Ninomiya Masashi 二宮匡史

… Alternative Names

二宮匡史ニノミヤマサシ

NINOMIYA Masashi 二宮匡史

Less

Researcher Number	70583938
Other IDs
Affiliation (Current)	2025: 東北大学, 高度教養教育・学生支援機構, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 東北大学, 高度教養教育・学生支援機構, 助教 2012: 東北大学, 病院, 医員 2011 – 2012: 東北大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 原発性胆汁性肝硬変 / 次世代シークエンサー / microRNA / 肝炎ウイルス / 肝臓学 Except Principal Investigator HBV / HCC / 自然免疫 / MxB / ミトコンドリア … More / 非アルコール性脂肪性肝炎 / 酸化ストレス / 遊離アミノ酸 / 非アルコール性脂肪性肝疾患 / VLDL / アミノ酸 / NASH / NAFLD / ウイルス性肝炎 / B型肝炎ウイルス / Rabタンパク質 / B型慢性肝炎 / CD63 / Rab5B / 小胞輸送 Less

ミトコンドリアを介する自然免疫応答を標的としたB型肝炎ウイルスの制御と肝発癌抑制
- Principal Investigator
  
  井上淳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Impact of free amino acids on intracellular stress response mechanisms in hepatic steatosis.
- Principal Investigator
  
  Kakazu Eiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Mechanistic analysis of hepatitis B virus infection focusing on vesicle trafficking system and its clinical application
- Principal Investigator
  
  Inoue Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
The possibility of unknown viral infection with primary biliary cirrhosis and the disease association with anellovirus infection.Principal Investigator
- Principal Investigator
  
  NINOMIYA Masashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

All 2024 2022 2021 2020 2019 2013 2012 2011

All Journal Article Presentation Book

[Book] アークメディア肝胆膵2011
- Author(s)
  二宮匡史、福島耕二、上野義之、下瀬川徹
- Publisher
  ウイルス感染とPBC
- Data Source
  KAKENHI-PROJECT-23790765
[Book] 肝胆膵2011
- Author(s)
  二宮匡史、福島耕二、上野義之、下瀬川徹
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-23790765
[Journal Article] Usefulness of the Fibrosis‐4 index and alanine aminotransferase at 1 year of nucleos(t)ide analog treatment for prediction of hepatocellular carcinoma in chronic hepatitis B patients2024
- Author(s)
  Inoue Jun、Akahane Takehiro、Kobayashi Tomoo、Kimura Osamu、Sato Kosuke、Ninomiya Masashi、Iwata Tomoaki、Takai Satoshi、Kisara Norihiro、Sato Toshihiro、Nagasaki Futoshi、Miura Masahito、Nakamura Takuya、Umetsu Teruyuki、Sano Akitoshi、Tsuruoka Mio、Onuki Masazumi、Sawahashi Satoko、Niitsuma Hirofumi、Masamune Atsushi
- Journal Title
  
  Hepatology Research
  
  Volume: 54 Issue: 2 Pages: 131-141
- DOI
  10.1111/hepr.13957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07390
[Journal Article] The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus2021
- Author(s)
  Ninomiya M, Inoue J, Krueger EW, Chen J, Cao H, Masamune A, McNiven MA
- Journal Title
  
  Hepatology Communications
  
  Volume: - Issue: 7 Pages: 1238-1251
- DOI
  10.1002/hep4.1709
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385
[Journal Article] Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1‐Nrf2 dependent manner2021
- Author(s)
  Sano Akitoshi、Kakazu Eiji、Hamada Shin、Inoue Jun、Ninomiya Masashi、Iwata Tomoaki、Tsuruoka Mio、Sato Kosuke、Masamune Atsushi
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 3 Pages: 1271-1286
- DOI
  10.1002/hep.31808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08322
[Journal Article] Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis2021
- Author(s)
  Inoue Jun、Sato Kosuke、Ninomiya Masashi、Masamune Atsushi
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 6 Pages: 1124-1124
- DOI
  10.3390/v13061124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08385
[Journal Article] Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production2019
- Author(s)
  Inoue Jun、Ninomiya Masashi、Umetsu Teruyuki、Nakamura Takuya、Kogure Takayuki、Kakazu Eiji、Iwata Tomoaki、Takai Satoshi、Sano Akitoshi、Fukuda Mitsunori、Watashi Koichi、Isogawa Masanori、Tanaka Yasuhito、Shimosegawa Tooru、McNiven Mark A.、Masamune Atsushi
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 15
- DOI
  10.1128/jvi.00621-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385, KAKENHI-PROJECT-17K09436, KAKENHI-PROJECT-17H04085
[Journal Article] Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis2013
- Author(s)
  Ninomiya M, Kondo H, Shimosegawa T
- Journal Title
  
  ISRN Hepatology
  
  Volume: 2013 Pages: 1-7
- DOI
  10.1155/2013/237870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790765
[Journal Article] Animal Models of Cholangiopathies and Possible Endogenous Viral Infecti2012
- Author(s)
  Ninomiya M, Ueno Y, Shimosegawa T
- Journal Title
  
  International journal of hepatology
  
  Volume: 2012 Pages: 649290-649290
- DOI
  10.1155/2012/649290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822, KAKENHI-PROJECT-23790765
[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012
- Author(s)
  Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
- Journal Title
  
  Journal of clinical microbiology
  
  Volume: 50 Issue: 3 Pages: 857-866
- DOI
  10.1128/jcm.05715-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590822, KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762, KAKENHI-PROJECT-23790765, KAKENHI-PROJECT-24700951
[Presentation] 代謝異常関連脂肪性肝疾患 (MAFLD) におけるペマフィブラートおよび各種代謝関連薬の効果の検討2022
- Author(s)
  佐野晃俊、井上　淳、嘉数英二、二宮匡史、岩田朋晃、鶴岡未央、佐藤公亮、小貫真純、澤橋里子、正宗　淳
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] B型肝炎ウイルス感染による小胞輸送の変化がウイルス放出に与える影響2021
- Author(s)
  井上　淳，二宮匡史，正宗　淳
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Exosome-associated tetraspanin CD63 is a potential target for the inhibition of infectious envelope formation of hepatitis B virus2021
- Author(s)
  Jun Inoue, Masashi Ninomiya, Atsushi Masamune
- Organizer
  第25回日本肝臓学会大会（JDDW2021）
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Hepatitis B virus infection affects expression of a small GTPase Rab5B resulting in the alteration of viral release2020
- Author(s)
  Jun Inoue, Masashi Ninomiya, Kosuke Sato, Eiji Kakazu, Tomoaki Iwata, Akitoshi Sano, Mio Tsuruoka, Atsushi Masamune
- Organizer
  AASLD The Liver Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] B型肝炎ウイルス粒子形成におけるCD63の役割に関する検討2020
- Author(s)
  井上　淳、二宮匡史、正宗　淳
- Organizer
  第43回　日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Steatotic hepatocytes release mature very-low-density lipoprotein via methionine and tyrosine metabolism in a Keap1-Nrf2 dependent manner.2020
- Author(s)
  Akitoshi Sano, Eiji Kakazu, Jun Inoue, Masashi Ninomiya, Tomoaki Iwata, Mio Tsuruoka, Kosuke Sato, Atsushi Masamune.
- Organizer
  米国肝臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08322
[Presentation] B型肝炎ウイルスに対するミリストイル化阻害の治療応用の可能性2019
- Author(s)
  井上　淳、二宮　匡史、正宗　淳
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Rab5BによるHBV粒子放出制御メカニズムの解明と治療応用に向けた検討2019
- Author(s)
  井上　淳、二宮匡史、正宗　淳
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K08385
[Presentation] Circulating microRNAs in some patients with viral hepatitis by deep sequencing showed characteristic expression2012
- Author(s)
  Ninomiya M
- Organizer
  AASLD
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いたC型肝炎ウイルスのアミノ酸配列解析と従来のSanger法シークエンスとの比較第48回2012
- Author(s)
  二宮匡史
- Organizer
  肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いて慢性B型肝炎患者血清内の特異的なmiRNAのプロファイリングを行い2012
- Author(s)
  二宮匡史
- Organizer
  新規miRNAの候補を見いだしたJDDW2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いたC型肝炎ウイルスのアミノ酸配列解析と従来のSanger法シークエンスとの比較2012
- Author(s)
  二宮匡史
- Organizer
  第48回　肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いた、C型肝炎ウイルスゲノム解析と血清内microRNAのプロファイリング2012
- Author(s)
  二宮匡史
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] Characterization of circulating microRNAs in patients with primary biliary cirrhosis by Illumina deep sequencing.2012
- Author(s)
  Ninomiya Masashi
- Organizer
  AASLD2012
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] Characterization of circulating microRNAs in patients with primary biliary cirrhosis by Illumina deep sequencing2012
- Author(s)
  Ninomiya M
- Organizer
  AASLD
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いた、C型肝炎ウイルスゲノム解析と血清内 microRNAのプロファイリング2012
- Author(s)
  二宮匡史
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いて慢性B型肝炎患者血清内の特異的なmiRNAのプロファイリングを行い、新規miRNAの候補を見いだした2012
- Author(s)
  二宮匡史
- Organizer
  JDDW2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] Circulating microRNAs in some patients with viral hepatitis by deep sequencing showed characteristic expression.2012
- Author(s)
  Ninomiya Masashi
- Organizer
  AASLD2012
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] HBc抗体陽性レシピエントに臍帯血移植を施行、HBV再活性化が認められたde novo B型肝炎の1例2011
- Author(s)
  二宮匡史　上野義之　福島耕治　近藤泰輝　井上淳　嘉数英二　涌井祐太　下瀬川徹
- Organizer
  第193回　日本内科学会東北地方会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] Efficiency of detecting hepatitis C virus using deep sequencing technology: high faculty to differentiate the viral variants compared with Sanger sequencing2011
- Author(s)
  Ninomiya M
- Organizer
  AASLD
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] 次世代シークエンサーを用いたC型肝炎ウイルスの解析2011
- Author(s)
  二宮匡史
- Organizer
  JDDW2011
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790765
[Presentation] Efficiency of detecting hepatitis C virus using deep sequencing technology: high faculty to differentiate the viral variants compared with Sanger sequencing2011
- Author(s)
  Masashi Ninomiya, Yoshiyuki Ueno, Ryo Funayama, Yuishiro Nishida, Yasuteru Kondo, Jun Inoue, Eiji Kakazu, Osamu Kimura, Takao Iwasaki, Keiko Nakayama, Tooru Shimosegawa
- Organizer
  AASLD
- Place of Presentation
  アメリカ
- Data Source
  KAKENHI-PROJECT-23790765

1. Inoue Jun (60455821)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. Kakazu Eiji (20509377)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 岩田朋晃 (30803647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 濱田晋 (20451560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 小暮高之 (70400330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 佐野晃俊 (20906060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 上野義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ninomiya Masashi 二宮 匡史

二宮 匡史 ニノミヤ マサシ

NINOMIYA Masashi 二宮 匡史

Research Projects

Research Products

Co-Researchers

ミトコンドリアを介する自然免疫応答を標的としたB型肝炎ウイルスの制御と肝発癌抑制

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of free amino acids on intracellular stress response mechanisms in hepatic steatosis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic analysis of hepatitis B virus infection focusing on vesicle trafficking system and its clinical application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The possibility of unknown viral infection with primary biliary cirrhosis and the disease association with anellovirus infection.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アークメディア肝胆膵2011

Author(s)

Publisher

Data Source

[Book] 肝胆膵2011

Author(s)

Publisher

Data Source

[Journal Article] Usefulness of the Fibrosis‐4 index and alanine aminotransferase at 1 year of nucleos(t)ide analog treatment for prediction of hepatocellular carcinoma in chronic hepatitis B patients2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Steatotic hepatocytes release mature VLDL via methionine and tyrosine metabolism in a Keap1‐Nrf2 dependent manner2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Animal Models of Cholangiopathies and Possible Endogenous Viral Infecti2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 代謝異常関連脂肪性肝疾患 (MAFLD) におけるペマフィブラートおよび各種代謝関連薬の効果の検討2022

Author(s)

Ninomiya Masashi 二宮匡史

二宮匡史ニノミヤマサシ

NINOMIYA Masashi 二宮匡史