ISHIMARU KAZUHIRO 石丸和宏

Researcher Number	70595446
Other IDs	https://orcid.org/0000-0002-4706-316X
Affiliation (based on the past Project Information) *help	2016 – 2021: 金沢大学, 医学系, 協力研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator スフィンゴ脂質代謝 / 老年医学 / 間質性肺炎 / 肺線維症 / オートファジー / 動脈硬化症 / 動脈硬化

Elucidation of aging lung pathophysiology through sphingolipid signalingPrincipal Investigator
- Principal Investigator
  
  ISHIMARU KAZUHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kanazawa University
Molecular mechanism in atheroprotective effects by the enzymes that control membrane sphingolipid levelsPrincipal Investigator
- Principal Investigator
  
  ISHIMARU KAZUHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kanazawa University

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice2020
- Author(s)
  Islam Shahidul、Yoshioka Kazuaki、Aki Sho、Ishimaru Kazuhiro、Yamada Hiroki、Takuwa Noriko、Takuwa Yoh
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 70 Issue: 1 Pages: 18-18
- DOI
  10.1186/s12576-020-00745-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07864, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-20K07260, KAKENHI-PROJECT-20K07273
[Journal Article] The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.2019
- Author(s)
  Aung KT, Yoshioka K, Ishimaru K, Aki S, Takuwa N, and Takuwa Y.
- Journal Title
  
  Journal of Physiological Sciences
  
  Volume: 69 Issue: 2 Pages: 263-280
- DOI
  10.1007/s12576-018-0644-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409, KAKENHI-PROJECT-17K08542
[Journal Article] Class II PI3Ks α nad β are required for Rho-dependent uterine smooth muscle contraction and parturition in mice.2019
- Author(s)
  Sarker AK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, and Takuwa Y.
- Journal Title
  
  Endocrinology
  
  Volume: 160 Issue: 1 Pages: 235-248
- DOI
  10.1210/en.2018-00756
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409
[Journal Article] Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation2019
- Author(s)
  Ishimaru Kazuhiro、Yoshioka Kazuaki、Kano Kuniyuki、Kurano Makoto、Saigusa Daisuke、Aoki Junken、Yatomi Yutaka、Takuwa Noriko、Okamoto Yasuo、Proia Richard L.、Takuwa Yoh
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18329-18329
- DOI
  10.1038/s41598-019-54877-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07864, KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542
[Journal Article] MTMR4, a phosphoinositide specific 3’-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.2018
- Author(s)
  Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, and Takuwa Y.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 8 Pages: 670-687
- DOI
  10.1111/gtc.12609
- NAID
  120006621947
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08532, KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PROJECT-16K15409
[Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.2018
- Author(s)
  Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 5 Pages: e0197604-e0197604
- DOI
  10.1371/journal.pone.0197604
- NAID
  120006605152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08542, KAKENHI-PROJECT-18K15010, KAKENHI-PLANNED-17H06394, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-16K15409
[Journal Article] iNOS as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: Possible involvement of sirt1 S- nitrosylation-mediated acetylation of p65 NFeΚB and p532017
- Author(s)
  Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki M
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 1 Pages: e0170391-e0170391
- DOI
  10.1371/journal.pone.0170391
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15409, KAKENHI-PROJECT-16K19048
[Presentation] Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor2018
- Author(s)
  Azadul Kabir Sarker, Sho Aki, Kazuaki Yoshioka, Koji Kuno, Kazuhiro Ishimaru, Noriko Takuwa, Yoh Takuwa
- Organizer
  第54回北陸生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells2018
- Author(s)
  Pham Quynh Hoa, Yoshioka Kazuaki, Azadul Sarker Kabir, Aung Thuzar Khin, Islam Shahidul, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells2018
- Author(s)
  Aung Thuzar Khin, Yoshioka Kazuaki, Aki Sho, Pham Quynh Hoa, Sarker Kabir Azadul, Islam Shahidul, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells2018
- Author(s)
  Pham Quynh Hoa, Yoshioka Kazuaki, Azadul Sarker Kabir, Aung Thuzar Khin, Islam Shahidul, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] S1P2によるブレオマイシン誘発肺線維症の増悪機構の検討:肺胞マクロファージの細胞老化制御の関与2018
- Author(s)
  多久和典子, 岡本安雄, 石丸和宏, 多久和陽
- Organizer
  日本病態生理学会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] Sphingosine Kinase 2 Inhibits Macrophage Cholesterol Accumulation and Atherosclerosis via Autophagy Stimulation2018
- Author(s)
  Kazuhiro Ishimaru, Yoh Takuwa
- Organizer
  American Heart Association 2018 Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] Class II phosphoinositide 3-kinase isoforms PI3K-C2αand PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells2018
- Author(s)
  Aung Thuzar Khin, Yoshioka Kazuaki, Aki Sho, Pham Quynh Hoa, Sarker Kabir Azadul, Islam Shahidul, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
- Organizer
  第 95 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K15409
[Presentation] 抗がん剤による臓器障害におけるスフィンゴシン-1-リン酸（S1P）情報伝達系の関与2017
- Author(s)
  多久和典子、石丸和宏、岡本安雄、多久和陽
- Organizer
  第27回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-16K15409

1. 吉岡和晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 多久和典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIMARU KAZUHIRO 石丸 和宏

Research Projects

Research Products

Co-Researchers

Elucidation of aging lung pathophysiology through sphingolipid signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism in atheroprotective effects by the enzymes that control membrane sphingolipid levelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Class II PI3Ks α nad β are required for Rho-dependent uterine smooth muscle contraction and parturition in mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MTMR4, a phosphoinositide specific 3’-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] iNOS as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: Possible involvement of sirt1 S- nitrosylation-mediated acetylation of p65 NFeΚB and p532017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor2018

Author(s)

Organizer

Data Source

[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells2018

Author(s)

Organizer

Data Source

[Presentation] Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells2018

Author(s)

Organizer

Data Source

[Presentation] Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells2018

Author(s)

Organizer

Data Source

[Presentation] S1P2によるブレオマイシン誘発肺線維症の増悪機構の検討:肺胞マクロファージの細胞老化制御の関与2018

Author(s)

Organizer

Data Source

[Presentation] Sphingosine Kinase 2 Inhibits Macrophage Cholesterol Accumulation and Atherosclerosis via Autophagy Stimulation2018

Author(s)

Organizer

Data Source

[Presentation] Class II phosphoinositide 3-kinase isoforms PI3K-C2αand PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells2018

Author(s)

Organizer

ISHIMARU KAZUHIRO 石丸和宏