YASUDA DAISUKE 安田大恭

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YASUDA Daisuke 安田大恭

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Researcher Number	70594951
Other IDs	https://orcid.org/0000-0001-5513-0695
Affiliation (Current)	2025: 秋田大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 秋田大学, 医学系研究科, 講師 2018 – 2020: 秋田大学, 医学系研究科, 助教 2013 – 2017: 秋田大学, 医学(系)研究科(研究院), 助教 2013: 秋田大学, 大学院・医学系研究科, 助教 2012: 秋田大学, 医学系研究科, 助教 2011: 秋田大学, 医学(系)研究科(研究院), 助教 2011: 秋田大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 49030:Experimental pathology-related / Functional biochemistry Except Principal Investigator General medical chemistry / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator リゾホスファチジン酸 / GPCR / Gタンパク質共役型受容体 / リンパ管内皮細胞 / LPA6 / LPA4 / YAP / Notch / DLL4 / YAP/TAZ … More / 血管新生 / LPA / リンパ管新生 / リンパ浮腫 / リンパ管形成 / リゾリン脂質 / がん / 血管内皮細胞 / がん病態モデルマウス / LPA受容体 / がん進展制御 / Sprouting / TAZ / Retinal angiogenesis / 胎生致死 / 血管形成異常 / 血管形成 / N型糖鎖修飾 / Nicotinic acid / STT3B / Cell signaling / N-glycosylation / Sequon / 形質膜発現 / シグナル伝達 / STT3 / GPR109A / Sequon 配列 / N 型糖鎖修飾 … More Except Principal Investigator LPA / シグナル伝達 / リゾフォスファチジン酸 / LPA4 / リゾホスファチジン酸 / 脂質 / Gタンパク質共役型受容体 / Gα12/13 / 化合物ライブラリー Less

生理活性脂質リゾホスファチジン酸によるリンパ管新生の分子機構と病態制御機能Principal Investigator
- Principal Investigator
  
  安田大恭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Akita University
Mechanisms of cancer progression control mediated by LPA-induced YAP activationPrincipal Investigator
- Principal Investigator
  
  Daisuke Yasuda
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Akita University
G12/13-dependent signaling of bioactive lipid receptors that regulate PPARgamma activity in adipocytes
- Principal Investigator
  
  Ishii Satoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Akita University
Biological regulation by Galpha12/13-mediated lipid mediator function
- Principal Investigator
  
  Satoshi Ishii
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Lysophosphatidic acid receptors mediate novel angiogenesis mechanismPrincipal Investigator
- Principal Investigator
  
  Yasuda Daisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Roles of non-Edg family LPA receptors in embryonic vascular developmentPrincipal Investigator
- Principal Investigator
  
  YASUDA DAISUKE
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Requirement of atypical N-glycosylation motif for the surface expression and the intracellular signalingPrincipal Investigator
- Principal Investigator
  
  YASUDA Daisuke
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Akita University
Targeting bioactive lipid receptors for drug development
- Principal Investigator
  
  ISHII Satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University

All 2023 2022 2019 2018 2017 2016 2015 2012

All Journal Article Presentation

[Journal Article] Lysophosphatidic acid?induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll42019
- Author(s)
  Yasuda Daisuke、Kobayashi Daiki、Akahoshi Noriyuki、Ohto-Nakanishi Takayo、Yoshioka Kazuaki、Takuwa Yoh、Mizuno Seiya、Takahashi Satoru、Ishii Satoshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 10 Pages: 4332-4349
- DOI
  10.1172/jci121955
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07472, KAKENHI-PROJECT-19H03411, KAKENHI-PROJECT-17K08532
[Journal Article] The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity2018
- Author(s)
  Yanagida Keisuke、Igarashi Hidemitsu、Yasuda Daisuke、Kobayashi Daiki、Ohto-Nakanishi Takayo、Akahoshi Noriyuki、Sekiba Atsushi、Toyoda Tsudoi、Ishijima Tomoko、Nakai Yuji、Shojima Nobuhiro、Kubota Naoto、Abe Keiko、Kadowaki Takashi、Ishii Satoshi、Shimizu Takao
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 24 Pages: 397293-397293
- DOI
  10.1172/jci.insight.97293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07726, KAKENHI-PROJECT-18K19556, KAKENHI-PROJECT-18K19728, KAKENHI-PROJECT-16H05136, KAKENHI-PROJECT-17H01962
[Journal Article] Lysophosphatidic acid receptor 4 activation augments drug delivery in tumors by tightening endothelial cell-cell contact.2017
- Author(s)
  Takara K., Eino D., Ando K., Yasuda D., Naito H., Tsukada Y., Iba T., Wakabayashi T., Muramatsu F., Kidoya H., Fukuhara S., Mochizuki N., Ishii S., Kishima H., Takakura N.
- Journal Title
  
  Cell Reports
  
  Volume: 20 Issue: 9 Pages: 2072-2086
- DOI
  10.1016/j.celrep.2017.07.080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19689, KAKENHI-PROJECT-16K20317, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-16H05125, KAKENHI-PROJECT-16H05136, KAKENHI-PROJECT-17J04925, KAKENHI-PROJECT-16H06147
[Journal Article] Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling2017
- Author(s)
  Tanishima, M., Takashima, S., Honda, A., Yasuda, D., Tanikawa, T., Ishii, S., and MaruYama, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 42 Pages: 17250-17257
- DOI
  10.1074/jbc.m117.813899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05136
[Journal Article] The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling2015
- Author(s)
  Yasuda, D., Imura, Y., Ishii, S., Shimizu, T., and Nakamura, M.
- Journal Title
  
  FASEB J.
  
  Volume: 印刷中 Issue: 6 Pages: 2412-2422
- DOI
  10.1096/fj.14-267096
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116703, KAKENHI-PROJECT-26860182, KAKENHI-PROJECT-26460061, KAKENHI-PROJECT-24229003
[Presentation] 生理活性脂質リゾホスファチジン酸が促す血管・リンパ管新生の分子メカニズム2023
- Author(s)
  安田大恭、佐藤菜、石井聡
- Organizer
  第96回日本生化学会大会 2023年11月(福岡)
- Invited
- Data Source
  KAKENHI-PROJECT-22K06877
[Presentation] リゾホスファチジン酸によるリンパ管新生の分子機構2022
- Author(s)
  安田大恭、佐藤菜、石井聡
- Organizer
  第95回日本生化学会大会 2022年11月（愛知）
- Invited
- Data Source
  KAKENHI-PROJECT-22K06877
[Presentation] 血管・リンパ管新生を制御するリゾリン脂質の分子メカニズム2022
- Author(s)
  安田大恭、佐藤菜、石井聡
- Organizer
  JVBMOシンポジウム　2022年12月（東京）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06877
[Presentation] Gα12/13-coupled LPA receptors play an important role in developmental angiogenesis2019
- Author(s)
  Daisuke Yasuda
- Organizer
  ICBL (60th International Conference on the Bioscience of Lipids)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] 転写共役因子YAP/TAZを介したリゾホスファチジン酸の血管新生制御機構2019
- Author(s)
  安田大恭、小林大礎、吉岡和晃、多久和陽、石井聡
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03411
[Presentation] 転写共役因子YAP/TAZを介したリゾホスファチジン酸の血管新生制御機構2019
- Author(s)
  安田大恭、小林大礎、吉岡和晃、多久和陽、石井聡
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07472
[Presentation] リゾホスファチジン酸受容体LPA4の脂肪細胞における機能2018
- Author(s)
  柳田圭介、安田大恭、小林大礎、清水孝雄、石井聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05136
[Presentation] 血管新生に働くリゾホスファチジン酸シグナルの分子機構2017
- Author(s)
  安田大恭、石井聡
- Organizer
  第3回生体調節研究所内分泌代謝シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] Gα12/13-coupled LPA receptors mediate novel angiogenesis mechanism2017
- Author(s)
  Daisuke Yasuda and Satoshi Ishii
- Organizer
  ASEB Summer Research Conferences; Lysophospholipid and Related Mediators: From Bench to Clinic
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05136
[Presentation] Gα12/13共役型リゾホスファチジン酸受容体が調節する血管新生の分子機構2017
- Author(s)
  安田大恭, 石井聡
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16H05136
[Presentation] 12/13共役型リゾホスファチジン酸受容体が調節する血管新生の分子機構2017
- Author(s)
  安田大恭、石井聡
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] Ga12/13-coupled LPA receptors mediate novel angiogenesis mechanism2017
- Author(s)
  Daisuke Yasuda and Satoshi Ishii
- Organizer
  FASEB Summer Research Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] リゾホスファチジン酸による血管新生調節機序2017
- Author(s)
  安田大恭, 石井聡
- Organizer
  第59回日本脂質生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05136
[Presentation] リゾホスファチジン酸による血管新生調節機序2017
- Author(s)
  安田大恭、石井聡
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] リゾホスファチジン酸受容体の血管形成における役割2016
- Author(s)
  安田大恭、石井聡
- Organizer
  第58回脂質生化学会
- Place of Presentation
  秋田県秋田市にぎわい交流会館AU
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26860182
[Presentation] 血管形成を制御するリゾホスファチジン酸受容体2016
- Author(s)
  安田大恭、石井聡
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] リゾホスファチジン酸受容体の血管形成における役割2016
- Author(s)
  安田大恭、石井聡
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  にぎわい交流館AU(秋田市)
- Data Source
  KAKENHI-PROJECT-16K08575
[Presentation] ニコチン酸受容体GPR109Aが有するN型糖鎖付加のための非Sequon配列の重要性について2012
- Author(s)
  安田大恭
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23770138
[Presentation] ニコチン酸受容体GPR109A が有するN 型糖鎖付加のための非Sequon 配列の重要性について2012
- Author(s)
  安田大恭、井村祐己、石井聡、清水孝雄、中村元直
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23770138

1. ISHII Satoshi (10300815)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. OHTO Takayo (80511378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 丸山貴司 (10622524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 赤星軌征 (70534551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 福原茂朋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YASUDA DAISUKE 安田 大恭

YASUDA Daisuke 安田 大恭

Research Projects

Research Products

Co-Researchers

生理活性脂質リゾホスファチジン酸によるリンパ管新生の分子機構と病態制御機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of cancer progression control mediated by LPA-induced YAP activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

G12/13-dependent signaling of bioactive lipid receptors that regulate PPARgamma activity in adipocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological regulation by Galpha12/13-mediated lipid mediator function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lysophosphatidic acid receptors mediate novel angiogenesis mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of non-Edg family LPA receptors in embryonic vascular developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Requirement of atypical N-glycosylation motif for the surface expression and the intracellular signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting bioactive lipid receptors for drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lysophosphatidic acid?induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll42019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysophosphatidic acid receptor 4 activation augments drug delivery in tumors by tightening endothelial cell-cell contact.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 生理活性脂質リゾホスファチジン酸が促す血管・リンパ管新生の分子メカニズム2023

Author(s)

YASUDA DAISUKE 安田大恭

YASUDA Daisuke 安田大恭