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Ono Maiko  小野 麻衣子

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小野 麻衣子  オノ マイコ

ONO Maiko  小野 麻衣子

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Researcher Number 70595876
Other IDs
Affiliation (Current) 2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 研究員
2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 脳機能イメージング研究部, 研究員
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 研究員
2023: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 研究員
2022: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 脳機能イメージング研究部, 研究員
2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常)
2016: 国立研究開発法人放射線医学総合研究所, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常)
2011 – 2012: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 52040:Radiological sciences-related / Basic Section 52020:Neurology-related / Nerve anatomy/Neuropathology / Radiation science
Keywords
Principal Investigator
生体核磁気共鳴 / アルツハイマー病 / PETイメージング / p62 / PET / 超偏極MRI / パーキンソン病 / グルタミン酸 / 神経障害 / αシヌクレイン … More / 神経原線維変化 / 神経細胞死 / 選択的オートファジー / タウ / トランスレーショナルリサーチ / 放射線 / 脳神経疾患 / 疾患マーカー / 神経変性疾患 / オートファジー / イメージング / ポジトロン断層撮影(PET) Less
  • Research Projects

    (4 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (8 People)
  •  革新的脳代謝イメージングと異常タンパクPETによるAD/PDの病態解明Principal Investigator

    • Principal Investigator
      小野 麻衣子
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  αシヌクレイン伝播に誘導される神経障害メカニズムの解明と制御の試みPrincipal Investigator

    • Principal Investigator
      小野 麻衣子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Development of novel PET ligands for p62/SQSTM1Principal Investigator

    • Principal Investigator
      Ono Maiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Radiation science
    • Research Institution
      National Institutes for Quantum and Radiological Science and Technology
  •  Pivotal roles of p62 and selective autophagy in tau deposition and consequent neurodegeneration revealed with tauopathy mouse modelsPrincipal Investigator

    • Principal Investigator
      ONO Maiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      National Institute of Radiological Sciences

All 2023 2022 2019 2018 2013 2012 2011

All Journal Article Presentation Patent

  • [Journal Article] Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease2023

    • Author(s)
      Hirata Kosei、Matsuoka Kiwamu、Tagai Kenji、Endo Hironobu、Tatebe Harutsugu、Ono Maiko、Kokubo Naomi、Oyama Asaka、Shinotoh Hitoshi、Takahata Keisuke、Obata Takayuki、Dehghani Masoumeh、Near Jamie、Kawamura Kazunori、Zhang Ming‐Rong、Shimada Hitoshi、Yokota Takanori、Tokuda Takahiko、Higuchi Makoto、Takado Yuhei
    • Journal Title

      Annals of Neurology

      Volume: 95 Issue: 1 Pages: 104-115

    • DOI

      10.1002/ana.26797

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393
  • [Journal Article] Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy2023

    • Author(s)
      Matsuoka Kiwamu、Takado Yuhei、Tagai Kenji、Kubota Manabu、Sano Yasunori、Takahata Keisuke、Ono Maiko、Seki Chie、Matsumoto Hideki、Endo Hironobu、Shinotoh Hitoshi、Sahara Yasuka、Obata Takayuki、Near Jamie、Kawamura Kazunori、Zhang Ming-Rong、Suhara Tetsuya、Shimada Hitoshi、Higuchi Makoto
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 444 Pages: 120514-120514

    • DOI

      10.1016/j.jns.2022.120514

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935, KAKENHI-PROJECT-20K16681, KAKENHI-PROJECT-23K24259
  • [Journal Article] Synthesis and structure?activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein2023

    • Author(s)
      Wongso Hendris、Ono Maiko、Yamasaki Tomoteru、Kumata Katsushi、Higuchi Makoto、Zhang Ming-Rong、Fulham Michael J.、Katsifis Andrew、Keller Paul A.
    • Journal Title

      RSC Medicinal Chemistry

      Volume: 14 Issue: 5 Pages: 858-868

    • DOI

      10.1039/d2md00358a

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-23K27558
  • [Journal Article] High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy2022

    • Author(s)
      Matsuoka Kiwamu、Ono Maiko、Takado Yuhei、Hirata Kosei、Endo Hironobu、Ohfusa Toshiyuki、Kojima Taichi、Yamamoto Takeshi、Onishi Tomohiro et al.
    • Journal Title

      Movement Disorders

      Volume: 37 Issue: 10 Pages: 2159-2161

    • DOI

      10.1002/mds.29186

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-20K07935
  • [Journal Article] Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography2022

    • Author(s)
      Vagenknecht Patrick、Luzgin Artur、Ono Maiko、Ji Bin、Higuchi Makoto、Noain Daniela、Maschio Cinzia A.、Sobek Jens、Chen Zhenyue、Konietzko Uwe、Gerez Juan A.、Riek Roland、Razansky Daniel、Klohs Jan、Nitsch Roger M.、Dean-Ben Xose Luis、Ni Ruiqing
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 7 Pages: 2137-2152

    • DOI

      10.1007/s00259-022-05708-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022

    • Author(s)
      Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
    • Journal Title

      Aging Cell

      Volume: 21 Issue: 7

    • DOI

      10.1111/acel.13615

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PLANNED-18H05414, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-23K24214
  • [Journal Article] A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model2022

    • Author(s)
      Kimura Taeko、Ono Maiko、Seki Chie、Sampei Kazuaki、Shimojo Masafumi、Kawamura Kazunori、Zhang Ming-Rong、Sahara Naruhiko、Takado Yuhei、Higuchi Makoto
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 13 Pages: 4298-4311

    • DOI

      10.1007/s00259-022-05898-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446
  • [Journal Article] A Machine Learning-Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images2022

    • Author(s)
      Endo Hironobu、Tagai Kenji、Ono Maiko、Ikoma Yoko、Oyama Asaka、Matsuoka Kiwamu、Kokubo Naomi、Hirata Kosei et al.
    • Journal Title

      Movement Disorders

      Volume: 37 Issue: 11 Pages: 2236-2246

    • DOI

      10.1002/mds.29173

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-21K15705, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935
  • [Journal Article] An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607)2022

    • Author(s)
      Tagai Kenji、Ikoma Yoko、Endo Hironobu、Debnath Oiendrila Bhowmik、Seki Chie、Matsuoka Kiwamu、Matsumoto Hideki、Oya Masaki、Hirata Kosei、Shinotoh Hitoshi、Takahata Keisuke、Kurose Shin、Sano Yasunori、Ono Maiko、Shimada Hitoshi、Kawamura Kazunori、Zhang Ming-Rong、Takado Yuhei、Higuchi Makoto
    • Journal Title

      NeuroImage

      Volume: 264 Pages: 119763-119763

    • DOI

      10.1016/j.neuroimage.2022.119763

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K15776, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935
  • [Journal Article] In vivo binding of a tau imaging probe, [ 11 C]PBB3, in patients with progressive supranuclear palsy2019

    • Author(s)
      Endo Hironobu、Shimada Hitoshi、Sahara Naruhiko、Ono Maiko、Koga Shunsuke、Kitamura Soichiro、Niwa Fumitoshi、Hirano Shigeki、Kimura Yasuyuki、Ichise Masanori、Shinotoh Hitoshi、Zhang Ming Rong、Kuwabara Satoshi、Dickson Dennis W.、Toda Tatsushi、Suhara Tetsuya、Higuchi Makoto
    • Journal Title

      Movement Disorders

      Volume: 34 Issue: 5 Pages: 744-754

    • DOI

      10.1002/mds.27643

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
  • [Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018

    • Author(s)
      Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 61 Issue: 3 Pages: 1037-1052

    • DOI

      10.3233/jad-170509

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
  • [Journal Article] Comparative in-vitro quantification of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models2018

    • Author(s)
      Ni R, Ji B, Ono M, Sahara N, Zhang M-R, Aoki I, Nordberg A, Suhara T, Higuchi M
    • Journal Title

      J. Nuclear Medicine

      Volume: 117 Issue: 6 Pages: 960-966

    • DOI

      10.2967/jnumed.117.201632

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K19872
  • [Journal Article] Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula2018

    • Author(s)
      Shinotoh Hitoshi、Shimada Hitoshi、Kokubo Yasumasa、Tagai Kenji、Niwa Fumitoshi、Kitamura Soichiro、Endo Hironobu、Ono Maiko、Kimura Yasuyuki、Hirano Shigeki、Mimuro Maya、Ichise Masanori、Sahara Naruhiko、Zhang Ming-Rong、Suhara Tetsuya、Higuchi Makoto
    • Journal Title

      Neurology

      Volume: 92 Issue: 2

    • DOI

      10.1212/wnl.0000000000006736

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-18K06575
  • [Patent] 新規化合物、αシヌクレイン凝集体結合剤及びその利用2023

    • Inventor(s)
      樋口真人、小野麻衣子、張明栄、高堂裕平、松岡究、他
    • Industrial Property Rights Holder
      樋口真人、小野麻衣子、張明栄、高堂裕平、松岡究、他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] αシヌクレインイメージング2023

    • Author(s)
      小野 麻衣子
    • Organizer
      第63回日本核医学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] 生体マクロイメージングへの化学的アプローチの展望 -視るものから治すものへ-2023

    • Author(s)
      小野 麻衣子
    • Organizer
      第10回バイオ関連化学シンポジウム若手フォーラム, 日本化学会生体機能関連化学部会若手の会、日本化学会バイオテクノロジー部会若手の会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] PETイメージングで捉えるアストロサイト活動と脳エネルギー代謝2023

    • Author(s)
      小野 麻衣子
    • Organizer
      第34回 臨床MR脳機能研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] オートファジー関連因子p62と認知症病態2022

    • Author(s)
      小野麻衣子
    • Organizer
      第41回日本認知症学会学術集会 第37回日本老年精神医学会 合同開催
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] 認知症モデルマウスを用いたタウ病態研究~治療標的の探索2022

    • Author(s)
      小野麻衣子
    • Organizer
      第23回 日本脳神経核医学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] Advances in Alpha-Synuclein Imaging2022

    • Author(s)
      Maiko Ono
    • Organizer
      34th Annual Congress of the European Association of Nuclear Medicine
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a multimodal PET probe2022

    • Author(s)
      Maiko Ono
    • Organizer
      Neuro2022
    • Data Source
      KAKENHI-PROJECT-22K07529
  • [Presentation] 認知症疾患のタウ病理とイメージング2018

    • Author(s)
      小野麻衣子
    • Organizer
      第37回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K19872
  • [Presentation] Development of a tau PET ligand, [18F]PM-PBB32018

    • Author(s)
      Maiko Ono, Hitoshi Shimada, Soichiro Kitamura, Kenji Tagai, Manabu Kubota, Hiroyuki Takuwa, Paul Tempest, Ming-Kuei Jang, John Seibyl, Olivier Barret, David Alagille, Kenneth Marek, Naruhiko Sahara, Tetsuya Suhara, Ming-Rong Zhang, and Makoto Higuchi
    • Organizer
      AAT-AD/PD Focus Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19872
  • [Presentation] タウから見たアルツハイマー病の診断から治療の可能性2018

    • Author(s)
      小野麻衣子
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K19872
  • [Presentation] Pivotal roles of p62 and selective autophagy in tau deposition and consequent neurodegeneration revealed with tauopathy mouse models2013

    • Author(s)
      Maiko Ono
    • Organizer
      BRAIN 2013
    • Place of Presentation
      Shanghai
    • Data Source
      KAKENHI-PROJECT-23700431
  • [Presentation] Pivotal roles of p62 and selective autophagy in tau deposition and consequent neurodegeneration revealed with tauopathy mouse models2013

    • Author(s)
      Maiko Ono, Bin Ji, Masaki Tokunaga, Masaaki Komatsu, Tetsuro Ishii, Tetsuya Suhara and Makoto Higuchi
    • Organizer
      BRAIN 2013
    • Place of Presentation
      Shanghai China
    • Data Source
      KAKENHI-PROJECT-23700431
  • [Presentation] Selective autophagy in neurons and its involvement in the tau pathogenesis2012

    • Author(s)
      Maiko Ono
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver
    • Data Source
      KAKENHI-PROJECT-23700431
  • [Presentation] Selective autophagy in neurons and its involvement in the tau pathogenesis2012

    • Author(s)
      Maiko Ono, Bin Ji, Masaki Tokunaga, Takeharu Minamihisamatsu, Masahiro Maruyama, Jun Maeda, Masaaki Komatsu, Tetsuro Ishii, Eiji Warabi, Toru Yanagawa, Tetsuya Suhara and Makoto Higuchi
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver Canada
    • Data Source
      KAKENHI-PROJECT-23700431
  • [Presentation] Selective autophagy in neurons and its involvement in the tau pathogenesis2011

    • Author(s)
      Maiko Ono, Bin Ji, Masahiro Maruyama, Jun Maeda, Takeharu Minamihisamatsu, Tetsuya Suhara, Makoto Higuchi
    • Organizer
      日本神経科学学会 第34回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23700431
  • [Presentation] 神経細胞におけるタウ病理発現への選択的オートファジーの関与2011

    • Author(s)
      小野麻衣子
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23700431
  • 1.  Higuchi Makoto
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 2.  Aoki Ichio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  平田 浩聖
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  横田 隆徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  前田 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  下條 雅文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  佐原 成彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  小久保 康昌
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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