Hirozane Toru 弘實透

Researcher Number	70594539
Other IDs
Affiliation (Current)	2025: 杏林大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023: 杏林大学, 医学部, 助教 2018 – 2023: 慶應義塾大学, 医学部(信濃町), 助教 2022: 地方独立行政法人栃木県立がんセンター(研究所), 研究所－がん医療研究G－肝胆膵悪性腫瘍研究分野, 研究医師
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator Wntシグナル / 骨肉腫 / 軟部腫瘍 / 骨腫瘍 / PPARG / TNIK / 滑膜肉腫 / 組織マイクロアレイ / 骨軟部腫瘍 / 細胞分化 … More / 化学療法 / がん幹細胞 / 分化転換 / がん幹細胞性 … More Except Principal Investigator クロマチン免疫沈降 / 遺伝子リプログラミング / 次世代シーケンサー / 細胞分化・系譜 / がん幹細胞 / エピゲノム / ゲノム / 分化転換 / 遺伝子転写 / TNIK / Wntシグナル / 骨肉腫 Less

Adipocytic transdifferentiation of osteosarcoma by global genetic reprogramming
- Principal Investigator
  
  Yamada Tesshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokyo Medical University
骨軟部腫瘍に対するWntシグナルを標的とした治療法の探索Principal Investigator
- Principal Investigator
  
  弘實透
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyorin University
  Tochigi Cancer Center (institute)
  Keio University
Investigation of Wnt-signaling-targeted therapy for osteosarcomaPrincipal Investigator
- Principal Investigator
  
  Hirozane Toru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Bilateral Upper Arm Granulomas Induced by Leuprorelin Acetate Injection Mimicking Malignant Soft Tissue Tumors: A Case Report2024
- Author(s)
  Yamaguchi Sakura、Yamaguchi Sayaka Iwai、Hirozane Toru、Mori Tomoaki、Asano Naofumi、Okita Hajime、Nakayama Robert、Nakamura Masaya、Matsumoto Morio
- Journal Title
  
  Case Reports in Oncology
  
  Volume: 17 Issue: 1 Pages: 17-24
- DOI
  10.1159/000533924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18040
[Journal Article] Multiple Recurrent Atypical Lipomatous Tumors/Well-Differentiated Liposarcomas and Dedifferentiated Liposarcomas Treated with Multiple Surgical Resections: A Case Report2023
- Author(s)
  Maejima Akira、Hirozane Toru、Yamaguchi Sayaka、Mori Tomoaki、Asano Naofumi、Kikuta Kazutaka、Hirabayashi Kaoru、Takeuchi Katsuhito、Nakayama Robert、Nakamura Masaya、Matsumoto Morio
- Journal Title
  
  Case Reports in Oncology
  
  Volume: 16 Issue: 1 Pages: 1223-1231
- DOI
  10.1159/000534181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18040
[Journal Article] A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall2023
- Author(s)
  Abe Makoto、Hoshi Nobuo、Hoshi Sayuri、Hirabayashi Kaoru、Kikuta Kazutaka、Hirozane Toru、Nakagawa Rumi、Mizuno Tsukasa、Nakamura Hiroshi、Inoue Koichi、Yamaguchi Takehiko
- Journal Title
  
  Case Reports in Pathology
  
  Volume: 2023 Pages: 1-5
- DOI
  10.1155/2023/9443027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18040
[Journal Article] Intramedullary osteoid osteoma in the humerus of a toddler-A case report and review of the literature.2022
- Author(s)
  Hiramatsu M, Nakayama R, Kasahara T, Nakagawa R, Hirozane T, Yamaguchi S, Mori T, Asano N, Okita H, Nakamura M, Matsumoto M.
- Journal Title
  
  Radiol Case Rep
  
  Volume: 17 Issue: 10 Pages: 3748-3753
- DOI
  10.1016/j.radcr.2022.07.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18040
[Journal Article] Recurrent malignant peripheral nerve sheath tumor presenting as an asymptomatic intravenous thrombus extending to the heart: a case report2022
- Author(s)
  Hirozane Toru、Nakayama Robert、Yamaguchi Sayaka、Mori Tomoaki、Asano Naofumi、Asakura Keisuke、Kikuta Kazutaka、Kawaida Miho、Sasaki Aya、Okita Hajime、Nakatsuka Seishi、Ito Tsutomu
- Journal Title
  
  World Journal of Surgical Oncology
  
  Volume: 20 Issue: 1 Pages: 8-8
- DOI
  10.1186/s12957-021-02473-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20474, KAKENHI-PROJECT-20K18040
[Journal Article] Malignant transformation of metastatic giant cell tumor of bone in a patient undergoing denosumab treatment: A case report2021
- Author(s)
  Yung David、Asano Naofumi、Hirozane Toru、Yamaguchi Sayaka、Mori Tomoaki、Susa Michiro、Okita Hajime、Morioka Hideo、Horiuchi Keisuke、Nakayama Robert
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 6 Pages: 1492-1496
- DOI
  10.1016/j.jos.2021.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20474, KAKENHI-PROJECT-19K09637
[Journal Article] Sequential imaging of hyperplastic callus formation in Osteogenesis Imperfecta type V: A case report and review of the literature2021
- Author(s)
  Yung David、Arai Manabu、Matsumoto Shunsuke、Sato Takeshi、Hirozane Toru、Yamaguchi Sayaka、Asano Naofumi、Hasegawa Tomonobu、Nakayama Robert
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 6 Pages: 1430-1435
- DOI
  10.1016/j.jos.2021.04.009
- Data Source
  KAKENHI-PROJECT-20K20474
[Journal Article] Direct conversion of osteosarcoma to adipocytes by targeting TNIK2021
- Author(s)
  Hirozane Toru、Masuda Mari、Sugano Teppei、Sekita Tetsuya、Goto Naoko、Aoyama Toru、Sakagami Takato、Uno Yuko、Moriyama Hideki、Sawa Masaaki、Asano Naofumi、Nakamura Masaya、Matsumoto Morio、Nakayama Robert、Kondo Tadashi、Kawai Akira、Kobayashi Eisuke、Yamada Tesshi
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 3
- DOI
  10.1172/jci.insight.137245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K20474, KAKENHI-PROJECT-20K18040, KAKENHI-PROJECT-19J21415, KAKENHI-PROJECT-21H03062, KAKENHI-PROJECT-19K09589
[Journal Article] Secondary peripheral chondrosarcoma arising from solitary osteochondroma of the clavicle: A case report2021
- Author(s)
  Takenoshita Shinichi、Asano Naofumi、Kasahara Tomoki、Hirozane Toru、Yamaguchi Sayaka、Mori Tomoaki、Ohkita Hajime、Nakayama Robert、Nakamura Masaya、Matsumoto Morio
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 6 Pages: 1592-1596
- DOI
  10.1016/j.jos.2021.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20474
[Journal Article] Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-08462020
- Author(s)
  Sugano Teppei、Masuda Mari、Takeshita Fumitaka、Motoi Noriko、Hirozane Toru、Goto Naoko、Kashimoto Shigeki、Uno Yuko、Moriyama Hideki、Sawa Masaaki、Nagakawa Yuichi、Tsuchida Akihiko、Seike Masahiro、Gemma Akihiko、Yamada Tesshi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 124 Issue: 1 Pages: 228-236
- DOI
  10.1038/s41416-020-01162-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K20474, KAKENHI-PROJECT-20K18040
[Journal Article] Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma2020
- Author(s)
  Sekita Tetsuya、Yamada Tesshi、Kobayashi Eisuke、Yoshida Akihiko、Hirozane Toru、Kawai Akira、Uno Yuko、Moriyama Hideki、Sawa Masaaki、Nagakawa Yuichi、Tsuchida Akihiko、Matsumoto Morio、Nakamura Masaya、Nakayama Robert、Masuda Mari
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1258-1258
- DOI
  10.3390/cancers12051258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09589, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K20474, KAKENHI-PROJECT-20K18040, KAKENHI-PROJECT-18H02933, KAKENHI-PROJECT-19J21415, KAKENHI-PROJECT-17H03603
[Presentation] 外科的治療を行った59例の軟骨芽細胞腫の臨床的特徴と臨床成績：多施設共同研究2024
- Author(s)
  弘實　透
- Organizer
  第7回日本サルコーマ治療研究学会学術集会
- Data Source
  KAKENHI-PROJECT-20K18040
[Presentation] コロナ禍における骨軟部腫瘍診療の当院での経験と対策2023
- Author(s)
  弘實　透
- Organizer
  第56回日本整形外科学会　骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-20K18040
[Presentation] 人工知能を用いた軟部腫瘍のMRI画像診断支援システムの構築2023
- Author(s)
  弘實　透
- Organizer
  第96回日本整形外科学会　学術総会
- Data Source
  KAKENHI-PROJECT-20K18040
[Presentation] 滑膜肉腫に対する TNIK 阻害剤の有効性2020
- Author(s)
  関田哲司，後藤尚子，弘實透，小林英介，川井章，松本守雄，中村雅也，中山ロバート，増田万里
- Organizer
  日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-20K18040
[Presentation] 滑膜肉腫に対するTNIK発現抑制の効果2020
- Author(s)
  関田哲也，山田哲司，小林英介，後藤尚子，弘實透，川井章，松本守雄，中村雅也，中山ロバート，増田万里
- Organizer
  日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-20K18040

1. Yamada Tesshi (30221659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. MASUDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 小林英介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirozane Toru 弘實 透

Research Projects

Research Products

Co-Researchers

Adipocytic transdifferentiation of osteosarcoma by global genetic reprogramming

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨軟部腫瘍に対するWntシグナルを標的とした治療法の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Wnt-signaling-targeted therapy for osteosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Bilateral Upper Arm Granulomas Induced by Leuprorelin Acetate Injection Mimicking Malignant Soft Tissue Tumors: A Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple Recurrent Atypical Lipomatous Tumors/Well-Differentiated Liposarcomas and Dedifferentiated Liposarcomas Treated with Multiple Surgical Resections: A Case Report2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intramedullary osteoid osteoma in the humerus of a toddler-A case report and review of the literature.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recurrent malignant peripheral nerve sheath tumor presenting as an asymptomatic intravenous thrombus extending to the heart: a case report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Malignant transformation of metastatic giant cell tumor of bone in a patient undergoing denosumab treatment: A case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequential imaging of hyperplastic callus formation in Osteogenesis Imperfecta type V: A case report and review of the literature2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct conversion of osteosarcoma to adipocytes by targeting TNIK2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secondary peripheral chondrosarcoma arising from solitary osteochondroma of the clavicle: A case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-08462020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 外科的治療を行った59例の軟骨芽細胞腫の臨床的特徴と臨床成績：多施設共同研究2024

Author(s)

Organizer

Hirozane Toru 弘實透