pages: 260-272
- DOI
  10.1002/1873-3468.12551
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-26460359, KAKENHI-PROJECT-26860185, KAKENHI-PROJECT-16K19029
[Journal Article] Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth2017
- Author(s)
  Maruyama Junichi、Inami Kazutoshi、Michishita Fumiyoshi、Jiang Xinliang、Iwasa Hiroaki、Nakagawa Kentaro、Ishigami-Yuasa Mari、Kagechika Hiroyuki、Miyamura Norio、Hirayama Jun、Nishina Hiroshi、Nogawa Daichi、Yamamoto Kouhei、Hata Yutaka
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 16 Issue: 2 Pages: 197-211
- DOI
  10.1158/1541-7786.mcr-17-0382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08624, KAKENHI-PUBLICLY-17H05996, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H03982, KAKENHI-PROJECT-16K08521
[Journal Article] Validation of the chemical compound library screening for TAZ inhibitors by use of　green fluorescence protein-fused TAZ.2016
- Author(s)
  Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: - Issue: 6 Pages: 791-802
- DOI
  10.1111/cas.12936
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460359, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-26860185
[Journal Article] RASSF6; the Putative Tumor Suppressor of the RASSF Family.2015
- Author(s)
  Iwasa H, Jiang X, Hata Y.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 9 Issue: 4 Pages: 2415-2426
- DOI
  10.3390/cancers7040899
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460359, KAKENHI-PROJECT-26293061
[Journal Article] A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells2015
- Author(s)
  Kodaka, M.; Yang, Z.; Nakagawa, K.; Maruyama, J.; Xu, X.; Sarkar, A.; Ichimura, A.; Nasu, Y.; Ozawa, T.; Iwasa, H.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, Y.
- Journal Title
  
  Exp. Cell. Res.
  
  Volume: 336 Issue: 2 Pages: 171-181
- DOI
  10.1016/j.yexcr.2015.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670052, KAKENHI-PROJECT-26860185, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-26220805
[Journal Article] A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.2015
- Author(s)
  Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 158 Issue: 5 Pages: 413-423
- DOI
  10.1093/jb/mvv051
- NAID
  40020646985
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460359, KAKENHI-PROJECT-26860185, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26293061
[Journal Article] MAGI2/S-SCAM outside brain2015
- Author(s)
  Nagashima S, Kodaka M, Iwasa H, Hata Y.
- Journal Title
  
  Journa of Biochemistry
  
  Volume: 157 Issue: 4 Pages: 177-184
- DOI
  10.1093/jb/mvv009
- NAID
  40020428694
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-26460359
[Journal Article] Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model.2014
- Author(s)
  Yang, Z. Y.; Nakagawa, K.; Sarkar, A.; Maruyama, J.; Iwasa, H.; Bao, Y. J.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, S.; Nishina, H.; Abe, S.; Kitagawa, M.; Hata, Y.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 34 Issue: 9 Pages: 1607-1621
- DOI
  10.1128/mcb.01346-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22136013, KAKENHI-PROJECT-23790325, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-26860185
[Presentation] 腫瘍抑制遺伝子Rassf6のノックアウトは膵島におけるリボソーム生合成を低下させる2023
- Author(s)
  岩佐宏晃、渡部栄地、西村渉
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K08677
[Presentation] 膵島内における成熟膵β細胞のサブタイプとその局在の解析2022
- Author(s)
  岩佐宏晃、前田健吾、堀岡希衣、三宅克也、松本征仁、安田和基、西村渉
- Organizer
  日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-22K08677
[Presentation] RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein2018
- Author(s)
  Shakhawoat Hossain, Hiroaki Iwasa, Yutaka Hata
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08624
[Presentation] 新規に同定したYAP1活性化化合物は多発性骨髄腫に置いてYAP1-p73経路依存的な細胞死を誘導する2016
- Author(s)
  丸山順一、江欣亮、岩佐宏晃、湯浅―石上磨里、影近弘之、仁科博史、畑裕
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜パシフィコ
- Data Source
  KAKENHI-PROJECT-26293061
[Presentation] UNC119Aは腫瘍抑制分子RASSF6と共にDNA損傷応答を制御する2015
- Author(s)
  岩佐宏晃、清水尊仁、畑裕
- Organizer
  日本分子生物学会、日本生化学会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293061
[Presentation] UNC119Aは腫瘍抑制分子RASSF6と共にDNA損傷応答を制御する2015
- Author(s)
  岩佐宏晃、清水尊仁、畑裕
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460359

1. Maruyama Junichi (30723639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Hata Yutaka (80313237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. NISHIMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 影近弘之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Iwasa Hiroaki 岩佐 宏晃

Research Projects

Research Products

Co-Researchers

膵β細胞のHippoシグナル伝達系に着目した糖尿病発症につながる撹乱遺伝子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of tumor suppressors RASSF on pleiotropic effectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of tumor suppressors RASSF3 and RASSF6Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the tumor suppressor Hippo pathway and RASSF proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 別冊・医学のあゆみ 広がるHippo pathway研究-癌から各種疾患へ2015

Author(s)

Publisher

Data Source

[Journal Article] Role of the transcription factor MAFA in the maintenance of pancreatic β-cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p532018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor suppressor C-RASSF proteins2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Domain analysis of Ras-association domain family member 6 upon interaction with MDM2.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Validation of the chemical compound library screening for TAZ inhibitors by use of green fluorescence protein-fused TAZ.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RASSF6; the Putative Tumor Suppressor of the RASSF Family.2015

Author(s)

Journal Title

Iwasa Hiroaki 岩佐宏晃

[Book] 別冊・医学のあゆみ　広がるHippo pathway研究-癌から各種疾患へ2015

[Journal Article] Validation of the chemical compound library screening for TAZ inhibitors by use of　green fluorescence protein-fused TAZ.2016