Motani Kou 茂谷康

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MOTANI Kou 茂谷康

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Researcher Number	70609049
Other IDs
External Links
Affiliation (Current)	2025: 徳島大学, 先端酵素学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 徳島大学, 先端酵素学研究所, 准教授 2020 – 2021: 徳島大学, 先端酵素学研究所, 講師 2018 – 2019: 徳島大学, 先端酵素学研究所(オープンイノベ), 講師 2016 – 2017: 徳島大学, 先端酵素学研究所(オープンイノベ), 助教 2015: 徳島大学, 藤井節郎記念医科学センター, 助教 2012: 京都大学, 医学(系)研究科(研究院), 研究員 2011 – 2012: 京都大学, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 43030:Functional biochemistry-related / Basic Section 49010:Pathological biochemistry-related / Immunology
Keywords	Principal Investigator STING / 細胞内輸送 / オルガネラコンタクト / ACBD3 / cGAMP / 炎症 / 免疫学 / 自然免疫 / Sec24 / Sec23 … More / APEX2 / ER exit sites / Sec24C / 小胞輸送 / ERES / COPII / シグナル伝達 / IFITM3 / ADAM17 / Tamavidin / BioID / SEMA4D / cGAS / DNA Less

自然免疫分子STINGの輸送を駆動する小胞体-ゴルジ体接触領域の時空間解析Principal Investigator
- Principal Investigator
  
  茂谷康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  The University of Tokushima
Combining genetics and proteomics to elucidate selective transport systems that regulate inflammation.Principal Investigator
- Principal Investigator
  
  MOTANI Kou
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  The University of Tokushima
Elucidation of the mechanisms underlying cyclic di-nucleotides-induced rheumatoid arthritis to develop novel therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  MOTANI Kou
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of production of the novel second messenger cGAMP and its inflammatory signalingPrincipal Investigator
- Principal Investigator
  
  MOTANI Kou
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Searching and functional analysis of an intracellular DNA sensorPrincipal Investigator
- Principal Investigator
  
  MOTANI Kou
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Optimized Workflow for Enrichment and Identification of Biotinylated Peptides Using Tamavidin 2-REV for BioID and Cell Surface Proteomics2022
- Author(s)
  Nishino Kohei、Yoshikawa Harunori、Motani Kou、Kosako Hidetaka
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 21 Issue: 9 Pages: 2094-2103
- DOI
  10.1021/acs.jproteome.2c00130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-20K07340, KAKENHI-PROJECT-21K06138
[Journal Article] The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER2022
- Author(s)
  Motani Kou、Saito-Tarashima Noriko、Nishino Kohei、Yamauchi Shunya、Minakawa Noriaki、Kosako Hidetaka
- Journal Title
  
  Cell Reports
  
  Volume: 41 Issue: 12 Pages: 111868-111868
- DOI
  10.1016/j.celrep.2022.111868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-20K07340, KAKENHI-PROJECT-21H02606, KAKENHI-PROJECT-21K19052
[Journal Article] Cell-autonomous <i>Toxoplasma</i> killing program requires Irgm2 but not its microbe vacuolar localization2021
- Author(s)
  Pradipta Ariel、Sasai Miwa、Motani Kou、Ma Ji Su、Lee Youngae、Kosako Hidetaka、Yamamoto Masahiro
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 7 Pages: e202000960-e202000960
- DOI
  10.26508/lsa.202000960
- NAID
  120007185166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05771, KAKENHI-PROJECT-19H00970, KAKENHI-PROJECT-20K07340, KAKENHI-PROJECT-18H02642
[Journal Article] BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)2020
- Author(s)
  Motani Kou、Kosako Hidetaka
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 32 Pages: 11174-11183
- DOI
  10.1074/jbc.ra120.014323
- NAID
  120007132263
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-20K07340, KAKENHI-PUBLICLY-19H04966
[Journal Article] AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions2020
- Author(s)
  Kido K, Yamanaka S, Nakano S, Motani K, Shinohara S, Nozawa A, Kosako H, Ito S and Sawasaki T
- Journal Title
  
  Elife
  
  Volume: 9
- DOI
  10.7554/elife.54983
- NAID
  120007125057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07340, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H04966, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H02951
[Journal Article] Phosphoproteomic identification and functional characterization of protein kinase substrates by 2D-DIGE and Phos-tag PAGE2019
- Author(s)
  Motani K, Kosako H
- Journal Title
  
  Biochim Biophys Acta Proteins Proteomics
  
  Volume: 1867 Issue: 1 Pages: 57-61
- DOI
  10.1016/j.bbapap.2018.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08635, KAKENHI-PROJECT-17K08661, KAKENHI-PROJECT-18KK0229
[Journal Article] Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.2018
- Author(s)
  Motani, K.*, and Kosako, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Issue: 20 Pages: 7717-7726
- DOI
  10.1074/jbc.ra118.002175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08661, KAKENHI-PROJECT-15K19024, KAKENHI-PROJECT-17K08635
[Journal Article] Global Identification of ERK Substrates by Phosphoproteomics Based on IMAC and 2D-DIGE.2017
- Author(s)
  H. Kosako, K. Motani.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1487 Pages: 137-149
- DOI
  10.1007/978-1-4939-6424-6_10
- ISBN
  9781493964222, 9781493964246
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440101, KAKENHI-PROJECT-15K19024
[Journal Article] DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.2015
- Author(s)
  Kou Motani, Shinji Ito, and Shigekazu Nagata
- Journal Title
  
  The Journal of Immunology
  
  Volume: 194 Issue: 10 Pages: 4914-4923
- DOI
  10.4049/jimmunol.1402705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19024, KAKENHI-PROJECT-22000013, KAKENHI-PROJECT-15H05785
[Presentation] 自然免疫分子STINGのオルガネラ間移行を駆動する小胞体ーゴルジ体コンタクトサイト形成因子の同定2023
- Author(s)
  茂谷　康、田良島　典子、西野　耕平、山内　駿弥、南川　典昭、小迫　英尊
- Organizer
  第75回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-20K07340
[Presentation] 自然免疫分子STINGのオルガネラ間移行を駆動する小胞体ーゴルジ体コンタクトサイト形成因子の同定2023
- Author(s)
  茂谷　康、田良島　典子、西野　耕平、山内　駿弥、南川　典昭、小迫　英尊
- Organizer
  第75回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-23K05697
[Presentation] 膜透過型STINGアゴニストとしてのbis-pivSATE-2'-F-c-di-dAMPの創製2022
- Author(s)
  山内駿弥, 田良島典子, 茂谷康, 小迫英尊, 南川典昭
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07340
[Presentation] ACBD3 forms specialized ER-Golgi contact sites to drive the ER exit of STING2022
- Author(s)
  Motani K, Saito-Tarashima N, Nishino K, Yamauchi S, Minakawa N, Kosako H
- Organizer
  The 17th International Symposium of the Institute Network
- Data Source
  KAKENHI-PROJECT-20K07340
[Presentation] 細胞質DNAによって活性化されるシグナル伝達機構2020
- Author(s)
  茂谷康
- Organizer
  第70回日本電気泳動学会シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07340
[Presentation] 細胞質DNAによって活性化されるシグナル伝達機構とその役割2019
- Author(s)
  茂谷　康
- Organizer
  核酸代謝鶴岡カンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-17K08661
[Presentation] BioID法によるビオチン化部位の大規模スクリーニングで明らかとなったSTINGタンパク質の相互作用因子2018
- Author(s)
  茂谷康
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08661
[Presentation] TBK1によるATG8ファミリー分子GABARAPL2のリン酸化の機能解析2017
- Author(s)
  茂谷康
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K19024
[Presentation] Identification of STING-dependent secreted proteins using quantitative proteomic analysis.2016
- Author(s)
  茂谷　康
- Organizer
  第26回ホットスプリングハーバー国際シンポジウム－Trans-Omics: New Approaches in Biology and Medicine－
- Place of Presentation
  九州大学病院キャンパスコラボステーションＩ（福岡県福岡市）
- Year and Date
  2016-11-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19024
[Presentation] 細胞内自己DNAによるcGAMP/STING経路依存的・非依存的なサイトカイン誘導2015
- Author(s)
  茂谷　康
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K19024

1. 小迫英尊

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 山本雅裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Motani Kou 茂谷 康

MOTANI Kou 茂谷 康

Research Projects

Research Products

Co-Researchers

自然免疫分子STINGの輸送を駆動する小胞体-ゴルジ体接触領域の時空間解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Combining genetics and proteomics to elucidate selective transport systems that regulate inflammation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms underlying cyclic di-nucleotides-induced rheumatoid arthritis to develop novel therapeutic strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of production of the novel second messenger cGAMP and its inflammatory signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Searching and functional analysis of an intracellular DNA sensorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Optimized Workflow for Enrichment and Identification of Biotinylated Peptides Using Tamavidin 2-REV for BioID and Cell Surface Proteomics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-autonomous <i>Toxoplasma</i> killing program requires Irgm2 but not its microbe vacuolar localization2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Phosphoproteomic identification and functional characterization of protein kinase substrates by 2D-DIGE and Phos-tag PAGE2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global Identification of ERK Substrates by Phosphoproteomics Based on IMAC and 2D-DIGE.2017

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.2015

Motani Kou 茂谷康

MOTANI Kou 茂谷康