Uesaka Naofumi 上阪直史

… Alternative Names

UESAKA Naofumi 上阪直史

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Researcher Number	70597624
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 教授 2020 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 教授 2018 – 2019: 東京大学, 大学院医学系研究科(医学部), 講師 2016 – 2017: 東京大学, 大学院医学系研究科(医学部), 助教 2011 – 2015: 東京大学, 医学(系)研究科(研究院), 助教 2012: 東京大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (IV) / Basic Section 46030:Function of nervous system-related / Neurophysiology / General neuroscience / Complex systems / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Neuroscience in general Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 51:Brain sciences and related fields
Keywords	Principal Investigator 小脳 / 発達 / シナプス刈り込み / グリア / カルシウム / シナプス / 神経活動 / スクリーニング / 登上線維 / プルキンエ細胞 … More / 神経回路形成 / 脳自発活動 / 同期性 / 自発活動 / 神経回路 / 脳発達 / 脳 / 分子メカニズム / 逆行性シグナル / イメージング / 同期 / 腫瘍進展 / 神経伝達物質 / ネットワーク / 活動動態 / グリオーマ / 脳腫瘍 / 相互作用 / グリア細胞 / 神経細胞 / 腫瘍 / 刈り込み / 逆行性分子 / 神経回路再編成 / 精子形成 / 活動操作 / in vivo / 精巣 / 遺伝子操作 / 神経活動依存性 / 分子機構 / バーグマングリア / シナプス入力 / 機能的神経回路形成 / Arc / セマフォリン / 蛍光タンパク / マルチカラー / リアルタイムイメージング / レンチウィルス / 蛍光タンパク質 … More Except Principal Investigator 脳 / コネクトミクス / 脳内微小環境 / 神経膠腫 / 髄芽腫 / DREADD / てんかん / ニューロン / 膠芽腫 / 脳腫瘍 / PDX / 神経活動 / 小児脳腫瘍 / マウスモデル / グリオーマ / 脂質ナノ粒子 / マイクロバブル / 経頭蓋集束超音波 / ゲノム編集 / 遺伝子導入 / 微小気泡 / ソノポレーション / 超音波 / 細菌叢解析 / RNA-sequencing / 行動実験 / 口腔内細菌叢破綻 / 腸内細菌叢 / 口腔内細菌叢 / 歯周病 Less

発達期同期自発活動のメカニズムと生理的意義の解明Principal Investigator
- Principal Investigator
  
  上阪直史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Institute of Science Tokyo
The effects of oral dysbiosis on brain -cross talk among organs-
- Principal Investigator
  
  片桐さやか
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of effect on brain function in oral dysbiosis
- Principal Investigator
  
  大杉勇人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Development of transcranial gene manipulation technologies
- Principal Investigator
  
  竹内雄一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Hokkaido University
Design-build of cerebellar circuit by generation and transtion of multi-dimension spontaneous activityPrincipal Investigator
- Principal Investigator
  
  上阪直史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  Tokyo Medical and Dental University
Design and Build of Brain by Emergence and Transition of Multidimensional Spontaneous ActivityArea Organizer
- Area Organizer
  
  上阪直史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
Design-build of brain by generation and transtion of multi-dimension spontaneous activityPrincipal Investigator
- Principal Investigator
  
  上阪直史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  Tokyo Medical and Dental University
Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor development
- Principal Investigator
  
  川内大輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Nagoya City University
  National Center of Neurology and Psychiatry
Elucidation of singularity mechanisms for brain tumor growthPrincipal Investigator
- Principal Investigator
  
  上阪直史
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University
Elucidation of a network between brain and testisPrincipal Investigator
- Principal Investigator
  
  Uesaka Naofumi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  The University of Tokyo
Activity-dependent mechanisms regulating synapse eliminationPrincipal Investigator
- Principal Investigator
  
  Uesaka Naofumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tokyo Medical and Dental University
  The University of Tokyo
Molecular mechanisms of activity dependent neural circuit refinementPrincipal Investigator
- Principal Investigator
  
  Uesaka Naofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  The University of Tokyo
Elucidation of activity-dependency and molecular mechanisms of synapse eliminationPrincipal Investigator
- Principal Investigator
  
  UESAKA Naofumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  The University of Tokyo
Real-time and multi-color imaging of synapse elimination in the CNS.Principal Investigator
- Principal Investigator
  
  UESAKA Naofumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo

[Journal Article] Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling2023
- Author(s)
  Walter Alexander、Uesaka Naofumi、Midorikawa Mitsuharu
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 17
- DOI
  10.3389/fncel.2023.1213640
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19367, KAKENHI-ORGANIZER-22H05092, KAKENHI-PLANNED-22H05093, KAKENHI-PROJECT-23K21347
[Journal Article] ATP activation of peritubular cells drives testicular sperm transport2021
- Author(s)
  Fleck David、Kenzler Lina、Mundt Nadine、Strauch Martin、Uesaka Naofumi、Moosmann Robert、Bruentgens Felicitas、Missel Annika、Mayerhofer Artur、Merhof Dorit、Spehr Jennifer、Spehr Marc
- Journal Title
  
  eLife
  
  Volume: 10 Pages: 10-10
- DOI
  10.7554/elife.62885
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02539
[Journal Article] AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication2020
- Author(s)
  Yamashiro Kunihiko、Hori Kei、Lai Esther S.K.、Aoki Ryo、Shimaoka Kazumi、Arimura Nariko、Egusa Saki F.、Sakamoto Asami、Abe Manabu、Sakimura Kenji、Watanabe Takaki、Uesaka Naofumi、Kano Masanobu、Hoshino Mikio
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 12 Pages: 101820-101820
- DOI
  10.1016/j.isci.2020.101820
- NAID
  120006979860
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07071, KAKENHI-ORGANIZER-16H06524, KAKENHI-PUBLICLY-19H05415, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-19H03536, KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538
[Journal Article] Phospholipase C β3 is required for climbing fiber synapse elimination in aldolase C-positive compartments of the developing mouse cerebellum2020
- Author(s)
  Rai Yurie、Watanabe Takaki、Matsuyama Kyoko、Sakimura Kenji、Uesaka Naofumi、Kano Masanobu
- Journal Title
  
  Neuroscience
  
  Volume: 462 Pages: 36-43
- DOI
  10.1016/j.neuroscience.2020.04.035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-18H02540, KAKENHI-PLANNED-20H05915, KAKENHI-PROJECT-21H04785, KAKENHI-ORGANIZER-20H05914
[Journal Article] Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex.2020
- Author(s)
  Sacai Hiroaki、Sakoori Kazuto、Konno Kohtarou、Nagahama Kenichiro、Suzuki Honoka、Watanabe Takaki、Watanabe Masahiko、Uesaka Naofumi、Kano Masanobu
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5140-5140
- DOI
  10.1038/s41467-020-18861-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05204, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-18H02539
[Journal Article] Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum2018
- Author(s)
  Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K and Kano M
- Journal Title
  
  Neuron
  
  Volume: 94（４）
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05568
[Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum2018
- Author(s)
  Kano Masanobu、Watanabe Takaki、Uesaka Naofumi、Watanabe Masahiko
- Journal Title
  
  The Cerebellum
  
  Volume: 17 Issue: 6 Pages: 722-734
- DOI
  10.1007/s12311-018-0964-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19322, KAKENHI-PROJECT-18H02539, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-25000015
[Journal Article] Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain2014
- Author(s)
  Uesaka N, Uchigashima,M, Mikuni T, Nakazawa T, Nakao H, Hirai K, Aiba A, Watanabe M, Kano M
- Journal Title
  
  Science
  
  Volume: 344 Issue: 6187 Pages: 1020-1023
- DOI
  10.1126/science.1252514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-25000015, KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-25640033, KAKENHI-PROJECT-25830004, KAKENHI-PROJECT-25830031
[Journal Article] Cellular and molecular mechanisms of synapse elimination in the Mammalian brai2014
- Author(s)
  Uesaka N, Kawata S, Kano M
- Journal Title
  
  Brain Nerve
  
  Volume: 66 Pages: 1069-77
- Data Source
  KAKENHI-PROJECT-25830004
[Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain2012
- Author(s)
  Uesaka N
- Journal Title
  
  J Neurosci
  
  Volume: 32 Issue: 34 Pages: 11688-11699
- DOI
  10.1523/jneurosci.1097-12.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220006, KAKENHI-PROJECT-22300125, KAKENHI-PROJECT-23650160, KAKENHI-PROJECT-23650204
[Journal Article] Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression2012
- Author(s)
  Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Manabu Abe, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura and Masanobu Kano
- Journal Title
  
  Proc Natl Acad Sci U S A
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650160
[Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain2012
- Author(s)
  Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M
- Journal Title
  
  J. Neurosci
  
  Volume: 32(34) Pages: 11657-11670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650160
[Patent] 神経膠腫治療剤、および神経膠腫細胞の増殖抑制方法2024
- Inventor(s)
  上阪直史, 川内大輔, 金村米博
- Industrial Property Rights Holder
  上阪直史, 川内大輔, 金村米博
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22H00459
[Patent] 小脳または大脳皮質における細胞において所定の遺伝子を発現させるためのベクター2023
- Inventor(s)
  上阪　直史　関口　真理子
- Industrial Property Rights Holder
  上阪　直史　関口　真理子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-193935
- Filing Date
  2023
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Patent] 小脳または大脳皮質における細胞において所定の遺伝子を発現させるためのベクター2023
- Inventor(s)
  上阪　直史　関口　真理子
- Industrial Property Rights Holder
  上阪　直史　関口　真理子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-193935
- Filing Date
  2023
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] 成長期の鼻呼吸障害が小脳の発達と機能に与える影響2023
- Author(s)
  谷川萌、加藤千帆、小野卓史、上阪直史
- Organizer
  第14回三叉神経領域の感覚運動統合機構研究会　抄録＿谷川1026
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] Neuronal and Synaptic Influences on Brain Tumors2023
- Author(s)
  Naofumi Uesaka, Daisuke Kawauchi
- Organizer
  シナプス研究会2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 発達期小脳オリゴデンドロサイトはシナプス刈り込みと脳機能を制御する2023
- Author(s)
  上阪直史
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] Development of cell-type specific AAV vectors in the mouse brain2023
- Author(s)
  上阪　直史、増村　嶺、関口　真理子
- Organizer
  日本生理学会　第１００回記念大会
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression2023
- Author(s)
  Naofumi Uesaka, Daisuke Kawauchi
- Organizer
  1st Heidelberg Conference on Cancer Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 成長期の鼻呼吸障害が小脳の神経回路と機能に及ぼす影響2023
- Author(s)
  谷川萌1、加藤千帆1、小野卓史1、上阪直史
- Organizer
  日本生理学会　第１００回記念大会
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 口腔システム不全による脳発達と脳機能の障害2023
- Author(s)
  上阪直史
- Organizer
  第 101 回日本生理学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 口腔システム不全による脳発達と脳機能の障害2023
- Author(s)
  上阪直史
- Organizer
  第 101 回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] 成長期の鼻呼吸障害が小脳の発達と機能に与える影響2023
- Author(s)
  谷川萌、加藤千帆、小野卓史、上阪直史
- Organizer
  第14回三叉神経領域の感覚運動統合機構研究会　抄録＿谷川1026
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] 神経細胞とシナプスによる脳腫瘍進展メカニズム2023
- Author(s)
  上阪直史
- Organizer
  第４６回日本神経組織培養研究会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] 発達期小脳オリゴデンドロサイトはシナプス刈り込みと脳機能を制御する2023
- Author(s)
  上阪直史
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] Developmental oligodendrocytes contribute to cerebellar maturation.2023
- Author(s)
  増村　嶺、上阪　直史
- Organizer
  日本生理学会　第１００回記念大会
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 神経細胞とシナプスによる脳腫瘍進展メカニズム2023
- Author(s)
  上阪直史
- Organizer
  第４６回日本神経組織培養研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] Neuronal and Synaptic Influences on Brain Tumors2023
- Author(s)
  Naofumi Uesaka, Daisuke Kawauchi
- Organizer
  シナプス研究会2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] 細胞タイプ特異的遺伝子操作法の確立と結節性硬化症の治療戦略への応用2023
- Author(s)
  上阪直史
- Organizer
  第11回日本結節性硬化症学会学術総会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 細胞タイプ特異的遺伝子操作法の確立と結節性硬化症の治療戦略への応用2023
- Author(s)
  上阪直史
- Organizer
  第11回日本結節性硬化症学会学術総会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] Developmental oligodendrocytes as a key player in developmental synchrony and the modulation of brain functionality2023
- Author(s)
  上阪直史
- Organizer
  第38回熊本医学・生物科学国際シンポジウム「機能的脳神経回路システムの構築メカニズム」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] 結紮誘導歯周炎モデルマウスを用いた口腔-脳-腸連関の解明2023
- Author(s)
  大杉勇人, 今井千尋, 片桐さやか, 廣田朝光, 芝多佳彦, 豊嶋啓汰, 上阪直史, 岩田隆紀
- Organizer
  第66回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] Developmental oligodendrocytes as a key player in developmental synchrony and the modulation of brain functionality2023
- Author(s)
  上阪直史
- Organizer
  第38回熊本医学・生物科学国際シンポジウム「機能的脳神経回路システムの構築メカニズム」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] Cerebellar oligodendrocytes during development shape cerebellar circuit and behaviors2023
- Author(s)
  増村嶺、上阪直史
- Organizer
  第４５回日本分子生物学会
- Data Source
  KAKENHI-ORGANIZER-22H05092
[Presentation] Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression2023
- Author(s)
  Naofumi Uesaka, Daisuke Kawauchi
- Organizer
  1st Heidelberg Conference on Cancer Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05093
[Presentation] From Astrocyte to Neuron signaling in developmental synapse remodeling2022
- Author(s)
  上阪　直史
- Organizer
  第3回先端脳科学国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00419
[Presentation] Astrocyte-Neuron signaling in developmental synapse remodeling2022
- Author(s)
  上阪　直史
- Organizer
  第99回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00419
[Presentation] アストロサイトは2型イノシトール3リン酸受容体を介して発達期小脳のシナプス刈り込みを制御する2021
- Author(s)
  上阪直史、赤松翼, 鈴木穂香, 狩野方伸
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Astrocytes regulate synapse elimination in the developing cerebellum.2021
- Author(s)
  上阪　直史
- Organizer
  第64回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00419
[Presentation] MEF2D は発達期の小脳において後期のシナプス刈り込みに関与する2021
- Author(s)
  鈴木穂香, Choo Myeongjeong, 渡邉貴樹, 崎村建司, 上阪直史, 狩野方伸
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Protocadherin 10は一部のアルドラーゼＣ陽性の小脳プルキンエ細胞において発達期の登上線維シナプスの刈り込みを遅延させる2020
- Author(s)
  渡邉貴樹, 佐郡和人, 鈴木穂香, 赤松翼, 松山恭子, 井上秀太郎, 阿部学, 﨑村建司, 上阪直史, 狩野方伸
- Organizer
  ４３回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum2020
- Author(s)
  Takaki Watanabe，Honoka Suzuki，Kazuto Sakoori，Shutaro Inoue，Tsubasa Akamatsu， Manabu Abe，Kenji Sakimura，Naofumi Uesaka，Masanobu Kano,
- Organizer
  第９７回日本生理学会大会・大分
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Astrocytes regulate synapse elimination in the developing cerebellum2020
- Author(s)
  上阪直史
- Organizer
  NIG Symposium 2020
- Invited
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum2020
- Author(s)
  Takaki Watanabe1, 2，Honoka Suzuki1，Kazuto Sakoori1，Shutaro Inoue1，Tsubasa Akamatsu1， Manabu Abe3，Kenji Sakimura3，Naofumi Uesaka1, 2，Masanobu Kano1,
- Organizer
  第９７回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Activity-dependent synapse elimination in the developing cerebellum2019
- Author(s)
  Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
- Organizer
  FAOPS2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] 精神疾患関連エピジェネティクス因子の欠損が、マウス内側前頭前野錐体細胞への興奮性シナプス入力の減弱と異常行動を引き起こす2019
- Author(s)
  濱健一郎 / 佐郡和人 / 渡邉貴樹 / 古戎道典 / 上阪直史 / 饗場篤 / 狩野方伸
- Organizer
  第４２回日本神経科学学会・新潟
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Activity-dependent synapse elimination in the developing cerebellum2019
- Author(s)
  Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
- Organizer
  FAOPS2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] 発達期小脳において、アルドラーゼC陽性プルキンエ細胞の登上線維シナプス刈り込みはアルドラーゼC陰性プルキンエ細胞よりも遅れ、ホスホリパーゼC β3を必要とする2019
- Author(s)
  渡邉貴樹 / 賴友梨恵 / 鈴木穂香 / 赤松翼 / 上阪直史 / 狩野方伸
- Organizer
  第４２回日本神経科学学会・新潟
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] 精神疾患関連エピジェネティクス因子の欠損が、マウス内側前頭前野錐体細胞への興奮性シナプス入力の減弱と異常行動を引き起こす2019
- Author(s)
  濱健一郎 / 佐郡和人 / 渡邉貴樹 / 古戎道典 / 上阪直史 / 饗場篤 / 狩野方伸
- Organizer
  第４２回日本神経科学学会・新潟
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 102019
- Author(s)
  Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 102019
- Author(s)
  Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum2019
- Author(s)
  Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] 発達期小脳において、アルドラーゼC陽性プルキンエ細胞の登上線維シナプス刈り込みはアルドラーゼC陰性プルキンエ細胞よりも遅れ、ホスホリパーゼC β3を必要とする2019
- Author(s)
  渡邉貴樹 / 賴友梨恵 / 鈴木穂香 / 赤松翼 / 上阪直史 / 狩野方伸
- Organizer
  第４２回日本神経科学学会・新潟
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor2019
- Author(s)
  Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum2019
- Author(s)
  Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor2019
- Author(s)
  Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2018
- Author(s)
  Tzu-Huei Kao, Kyoko Matsuyama, Naofumi Uesaka, Masanobu Kano
- Organizer
  第４１回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum2018
- Author(s)
  Myeong Jeong Choo:Naofumi Uesaka:Masahiko Watanabe:Kenji Sakimura:Masanobu Kano:
- Organizer
  第４１回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum2018
- Author(s)
  Myeong Jeong Choo, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
- Organizer
  第４１回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2018
- Author(s)
  Tzu-Huei Kao:Kyoko Matsuyama:Naofumi Uesaka:Masanobu Kano
- Organizer
  第４１回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] Impaired Synapse Development in Mouse Medial Prefrontal Cortex by Deletion of a Histone-Modifying Enzyme Implicated in Psychiatric Disorder2018
- Author(s)
  Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe,　Naofumi Uesaka,　Masanobu Kano
- Organizer
  第４１回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-18H02539
[Presentation] Impaired Synapse Development in Mouse Medial Prefrontal Cortex by Deletion of a Histone-Modifying Enzyme Implicated in Psychiatric Disorder2018
- Author(s)
  Kenichiro Nagahama: Kazuto Sakoori:Takaki Watanabe:Naofumi Uesaka:Masanobu Kano
- Organizer
  第４１回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K19322
[Presentation] BDNF to TrkB signaling promotes climbing fiber synapse elimination in the developing cerebellum2017
- Author(s)
  Myeong Jeong Choo,Taisuke Miyazaki, Maya Yamasaki, Meiko Kawamura, Takanobu Nakazawa, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
- Organizer
  第４０回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Calcium channels in cerebellar synapses bind to extracellular ligand and organize presynaptic active zones2017
- Author(s)
  Hiroshi Nishimune,Takafumi Mizushige, Naofumi Uesaka, Tomohiro Numata, Jie Chen, Badawi Yomna, Yomna Badawi, Yasuo Mori, Masanobu Kano
- Organizer
  第４０回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Regulation of climbing fiber synapse elimination in the developing cerebellum by retrograde signaling2017
- Author(s)
  Naofumi Uesaka and Masanobu Kano
- Organizer
  第４０回日本神経科学学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Roles of retrograde signaling in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2017
- Author(s)
  Naofumi Uesaka and Masanobu Kano
- Organizer
  the 8th International Symposium of the Society for Research on the Cerebellum and Ataxia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Involvement of Fndc3b, a fibronectin type III domain-containing protein, in climbing fiber synapse elimination during postnatal cerebellar development2017
- Author(s)
  Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
- Organizer
  第４０回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Screening of autism spectrum disorder-associated molecules that are involved in climbing fiber-Purkinje cell synapse elimination in the developing mouse cerebellum2017
- Author(s)
  Takaki Watanabe, Shutaro Inoue, Naofumi Uesaka, Masanobu Kano
- Organizer
  第４０回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] The frontotemporal dementia related gene, granulin regulates developmental synapse elimination in the cerebellum2016
- Author(s)
  上阪　直史、狩野　方伸
- Organizer
  第９３回　日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Type 1 metabotropic glutamate receptor maintains matu re retinogenicu late synaptic connectivity in the visual thalamus2016
- Author(s)
  鳴島　円、内ヶ島　基政、矢ヶ崎　有希、原田　武志、南雲　康之、上阪　直史、渡邉　貴樹、橋本　浩一、饗場　篤、渡辺　雅彦、宮田　麻理子、狩野　方伸
- Organizer
  第９３回　日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Progranulin regulates climbing fiber synapse elimination during postnatal cerebellar development2015
- Author(s)
  上阪直史、阿部学、山崎真弥、今野幸太郎、三國貴康、渡辺雅彦、崎村建司、狩野方伸
- Organizer
  第３８回　日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫・神戸）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] 脳の機能発達を担うシナプス刈り込みの機構2015
- Author(s)
  上阪直史
- Organizer
  若手研究者による小脳研究の最前線
- Place of Presentation
  東京・品川
- Year and Date
  2015-01-10
- Invited
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] Knockdown of CNTNAP2 in neurons of the prefrontal cortex impairs synaptic function and causes impaired social behavior2015
- Author(s)
  酒井浩旭、佐郡和人、上阪直史、狩野方伸
- Organizer
  第３８回　日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫・神戸）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] 逆行性シグナルによる発達期シナプス刈り込みの制御2015
- Author(s)
  上阪直史
- Organizer
  生理研研究会「シナプスの構造構築と機能発現の分子基盤」
- Place of Presentation
  生理学研究所（愛知・岡崎）
- Year and Date
  2015-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Roles of neuroligin-2 in inhibitory synaptic transmission and climbing fiber synapse elimination in Purkinje cells during postnatal cerebellar development2015
- Author(s)
  Suk King Lai、Naofumi Uesaka、Masanobu Kano
- Organizer
  第３８回　日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫・神戸）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Retrograde signaling involved in climbing fiber synapse elimination in the developing cerebellum2015
- Author(s)
  狩野方伸、上阪直史
- Organizer
  第３８回　日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫・神戸）
- Year and Date
  2015-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H05568
[Presentation] Retrograde signaling regulates synapse elimination in developing brain2014
- Author(s)
  Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Hirai Hirokazu, Watanabe Masahiko, Kano Masanobu
- Organizer
  第９１回日本生理学会
- Place of Presentation
  鹿児島、日本
- Invited
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] Functional screening of molecules required for developmental synapse elimination in the cerebellum by RNAi-based approach2013
- Author(s)
  Naofumi Uesaka, Takayasu Mikuni, Hirokazu Hirai, Masanobu Kano
- Organizer
  Gordon Research Conference on the Cerebellum
- Place of Presentation
  Colby-Sawyer College New London, NH, USA
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズムの解明2013
- Author(s)
  上阪直史
- Organizer
  第90回日本生理学会
- Place of Presentation
  東京・タワーホール船堀
- Invited
- Data Source
  KAKENHI-PROJECT-23650160
[Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズムの解明2013
- Author(s)
  上阪直史
- Organizer
  第90回(平成24年度)日本生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650160
[Presentation] Identification of retrograde signaling molecules required for developmental synapse elimination in the cerebellum by an RNAi-based approach2013
- Author(s)
  Naofumi Uesaka, Takayasu Mikuni, Hirokazu Hirai, Masanobu Kano
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 2-アラキドノイルグリセロールリパーゼは小脳皮質においてシナプス非特異的に分解される2011
- Author(s)
  谷村あさみ, 山崎真弥, 内が島基政, 上阪直史, 三国貴康, 橋本浩一, 渡辺雅彦, 崎村建二, 狩野方伸
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、神奈川
- Data Source
  KAKENHI-PROJECT-23650160
[Presentation] Postsynaptic Purkinje cell activity accelerates climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata2011
- Author(s)
  三國貴康, 上阪直史, 狩野方伸
- Organizer
  Neuroscience 2011
- Place of Presentation
  ワシントン、米国
- Data Source
  KAKENHI-PROJECT-23650160
[Presentation] 発達期におこるシナプス刈り込みを制御する逆行性シグナル
- Author(s)
  上阪直史
- Organizer
  生理研研究会「シナプス・神経ネットワークの機能ダイナミクス」
- Place of Presentation
  愛知・岡崎
- Year and Date
  2014-12-02 – 2014-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] SCREENING OF RETROGRADE SIGNALING MOLECULES FOR SYNAPSE ELIMINATION IN THE DEVELOPING CEREBELLUM
- Author(s)
  N. Uesaka, M. Uchigashima, T. Mikuni, T. Nakazawa, H. Hirai, M. Watanabe, M. Kano
- Organizer
  ヨーロッパ神経科学学会（FENS）
- Place of Presentation
  イタリア・ミラノ
- Year and Date
  2014-07-05 – 2014-07-09
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 発達期小脳シナプス刈り込みにプルキンエ細胞由来BDNFが寄与している
- Author(s)
  秋明貞,　宮崎太輔, 山崎真弥, 谷村あさみ, 上阪直史, 渡辺雅彦, 崎村健司,狩野方伸
- Organizer
  第３７回日本神経科学学会
- Place of Presentation
  神奈川・横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 発達期シナプス刈り込みを制御する逆行性シグナル分子の同定
- Author(s)
  上阪直史、狩野方伸
- Organizer
  第９２回生理学会大会
- Place of Presentation
  兵庫・神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 前頭側頭型認知症原因遺伝子granulinが発達期シナプス刈り込みを制御する
- Author(s)
  上阪直史,阿部学,山崎真弥,今野幸太郎,三國貴康,渡辺雅彦,崎村建司,狩野方伸
- Organizer
  第３８回日本神経科学学会
- Place of Presentation
  兵庫・神戸
- Year and Date
  2015-07-28 – 2015-07-31
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] Sema3AとSema7Aによる逆行性シグナルがシナプス刈り込みを制御している
- Author(s)
  上阪直史，内ヶ島基政，三國貴康，中澤敬信，中尾晴美，平井宏和，饗場篤，渡辺雅彦，狩野方伸
- Organizer
  第３７回日本神経科学学会
- Place of Presentation
  神奈川・横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] IMPAIRMENT OF DEVELOPMENTAL SYNAPSE ELIMINATION IN THE CEREBELLUM OF PURKINJE CELL-SPECIFIC BDNF KNOCKOUT MICE
- Author(s)
  M. Choo, T. Miyazaki, M. Yamasaki, A. Tanimura, N. Uesaka, M. Watanabe, K. Sakimura, M. Kano
- Organizer
  ヨーロッパ神経科学学会（FENS）
- Place of Presentation
  イタリア・ミラノ
- Year and Date
  2014-07-05 – 2014-07-09
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] Granulin-Sort1シグナルが発達期シナプス刈り込みにおけるシナプス強化・維持シグナルとして働く
- Author(s)
  上阪直史
- Organizer
  グリアクラブ
- Place of Presentation
  北海道・函館
- Year and Date
  2015-01-26 – 2015-01-28
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 自閉症感受性遺伝子を前頭前野でノックダウンしたマウスのシナプス機能異常と社会的行動の異常
- Author(s)
  酒井浩旭,　佐郡和人,　上阪直史, 狩野方伸
- Organizer
  第９２回生理学会大会
- Place of Presentation
  兵庫・神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25830004
[Presentation] 前頭前野ニューロンにおけるCNTNAP2のノックダウンはシナプス機能の障害と自閉症様行動を引き起こす
- Author(s)
  酒井浩旭,上阪直史, 狩野方伸
- Organizer
  第３８回日本神経科学学会
- Place of Presentation
  兵庫・神戸
- Year and Date
  2015-07-28 – 2015-07-31
- Data Source
  KAKENHI-PROJECT-25830004
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1. 廣田朝光 (50435674)

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2. 水野秀信 (00567159)

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3. 早川隆 (30756789)

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4. 千葉逸人 (70571793)

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# of Collaborated Products: 0 results
5. 片桐さやか (60510352)

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6. 高橋宏和 (20607783)

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7. 杉原玄一 (70402261)

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8. 大杉勇人 (80846791)

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9. 田村赳紘 (70793876)

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10. 竹内雄一 (70588384)

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11. 真栄城正寿 (40744248)

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12. 川内大輔 (10400996)

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13. 丸山玲緒 (60607985)

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14. 岩崎真樹 (00420018)

# of Collaborated Projects: 1 results

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15. NARIKO Arimura

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# of Collaborated Products: 1 results
16. NAKAZAWA Takanobu

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# of Collaborated Products: 1 results
17. 狩野方伸

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# of Collaborated Products: 3 results
18. 平井宏和

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# of Collaborated Products: 1 results
19. 阿部修

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20. 渡辺雅彦

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# of Collaborated Products: 1 results
21. 饗場篤

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# of Collaborated Products: 1 results
22. 緑川光春

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# of Collaborated Products: 1 results

Uesaka Naofumi 上阪 直史

UESAKA Naofumi 上阪 直史

Research Projects

Research Products

Co-Researchers

発達期同期自発活動のメカニズムと生理的意義の解明Principal Investigator

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The effects of oral dysbiosis on brain -cross talk among organs-

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Elucidation of effect on brain function in oral dysbiosis

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Development of transcranial gene manipulation technologies

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Design-build of cerebellar circuit by generation and transtion of multi-dimension spontaneous activityPrincipal Investigator

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Design and Build of Brain by Emergence and Transition of Multidimensional Spontaneous ActivityArea Organizer

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Design-build of brain by generation and transtion of multi-dimension spontaneous activityPrincipal Investigator

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Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor development

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Elucidation of singularity mechanisms for brain tumor growthPrincipal Investigator

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Elucidation of a network between brain and testisPrincipal Investigator

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Activity-dependent mechanisms regulating synapse eliminationPrincipal Investigator

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Molecular mechanisms of activity dependent neural circuit refinementPrincipal Investigator

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Elucidation of activity-dependency and molecular mechanisms of synapse eliminationPrincipal Investigator

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Uesaka Naofumi 上阪直史

UESAKA Naofumi 上阪直史